Cited by 261Alcoholism and Thiamine DeficiencyBiochemical Acid Research StudiesFolate and B Vitamins Research

High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease

Open access
Thornalley, P. J., Babaei-Jadidi, R., Al Ali, H., Rabbani, N., Antonysunil, A., Larkin, J., Ahmed, A., Rayman, G. +1 more·2007·Diabetologia

Abstract

AIMS/HYPOTHESIS: To assess thiamine status by analysis of plasma, erythrocytes and urine in type 1 and type 2 diabetic patients and links to markers of vascular dysfunction. METHODS: Diabetic patients (26 type 1 and 48 type 2) with and without microalbuminuria and 20 normal healthy control volunteers were recruited. Erythrocyte activity of transketolase, the concentrations of thiamine and related phosphorylated metabolites in plasma, erythrocytes and urine, and markers of metabolic control and vascular dysfunction were determined. RESULTS: Plasma thiamine concentration was decreased 76% in type 1 diabetic patients and 75% in type 2 diabetic patients: normal volunteers 64.1 (95% CI 58.5-69.7) nmol/l, type 1 diabetes 15.3 (95% CI 11.5-19.1) nmol/l, p < 0.001, and type 2 diabetes 16.3 (95% CI 13.0-9.6) nmol/l, p < 0.001. Renal clearance of thiamine was increased 24-fold in type 1 diabetic patients and 16-fold in type 2 diabetic patients. Plasma thiamine concentration correlated negatively with renal clearance of thiamine (r = -0.531, p < 0.001) and fractional excretion of thiamine (r = -0.616, p < 0.001). Erythrocyte transketolase activity correlated negatively with urinary albumin excretion (r = -0.232, p < 0.05). Thiamine transporter protein contents of erythrocyte membranes of type 1 and type 2 diabetic patients were increased. Plasma thiamine concentration and urinary excretion of thiamine correlated negatively with soluble vascular adhesion molecule-1 (r = -0.246, p < 0.05, and -0.311, p < 0.01, respectively). CONCLUSIONS/INTERPRETATION: Low plasma thiamine concentration is prevalent in patients with type 1 and type 2 diabetes, associated with increased thiamine clearance. The conventional assessment of thiamine status was masked by increased thiamine transporter content of erythrocytes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s00125-007-0771-4

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Several training interventions did not change basal IL-6 or CRP concentrations.

    “Several training interventions have not produced changes in basal IL-6 or CRP concentrations (213 -218) , while significant reductions in inflammatory markers have been observed following training without changes in BMI or body fat in elderly participants (219,220) .”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Thornalley, P. J., Babaei-Jadidi, R., Al Ali, H., Rabbani, N., Antonysunil, A., Larkin, J., Ahmed, A., Rayman, G., & Bodmer, C. W.
Affiliations
  • University of Essex (GB)
  • Colchester Hospital (GB)
  • National Health Service (GB)
Corresponding author
Thornalley, P. J.
Venue
Diabetologia
Published
2007-08-04
Volume
50
Issue
10
Pages
2164-2170
ISSN
  • 0012-186X (ISSN-L)
  • 1432-0428
OpenAlex
W2039005156
Cited by
260
References
46
Citations by year
2026: 6 · 2025: 7 · 2024: 9 · 2023: 20 · 2022: 24 · 2021: 22 · 2020: 18 · 2019: 15 · 2018: 18 · 2017: 14 · 2016: 15 · 2015: 15 · 2014: 7 · 2013: 10 · 2012: 18
FWCI
6.95
Type
journal article
Language
en
Open access
Locations
  • Diabetologia (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (acceptedVersion)
Funders
Diabetes UK
Topics
  • Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
  • Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
Keywords
thiamine deficiency, type 1 diabetes, type 2 diabetes, microalbuminuria, erythrocyte transketolase, thiamine transporter, vascular dysfunction
MeSH terms
Albuminuria, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Glomerular Filtration Rate, Humans, Reference Values, Thiamine, Thiamine Deficiency, Thiamine Monophosphate, Thiamine Pyrophosphate, Vascular Diseases, Biomarkers

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review