The multifaceted role of reactive oxygen species in tumorigenesis

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21492 · Cited by 84,109

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691

Regulation of Ferroptotic Cancer Cell Death by GPX4

Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713

ROS function in redox signaling and oxidative stress

Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931

5-Fluorouracil: mechanisms of action and clinical strategies

Longley, D. B., Harkin, D. P., & Johnston, P. G. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1074 · Cited by 5,332

Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients

Gopalakrishnan, V., Spencer, C. N., Nezi, L., Reuben, A., Andrews, M. C., Karpinets, T. V., Prieto, P. A., Vicente, D., Hoffman, K., Wei, S. C., et al. (2018) · Science · doi:10.1126/science.aan4236 · Cited by 4,812

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732

Ferroptosis: process and function

Xie, Y., Hou, W., Song, X., Yu, Y., Huang, J., Sun, X., Kang, R., & Tang, D. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.158 · Cited by 3,727

ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis

D'Autréaux, B., & Toledano, M. B. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2256 · Cited by 3,642

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634

Modulation of oxidative stress as an anticancer strategy

Gorrini, C., Harris, I. S., & Mak, T. W. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4002 · Cited by 3,579

GLUTATHIONE TRANSFERASES

Hayes, J. D., Flanagan, J. U., & Jowsey, I. R. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.095857 · Cited by 3,565

Crosstalk of reactive oxygen species and NF-κB signaling

Morgan, M. J., & Liu, Z.-G. (2011) · Cell Research · doi:10.1038/cr.2010.178 · Cited by 3,505

Ferroptosis: Death by Lipid Peroxidation

Yang, W. S., & Stockwell, B. R. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.10.014 · Cited by 3,088

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Kagan, V. E., Mao, G., Qu, F., Angeli, J. P. F., Doll, S., Croix, C. S., Dar, H. H., Liu, B., Tyurin, V. A., Ritov, V. B., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2238 · Cited by 3,029

Signal integration by JNK and p38 MAPK pathways in cancer development

Wagner, E. F., & Nebreda, Á. R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2694 · Cited by 2,635

Physiological Roles of Mitochondrial Reactive Oxygen Species

Sena, L. A., & Chandel, N. S. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.09.025 · Cited by 2,632

Oxidative stress shortens telomeres

von Zglinicki, T. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02110-2 · Cited by 2,524

Requirement for Generation of H 2 O 2 for Platelet-Derived Growth Factor Signal Transduction

Sundaresan, M., Yu, Z.-X., Ferrans, V. J., Irani, K., & Finkel, T. (1995) · Science · doi:10.1126/science.270.5234.296 · Cited by 2,520

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

Ichijo, H., Nishida, E., Irie, K., ten Dijke, P., Saitoh, M., Moriguchi, T., Takagi, M., Matsumoto, K., Miyazono, K., & Gotoh, Y. (1997) · Science · doi:10.1126/science.275.5296.90 · Cited by 2,310

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

DeNicola, G. M., Karreth, F. A., Humpton, T. J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K. H., Yeo, C. J., Calhoun, E. S., et al. (2011) · Nature · doi:10.1038/nature10189 · Cited by 2,277

Transcriptional Regulation by Nrf2

Tonelli, C., Chio, I. I. C., & Tuveson, D. A. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7342 · Cited by 2,264

H 2 O 2 , a Necessary Evil for Cell Signaling

Rhee, S. G. (2006) · Science · doi:10.1126/science.1130481 · Cited by 2,160

ROS and the DNA damage response in cancer

Srinivas, U. S., Tan, B. W. Q., Vellayappan, B. A., & Jeyasekharan, A. D. (2019) · Redox Biology · doi:10.1016/j.redox.2018.101084 · Cited by 2,144

Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

Dixon, S. J., Patel, D. N., Welsch, M., Skouta, R., Lee, E. D., Hayano, M., Thomas, A. G., Gleason, C. E., Tatonetti, N. P., Slusher, B. S., et al. (2014) · eLife · doi:10.7554/elife.02523 · Cited by 2,088

Ferroptosis, a new form of cell death: opportunities and challenges in cancer

Mou, Y., Wang, J., Wu, J., He, D., Zhang, C., Duan, C., & Li, B. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0720-y · Cited by 1,964

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice

Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B. (2012) · Nature · doi:10.1038/nature11225 · Cited by 1,904

Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.

Yang, W. S., & Stockwell, B. R. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.02.010 · Cited by 1,876

Oxygen radicals and human disease

CROSS, C. E., HALLIWELL, B., BORISH, E. T., PRYOR, W. A., AMES, B. N., SAUL, R. L., McCORD, J. M., & HARMAN, D. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-4-526 · Cited by 1,856

Diversity of structures and properties among catalases

Chelikani, P., Fita, I., & Loewen, P. C. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3206-5 · Cited by 1,760

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

Weinberg, F., Hamanaka, R., Wheaton, W. W., Weinberg, S., Joseph, J., Lopez, M., Kalyanaraman, B., Mutlu, G. M., Budinger, G. R. S., & Chandel, N. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003428107 · Cited by 1,742

Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?

Sabharwal, S. S., & Schumacker, P. T. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3803 · Cited by 1,680

NRF2 and the Hallmarks of Cancer

Rojo de la Vega, M., Chapman, E., & Zhang, D. D. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.022 · Cited by 1,672

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

Irani, K., Xia, Y., Zweier, J. L., Sollott, S. J., Der, C. J., Fearon, E. R., Sundaresan, M., Finkel, T., & Goldschmidt-Clermont, P. J. (1997) · Science · doi:10.1126/science.275.5306.1649 · Cited by 1,588

Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Cycle or a Double-Edged Sword?

Malhotra, J. D., & Kaufman, R. J. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1782 · Cited by 1,588

Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia

Stein, E. M., DiNardo, C. D., Pollyea, D. A., Fathi, A. T., Roboz, G. J., Altman, J. K., Stone, R. M., DeAngelo, D. J., Levine, R. L., Flinn, I. W., et al. (2017) · Blood · doi:10.1182/blood-2017-04-779405 · Cited by 1,516

Mechanisms of ferroptosis

Cao, J. Y., & Dixon, S. J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2194-1 · Cited by 1,515

Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages

Ishii, T., Itoh, K., Takahashi, S., Sato, H., Yanagawa, T., Katoh, Y., Bannai, S., & Yamamoto, M. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.21.16023 · Cited by 1,473

Cancer and the microbiota

Garrett, W. S. (2015) · Science · doi:10.1126/science.aaa4972 · Cited by 1,404

Mitochondria are required for antigen-specific t cell activation through reactive oxygen species signaling

Sena, L. A., Li, S., Jairaman, A., Prakriya, M., Ezponda, T., Hildeman, D. A., Wang, C.-R., Schumacker, P. T., Licht, J. D., Perlman, H., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.10.020 · Cited by 1,338

The emerging role of the Nrf2–Keap1 signaling pathway in cancerPreprint

Jaramillo, M. C., & Zhang, D. D. (2013) · Genes & Development · doi:10.1101/gad.225680.113 · Cited by 1,328

Oxidative stress inhibits distant metastasis by human melanoma cells

Piskounova, E., Agathocleous, M., Murphy, M. M., Hu, Z., Huddlestun, S. E., Zhao, Z., Leitch, A. M., Johnson, T. M., DeBerardinis, R. J., & Morrison, S. J. (2015) · Nature · doi:10.1038/nature15726 · Cited by 1,269

Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

Aggarwal, V., Tuli, H. S., Varol, A., Thakral, F., Yerer, M. B., Sak, K., Varol, M., Jain, A., Khan, M. A., & Sethi, G. (2019) · Biomolecules · doi:10.3390/biom9110735 · Cited by 1,260

Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways?

Son, Y., Cheong, Y.-K., Kim, N.-H., Chung, H.-T., Kang, D. G., & Pae, H.-O. (2011) · Journal of Signal Transduction · doi:10.1155/2011/792639 · Cited by 1,219

Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide

Bae, Y. S., Kang, S. W., Seo, M. S., Baines, I., Tekle, E., Chock, P. B., & Rhee, S. G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.1.217 · Cited by 1,208

Cancer prevention by tea: animal studies, molecular mechanisms and human relevance

Yang, C. S., Wang, X., Lü, G., & Picinich, S. C. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2641 · Cited by 1,153

Free radicals and diabetes

Oberley, L. W. (1988) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(88)90036-6 · Cited by 1,105

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

Zilka, O., Shah, R., Li, B., Angeli, J. P. F., Grießer, M., Conrad, M., & Pratt, D. A. (2017) · ACS Central Science · doi:10.1021/acscentsci.7b00028 · Cited by 1,084

Reversible Inactivation of the Tumor Suppressor PTEN by H2O2

Lee, S.-R., Yang, K., Kwon, J., Lee, C., Jeong, W., & Rhee, S. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111899200 · Cited by 1,061

Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

Dewhirst, M. W., Cao, Y., & Moeller, B. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2397 · Cited by 1,022

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

Shimada, K., Skouta, R., Kaplan, A., Yang, W. S., Hayano, M., Dixon, S. J., Brown, L. M., Valenzuela, C. A., Wolpaw, A. J., & Stockwell, B. R. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2079 · Cited by 1,017

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

Harris, I. S., Treloar, A. E., Inoue, S., Sasaki, M., Gorrini, C., Lee, K. C., Yung, K. Y., Brenner, D., Knobbe-Thomsen, C. B., Cox, M. A., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.11.019 · Cited by 993

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

Rottenberg, S., Jaspers, J. E., Kersbergen, A. J., van der Burg, E., Nygren, A. O. H., Zander, S. A. L., Derksen, P. W. B., de Bruin, M., Zevenhoven, J., Lau, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806092105 · Cited by 975

Mitochondria in the Regulation of Innate and Adaptive Immunity

Weinberg, S. E., Sena, L. A., & Chandel, N. S. (2015) · Immunity · doi:10.1016/j.immuni.2015.02.002 · Cited by 960

Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

Salmeen, A., Andersen, J. N., Myers, M. P., Meng, T.-C., Hinks, J. A., Tonks, N. K., & Barford, D. (2003) · Nature · doi:10.1038/nature01680 · Cited by 951

Mechanisms of action of arsenic trioxide.

Miller, W. H., Schipper, H. M., Lee, J. S., Singer, J. W., & Waxman, S. (2002) · PubMed · Cited by 941

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

Yun, J., Mullarky, E., Lu, C., Bosch, K. N., Kavalier, A., Rivera, K., Roper, J., Chio, I. I. C., Giannopoulou, E. G., Rago, C., et al. (2015) · Science · doi:10.1126/science.aaa5004 · Cited by 913

ROS-dependent signal transduction

Reczek, C. R., & Chandel, N. S. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.09.010 · Cited by 877

Nrf2–Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species

Kobayashi, M., & Yamamoto, M. P. (2006) · Advances in Enzyme Regulation · doi:10.1016/j.advenzreg.2006.01.007 · Cited by 862

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

Wang, X.-J., Sun, Z., Villeneuve, N. F., Zhang, S., Zhao, F., Li, Y., Chen, W., Yi, X., Zheng, W., Wondrak, G. T., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn095 · Cited by 839

Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer

Dong, C., Yuan, T., Wu, Y., Wang, Y., Fan, T. W. ‐., Miriyala, S., Lin, Y., Yao, J., Shi, J., Kang, T., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.01.022 · Cited by 819

The superoxide-generating NADPH oxidase: structural aspects and activation mechanism

Vignais, P. V. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8520-9 · Cited by 799

Ferroptosis: A Novel Anti-tumor Action for Cisplatin

Guo, J., Xu, B.-F., Han, Q., Zhou, H., Xia, Y. F., Gong, C., Dai, X., Li, Z., & Wu, G. (2017) · Cancer Research and Treatment · doi:10.4143/crt.2016.572 · Cited by 796

The Anthracycline Antineoplastic Drugs

Young, R. C., Ozols, R. F., & Myers, C. E. (1981) · New England Journal of Medicine · doi:10.1056/nejm198107163050305 · Cited by 794

The role of cellular reactive oxygen species in cancer chemotherapy

Yang, H., Villani, R. M., Wang, H., Simpson, M. J., Roberts, M. S., Tang, M., & Liang, X. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0909-x · Cited by 794

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

Gaschler, M. M., Andia, A. A., Liu, H., Csuka, J. M., Hurlocker, B., Vaiana, C. A., Heindel, D. W., Zuckerman, D. S., Bos, P. H., Reznik, E., et al. (2018) · Nature Chemical Biology · doi:10.1038/s41589-018-0031-6 · Cited by 750

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

Scharping, N. E., Menk, A. V., Moreci, R. S., Whetstone, R. D., Dadey, R., Watkins, S. C., Ferris, R. L., & Delgoffe, G. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.08.009 · Cited by 705

Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis

Roh, J.-L., Kim, E. H., Jang, H., & Shin, D. (2017) · Redox Biology · doi:10.1016/j.redox.2016.12.010 · Cited by 662

Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis -induced colon tumorigenesis

Goodwin, A. C., Shields, C. E. D., Wu, S., Huso, D. L., Wu, X., Murray-Stewart, T. R., Hacker-Prietz, A., Rabizadeh, S., Woster, P. M., Sears, C. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010203108 · Cited by 612

Salinomycin kills cancer stem cells by sequestering iron in lysosomes

Mai, T. T., Hamaï, A., Hienzsch, A., Cañeque, T., Müller, S., Wicinski, J., Cabaud, O., Leroy, C., David, A., Acevedo, V., et al. (2017) · Nature Chemistry · doi:10.1038/nchem.2778 · Cited by 612

Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides

Rhee, S. G., Woo, H. A., Kil, I. S., & Bae, S. H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r111.283432 · Cited by 603

Redox regulation of mitochondrial function

Handy, D. E., & Loscalzo, J. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4123 · Cited by 588

Reactive Oxygen Species (ROS)––Induced genetic and epigenetic alterations in human carcinogenesis

Ziech, D., Franco, R., Pappa, A., & Panayiotidis, M. I. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.02.015 · Cited by 587

Hallmarks of cancer stem cell metabolism

Sancho, P., Barneda, D., & Heeschen, C. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.152 · Cited by 577

Longitudinal molecular trajectories of diffuse glioma in adults

Barthel, F. P., Johnson, K. C., Varn, F. S., Moskalik, A. D., Tanner, G., Kocakavuk, E., Anderson, K. J., Abiola, O., Aldape, K., Alfaro-Munoz, K. D., et al. (2019) · Nature · doi:10.1038/s41586-019-1775-1 · Cited by 565

Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells

Sahra, I. B., Laurent, K., Giuliano, S., Larbret, F., Ponzio, G., Gounon, P., MARCHAND‐BRUSTEL, Y. L., Giorgetti‐Peraldi, S., Cormont, M., Bertolotto, C., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2782 · Cited by 549

System x c ‐ cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS

Bridges, R. J., Natale, N. R., & Patel, S. A. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01480.x · Cited by 542

Reactive oxygen species in oncogenic transformation

Behrend, L., Henderson, G., & Zwacka, R. M. (2003) · Biochemical Society Transactions · doi:10.1042/bst0311441 · Cited by 531

Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells

Eling, N., Reuter, L., Hazin, J., Hamacher-Brady, A., & Brady, N. R. (2015) · Oncoscience · doi:10.18632/oncoscience.160 · Cited by 524

The Multifaceted Role of Curcumin in Cancer Prevention and Treatment

Shanmugam, M. K., Rane, G., Kanchi, M. M., Arfuso, F., Chinnathambi, A., Zayed, M. E., Alharbi, S. A., Tan, B. K. H., Kumar, A. P., & Sethi, G. (2015) · Molecules · doi:10.3390/molecules20022728 · Cited by 522

Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia

Scharping, N. E., Menk, A. V., Whetstone, R. D., Zeng, X., & Delgoffe, G. M. (2017) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-16-0103 · Cited by 520

Mitochondrial complex III is essential for suppressive function of regulatory T cells

Weinberg, S. E., Singer, B. D., Steinert, E. M., Martinez, C. A., Mehta, M., Martínez‐Reyes, I., Gao, P., Helmin, K. A., Abdala‐Valencia, H., Sena, L. A., et al. (2019) · Nature · doi:10.1038/s41586-018-0846-z · Cited by 505

Enterococcus faecalis produces extracellular superoxide and hydrogen peroxide that damages colonic epithelial cell DNA

Huycke, M. M., Abrams, V., & Moore, D. R. (2002) · Carcinogenesis · doi:10.1093/carcin/23.3.529 · Cited by 503

Reactive Oxygen Species in the Tumor Microenvironment: An Overview

Weinberg, F., Ramnath, N., & Nagrath, D. (2019) · Cancers · doi:10.3390/cancers11081191 · Cited by 502

PTEN signaling pathways in melanoma

Wu, H., Goel, V., & Haluska, F. G. (2003) · Oncogene · doi:10.1038/sj.onc.1206451 · Cited by 478

Thioredoxin and Thioredoxin Target Proteins: From Molecular Mechanisms to Functional Significance

Lee, S., Kim, S. M., & Lee, R. T. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4322 · Cited by 455

Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer

Koundouros, N., & Poulogiannis, G. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00160 · Cited by 425

p38α MAP Kinase as a Sensor of Reactive Oxygen Species in Tumorigenesis

Dolado, I., Swat, A., Ajenjo, N., Vita, G. D., Cuadrado, A., & Nebreda, Á. R. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.12.013 · Cited by 422

Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells

Marzano, C., Gandin, V., Folda, A., Scutari, G., Bindoli, A., & Rigobello, M. P. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.12.021 · Cited by 420

Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors.

Lachaier, E., Louandre, C., Godin, C., Saidak, Z., Baert, M., Diouf, M., Chauffert, B., & Galmiche, A. (2014) · PubMed · Cited by 396

Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma

Siska, P. J., Beckermann, K. E., Mason, F. M., Andrejeva, G., Greenplate, A. R., Sendor, A. B., Chiang, Y.-C. J., Corona, A. L., Gemta, L. F., Vincent, B. G., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.93411 · Cited by 389

Epigenetic Changes Induced by Reactive Oxygen Species in Hepatocellular Carcinoma: Methylation of the E-cadherin Promoter

Lim, S., Gu, J.-M., Kim, M. S., Kim, H. S., Park, Y. N., Park, C. K., Cho, J. W., Park, Y. M., & Jung, G. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.07.027 · Cited by 386

Identification of differentially expressed genes in pancreatic cancer cells using cDNA microarray.

Han, H., Bearss, D. J., Browne, L. W., Calaluce, R., Nagle, R. B., & Hoff, D. D. V. (2002) · PubMed · Cited by 380

Controlled Elimination of Intracellular H 2 O2: Regulation of Peroxiredoxin, Catalase, and Glutathione Peroxidase via Post-translational Modification

Rhee, S. G., Yang, K.-S., Kang, S. W., Woo, H. A., & Chang, T.-S. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.619 · Cited by 376

Loss of Kelch-Like ECH-Associated Protein 1 Function in Prostate Cancer Cells Causes Chemoresistance and Radioresistance and Promotes Tumor Growth

Zhang, P., Singh, A., Yegnasubramanian, S., Esopi, D., Kombairaju, P., Bodas, M., Wu, H., Bova, G. S., & Biswal, S. S. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0589 · Cited by 376

Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure

Müller, T., Dewitz, C., Schmitz, J., Schröder, A. S., Bräsen, J. H., Stockwell, B. R., Murphy, J. M., Kunzendorf, U., & Krautwald, S. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2547-4 · Cited by 370

Beneficial role of Nrf2 in regulating NADPH generation and consumption

Wu, K. C., Cui, J. Y., & Klaassen, C. D. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr183 · Cited by 368

Bioactive natural products in cancer prevention and therapy: Progress and promise

Bishayee, A., & Sethi, G. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2016.08.006 · Cited by 360

Bile acids as endogenous etiologic agents in gastrointestinal cancer

Bernstein, H., Bernstein, C., Payne, C. M., & Dvorak, K. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.3329 · Cited by 340

Reactive Oxygen Species in Cancer Stem Cells

Shi, X., Zhang, Y., Zheng, J., & Pan, J. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4529 · Cited by 334

An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential

Wang, L., de Oliveira, R. L., Huijberts, S. C. F. A., Bosdriesz, E., Pencheva, N., Brunen, D., Bosma, A. R., Song, J., Zevenhoven, J., Vries, G. T. L.-D., et al. (2018) · Cell · doi:10.1016/j.cell.2018.04.012 · Cited by 334

PML/RARA Oxidation and Arsenic Binding Initiate the Antileukemia Response of As2O3

Jeanne, M., Lallemand-Breitenbach, V., Ferhi, O., Koken, M. H. M., Bras, M. L., Duffort, S., Pérès, L., Berthier, C., Soilihi, H., Raught, B., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.06.003 · Cited by 332

β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation

Park, K., Nam, D., Yun, H., Lee, S., Jang, H.-J., Sethi, G., Cho, S. K., & Ahn, K. S. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.08.001 · Cited by 331

Antioxidant Role of Glutathione S -Transferases: Protection Against Oxidant Toxicity and Regulation of Stress-Mediated Apoptosis

Sharma, R., Yang, Y., Sharma, A., Awasthi, S., & Awasthi, S. (2004) · Antioxidants and Redox Signaling · doi:10.1089/152308604322899350 · Cited by 326

PI3K is a key molecule in the Nrf2‐mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells

Nakaso, K., Yano, H., Fukuhara, Y., Takeshima, T., Wada‐Isoe, K., & Nakashima, K. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00517-9 · Cited by 324

Ferroptosis: bug or feature?

Dixon, S. J. (2017) · Immunological Reviews · doi:10.1111/imr.12533 · Cited by 314

Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells

Liu, P., Brown, S., Goktug, T., Channathodiyil, P., Kannappan, V., Hugnot, J.-P., Guichet, P., Bian, X., Armesilla, A. L., Darling, J. L., et al. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.442 · Cited by 300

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function

Sasaki, M., Knobbe, C. B., Itsumi, M., Elia, A. J., Harris, I. S., Chio, I. I. C., Cairns, R. A., McCracken, S., Wakeham, A., Haight, J., et al. (2012) · Genes & Development · doi:10.1101/gad.198200.112 · Cited by 296

Genomic instability in myeloid malignancies: Increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair

Sallmyr, A., Fan, J., & Rassool, F. V. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.036 · Cited by 285

Reactive oxygen species-dependent signaling regulates cancer

Weinberg, F. D., & Chandel, N. S. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0099-y · Cited by 279

EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer

Shankar, S. (2007) · Frontiers in bioscience · doi:10.2741/2691 · Cited by 273

Overexpression of Akt converts radial growth melanoma to vertical growth melanoma

Govindarajan, B., Sligh, J. E., Vincent, B. J., Li, M., Canter, J. A., Nickoloff, B. J., Rodenburg, R. J., Smeitink, J. A. M., Oberley, L. W., Zhang, Y., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30102 · Cited by 270

Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions

Liou, G.-Y., Döppler, H., DelGiorno, K. E., Zhang, L., Leitges, M., Crawford, H. C., Murphy, M. P., & Storz, P. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.029 · Cited by 270

Telomerase: central regulator of all of the hallmarks of cancer

Low, K. C., & Tergaonkar, V. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.07.001 · Cited by 265

Glutathione S-Transferase p Elicits Protection against H2O2-induced Cell Death via Coordinated Regulation of Stress Kinases

Yin, Z., Ivanov, V. N., Habelhah, H., Tew, K. D., & Ronai, Z. A. (2000) · PubMed · doi:10.7916/d8571b9j · Cited by 264

Clinical trials of antioxidants as cancer prevention agents: Past, present, and future

Goodman, M. G., Bostick, R. M., Küçük, Ö., & Jones, D. P. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.018 · Cited by 262

Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis

Buccarelli, M., Marconi, M., Pacioni, S., Pascalis, I. D., D’Alessandris, Q. G., Martini, M., Ascione, B., Malorni, W., Larocca, L. M., Pallini, R., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0864-7 · Cited by 262

MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer

Hart, P. C., Mao, M., de Abreu, A. L. P., Ansenberger-Fricano, K., Ekoue, D. N., Ganini, D., Kajdacsy-Balla, A., Diamond, A. M., Minshall, R. D., Consolaro, M. E. L., et al. (2015) · Nature Communications · doi:10.1038/ncomms7053 · Cited by 260

Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis

Satoh, H., Moriguchi, T., Takai, J., Ebina, M., & Yamamoto, M. P. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4499 · Cited by 254

Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species

Kraaij, M. D., Savage, N. D. L., van der Kooij, S. W., Koekkoek, K. M., Wang, J., van den Berg, J. M., Ottenhoff, T. H. M., Kuijpers, T. W., Holmdahl, R., van Kooten, C., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012016107 · Cited by 253

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress

Shaw, A. T., Winslow, M. M., Magendantz, M., Ouyang, C., Dowdle, J. A., Subramanian, A., Lewis, T. A., Maglathin, R. L., Tolliday, N. J., & Jacks, T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105941108 · Cited by 232

Reactive Oxygen Production Induced by the Gut Microbiota: Pharmacotherapeutic Implications

Jones, R. M., Mercante, J. W., & Neish, A. S. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712799828283 · Cited by 232

Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds

Shanmugam, M. K., Lee, J. H., Chai, E. Z. P., Kanchi, M. M., Kar, S., Arfuso, F., Dharmarajan, A., Kumar, A. P., Samy, R. P., Looi, C. Y., et al. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2016.03.005 · Cited by 232

Increased expression of thioredoxin-1 in human colorectal cancer is associated with decreased patient survival

Raffel, J., Bhattacharyya, A. K., Gallegos, A. C., Cui, H., Einspahr, J. G., Alberts, D. S., & Powis, G. (2003) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(03)00068-4 · Cited by 223

Oxygen Sensing and Homeostasis

Prabhakar, N. R., & Semenza, G. L. (2015) · Physiology · doi:10.1152/physiol.00022.2015 · Cited by 223

Coexpressed Catalase Protects Chimeric Antigen Receptor–Redirected T Cells as well as Bystander Cells from Oxidative Stress–Induced Loss of Antitumor Activity

Ligtenberg, M. A., Mougiakakos, D., Mukhopadhyay, M., Witt, K., Lladser, Á., Chmielewski, M. M., Riët, T., Abken, H., & Kiessling, R. W. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401710 · Cited by 222

PARP inhibitors in ovarian cancer

Franzese, E., Centonze, S., Diana, A., Carlino, F., Guerrera, L. P., Napoli, M. D., Vita, F. D., Pignata, S., Ciardiello, F., & Orditura, M. (2018) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2018.12.002 · Cited by 220

Interleukin-1β Induction of NFκB Is Partially Regulated by H2O2-mediated Activation of NFκB-inducing Kinase

Li, Q., & Engelhardt, J. F. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511153200 · Cited by 219

Phenethyl isothiocyanate: A comprehensive review of anti-cancer mechanisms

Gupta, P., Wright, S. E., Kim, S., & Srivastava, S. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.08.003 · Cited by 216

The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML

Zhou, J., Bi, C., Cheong, L.-L., Mahara, S., Liu, S.-C., Tay, K.-G., Koh, T.-L., Yu, Q., & Chng, W. J. (2011) · Blood · doi:10.1182/blood-2010-07-294827 · Cited by 216

Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS

Woo, C. C., Hsu, A., Kumar, A. P., Sethi, G., & Tan, K. H. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075356 · Cited by 216

The multifaceted role of glutathione S-transferases in cancer

Chatterjee, A., & Gupta, S. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.06.028 · Cited by 215

Potential Role of Natural Compounds as Anti-Angiogenic Agents in Cancer

Shanmugam, M. K., Warrier, S. R., Kumar, A. P., Sethi, G., & Arfuso, F. (2017) · Current Vascular Pharmacology · doi:10.2174/1570161115666170713094319 · Cited by 214

Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse

Garg, M., Nagata, Y., Kanojia, D., Mayakonda, A., Yoshida, K., Keloth, S. H., Zang, Z. J., Okuno, Y., Shiraishi, Y., Chiba, K., et al. (2015) · Blood · doi:10.1182/blood-2015-05-646240 · Cited by 212

The Promise and Perils of Antioxidants for Cancer Patients

Chandel, N. S., & Tuveson, D. A. (2014) · New England Journal of Medicine · doi:10.1056/nejmcibr1405701 · Cited by 211

Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis

Santos, J. H., Meyer, J. N., & Houten, B. V. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl098 · Cited by 208

Ginkgolic Acid Inhibits Invasion and Migration and TGF‐β‐Induced EMT of Lung Cancer Cells Through PI3K/Akt/mTOR Inactivation

Baek, S. H., Ko, J., Lee, J. H., Kim, C., Lee, H., Nam, D., Lee, J., Lee, S., Yang, W. M., Um, J., et al. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25426 · Cited by 207

Reactive oxygen species regulate epidermal growth factor-induced vascular endothelial growth factor and hypoxia-inducible factor-1α expression through activation of AKT and P70S6K1 in human ovarian cancer cells

Liu, L.-Z., Hu, Z., Xia, C., He, J., Zhou, Q., Shi, X., Fang, J. S., & Jiang, B. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.08.003 · Cited by 205

Chemical Approaches to Discovery and Study of Sources and Targets of Hydrogen Peroxide Redox Signaling Through NADPH Oxidase Proteins

Brewer, T. F., García, F., Onak, C. S., Carroll, K. S., & Chang, C. J. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034018 · Cited by 200

NF-κB in cancer therapy

Li, F., Zhang, J., Arfuso, F., Chinnathambi, A., Zayed, M. E., Alharbi, S. A., Kumar, A. P., Ahn, K. S., & Sethi, G. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1470-4 · Cited by 199

Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model

Kim, C., Lee, S., Yang, W. M., Arfuso, F., Um, J., Kumar, A. P., Bian, J., Sethi, G., & Ahn, K. S. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.05.038 · Cited by 196

Sodium arsenite induces ROS generation, DNA oxidative damage, HO-1 and c-Myc proteins, NF-κB activation and cell proliferation in human breast cancer MCF-7 cells

Ramos, R. R., López‐Carrillo, L., Rios-Perez, A. D., Vizcaya‐Ruíz, A. D., & Cebrián, M. E. (2008) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2008.09.021 · Cited by 195

Feasibility and correlates of arsenic trioxide combined with ascorbic acid-mediated depletion of intracellular glutathione for the treatment of relapsed/refractory multiple myeloma.

Bahlis, N. J., Grad, J. M., Jordan-McMurry, I., Neil, J., Reis, I., Kharfan‐Dabaja, M. A., Eckman, J. R., Goodman, M. S., Fernandez, H. F., Boise, L., et al. (2002) · PubMed · Cited by 190

Redox-sensitive alteration of replisome architecture safeguards genome integrity

Somyajit, K., Gupta, R., Polášek-Sedláčková, H., Neelsen, K. J., Ochs, F., Rask, M., Choudhary, C., & Lukas, J. (2017) · Science · doi:10.1126/science.aao3172 · Cited by 190

Tumor-induced myeloid-derived suppressor cells promote tumor progression through oxidative metabolism in human colorectal cancer

OuYang, L.-Y., Wu, X.-J., Ye, S., Zhang, R.-X., Li, Z.-L., Liao, W., Pan, Z.-Z., Zheng, L., Zhang, X.-S., Wang, Z., et al. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0410-7 · Cited by 189

New horizons in hypoxia signaling pathways

Pugh, C. W., & Ratcliffe, P. J. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.03.008 · Cited by 186

Comprehensive review on how platinum- and taxane-based chemotherapy of ovarian cancer affects biology of normal cells

Mikuła‐Pietrasik, J., Witucka, A., Pakuła, M., Uruski, P., Krasińska, B., Niklas, A. A., Tykarski, A., & Książek, K. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2954-1 · Cited by 181

Cell cycle arrest, apoptosis induction and inhibition of nuclear factor kappa B activation in anti-proliferative activity of benzyl isothiocyanate against human pancreatic cancer cells

Srivastava, S. K. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh179 · Cited by 180

Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria

Sharma, N. K., Reyes, A., Green, P., Caron, M. J., Bonini, M. G., Gordon, D. M., Holt, I. J., & Santos, J. H. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr758 · Cited by 179

Cisplatin Resistance Associated with PARP Hyperactivation

Michels, J., Vitale, I., Galluzzi, L., Adam, J., Olaussen, K. A., Kepp, O., Senovilla, L., Talhaoui, I., Guegan, J., Enot, D. P., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3000 · Cited by 176

Host mitochondria influence gut microbiome diversity: A role for ROS

Yardeni, T., Tanes, C., Bittinger, K. L., Mattei, L. M., Schaefer, P. M., Singh, L. N., Wu, G. D., Murdock, D. G., & Wallace, D. C. (2019) · Science Signaling · doi:10.1126/scisignal.aaw3159 · Cited by 172

Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo

Sethi, G., Chatterjee, S., Rajendran, P., Li, F., Shanmugam, M. K., Wong, K., Kumar, A. P., Senapati, P., Behera, A. K., Hui, K. M., et al. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-66 · Cited by 171

Dual targeting of the thioredoxin and glutathione systems in cancer and HIV

Benhar, M., Shytaj, I. L., Stamler, J. S., & Savarino, A. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85339 · Cited by 170

ROS-NFκΒ mediates TGF-β1-induced expression of urokinase-type plasminogen activator, matrix metalloproteinase-9 and cell invasion

Tobar, N., Villar, V. H., & Santibanez, J. F. (2010) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-010-0418-5 · Cited by 168

Activation of STAT3 and Bcl-2 and reduction of reactive oxygen species (ROS) promote radioresistance in breast cancer and overcome of radioresistance with niclosamide

Lu, L., Dong, J., Wang, L., Xia, Q., Zhang, D., Kim, H.-J., Yin, T., Fan, S., & Shen, Q. (2018) · Oncogene · doi:10.1038/s41388-018-0340-y · Cited by 166

Phase I trial of buthionine sulfoximine in combination with melphalan in patients with cancer.

O'Dwyer, P. J., Hamilton, T. C., LaCreta, F. P., Gallo, J. M., Kilpatrick, D. L., Halbherr, T., Brennan, J. M., Bookman, M. A., Hoffman, J., Young, R. C., et al. (1996) · Journal of Clinical Oncology · doi:10.1200/jco.1996.14.1.249 · Cited by 162

Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model

Zhang, J., Ahn, K. S., Kim, C., Shanmugam, M. K., Siveen, K. S., Arfuso, F., Samy, R. P., Deivasigamanim, A., Lim, L. H. K., Wang, L., et al. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6418 · Cited by 162

Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κB signaling cascade in gastric cancer

Manu, K. A., Shanmugam, M. K., Ramachandran, L., Li, F., Siveen, K. S., Chinnathambi, A., Zayed, M. E., Alharbi, S. A., Arfuso, F., Kumar, A. P., et al. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.03.033 · Cited by 159

Pancratistatin: A natural anti-cancer compound that targets mitochondria specifically in cancer cells to induce apoptosis

McLachlan, A., Kekre, N. K., McNulty, J., & Pandey, S. (2005) · APOPTOSIS · doi:10.1007/s10495-005-1896-x · Cited by 156

Targeting Glutathione Metabolism: Partner in Crime in Anticancer Therapy

Desideri, E., Ciccarone, F., & Ciriolo, M. R. (2019) · Nutrients · doi:10.3390/nu11081926 · Cited by 155

γ-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model

Siveen, K. S., Ahn, K. S., Ong, T. H., Shanmugam, M. K., Li, F., Yap, W. N., Kumar, A. P., Fong, C. W., Tergaonkar, V., Hui, K. M., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.1876 · Cited by 153

2-Deoxy-d-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer

Coleman, M. C., Asbury, C., Daniels, D. H., Du, J., Aykin‐Burns, N., Smith, B. J., Li, L., Spitz, D. R., & Cullen, J. J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.08.032 · Cited by 153

Long-Range Chromatin Interactions Drive Mutant TERT Promoter Activation

Akıncılar, S. C., Khattar, E., Boon, P. L. S., Unal, B., Fullwood, M. J., & Tergaonkar, V. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0177 · Cited by 152

Attenuation of CD4+CD25+ Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug

Kunisada, Y., Eikawa, S., Tomonobu, N., Domae, S., Uehara, T., Hori, S., Furusawa, Y., Hase, K., Sasaki, A., & Udono, H. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.10.009 · Cited by 152

Butein induces G2/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation

Moon, D.-O., Kim, M.-O., Choi, Y. H., Hyun, J. W., Chang, W. Y., & Kim, G.-Y. (2010) · Cancer Letters · doi:10.1016/j.canlet.2009.07.002 · Cited by 151

2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism.

Lin, X. J., Zhang, F., Bradbury, C. M., Kaushal, A., Li, L., Spitz, D. R., Aft, R., & Gius, D. R. (2003) · PubMed · Cited by 149

Honokiol inhibits signal transducer and activator of transcription‐3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP‐1

Rajendran, P., Li, F., Shanmugam, M. K., Vali, S., Abbasi, T., Kapoor, S., Ahn, K. S., Kumar, A. P., & Sethi, G. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22954 · Cited by 148

First Evidence That γ-Tocotrienol Inhibits the Growth of Human Gastric Cancer and Chemosensitizes It to Capecitabine in a Xenograft Mouse Model through the Modulation of NF-κB Pathway

Manu, K. A., Shanmugam, M. K., Ramachandran, L., Li, F., Fong, C. W., Kumar, A. P., Tan, P. B. O., & Sethi, G. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2470 · Cited by 146

Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-κB and Nrf2

Xu, B., Wang, S., Li, R., Chen, K., He, L., Deng, M., Kannappan, V., Zha, J., Dong, H., & Wang, W. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.176 · Cited by 145

Novel Role for Mitochondria: Protein Kinase Cθ-Dependent Oxidative Signaling Organelles in Activation-Induced T-Cell Death

Kamiński, M. M., Kießling, M. K., Süss, D., Krammer, P. H., & Gülow, K. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02295-06 · Cited by 144

Overexpression of peroxiredoxin I and thioredoxin1 in human breast carcinoma

Cha, M., Suh, K.-H., & Kim, I.-H. (2009) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-28-93 · Cited by 143

A catalogue of somatic NRF2 gain-of-function mutations in cancer

Kerins, M. J., & Ooi, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-31281-0 · Cited by 140

Mitochondrial Genome Instability and ROS Enhance Intestinal Tumorigenesis in APC Mice

Woo, D. K., Green, P. D., Santos, J. H., D’Souza, A. D., Walther, Z., Martin, W. D., Christian, B. E., Chandel, N. S., & Shadel, G. S. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.10.003 · Cited by 138

Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression

Khattar, E., Kumar, P., Liu, C. Y., Akıncılar, S. C., Raju, A., Lakshmanan, M., Maury, J. J. P., Yu, Q., Li, S., Tan, E. Y., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86042 · Cited by 135

The x c − cystine/glutamate antiporter as a potential therapeutic target for small-cell lung cancer: use of sulfasalazine

Guan, J., Lo, M., Dockery, P., Mahon, S., Karp, C. M., Buckley, A. R., Lam, S., Gout, P. W., & Wang, Y.-Z. (2009) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-008-0894-4 · Cited by 134

Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema

Sehm, T., Fan, Z., Ghoochani, A., Rauh, M., Engelhorn, T., Minakaki, G., Dörfler, A., Klucken, J., Buchfelder, M., Eyüpoglu, I. Y., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8651 · Cited by 134

DEAD-box helicase DP103 defines metastatic potential of human breast cancers

Shin, E. M., Hay, H. S., Lee, M. H., Goh, J. N., Tan, T. Z., Sen, Y. P., Lim, S. W., Yousef, E. M., Ong, H. T., Thike, A. A., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci73451 · Cited by 132

Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas.

Choi, J. H., Tn, K., Kim, S., Baek, S., Jh, K., Lee, & Kim, J.-R. (2002) · PubMed · Cited by 130

Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-κB signaling

Qu, Y., Wang, J., Ray, P., Guo, H., Huang, J., Shin-Sim, M., Bukoye, B. A., Liu, B., Lee, A. V., Lin, X., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43144 · Cited by 128

Targeting STAT3 and oxidative phosphorylation in oncogene-addicted tumors

Lee, M., Hirpara, J. L., Eu, J. Q., Sethi, G., Wang, L., Goh, B.-C., & Wong, A. L. A. (2018) · Redox Biology · doi:10.1016/j.redox.2018.101073 · Cited by 128

High NRF2 level mediates cancer stem cell-like properties of aldehyde dehydrogenase (ALDH)-high ovarian cancer cells: inhibitory role of all-trans retinoic acid in ALDH/NRF2 signaling

Kim, D., Choi, B.-H., Ryoo, I.-G., & Kwak, M. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0903-4 · Cited by 126

Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistance

Hirpara, J. L., Eu, J. Q., Tan, J. K. M., Wong, A. L., Clement, M., Kong, L. R., Ohi, N., Tsunoda, T., Qu, J., Goh, B. C., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2018.101076 · Cited by 126

Elevated level of mitochondrial reactive oxygen species via fatty acid β-oxidation in cancer stem cells promotes cancer metastasis by inducing epithelial–mesenchymal transition

Wang, C., Shao, L., Pan, C., Ye, J., Ding, Z., Wu, J., Du, Q., Ren, Y., & Zhu, C. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1265-2 · Cited by 126

Estrogen controls the survival of BRCA1-deficient cells via a PI3K–NRF2-regulated pathway

Gorrini, C., Gang, B. P., Bassi, C., Wakeham, A. C., Baniasadi, S. P., Hao, Z., Li, W. Y., Cescon, D. W., Li, Y.-T., Molyneux, S. D., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1324136111 · Cited by 124

The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies

Arora, L., Kumar, A. P., Arfuso, F., Chng, W. J., & Sethi, G. (2018) · Cancers · doi:10.3390/cancers10090327 · Cited by 124

Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4

Manu, K. A., Shanmugam, M. K., Rajendran, P., Li, F., Ramachandran, L., Hay, H. S., Kannaiyan, R., Swamy, S. N., Vali, S., Kapoor, S., et al. (2011) · Molecular Cancer · doi:10.1186/1476-4598-10-107 · Cited by 122

A role for GPx3 in activity of normal and leukemia stem cells

Hérault, O., Hope, K. J., Deneault, É., Mayotte, N., Chagraoui, J., Wilhelm, B. T., Cellot, S., Sauvageau, M., Andrade-Navarro, M. A., Hébert, J., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20102386 · Cited by 122

Potential Use of the Anti-Inflammatory Drug, Sulfasalazine, for Targeted Therapy of Pancreatic Cancer

Lo, M., Ling, V., Low, C., Wang, Y. Z., & Gout, P. W. (2010) · Current Oncology · doi:10.3747/co.v17i3.485 · Cited by 120

Metabolic Regulation of Redox Balance in Cancer

Purohit, V., Simeone, D. M., & Lyssiotis, C. A. (2019) · Cancers · doi:10.3390/cancers11070955 · Cited by 120

Metformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma

Zhou, X., Chen, J., Gao, Y., Deng, M., Liu, H., Liang, M., Shi, B., Fu, X., Chen, Y., Chen, L., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6418 · Cited by 113

Phase 2 study of neoadjuvant treatment with NOV-002 in combination with doxorubicin and cyclophosphamide followed by docetaxel in patients with HER-2 negative clinical stage II–IIIc breast cancer

Montero, A. J., Diaz-Montero, C. M., Deutsch, Y. E., Hurley, J. E., Koniaris, L. G., Rumboldt, T., Yasir, S., Jorda, M., Garret-Mayer, E., Avisar, E., et al. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1889-0 · Cited by 112

Elimination of stem-like cancer cell side-population by auranofin through modulation of ROS and glycolysis

Hou, G., Liu, P., Zhang, S., Yang, M., Liao, J., Yang, J., Hu, Y., Jiang, W.-Q., Wen, S., & Huang, P. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0159-4 · Cited by 109

Preferential elevation of Prx I and Trx expression in lung cancer cells following hypoxia and in human lung cancer tissues

Kim, H. J., Chae, H. Z., KIM, Y., Kim, Y. H., Hwang, T. S., Park, E.-M., & Park, Y.-M. (2003) · Cell Biology and Toxicology · doi:10.1023/b:cbto.0000004952.07979.3d · Cited by 108

Redox Regulation of MAP Kinase Phosphatase 3

Seth, D., & Rudolph, J. (2006) · Biochemistry · doi:10.1021/bi060157p · Cited by 105

Non-apoptotic cell death in malignant tumor cells and natural compounds

Ye, J., Zhang, R., Wu, F., Zhai, L., Wang, K., Xiao, M., Xie, T., & Sui, X. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.01.061 · Cited by 103

NADPH Oxidase-generated Hydrogen Peroxide Induces DNA Damage in Mutant FLT3-expressing Leukemia Cells

Stanicka, J., Russell, E. G., Woolley, J. F., & Cotter, T. G. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.510495 · Cited by 101

Metastasis and Oxidative Stress: Are Antioxidants a Metabolic Driver of Progression?

Peiris‐Pagès, M., Martinez‐Outschoorn, U., Sotgia, F., & Lisanti, M. P. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.11.008 · Cited by 101

Activation of mutant TERT promoter by RAS-ERK signaling is a key step in malignant progression of BRAF-mutant human melanomas

Li, Y., Cheng, H. S., Chng, W. J., & Tergaonkar, V. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1611106113 · Cited by 101

Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy

Gao, W., Wang, Y., Zhou, Y., Wang, X., & Yu, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01046-3 · Cited by 1,078

Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

Paskeh, M. D. A., Entezari, M., Mirzaei, S., Zabolian, A., Saleki, H., Naghdi, M. J., Sabet, S., Khoshbakht, M. A., Hashemi, M., Hushmandi, K., et al. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01305-4 · Cited by 582

From imbalance to impairment: the central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration

Afzal, S., Manap, A. S. A., Attiq, A., Albokhadaim, I. F., Kandeel, M. K., & Alhojaily, S. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1269581 · Cited by 482

The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities

Weaver, K., & Skouta, R. (2022) · Biomedicines · doi:10.3390/biomedicines10040891 · Cited by 288

Tanshinone IIA induces ferroptosis in gastric cancer cells through p53-mediated SLC7A11 down-regulation

Guan, Z., Chen, J., Li, X., & Dong, N. (2020) · Bioscience Reports · doi:10.1042/bsr20201807 · Cited by 235

On the Edge of Benefit and Harm: Reactive Oxygen Species in Cancer

Nikiforova, A. B. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27156887 · Cited by 1

Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

Aggarwal, V., Tuli, H. S., Varol, A., Thakral, F., Yerer, M. B., Sak, K., Varol, M., Jain, A., Khan, M. A., & Sethi, G. (2019) · Biomolecules · doi:10.3390/biom9110735 · Cited by 1,260

Role of Reactive Oxygen Species in Cancer Progression

Kashyap, D., Tuli, H. S., Sak, K., Garg, V. K., Goel, N., Punia, S., & Chaudhary, A. (2019) · Current Pharmacology Reports · doi:10.1007/s40495-019-00171-y · Cited by 70

Reactive oxygen species in cancer: a paradox between pro- and anti-tumour activities

Kohan, R., Collin, A., Guizzardi, S., de Talamoni, N. T., & Picotto, G. (2020) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-020-04103-2 · Cited by 45

Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications

Akter, S., Madhuvilakku, R., Kar, A. K., Nila, I. S., Liu, P., Inuzuka, H., Wei, W., & Hong, Y. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02583-x · Cited by 124