Association of glucose levels and glucose variability with mood in type 1 diabetic patients
Open accessAbstract
Aims/hypothesis The aim of this study was to investigate the association of glucose levels and variability of glucose, assessed by continuous glucose monitoring, with mood in type 1 diabetic patients.Materials and methods Thirty-six type 1 diabetic patients (77.8% male, age: 31.1 +/- 10.0 years; disease duration: 14.7 +/- 7.1 years, BMI: 26.7 +/- 5.1 kg/m2, HbA1c 8.4 +/-1.8%, 27.8% with continuous subcutaneous insulin infusion [CSII] therapy) used a continuous glucose monitoring system for 48.8 h. During this time the patients rated their current mood states 14.6 times on average, using the University of Wales Institute of Science and Technology Mood Adjective Checklist and hand-held computers.Results Sensor performance was satisfactory, with a mean absolute difference from reference laboratory glucose measurement of 13.7%. Current glucose values were significantly associated with ratings of 'tension' (z = 2.40), 'hedonic tone' (z = -2.63) and 'energetic arousal' (z = -2.09). 'Anger' (z = 1.64) was not significantly associated with glucose values. The glucose AUC during the 60 min prior to the mood rating showed similar associations. The two parameters of glucose variability-coefficient of variation and absolute glucose change during the 60 min prior to the mood ratings-did not show any significant association with the mood ratings. The magnitude of association was significantly higher for glucose level than for glucose variability in the scales 'tension' and 'hedonic tone'.Conclusions/interpretation High glucose values had a negative impact on mood; positive mood ratings decreased, whereas negative mood ratings increased. The association between mood and glucose variability seemed to be less important than that between glucose level and mood.
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Stress affects glucose levels and increases glucose variability in patients with type 1 and type 2 diabetes.
“stress affects glucose levels and increased glucose variability in both patients with type 1 and 2 diabetes”
From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Hermanns et al., 2007
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- Authors
- Hermanns, N., Scheff, C., Kulzer, B., Weyers, P., Pauli, P., Kubiak, T., & Haak, T.
- Affiliations
- Forschungsinstitut der Diabetes Akademie Mergentheim (DE)
- University of Würzburg (DE)
- Universität Greifswald (DE)
- Corresponding author
- Hermanns, N.
- Venue
- Diabetologia
- Published
- 2007-03-17
- Volume
- 50
- Issue
- 5
- Pages
- 930-933
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2008687086
- Cited by
- 66
- References
- 9
- Citations by year
- 2026: 2 · 2024: 12 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 7
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- type 1 diabetes, mood, glycemic variability, blood glucose, continuous glucose monitoring, tension, hedonic tone, energetic arousal, anger, coefficient of variation, insulin pump therapy
- MeSH terms
- Adult, Affect, Anger, Arousal, Blood Glucose, Diabetes Mellitus, Type 1, Female, Humans, Hyperglycemia, Hypoglycemia, Male, Stress, Physiological, Reproducibility of Results, Monitoring, Ambulatory
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