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The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Sorting receptor sortilin—a culprit in cardiovascular and neurological diseases

Carlo, Anne-Sophie, Nykjaer, Anders, Willnow, Thomas E.·2014·Journal of Molecular Medicine
DOI 10.1007/s00109-014-1152-3
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Abstract

Sortilin is a sorting receptor that directs target proteins, such as growth factors, signaling receptors, and enzymes, to their destined location in secretory or endocytic compartments of cells. The activity of sortilin is essential for proper function of not only neurons but also non-neuronal cell types, and receptor (dys)function emerges as a major cause of malignancies, including hypercholesterolemia, retinal degeneration, neuronal cell loss in stroke and spinal cord injury, or Alzheimer's disease and other neurodegenerative disorders. In this article, we describe the molecular mechanisms of sortilin action in protein sorting and signaling and how modulation of receptor function may offer novel therapeutic strategies for treatment of common diseases of the cardiovascular and nervous systems.

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Research works printed but not linked: 54

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Metadata

Authors
Carlo, A.-S., Nykjaer, A., & Willnow, T. E.
Venue
Journal of Molecular Medicine
Publisher
Springer Science and Business Media LLC
Published
2014-05-18
Volume
92
Issue
9
Pages
905-911
ISSN
  • 0946-2716
  • 1432-1440
DOI
10.1007/s00109-014-1152-3
Cited by
56
References
10
Language
en
Licence
www.springer.com/tdm (tdm)

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