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The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin

Hu, Fenghua, Padukkavidana, Thihan, Vægter, Christian B., Brady, Owen A., Zheng, Yanqiu, Mackenzie, Ian R., Feldman, Howard H., Nykjaer, Anders, Strittmatter, Stephen M.·2010·Neuron
DOI 10.1016/j.neuron.2010.09.034PMC PMC2990962
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Crossref · 10.1016/j.neuron.2010.09.034

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  • Sortilin localizes to the plasma membrane in clathrin-coated pits where it can function as an internalization receptor for progranulin, APOA-V, and LPL.

    “Sortilin also localizes to the plasma membrane in clathrin-coated pits where it can function as an internalization receptor for progranulin (12), APOA-V (13), and LPL (ref.14 and Supplemental Figure 1B).”

    From Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism (2012) · cites this paper as [12]

    The Results section, “Rapid Sortilin-Mediated Endocytosis of PGRN to Lysosomes,” shows progranulin binding to cell-surface sortilin and being rapidly internalized. The cited paper does not establish that sortilin localizes specifically to clathrin-coated pits. APOA-V and LPL have separate citations in the citing sentence and are not attributed to this source. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • A sortilin knockout mouse with residual truncated sortilin expression, when fed a Western-type diet, had reduced VLDL production.

    “It was previously reported that a sortilinknockout mouse that had some residual truncated sortilin expression (12), upon feeding with a Western-type diet, had reduced VLDL production (23).”

    From Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism (2012) · cites this paper as [12]

  • Sortilin's role in FTD is linked to its ability to act as a clearance receptor for progranulin, a major aetiological agent in FTD.

    “Sortilin’s role in FTD is linked to its ability to act as clearance receptor for progranulin, a major aetiological agent in FTD69–71, while its mode of action in Alzheimer disease remains unclear.”

    From Interaction of sortilin with apolipoprotein E3 enables neurons to use long-chain fatty acids as alternative metabolic fuel (2025) · cites this paper as [69]

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Citations

Cites

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Research works printed but not linked: 41

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Metadata

Authors
Hu, F., Padukkavidana, T., Vægter, C. B., Brady, O. A., Zheng, Y., Mackenzie, I. R., Feldman, H. H., Nykjaer, A., & Strittmatter, S. M.
Venue
Neuron
Publisher
Elsevier BV
Published
2010-11
Volume
68
Issue
4
Pages
654-667
ISSN
0896-6273
DOI
10.1016/j.neuron.2010.09.034
PMC
PMC2990962
Cited by
536
References
11
Language
en
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