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Targeted manipulation of the sortilin–progranulin axis rescues progranulin haploinsufficiency
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Sortilin's role in FTD is linked to its ability to act as a clearance receptor for progranulin, a major aetiological agent in FTD.
“Sortilin’s role in FTD is linked to its ability to act as clearance receptor for progranulin, a major aetiological agent in FTD69–71, while its mode of action in Alzheimer disease remains unclear.”
From Interaction of sortilin with apolipoprotein E3 enables neurons to use long-chain fatty acids as alternative metabolic fuel (2025) · cites this paper as [71]
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Greda, A. K., Gomes, J. P., Schmidt-Krueger, V., Zurawska-Plaksej, E., Fritsche-Guenther, R., Rudolph, I.-M., Telugu, N. S., Cömert, C., Kirwan, J., Kunz, S., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01389-5 · Cited by 21
Human iPSC Models in Drug Discovery: Opportunities and Challenges
Silva, M. C., Cross, A., Brandon, N. J., & Haggarty, S. J. (2017) · Comprehensive Medicinal Chemistry III · doi:10.1016/b978-0-12-409547-2.12284-x · Cited by 6
Metadata
- Authors
- Lee, W. C., Almeida, S., Prudencio, M., Caulfield, T. R., Zhang, Y.-J., Tay, W. M., Bauer, P. O., Chew, J., Sasaguri, H., Jansen-West, K. R., Gendron, T. F., Stetler, C. T., Finch, N., Mackenzie, I. R., Rademakers, R., Gao, F.-B., & Petrucelli, L.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-10-26
- Volume
- 23
- Issue
- 6
- Pages
- 1467-1478
- ISSN
- 1460-2083
- 0964-6906
- PMC
- PMC3929086
- Cited by
- 125
- References
- 4
- Language
- en
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