Synthesis, antioxidant evaluation, and quantitative structure–activity relationship studies of chalcones

Sivakumar, P. M.; Prabhakar, P. K.; Doble, M.

doi:10.1007/s00044-010-9342-1

Cited by 145Synthesis and biological activityFree Radicals and AntioxidantsSynthesis of Organic Compounds

Synthesis, antioxidant evaluation, and quantitative structure–activity relationship studies of chalcones

Sivakumar, P. M., Prabhakar, P. K., Doble, M.·2011·Medicinal Chemistry Research

DOI 10.1007/s00044-010-9342-1

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Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels
Beauchamp, C., & Fridovich, I. (1971) · Analytical Biochemistry · doi:10.1016/0003-2697(71)90370-8 · Cited by 12,892 · see citing works
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works
Structure-antioxidant activity relationships of flavonoids and phenolic acids
Rice-Evans, C. A., Miller, N. J., & Paganga, G. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02227-9 · Cited by 9,085 · see citing works
Studies on products of browning reaction. Antioxidative activities of products of browning reaction prepared from glucosamine.
Oyaizu, M. (1986) · The Japanese Journal of Nutrition and Dietetics · doi:10.5264/eiyogakuzashi.44.307 · Cited by 7,733 · see citing works
Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958 · see citing works
Flavonoids as Antioxidants
Pietta, P. (2000) · Journal of Natural Products · doi:10.1021/np9904509 · Cited by 4,881 · see citing works
Antioxidant properties of phenolic compounds
Rice-Evans, C. A., Miller, N., & Paganga, G. (1997) · Trends in Plant Science · doi:10.1016/s1360-1385(97)01018-2 · Cited by 4,407 · see citing works
Handbook of Molecular Descriptors
Todeschini, R., & Consonni, V. (2000) · Methods and Principles in Medicinal Chemistry · doi:10.1002/9783527613106 · Cited by 4,107 · cited 1× · see citing works
“Several papers deal with the explanation of these structural descriptors (Todeschini et al., 1994; Todeschini and Consonni, 2000; Karelson, 2000).”
Background
Analysis of Antioxidant Activities of Common Vegetables Employing Oxygen Radical Absorbance Capacity (ORAC) and Ferric Reducing Antioxidant Power (FRAP) Assays: A Comparative Study
Ou, B., Huang, D., Hampsch‐Woodill, M., Flanagan, J. A., & Deemer, E. K. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0116606 · Cited by 1,307 · see citing works
Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials
Vivekananthan, D. P., Penn, M. S., Sapp, S. K., Hsu, A., & Topol, E. J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13637-9 · Cited by 1,083 · see citing works
Free Radical Scavenging Properties of Wheat Extracts
Yu, L., Haley, S. D., Perret, J., Harris, M., Wilson, J., & Qian, M. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010964p · Cited by 1,001 · see citing works
Application of Genetic Function Approximation to Quantitative Structure-Activity Relationships and Quantitative Structure-Property Relationships
Rogers, D. O. W., & Hopfinger, A. J. (1994) · Journal of Chemical Information and Computer Sciences · doi:10.1021/ci00020a020 · Cited by 988 · see citing works
Characterization of the Total Free Radical Scavenger Capacity of Vegetable Oils and Oil Fractions Using 2,2-Diphenyl-1-picrylhydrazyl Radical
Espı́n, J. C., Soler‐Rivas, C., & Wichers, H. J. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9908188 · Cited by 703 · see citing works
Molecular descriptors in QSAR/QSPR
Karelson, M. M. (2000) · Cited by 702 · see citing works
Development and use of charged partial surface area structural descriptors in computer-assisted quantitative structure-property relationship studies
Stanton, D. T., & Jurs, P. C. (1990) · Analytical Chemistry · doi:10.1021/ac00220a013 · Cited by 654 · see citing works
Free radicals in cerebral ischemia.
Flamm, E. S., Demopoulos, H. B., Seligman, M. L., Poser, R. G., & Ransohoff, J. (1978) · Stroke · doi:10.1161/01.str.9.5.445 · Cited by 577 · see citing works
Invited Review Free Radicals in Disease Processes: A Compilation of Cause and Consequence
Gutteridge, J. M. C., & Halliwell, B. B. (1993) · Free Radical Research Communications · doi:10.3109/10715769309111598 · Cited by 571 · see citing works
Antioxidant Constituents from Licorice Roots: Isolation, Structure Elucidation and Antioxidative Capacity Toward LDL Oxidation
Vaya, J., Belinky, P. A., & Aviram, M. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00089-0 · Cited by 550 · see citing works
Excitotoxic and Excitoprotective Mechanisms: Abundant Targets for the Prevention and Treatment of Neurodegenerative Disorders
Mattson, M. P. (2003) · NeuroMolecular Medicine · doi:10.1385/nmm:3:2:65 · Cited by 475 · see citing works
Antioxidant properties of phenols
Foti, M. C. (2007) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.59.12.0010 · Cited by 382 · see citing works
The chemistry of chalcones and related compounds
DHAR, D. N. (1981) · Medical Entomology and Zoology · Cited by 346 · see citing works
The Chemistry of Chalcones and Related Compounds
Donnelly, D. M. X. (1982) · Phytochemistry · doi:10.1016/0031-9422(82)85234-5 · Cited by 331 · see citing works
Anthocyanin-Based Natural Colorants: A New Source of Antiradical Activity for Foodstuff
Espı́n, J. C., Soler‐Rivas, C., Wichers, H. J., & García‐Viguera, C. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9911390 · Cited by 325 · see citing works
New molecular descriptors for 2D and 3D structures. Theory
Todeschini, R., Lasagni, M., & Marengo, E. (1994) · Journal of Chemometrics · doi:10.1002/cem.1180080405 · Cited by 303 · see citing works
New optimization method for conformational energy calculations on polypeptides: Conformational space annealing
Lee, J., Scheraga, H. A., & Rackovsky, S. R. (1997) · Journal of Computational Chemistry · doi:10.1002/(sici)1096-987x(19970715)18:9 · Cited by 300 · see citing works
Oxidative DNA damage: assessment of the role in carcinogenesis, atherosclerosis, and acquired immunodeficiency syndrome1 1This article is part of a series of reviews on “Oxidative DNA Damage and Repair.” The full list of papers may be found on the homepage of the journal.
Oliński, R., Gackowski, D., Foksiński, M., Różalski, R., Roszkowski, K., & Jaruga, P. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00878-x · Cited by 283 · see citing works
Antioxidants in cancer therapy; their actions and interactions with oncologic therapies.
Lamson, D. W., & Brignall, M. S. (1999) · PubMed · Cited by 241 · see citing works
Descriptions of molecular shape applied in studies of structure/activity and structure/property relationships
Rohrbaugh, R. H., & Jurs, P. C. (1987) · Analytica Chimica Acta · doi:10.1016/s0003-2670(00)82801-9 · Cited by 227 · see citing works
Differential responses of superoxide dismutase in freezing resistant Solanum curtilobum and freezing sensitive Solanum tuberosum subjected to oxidative and water stress
Martínez, C. A., Loureiro, M., Oliva, M. A., & Maestri, M. (2001) · Plant Science · doi:10.1016/s0168-9452(00)00418-0 · Cited by 219 · see citing works
Density Functional Theory Study of the Conformational, Electronic, and Antioxidant Properties of Natural Chalcones
Kozlowski, D., Trouillas, P., Calliste, C.-A., Marsal, P., Lazzaroni, R., & Duroux, J. (2007) · The Journal of Physical Chemistry A · doi:10.1021/jp066496+ · Cited by 166 · see citing works
Determination of carotenoids in Dunaliella salina cultivated in Taiwan and antioxidant capacity of the algal carotenoid extract
Hu, C.-C., Lin, J.-T., Lu, F.-J., Chou, F., & Yang, D. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2007.12.043 · Cited by 164 · see citing works
Therapeutic strategies for the treatment of stroke
Green, A. R., & Shuaib, A. M. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.06.001 · Cited by 157 · see citing works
Quantitative Structure – Antioxidant Activity Relationships of Flavonoid Compounds
Farkas, O., Jakus, J., & Héberger, K. (2004) · Molecules · doi:10.3390/91201079 · Cited by 146 · see citing works
QSAR Studies on Chalcones and Flavonoids as Anti-tuberculosis Agents Using Genetic Function Approximation (GFA) Method
Sivakumar, P. M., Babu, S. K. G., & Mukesh, D. (2007) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.55.44 · Cited by 144 · see citing works
Self-citation
Anti‐tumorigenic chalcones
Shibata, S. (1994) · Stem Cells · doi:10.1002/stem.5530120109 · Cited by 116 · see citing works
The powerhouse takes control of the cell: Is the mitochondrial permeability transition a viable therapeutic target against neuronal dysfunction and death?
Stavrovskaya, I. G., & Kristal, B. S. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.11.032 · Cited by 113 · see citing works
Synthesis, antimycobacterial activity evaluation, and QSAR studies of chalcone derivatives
Sivakumar, P. M., Seenivasan, S. P., Kumar, V., & Doble, M. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.12.112 · Cited by 112 · see citing works
Self-citation
Influence of Molecular Structure on Substrate Binding to the Human Organic Cation Transporter, hOCT1
Bednarczyk, D., Ekins, S., Wikel, J. H., & Wright, S. H. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.3.489 · Cited by 111 · see citing works
Antioxidants in Cancer Therapy
Prasad, K. N., & Cole, W. C. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.04.1327 · Cited by 89 · see citing works
Prevention of cataracts by nutritional and metabolic antioxidants
Varma, S. D., Devamanoharan, P. S., & Morris, S. M. (1995) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408399509527691 · Cited by 84 · see citing works
Water solubility, antioxidant activity and cytochrome C binding of four families of exohedral adducts of C60 and C70
Witte, P., Beuerle, F., Hartnagel, U., Lebovitz, R. M., Savouchkina, A., Sali, S., Guldi, D. M., Chronakis, N., & Hirsch, A. (2007) · Organic & Biomolecular Chemistry · doi:10.1039/b711912g · Cited by 77 · see citing works
Molecular shape and the prediction of high-performance liquid chromatographic retention indexes of polycyclic aromatic hydrocarbons
Rohrbaugh, R. H., & Jurs, P. C. (1987) · Analytical Chemistry · doi:10.1021/ac00134a025 · Cited by 70 · see citing works
Antioxidant Chalcone Glycosides and Flavanones fromMaclura(Chlorophora)tinctoria
Cioffi, G., Escobar, L. M., Braca, A., & Tommasi, N. D. (2003) · Journal of Natural Products · doi:10.1021/np030127c · Cited by 67 · see citing works
Effects of culture duration on hydrogen peroxide-induced hepatocyte toxicity
Ruch, R. J., Crist, K. A., & Klaunig, J. E. (1989) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(89)90293-7 · Cited by 66 · see citing works
Down regulation of superoxide dismutases and glutathione peroxidase by reactive oxygen and nitrogen species
Fujii, J., & Taniguchi, N. (1999) · Free Radical Research · doi:10.1080/10715769900300861 · Cited by 66 · see citing works
Basic Statistics: Tools for Continuous Improvement
(1994) · Technometrics · doi:10.1080/00401706.1994.10485831 · Cited by 63 · see citing works
New analogues of butylated hydroxytoluene as anti-inflammatory and antioxidant agents
Ziakas, G. N., Rekka, E. A., Gavalas, A. M., Eleftheriou, P. T., & Kourounakis, P. N. (2006) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2006.04.030 · Cited by 55 · see citing works
How to understand the dichotomy of antioxidants
Shen, L., Ji, H., & Zhang, H. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.07.125 · Cited by 45 · see citing works
Synthesis and Biological Activities of N -Alkyl Derivatives of o-, m -, and p-Nitro (E )-4-Azachalcones and Stereoselective Photochemistry in Solution, with Theoretical Calculations
Yaylı, N., Üçüncü, O., Yaşar, A., Küçük, M., Yaylı, N., AKYÜZ, E., & Karaoğlu, Ş. A. (2006) · DergiPark (Istanbul University) · Cited by 37 · see citing works
Basic Statistics: Tools for Continuous Improvement
Nemeth, M. A., Kiemele, M. J., & Schmidt, S. R. (1992) · Technometrics · doi:10.2307/1269249 · Cited by 27 · see citing works
Stereoselective photochemistry of heteroaryl chalcones in solution and the antioxidant activities
Yaylı, N., Üçüncü, O., Aydın, E., Gök, Y., Yaşar, A., Baltacı, C., Yıldırım, N., & Küçük, M. (2004) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2004.06.015 · Cited by 25 · see citing works
Quantitative structure–activity relationship studies for antioxidant hydroxybenzalacetones by quantum chemical- and 3-D-QSAR(CoMFA) analyses
Yamagami, C., Akamatsu, M., Motohashi, N., Hamada, S., & Tanahashi, T. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.03.087 · Cited by 25 · see citing works
The preparation and photochemical properties of some 1,3-Diphenyl-2-pyrazolines containing a heteroaromatic substituent
Lin, J.-Y., Rivett, D., & Wilshire, J. (1977) · Australian Journal of Chemistry · doi:10.1071/ch9770629 · Cited by 24 · see citing works
Antiinflammatory, analgesic and antipyretic activities of 3-[4-[3-(4- dimethylaminophenyl)-1-oxo-2-propenyl]phenyl]sydnone
Satyanarayana, K. V. V. V., & Rao, M. (1993) · INDIAN DRUGS · Cited by 18 · see citing works
A molecular mechanism of the energetic coupling of a sequence of electron transfer reactions to endergonic reactions
Cartling, B. G., & Ehrenberg, A. (1978) · Biophysical Journal · doi:10.1016/s0006-3495(78)85461-7 · Cited by 15 · see citing works
Quantitative structure-activity relationships studies of antioxidant hexahydropyridoindoles and flavonoid derivatives
Durand, A., Farce, A., Carato, P., Dilly, S., Yous, S., Berthelot, P., & Chavatte, P. (2007) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756360701425238 · Cited by 14 · see citing works
Intramolecular 4π photocyclization of chalconoid-like compounds in solution and antimicrobial activities
Yaylı, N., SİVRİKAYA, S. Ö., Yaşar, A., Üçüncü, O., Güleç, C., Kolaylı, S., Küçük, M., & Çelik, E. (2005) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2005.03.025 · Cited by 11 · see citing works
Quantitative Structure–Activity Relationship Modeling of Growth Hormone Secretagogues Agonist Activity of some Tetrahydroisoquinoline 1‐Carboxamides
Caballero, J., Zampini, F. M., Collina, S., & Fernández, M. (2007) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2007.00467.x · Cited by 7 · see citing works

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Singh, P., Ȧnand, A., & Kumar, V. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.08.033 · Cited by 718 · see citing works
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Papuc, C. P., GORAN, G. V., Predescu, N. C., Nicorescu, V., & Ștefan, G. (2017) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12298 · Cited by 576 · see citing works
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Xu, M., Wu, P., Shen, F., Ji, J., & Rakesh, K. P. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.103133 · Cited by 260 · see citing works
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Gaonkar, S. L., & Vignesh, U. N. (2017) · Research on Chemical Intermediates · doi:10.1007/s11164-017-2977-5 · Cited by 214 · see citing works
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Tran, T., Nguyen, T.-T.-N., Do, T.-H., Huynh, T.-N.-P., Tran, C.-D., & Thai, K. (2012) · Molecules · doi:10.3390/molecules17066684 · Cited by 126 · see citing works
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Badalkhani‐Khamseh, F., Ebrahim‐Habibi, A., & Hadipour, N. L. (2018) · Journal of Molecular Recognition · doi:10.1002/jmr.2757 · Cited by 36 · see citing works
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Kudlicková, Z., Michalková, R., Salayová, A., Ksiažek, M., Vilková, M., Bekešová, S., & Mojžíš, J. (2023) · Molecules · doi:10.3390/molecules28186583 · Cited by 35 · see citing works
Synthesis of leading chalcones with high antiparasitic, against Hymenolepis nana, and antioxidant activities
Díaz-Carrillo, J. T., Díaz‐Camacho, S. P., Delgado‐Vargas, F., Rivero, I. A., López‐Ángulo, G., Sarmiento‐Sánchez, J. I., & Montes‐Ávila, J. (2018) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902018000317343 · Cited by 35 · see citing works
The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria
Meier, D., Vázquez‐Hernández, M., van Geelen, L., Muharini, R., Proksch, P., Bandow, J. E., & Kalscheuer, R. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.115151 · Cited by 35 · see citing works
Ferrocenyl chalcones with O-alkylated vanillins: synthesis, spectral characterization, microbiological evaluation, and single-crystal X-ray analysis
Muškinja, J., Burmudžija, A., Ratković, Z., Ranković, B., Kosanić, M., Bogdanović, G. A., & Novaković, S. B. (2016) · Medicinal Chemistry Research · doi:10.1007/s00044-016-1609-8 · Cited by 34 · see citing works
Design, Synthesis and Docking Studies of Flavokawain B Type Chalcones and Their Cytotoxic Effects on MCF-7 and MDA-MB-231 Cell Lines
Addila, A. B., Akhtar, M. N., Ali, N. M., Yeap, S. K., Quah, C. K., Loh, W.-S., Alitheen, N. B., Zareen, S., Ul‐Haq, Z., & Shah, S. A. A. (2018) · Molecules · doi:10.3390/molecules23030616 · Cited by 34 · see citing works
Depot Subcutaneous Injection with Chalcone CH8-Loaded Poly(Lactic-Co-Glycolic Acid) Microspheres as a Single-Dose Treatment of Cutaneous Leishmaniasis
Sousa-Batista, A. J., Lima, W. P., Arruda-Costa, N., Falcão, C. A. B., Ré, M. I., & Rossi‐Bergmann, B. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01822-17 · Cited by 32 · see citing works
Aqua‐mediated rapid and benign synthesis of 1,2,6,7‐tetrahydro‐8H‐indeno[5,4‐b]furan‐8‐one‐appended novel 2‐arylidene indanones of pharmacological interest at ambient temperature
Adole, V. A., Pawar, T. B., & Jagdale, B. S. (2019) · Journal of the Chinese Chemical Society · doi:10.1002/jccs.201900015 · Cited by 31 · see citing works
Chalcones, semicarbazones and pyrazolines as inhibitors of cathepsins B, H and L
Raghav, N., & Kaur, R. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.07.029 · Cited by 31 · see citing works
Structural, Vibrational and Electrochemical Analysis and Antibacterial Potential of Isomeric Chalcones Derived from Natural Acetophenone
da Silva, P. T., de Freitas, T. S., Sena, D. M., Bandeira, P. N., Julião, M. S. D. S., Marinho, E. S., Alcanfor, A. A. C., Marinho, E. M., de Lima‐Neto, P., Nogueira, C. E. S., et al. (2020) · Applied Sciences · doi:10.3390/app10144713 · Cited by 30 · see citing works
Synthesis, In Vitro Antitubercular Activity and 3D‐QSAR of Novel Quinoxaline Derivatives
Puratchikody, A., Natarajan, R., Jayapal, M., & Doble, M. (2011) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2011.01246.x · Cited by 30 · see citing works
Self-citation
Antioxidant and antimalarial properties of butein and homobutein based on their ability to chelate iron (II and III) cations: a DFT study in vacuo and in solution
Serobatse, K. R. N., & Kabanda, M. M. (2015) · European Food Research and Technology · doi:10.1007/s00217-015-2520-0 · Cited by 29 · see citing works
Hansch’s analysis application to chalcone synthesis by Claisen–Schmidt reaction based in DFT methodology
Mellado, M., Madrid, A., Martínez, Ú., Mella, J., Salas, C. O., & Cuéllar, M. (2017) · Chemical Papers · doi:10.1007/s11696-017-0316-3 · Cited by 29 · see citing works
Synthesis, Structure, and Anti-Inflammatory Activity of Functionally Substituted Chalcones and Their Derivatives
Нуркенов, О. А., Ibraev, M. K., Schepetkin, I. A., Khlebnikov, А. I., Сейлханов, Т. М., Аринова, А. Е., & Isabaeva, M. B. (2019) · Russian Journal of General Chemistry · doi:10.1134/s1070363219070028 · Cited by 29 · see citing works
Synthesis, crystal structure, spectroscopic characterization, docking simulation and density functional studies of 1-(3,4-dimethoxyphenyl) -3-(4-flurophenyl)-propan-1-one
Khamees, H. A., Jyothi, M., Khanum, S. A., & Mahendra, M. (2018) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2018.02.045 · Cited by 29 · see citing works
Synthesis of Coumarins Linked With 1,2,3-Triazoles under Microwave Irradiation and Evaluation of their Antimicrobial and Antioxidant Activity
Muthipeedika, N. J., Bodke, Y. D., Telkar, S. B., & Bakulev, V. A. (2019) · Journal of the Mexican Chemical Society · doi:10.29356/jmcs.v64i1.1116 · Cited by 29 · see citing works
Pharmacological treatment strategies of pterygium: Drugs, biologics, and novel natural products
Baheran, S. S., Alany, R. G., Schwikkard, S., Muen, W. J., Salman, L. N., Freestone, N., & Al-Kinani, A. A. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.103416 · Cited by 28 · see citing works
PEG-mediated synthesis, antibacterial, antifungal and antioxidant studies of some new 1,3,5-trisubstituted 2-pyrazolines
Dhonnar, S. L., Jagdale, B. S., Adole, V. A., & Sadgir, N. V. (2022) · Molecular Diversity · doi:10.1007/s11030-022-10562-x · Cited by 28 · see citing works
Use of quantum-chemical descriptors to analyse reaction rate constants between organic chemicals and superoxide/hydroperoxyl (O2•−/HO2•)
Nolte, T. M., & Peijnenburg, W. J. G. M. (2018) · Free Radical Research · doi:10.1080/10715762.2018.1529867 · Cited by 27 · see citing works
Design, Synthesis, and Evaluation of Chalcone Derivatives as Multifunctional Agents against Alzheimer's Disease
Wang, X., Zhou, L., Tan, R., Liang, G., Fang, S., Li, W., Xie, M., Wen, Y., Wu, J., & Chen, Y. (2021) · Chemistry & Biodiversity · doi:10.1002/cbdv.202100341 · Cited by 26 · see citing works
2-Amino-4-aryl thiazole: a promising scaffold identified as a potent 5-LOX inhibitor
Sinha, S., Sravanthi, T. V., Yuvaraj, S., Manju, S. L., & Doble, M. (2016) · RSC Advances · doi:10.1039/c5ra28187c · Cited by 26 · see citing works
Self-citation
Synthesis, structure, and antioxidant activity of methoxy- and hydroxyl-substituted 2'-aminochalcones
Sulpizio, C., Roller, A., Giester, G., & Rompel, A. (2016) · Monatshefte für Chemie - Chemical Monthly · doi:10.1007/s00706-016-1812-9 · Cited by 26 · see citing works
An ongoing journey of chalcone analogues as single and multi-target ligands in the field of Alzheimer's disease: A review with structural aspects
Sharma, P., & Singh, M. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121568 · Cited by 25 · see citing works
α-Dihydroxychalcone-glycoside (α-DHC) isolated from the heartwood of Pterocarpus marsupium inhibits LPS induced MAPK activation and up regulates HO-1 expression in murine RAW 264.7 macrophage
Chakraborty, P., Saraswat, G., & Kabir, S. N. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.03.011 · Cited by 23 · see citing works
Lipoxygenase Inhibitors as Cancer Chemopreventives: Discovery, Recent Developments and Future Perspectives
Mahboubi‐Rabbani, M., & Zarghi, A. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666191210104820 · Cited by 22 · see citing works
Lannea coromandelica (Houtt.) Merr. Induces Heme Oxygenase 1 (HO-1) Expression and Reduces Oxidative Stress via the p38/c-Jun N-Terminal Kinase–Nuclear Factor Erythroid 2-Related Factor 2 (p38/JNK–NRF2)-Mediated Antioxidant Pathway
Alam, M. B., Kwon, K.-R., Lee, S.-H., & Lee, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020266 · Cited by 22 · see citing works
Design, synthesis and identification of novel coumaperine derivatives for inhibition of human 5-LOX: Antioxidant, pseudoperoxidase and docking studies
Muthuraman, S., Sinha, S., Vasavi, C. S., Waidha, K., Basu, B., Munusami, P., Balamurali, M. M., Doble, M., & Kumar, R. S. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2018.12.043 · Cited by 22 · see citing works
Self-citation
Lablab purpureus Protects HaCaT Cells from Oxidative Stress-Induced Cell Death through Nrf2-Mediated Heme Oxygenase-1 Expression via the Activation of p38 and ERK1/2
Diniyah, N., Alam, M. B., Choi, H.-J., & Lee, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228583 · Cited by 21 · see citing works
Design, Synthesis, and Bioactivity of Chalcone Derivatives Containing Indanone
Sun, N., Gong, C., Zhou, Y., Zhang, Y., Zhang, N., Li, X., & Xue, W. (2023) · ACS Omega · doi:10.1021/acsomega.2c07071 · Cited by 20 · see citing works
Synthesis, spectroscopic characterization, XRD crystal structure, DFT and antimicrobial study of (2E)-3-(2,6-dichlorophenyl)-1-(4-methoxyphenyl)-prop-2-en-1-one
Sadgir, N. V., Dhonnar, S. L., Jagdale, B. S., & Sawant, A. B. (2020) · SN Applied Sciences · doi:10.1007/s42452-020-2923-9 · Cited by 20 · see citing works
Synthesis and Selective Cytotoxic Activities on Rhabdomyosarcoma and Noncancerous Cells of Some Heterocyclic Chalcones
Do, T.-H., Nguyen, D.-M., Truong, V.-D., Do, T., Le, M.-T., Pham, T.-Q., Thai, K., & Tran, T.-D. (2016) · Molecules · doi:10.3390/molecules21030329 · Cited by 18 · see citing works
Synthesis, characterization and antiamoebic activity of chalcones bearing N-substituted ethanamine tail
Zaidi, S. L., Mittal, S., Rajala, M. S., Avecilla, F., Husain, M., & Azam, A. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.05.013 · Cited by 18 · see citing works
Novel proanthocyanidin dimer analogues with the C-ring-opened diaryl-propan-2-gallate structural unit and enhanced antioxidant activities
Chen, J., Xu, Z., Zhu, W., Nie, R., & Li, C. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.12.023 · Cited by 18 · see citing works
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Tran, T., Le, M.-T., Nguyen, T.-C.-V., Tran, T., Tran, T., & Thai, K. (2020) · Molecules · doi:10.3390/molecules25173916 · Cited by 17 · see citing works
In silico modeling and synthesis of phenyl and thienyl analogs of chalcones for potential leads as anti-bacterial agents
Kar, S., Mishra, R. K., Pathak, A. K., Dikshit, A., & Golakoti, N. R. (2017) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2017.12.002 · Cited by 17 · see citing works
N‐methylpiperazinyl and piperdinylalkyl‐ O‐chalcone derivatives as potential polyfunctional agents against Alzheimer's disease: Design, synthesis and biological evaluation
Sharma, P., Singh, V., & Singh, M. (2023) · Chemical Biology & Drug Design · doi:10.1111/cbdd.14318 · Cited by 16 · see citing works
A novel class of tyrosine derivatives as dual 5-LOX and COX-2/mPGES1 inhibitors with PGE 2 mediated anticancer properties
Puratchikody, A., Umamaheswari, A., Navabshan, I., Sinha, S., Manju, S. L., Ramanan, M., Ramamoorthy, G., & Doble, M. (2018) · New Journal of Chemistry · doi:10.1039/c8nj04385j · Cited by 16 · see citing works
Self-citation
Synthesis of diarylidenecyclohexanone derivatives as potential anti-inflammatory leads against COX-2/mPGES1 and 5-LOX
Kar, S., Ramamoorthy, G., Sinha, S., Ramanan, M., Pola, J. K., Golakoti, N. R., Nanubolu, J. B., Sahoo, S. K., Dandamudi, R. B., & Doble, M. (2019) · New Journal of Chemistry · doi:10.1039/c9nj00726a · Cited by 16 · see citing works
Self-citation
3′-Geranyl-mono-substituted chalcone Xanthoangelovl induces apoptosis in human leukemia K562 cells via activation of mitochondrial pathway
Teng, Y., Wang, L., Liu, H., Yuan, Y., Zhang, Q., Wu, M., Wang, L., Wang, H., Liu, Z., & Yu, P. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.11.025 · Cited by 15 · see citing works
Improved drug loading via spray drying of a chalcone implant for local treatment of cutaneous leishmaniasis
Sousa-Batista, A. J., Arruda-Costa, N., Rossi‐Bergmann, B., & Ré, M. I. (2018) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2018.1461903 · Cited by 15 · see citing works
One-pot diastreoselective synthesis of highly functionalized cyclohexenones: 2-oxo-N,4,6-triarylcyclohex-3-enecarboxamides
Mousavi, M. R., Maghsoodlou, M. T., & Habibi‐Khorassani, S. M. (2014) · Molecular Diversity · doi:10.1007/s11030-014-9541-7 · Cited by 15 · see citing works
Single-dose treatment for cutaneous leishmaniasis with an easily synthesized chalcone entrapped in polymeric microparticles
Sousa-Batista, A. J., Arruda-Costa, N., Escrivani, D. O., Reynaud, F., Steel, P. G., & Rossi‐Bergmann, B. (2020) · Parasitology · doi:10.1017/s0031182020000712 · Cited by 14 · see citing works
Mechanochemical synthesis and characterizations of chalcone derivatives: (2E)-3-[4-(Benzyloxy)phenyl]-1-(thiophen-2-yl)prop ‑2-en-1-one and (2E)-3-(Anthracen-9-yl)-1- (thiophen-2-yl)prop‑2-en-1-one
Praveena, P., Sarojini, B. K., & Kumar, S. M. (2019) · Chemical Data Collections · doi:10.1016/j.cdc.2019.100298 · Cited by 13 · see citing works
Ferrocenyl chalcone derivative (E)-3-(2-methylpyrimidin-5-yl)-1-ferroceynlprop-2-en-1-one: Synthesis, Structural analysis, Docking study and their Antibacterial evaluation
Twinkle, A. R., Leenaraj, D. R., Ratković, Z., Arunsasi, B. S., Bright, K. C., & Reshma, R. (2020) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2020.128049 · Cited by 13 · see citing works
Sensitive fluorescent chemosensor for Hg(II) in aqueous solution using 4’-dimethylaminochalcone
Mellado, M., Roldán, N., Miranda, R., Aguilar, L. F., Bravo, M. A., & Waldo Quiroz, V. (2022) · Journal of Fluorescence · doi:10.1007/s10895-022-02941-2 · Cited by 12 · see citing works
Recent Development of Novel Aminoethyl-Substituted Chalcones as Potential Drug Candidates for the Treatment of Alzheimer’s Disease
Sharma, P., Singh, M., Singh, V., Singh, T. G., Singh, T., & Ahmad, S. F. (2023) · Molecules · doi:10.3390/molecules28186579 · Cited by 12 · see citing works
Synthesis and anticancer activity of chalcone analogues with sulfonyl groups
Muškinja, J., Burmudžija, A., Baskić, D., Popović, S., Todorović, D., Zarić, M., & Ratković, Z. (2019) · Medicinal Chemistry Research · doi:10.1007/s00044-018-02283-4 · Cited by 12 · see citing works
Characterization and biological activities of cyclic (1 → 3, 1 → 6)-β-glucans from Bradyrhizobium japonicum
Nair, A. V., Gummadi, S. N., & Doble, M. (2016) · Biotechnology Letters · doi:10.1007/s10529-016-2122-3 · Cited by 11 · see citing works
Self-citation
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Suhana Arshad, B., Pillai, R. R., Zainuri, D. A., Khalib, N. C., Razak, I. A., Armaković, S., Armaković, S. J., Panicker, C. Y., & Alsenoy, C. V. (2017) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2017.01.080 · Cited by 11 · see citing works
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Al‐Maqtari, H. M., Hasan, A. H., Suleiman, M., Abid, F. M. A., Bhat, A. R., Zahidi, M. A. A., Noamaan, M. A., Murugesan, S., Ahmed, S., & Jamalis, J. (2025) · ChemistrySelect · doi:10.1002/slct.202501227 · Cited by 10 · see citing works
Synthesis, spectroscopic characterization, electronic and optical studies of (2Z)‐5,6‐dimethyl‐2‐[(4‐nitrophenyl)methylidene]‐2,3‐dihydro‐1‐benzofuran‐3‐one
Diwaker, Kumar, C. S. C., Kumar, A., Chandraju, S., Quah, C. K., & Fun, H. (2014) · Journal of Computational Science · doi:10.1016/j.jocs.2014.11.005 · Cited by 10 · see citing works
Synthesis and Antimicrobial Evaluation of some Functionalized Heterocycles Derived from Novel Quinolinyl Chalcone
Hassan, M. M., & Farouk, O. (2017) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.2927 · Cited by 10 · see citing works
Synthesis, molecular structure, DFT studies, in silico docking and molecular dynamics simulations of 2,6 dimethoxychalcone derivatives as BRD4 inhibitors
Khamees, H. A., Mahendra, M., Ananda, S., Sangappa, Y., Al-Ostoot, F. H., & Abad, N. (2021) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2021.131032 · Cited by 9 · see citing works
Substituted chalcones with different positions of the isobornyl substituent: the synthesis and antioxidant activity
Popova, S. A., Pavlova, E. V., Шевченко, О. Г., Chukicheva, I. Y., & Kutchin, A. V. (2022) · Russian Chemical Bulletin · doi:10.1007/s11172-022-3666-0 · Cited by 9 · see citing works
Synthesis and Biological Evaluation of a Novel Series of 1,3-Dicoumarinyl-5-aryl-2-pyrazolines
Čačić, M., Molnar, M., & Strelec, I. (2011) · Heterocycles · doi:10.3987/com-11-12196 · Cited by 9 · see citing works
Novel Nitrogen-Based Chalcone Analogs Provoke Substantial Apoptosis in HER2-Positive Human Breast Cancer Cells via JNK and ERK1/ERK2 Signaling Pathways
Rizeq, B. R., Gupta, I., Kheraldine, H., Elkhalifa, D. H., Farsi, H. F. A., Moustafa, A. A., & Khalil, A. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179621 · Cited by 9 · see citing works
Chemistry of plant extracts
Rashmi, H. B., & Negi, P. S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822475-5.00004-1 · Cited by 9 · see citing works
Synthesis and Biological Evaluation of Novel Chalcone and Pyrazoline Derivatives Bearing Substituted Vanillin Nucleus
Patel, P. A., Bhadani, V. N., Bhatt, P. V., & Purohit, D. M. (2014) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.2215 · Cited by 8 · see citing works
Theoretical studies on the interaction between chalcone dyes and Concanavalin A—The reactive group effects on the photophysical and biological properties of the fluorescence probe
Krawczyk, P., Czeleń, P., Szefler, B., & Cysewski, P. (2017) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2017.06.024 · Cited by 8 · see citing works
Employment of thermal analysis applied to the oxidative stability evaluation of biodiesel using chalcone analogues
Berneira, L. M., Rockembach, C. T., da Silva, C. C., de Freitas, S. C., da Rosa, B. N., Pinto, E., dos Anjos, F. M., dos Santos, M. A. Z., & de Pereira, C. M. P. (2020) · Journal of Thermal Analysis and Calorimetry · doi:10.1007/s10973-020-10189-w · Cited by 8 · see citing works
A Comprehensive Appraisal of Chalcones and Their Heterocyclic Analogs as Antimicrobial Agents
Salotra, R., & Utreja, D. (2020) · Current Organic Chemistry · doi:10.2174/1385272824999200922090524 · Cited by 8 · see citing works
Chalcone-based bioactive scaffolds: Comparative antioxidant, antibacterial, and anti-Alzheimer activities supported by docking analysis
Öztürk, C., Bayrak, S., Gerni, S., Atmaca, U., Bayrak, Ç., & Kızıltaş, H. (2026) · Journal of the Indian Chemical Society · doi:10.1016/j.jics.2026.102435 · Cited by 7 · see citing works
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Singh, D., Kaundal, V., Aggarwal, N., Jindal, S., Ankalgi, A. D., & Goyal, K. (2022) · Asian Journal of Pharmaceutical Research · doi:10.52711/2231-5691.2022.00007 · Cited by 7 · see citing works
Synthesis of O-alkyl derivatives of dehydrozingerone analogues
Muškinja, J., Ratković, Z., Ranković, B., & Kosanić, M. (2016) · Kragujevac Journal of Science · doi:10.5937/kgjsci1638097m · Cited by 7 · see citing works
Synthesis, Characterization and Antiinflammatory Activity of Chalcone Derivatives Linked with Apocynin and 5-Nitrofuran Moiety
Reddy, A. L. V. K., & Kathale, N. E. (2017) · Asian Journal of Chemistry · doi:10.14233/ajchem.2018.20950 · Cited by 7 · see citing works
Chalcones as Scavengers of HOCl and Inhibitors of Oxidative Burst: Structure-Activity Relationship Studies
Martins, T. S., Silva, V. L. M., Silva, A. M. S., Lima, J. L. F. C., Fernandes, E. G. R., & Ribeiro, D. (2020) · Medicinal Chemistry · doi:10.2174/1573406417666201230093207 · Cited by 7 · see citing works
Synthesis and characterization of new 3,5-disubstituted-4,5-dihydro-1H-pyrazole and their carbothioamide derivatives
Ibrahim, M. (2015) · European Journal of Chemistry · doi:10.5155/eurjchem.6.1.78-83.1148 · Cited by 7 · see citing works
Computational Modeling, Synthesis, and Antioxidant Potential of Novel Phenylcarbamoylbenzoic Acid Analogs in Combating Oxidative Stress
Bayoumi, W. A., El‐Sayed, M. A. ‐., Baraka, H. N., & Abou-zeid, L. A. (2012) · Archiv der Pharmazie · doi:10.1002/ardp.201200183 · Cited by 7 · see citing works
Claisen–Schmidt condensation: Synthesis of (1S,6R)/(1R,6S)‐2‐oxo‐N,4,6‐triarylcyclohex‐3‐enecarboxamide derivatives with different substituents in H2O/EtOH
Mousavi, S. R. (2016) · Chirality · doi:10.1002/chir.22653 · Cited by 7 · see citing works
Synthesis and biological evaluation of glycosides containing triazene-chalcones
Qiang, L., Zhang, S., Liu, M., Li, J., Zhang, X., & Long, Y. (2017) · Molecular Diversity · doi:10.1007/s11030-017-9768-1 · Cited by 7 · see citing works
Synthesis a novel Schiff base and Chalcone derivatives compounds and using as flame retardant for unsaturated polyester and epoxy resins
Jawad, S. F., Behget, S. A., & Al-Baiati, M. N. (2019) · IOP Conference Series Materials Science and Engineering · doi:10.1088/1757-899x/571/1/012090 · Cited by 6 · see citing works
Investigating the Anticancer Properties of the Essential Oil and Aqueous Extract of Moringa oleifera and its Biosynthesized Metal Nanoparticles on MCF-7 and BT-549 Cell Lines
Noruzpour, M., Zakaria, R. A., Zare, N., Ebrahimi, H. A., Khankandi, H. P., & Bourang, S. (2024) · Journal of Breast Disease · doi:10.61186/ijbd.17.1.59 · Cited by 6 · see citing works

DESIGN AND VALIDATION OF PREDICTIVE ANTIOXIDANT MODELS FOR CHALCONES
Alisi, I. O., Uzairu, A., & Abechi, S. E. (2019) · Cited by 1 · see citing works
Spectral Characterization, ADME Prediction, and Antioxidant Activity of Chalcone Derivatives
Mahmood, M. M. H. (2026) · kerbala journal of pharmaceutical sciences · doi:10.62472/kjps.v17.i28.249-259
Design, Synthesis and Evaluation of Chalcone Derivatives as Anti- Inflammatory, Antioxidant and Antiulcer Agents
Choudhary, A. N., Kumar, A., & Juy, V. (2012) · Letters in Drug Design & Discovery · doi:10.2174/157018012800389368 · Cited by 30 · see citing works
Free Radical Scavenging Activity of Chlorochalcones: An Integrated Computational and Experimental Study
Puspitasari, A. D., Ulfah, M., Hartati, I., Vifta, R. L., Hermawan, F., Ekasari, M., & Marlina, L. A. (2025) · Indonesian Journal of Chemistry · doi:10.22146/ijc.106221
Study on the Relationship between the Structure and Antioxidant Activeities of Chalcones
Park, Y., Lee, H., Ho, H. B., Lee, H., Ahn, J.-K., & Lee, W. (2006) · Journal of the Korean Wood Science and Technology

Authors: Sivakumar, P. M., Prabhakar, P. K., & Doble, M.
Affiliations: Indian Institute of Technology Madras (IN)
Corresponding author: Doble, M.
ORCID: Sivakumar, P. M.
Prabhakar, P. K.
Doble, M.
Venue: Medicinal Chemistry Research
Publisher: Springer Science and Business Media LLC
Published: 2010-03-23
Volume: 20
Issue: 4
Pages: 482-492
ISSN: 1054-2523 (ISSN-L)
1554-8120
DOI: 10.1007/s00044-010-9342-1
OpenAlex: W2092646120
Cited by: 144
References: 58
Citations by year: 2026: 4 · 2025: 6 · 2024: 7 · 2023: 11 · 2022: 11 · 2021: 5 · 2020: 14 · 2019: 12 · 2018: 13 · 2017: 14 · 2016: 15 · 2015: 9 · 2014: 9 · 2013: 5 · 2012: 5
FWCI: 2.22
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Medicinal Chemistry Research (publishedVersion)
Funders: Indian Institute of Technology Madras
Topics: Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
Health Sciences › Medicine › Pharmacology › Synthesis of Organic Compounds
Keywords: chalcones, chalcone derivatives, antioxidant activity, QSAR, Claisen-Schmidt condensation, superoxide radical scavenging, hydrogen peroxide scavenging, DPPH radical scavenging, reducing power, substituent effects, lipophilicity, structure-activity relationship

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Synthesis, antioxidant evaluation, and quantitative structure–activity relationship studies of chalcones

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