Cited by 334Adipokines, Inflammation, and Metabolic DiseasesLiver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease

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Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

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Matthews, V. B., Allen, T. L., Risis, S., Chan, M. H. S., Henstridge, D. C., Watson, N., Zaffino, L. A., Babb, J. R., Boon, J., Meikle, P. J., Jowett, J. B., Watt, M. J., Jansson, J.-O., Bruce, C. R., Febbraio, M. A.·2010·Diabetologia

DOI 10.1007/s00125-010-1865-y

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Abstract

Aims/hypothesis The role of IL-6 in the development of obesity and hepatic insulin resistance is unclear and still the subject of controversy. We aimed to determine whether global deletion of Il6 in mice (Il6 (-/-)) results in standard chow-induced and high-fat diet (HFD)-induced obesity, hepatosteatosis, inflammation and insulin resistance.Methods Male, 8-week-old Il6 (-/-) and littermate control mice were fed a standard chow or HFD for 12 weeks and phenotyped accordingly.Results Il6 (-/-) mice displayed obesity, hepatosteatosis, liver inflammation and insulin resistance when compared with control mice on a standard chow diet. When fed a HFD, the Il6 (-/-) and control mice had marked, equivalent gains in body weight, fat mass and ectopic lipid deposition in the liver relative to chow-fed animals. Despite this normalisation, the greater liver inflammation, damage and insulin resistance observed in chow-fed Il6 (-/-) mice relative to control persisted when both were fed the HFD. Microarray analysis from livers of mice fed a HFD revealed that genes associated with oxidative phosphorylation, the electron transport chain and tricarboxylic acid cycle were uniformly decreased in Il6 (-/-) relative to control mice. This coincided with reduced maximal activity of the mitochondrial enzyme β-hydroxyacyl-CoA-dehydrogenase and decreased levels of mitochondrial respiratory chain proteins.Conclusions/interpretation Our data suggest that IL-6 deficiency exacerbates HFD-induced hepatic insulin resistance and inflammation, a process that appears to be related to defects in mitochondrial metabolism.

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Ksovreli, M., Kachlishvili, T., Skhvitaridze, M., Nadaraia, L., Goliadze, R., Kamashidze, L., Zurabiani, K., Batsatsashvili, T., Kvachantiradze, N., Gverdtsiteli, M. G., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179641 · Cited by 3
IL-6 in non-alcoholic fatty liver disease – good, evil or both?
Buechler, C. (2012) · Endocrinology & Metabolic Syndrome · doi:10.4172/2161-1017.1000e101 · Cited by 3
Suppression of Anti-Inflammatory Mediators in Metabolic Disease May Be Driven by Overwhelming Pro-Inflammatory Drivers
Sajid, S., Zariwala, M. G., Mackenzie, R., Turner, M. C., Nell, T. A., Bellary, S., & Renshaw, D. W. (2022) · Nutrients · doi:10.3390/nu14112360 · Cited by 3
The effects of tissue inflammation on cancer cachexia
Pryce, B. R., & Kerr, H. L. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.168144 · Cited by 3
NAMPT, IL-6, and vaspin gene expressions and serum protein levels in type 2 diabetes mellitus and related complication
Çelik, S. P., Parıltı, D. N., Açık, L., Yalçın, M. M., Yetkin, İ., & Yunusov, E. (2024) · TURKISH JOURNAL OF BIOLOGY · doi:10.55730/1300-0152.2688 · Cited by 3
Effect of Metformin on Interleukin-6 Expression in Human Fibroblast Cell Aging Model
Achadiyani, A., Prabhasiwi, D., Pratiwi, A. E., Hamudin, A., Heryaman, H., Alfarafisa, N. M., & Atik, N. (2024) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/2977 · Cited by 2
Role of Adipokines in Controlling Insulin Signaling Pathways in Type-2 Diabetes and Obesity. Current and Future Perspectives
Bouzid, T., Hamel, F. G., & Lim, J. Y. (2016) · Cited by 2
Adipokines, Inflammation, and Insulin Resistance in Obesity
Kwon, H., & Pessin, J. E. (2018) · Springer eBooks · doi:10.1007/978-3-319-89506-2_9 · Cited by 3
Effect of Roux-en-Y Gastric Bypass on circulating oxylipin profile in women with obesity and type 2 diabetes
Cavalari-Mancuzo, D., Machado, N. M., Alves, J. T. M., Santander, L., Calder, P. C., Waitzberg, D. L., & Torrinhas, R. S. (2023) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2023.102605 · Cited by 2
Interleukin-6 inhibitors
Hassan, N., & Choy, E. (2020) · doi:10.1093/med/9780198831433.003.0032 · Cited by 2
Grand paternal inheritance of an acquired metabolic trait induced by ancestral obesity is associated with sperm RNAPreprint
Cropley, J. E., Eaton, S. A., Aiken, A., Young, P. E., Giannoulatou, E., Ho, J. W. K., Buckland, M. E., Keam, S. P., Hutvágner, G., Humphreys, D. T., et al. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/042101 · Cited by 2
Peripheral sgp130-mediated trans -signaling blockade induces obesity and insulin resistance in mice via PPARα suppressionPreprint
Lanton, T., Levkovitch‐Siany, O., Udi, S., Tam, J., Abramovitch, R., Perles, S., Williams, E. G., Rachmilewitz, J., Mor, U., Elinav, E., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.24.309716 · Cited by 3
Nonpregnant and pregnant adult female rats affected by maternal diabetes environment
Paula, V. G., de Souza, M. R., Sinzato, Y. K., Villaverde, A. I. S. B., Corrente, J. E., Volpato, G. T., & Damasceno, D. C. (2022) · Systems Biology in Reproductive Medicine · doi:10.1080/19396368.2022.2115326 · Cited by 1
Altered Cytokine Secretory Fingerprint of the Adipocytes Derived from Stem Cells of Morbidly Obese Patients—A Preliminary Study
Łukaszuk, B., Supruniuk, E., Chabowski, A., & Mikłosz, A. (2024) · Cells · doi:10.3390/cells13191603 · Cited by 1
Increased levels of systemic iron content in adult-onset interleukin-6 knockout mice
Zhang, F., Zhang, C., Luo, Q., Li, J., Qiu, X., & Qian, Z. (2025) · Redox Report · doi:10.1080/13510002.2025.2602306 · Cited by 1
Superior inflammatory response and MASH progression in Apoe-/- mice compared to wild-type mice: a comprehensive time-course analysis
Geisler, A. R., Meinhardt, N., Otto, L., Hupfer, Y., Hebecker, B., Perkowski, B. J., Werner, M., Zhao, W.-T., Herrmann, K., Ebert, M., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1895809 · Cited by 1
Stretch Control of Adipocyte Insulin Signaling
Bouzid, T. (2017) · Lincoln (University of Nebraska) · Cited by 1
Differential Roles of Interleukin-6 in Severe Acute Respiratory Syndrome-Coronavirus-2 Infection and Cardiometabolic Diseases
Ren, J., Wang, X., Nakao, T., Libby, P., & Shi, G. (2023) · Cardiology Discovery · doi:10.1097/cd9.0000000000000096 · Cited by 1
Circ-METTL15 stimulates the aggressive behaviors of papillary thyroid cancer cells by coordinating the miR-200c-3p/XIAP axis
HUANG, Y., Zeng, X., CAI, Y., YANG, Y., ZHANG, Y., Ma, Y., & LI, S. (2024) · TURKISH JOURNAL OF BIOLOGY · doi:10.55730/1300-0152.2689 · Cited by 1
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Nieradko‐Iwanicka, B., Ruszel, K., Herbet, M., & Pawłowski, K. (2024) · Polish Hyperbaric Research · doi:10.2478/phr-2024-0018 · Cited by 1
The function of dietary phenolic acids in cardiovascular health
Mubarak, A. (2013) · UWA Profiles and Research Repository (UWA) · Cited by 1
Effects of heme oxygenase system on inflammation, oxidative stress, insulin signaling and tissue injury in liver, heart, kidney and pancreas in obese, diabetic and hypertensive rats
Mishra, M. (2017) · University Library - University of Saskatchewan (University of Saskatchewan) · Cited by 1
Obesity-associated inflammation in adipose tissue
Alvehus, M. (2012) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Studies on the mechanisms of action and physiological relevance of SOCS proteins
Zadjali, F. (2011) · Figshare
Exercise, Nutrition, and Inflammation
Kraakman, M. J., Whitham, M., & Febbraio, M. A. (2013) · Wiley eBooks · doi:10.1002/9781118692318.ch38
Factors of Inflammation in Haitian Americans and African Americans with and without Type 2 Diabetes
Antwi, J. (2014) · FIU - Digital Commons (Florida International University) · doi:10.25148/etd.fi14110719
UWA Research Publication
Kowal, E., Pearson, G., Peacock, C. S., Jamieson, S. E., & Blackwell, J. M. (2013)
IL-6 and GLP-1 in body fat regulating parts of the CNS in healthy mice
Anesten, F. (2016) · Gothenburg University Publications Electronic Archive (Gothenburg University)
In Vivo Role of JAK2 in the Pathogenesis of Obesity and the Metabolic Syndrome
Shi, S. Y. (2015) · TSpace (University of Toronto)
Effects of pro-inflammatory cytokines on central actions of leptin and insulin
Allister, E. M. (2014) · Repository for Publications and Research Data (ETH Zurich) · doi:10.3929/ethz-a-010262596
The role of central IL-6 signalling in the development of Type 2 diabetes
Yiannakas, A. (2016) · Discovery Research Portal (University of Dundee)
Pro-inflammatory cytokines induce lipocalin-2 expression in vivo and in vitro
Zhao, P. (2013) · doi:10.31390/gradschool_dissertations.3356
Стрес-індукована гіперлікімія при критичних станах: концепція метаболічної терапії
Сорокіна, Е. Ю. (2015) · Pain anesthesia and intensive care · doi:10.25284/2519-2078.3(72).2015.84437

Authors: Matthews, V. B., Allen, T. L., Risis, S., Chan, M. H. S., Henstridge, D. C., Watson, N., Zaffino, L. A., Babb, J. R., Boon, J., Meikle, P. J., Jowett, J. B., Watt, M. J., Jansson, J.-O., Bruce, C. R., & Febbraio, M. A.
Affiliations: Baker Heart and Diabetes Institute (AU)
Monash University (AU)
University of Gothenburg (SE)
Corresponding author: Febbraio, M. A.
ORCID: Matthews, V. B.
Henstridge, D. C.
Meikle, P. J.
Watt, M. J.
Jansson, J.-O.
Bruce, C. R.
Febbraio, M. A.
Venue: Diabetologia
Publisher: Springer Science and Business Media LLC
Published: 2010-08-11
Volume: 53
Issue: 11
Pages: 2431-2441
ISSN: 0012-186X (ISSN-L)
1432-0428
DOI: 10.1007/s00125-010-1865-y
OpenAlex: W2089567564
Cited by: 334
References: 50
Citations by year: 2026: 5 · 2025: 8 · 2024: 12 · 2023: 15 · 2022: 23 · 2021: 21 · 2020: 26 · 2019: 27 · 2018: 21 · 2017: 29 · 2016: 26 · 2015: 22 · 2014: 20 · 2013: 31 · 2012: 25
FWCI: 18.39
Type: journal article
Language: en
Open access: green
figshare.com
Licence: cc-by
www.springer.com/tdm (tdm)
Locations: Diabetologia (publishedVersion)
PubMed (publishedVersion)
RMIT Research Repository (RMIT University Library) (submittedVersion)
Figshare (submittedVersion, cc-by)
Figshare (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords: interleukin-6, hepatic insulin resistance, liver inflammation, obesity, high-fat diet, hepatic steatosis, mitochondrial metabolism, oxidative phosphorylation, beta-hydroxyacyl-CoA dehydrogenase, mitochondrial respiratory chain, liver fat deposition
MeSH terms: Animals, Body Composition, Calorimetry, Indirect, Diglycerides, Fatty Liver, Female, Inflammation, Insulin Resistance, Liver, Male, Mice, Inbred C57BL, Obesity, Triglycerides, Interleukin-6, Adipocytes, Mice, Knockout, Cell Size, Adiposity, Mice

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Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

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