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Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance
Open accessAbstract
Aims/hypothesis The role of IL-6 in the development of obesity and hepatic insulin resistance is unclear and still the subject of controversy. We aimed to determine whether global deletion of Il6 in mice (Il6 (-/-)) results in standard chow-induced and high-fat diet (HFD)-induced obesity, hepatosteatosis, inflammation and insulin resistance.Methods Male, 8-week-old Il6 (-/-) and littermate control mice were fed a standard chow or HFD for 12 weeks and phenotyped accordingly.Results Il6 (-/-) mice displayed obesity, hepatosteatosis, liver inflammation and insulin resistance when compared with control mice on a standard chow diet. When fed a HFD, the Il6 (-/-) and control mice had marked, equivalent gains in body weight, fat mass and ectopic lipid deposition in the liver relative to chow-fed animals. Despite this normalisation, the greater liver inflammation, damage and insulin resistance observed in chow-fed Il6 (-/-) mice relative to control persisted when both were fed the HFD. Microarray analysis from livers of mice fed a HFD revealed that genes associated with oxidative phosphorylation, the electron transport chain and tricarboxylic acid cycle were uniformly decreased in Il6 (-/-) relative to control mice. This coincided with reduced maximal activity of the mitochondrial enzyme β-hydroxyacyl-CoA-dehydrogenase and decreased levels of mitochondrial respiratory chain proteins.Conclusions/interpretation Our data suggest that IL-6 deficiency exacerbates HFD-induced hepatic insulin resistance and inflammation, a process that appears to be related to defects in mitochondrial metabolism.
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“The anti-inflammatory properties of IL-6 are illustrated by IL-6−/− mice, which exhibit hepatosteatosis, insulin resistance, and liver inflammation (44).”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [44]
In the citing paper
“On the other hand, in these same contexts, others have shown that IL6 induces insulin sensitivity (Carey et al., 2006; Findeisen et al., 2019; Matthews et al., 2010; Mauer et al., 2014; Steensberg et al., 2003; Timper et al., 2017), while IL6 has been shown to be insulin sensitizing in exercise (Benrick et al., 2012).”
From Origin and function of stress-induced IL-6 in murine models (2020) · cites this paper as Matthews et al., 2010
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Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Ghrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107
Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952
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Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737
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Scheller, J., Chalaris, A., Schmidt-Arras, D., & Rose-John, S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.01.034 · Cited by 3,212
Macrophage Cytokines: Involvement in Immunity and Infectious Diseases
Arango Duque, G., & Descoteaux, A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00491 · Cited by 2,708
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BackgroundThe cellular and signaling networks linking the immune system and metabolism in disease
Osborn, O., & Olefsky, J. M. (2012) · Nature Medicine · doi:10.1038/nm.2627 · Cited by 1,551
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Severinsen, M. C. K., & Pedersen, B. K. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa016 · Cited by 1,226
“Systemic IL-6 knockout mice accumulate adipose tissue (106, 107), whereas central overexpression of IL-6 (116, 117) leads to a decrease in body weight, indicating that IL-6 is a player in body weight control.”
BackgroundRecent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer
Jones, S. A., & Jenkins, B. J. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0066-7 · Cited by 1,102
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Schmidt-Arras, D., & Rose-John, S. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.02.004 · Cited by 881
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Boden, G. (2011) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e3283444b09 · Cited by 848
Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training
Roberts, C. K., Hevener, A. L., & Barnard, R. J. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110062 · Cited by 966
Interleukin-6 Family CytokinesPreprint
Rose‐John, S. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028415 · Cited by 846
Physical activity and muscle-brain crosstalk
Pedersen, B. K. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0174-x · Cited by 772
Mauer, J., Chaurasia, B., Goldau, J., Vogt, M. C., Ruud, J., Nguyen, K. D., Theurich, S., Hausen, A. C., Schmitz, J., Brönneke, H. S., et al. (2014) · Nature Immunology · doi:10.1038/ni.2865 · Cited by 727
IL-6 and related cytokines as the critical lynchpins between inflammation and cancer
Taniguchi, K., & Karin, M. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.01.001 · Cited by 724
Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
Jones, S. A., Scheller, J., & Rose‐John, S. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57158 · Cited by 689
Adipokines Mediate Inflammation and Insulin Resistance
Kwon, H., & Pessin, J. E. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00071 · Cited by 723
Interleukin-6: designing specific therapeutics for a complex cytokine
Garbers, C., Heink, S., Korn, T., & Rose-John, S. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.45 · Cited by 643
Versatile functions for IL-6 in metabolism and cancer
Mauer, J., Denson, J. L., & Brüning, J. C. (2015) · Trends in Immunology · doi:10.1016/j.it.2014.12.008 · Cited by 415
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Garbers, C., Hermanns, H. M., Schaper, F., Müller‐Newen, G., Grötzinger, J., Rose‐John, S., & Scheller, J. (2012) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2012.04.001 · Cited by 409
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Barber, M., Risis, S., Yang, C., Meikle, P. J., Staples, M., Febbraio, M. A., & Bruce, C. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041456 · Cited by 376
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Origin and function of stress-induced IL-6 in murine models
Qing, H., Desrouleaux, R., Israni-Winger, K., Mineur, Y. S., Fogelman, N., Zhang, C., Rashed, S., Palm, N. W., Sinha, R., Picciotto, M. R., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.054 · Cited by 303
IL-6 signalling pathways and the development of type 2 diabetes
Akbari, M., & Hassan‐Zadeh, V. (2018) · Inflammopharmacology · doi:10.1007/s10787-018-0458-0 · Cited by 315
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Czech, M., Tencerová, M., Pedersen, D. J., & Aouadi, M. (2013) · Diabetologia · doi:10.1007/s00125-013-2869-1 · Cited by 289
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Dodington, D. W., Desai, H. R., & Woo, M. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.11.001 · Cited by 287
From cytokine to myokine: The emerging role of interleukin-6 in metabolic regulation
Pal, M., Febbraio, M. A., & Whitham, M. (2014) · Immunology & Cell Biology · doi:10.1038/icb.2014.16 · Cited by 258
Emerging avenues linking inflammation and cancer
Kundu, J. K., & Surh, Y. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.035 · Cited by 272
Kraakman, M. J., Kammoun, H. L., Allen, T. L., Deswaerte, V., Henstridge, D. C., Estevez, E., Matthews, V. B., Neill, B., White, D. A., Murphy, A. J., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.02.006 · Cited by 257
Adipose tissue inflammation in obesity: A metabolic or immune response?
Stolarczyk, E. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.08.006 · Cited by 247
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Gehrke, N., & Schattenberg, J. M. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.02.020 · Cited by 216
Chen, Y., Bui, A., Diesch, J., Manasseh, R., Hausding, C., Rivera, J., Haviv, I., Agrotis, A., Htun, N., Jowett, J. B. M., et al. (2013) · Circulation Research · doi:10.1161/circresaha.113.301562 · Cited by 208
Henstridge, D. C., Bruce, C. R., Drew, B. G., Tory, K., Kolonics, A., Estevez, E., Chung, J., Watson, N., Gardner, T., Lee-Young, R. S., et al. (2014) · Diabetes · doi:10.2337/db13-0967 · Cited by 201
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Dali‐Youcef, N., Mecili, M., Ricci, R., & Andrès, E. (2012) · Annals of Medicine · doi:10.3109/07853890.2012.705015 · Cited by 201
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Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity
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Qu, D. C., Liu, J., Lau, C. W., & Huang, Y. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12713 · Cited by 166
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Giraldez, M. D., Carneros, D., Garbers, C., Rose-John, S., & Bustos, M. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00473-x · Cited by 156
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Orange, S. T., Leslie, J., Ross, M., Mann, D. A., & Wackerhage, H. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.08.001 · Cited by 158
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Fresno, M., Álvarez, R., & Cuesta, N. (2011) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2011.562514 · Cited by 150
Drew, B. G., Ribas, V., Le, J. A., Henstridge, D. C., Phun, J., Zhou, Z., Soleymani, T., Daraei, P., Sitz, D., Vergnes, L., et al. (2014) · Diabetes · doi:10.2337/db13-0665 · Cited by 145
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Lesina, M., Wörmann, S. M., Neuhöfer, P., Song, L., & Algül, H. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.01.002 · Cited by 149
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Schett, G. A. (2018) · Rheumatology · doi:10.1093/rheumatology/kex513 · Cited by 148
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Auger, C., Samadi, O., & Jeschke, M. G. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.02.019 · Cited by 143
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Gregersen, S., Samocha‐Bonet, D., Heilbronn, L. K., & Campbell, L. V. (2012) · Journal of Nutrition and Metabolism · doi:10.1155/2012/238056 · Cited by 136
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Dong, J., Viswanathan, S., Adami, E., Singh, B. K., Chothani, S. P., Ng, B., Lim, W., Zhou, J., Tripathi, M., Ko, N. S. J., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20303-z · Cited by 125
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Yu, H., Dilbaz, S., Coßmann, J., Hoang, A. C., Diedrich, V., Herwig, A., Harauma, A., Hoshi, Y., Moriguchi, T., Landgraf, K., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci125646 · Cited by 128
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Caputo, T., Gilardi, F., & Desvergne, B. (2017) · FEBS Letters · doi:10.1002/1873-3468.12742 · Cited by 112
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Pasquarelli-do-Nascimento, G., Braz-de-Melo, H. A., Faria, S. S., Santos, I. D. O., Kobinger, G., & Magalhães, K. G. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00530 · Cited by 103
Ikeda, S., Tamura, Y., Kakehi, S., Sanada, H., Kawamori, R., & Watada, H. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.03.159 · Cited by 100
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Lehrskov, L. L., & Christensen, R. H. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00747-2 · Cited by 114
Chiricozzi, A., Raimondo, A., Lembo, S., Fausti, F., Dini, V., Costanzo, A., Monfrecola, G., Balato, N., Ayala, F., Romanelli, M., et al. (2016) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2016.1201423 · Cited by 98
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Self-citationMubarak, A., Hodgson, J. M., Considine, M. J., Croft, K. D., & Matthews, V. B. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf400920x · Cited by 92
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Cao, R. Y., Tian, H., Zhang, Y., Liu, G., Xu, H., Rao, G., Tian, Y., & Fu, X. (2023) · MedComm · doi:10.1002/mco2.283 · Cited by 98
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Ma, Y., Gao, M., Sun, H. Y., & Liu, D. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.01.017 · Cited by 92
Chuang, H., Sheu, W. H., Lin, Y.-T., Tsai, C.-Y., Yang, C. Y., Cheng, Y.-J., Huang, P. Y., Li, J.-P., Chiu, L.-L., Wang, X., et al. (2014) · Nature Communications · doi:10.1038/ncomms5602 · Cited by 88
Treatment of type 2 diabetes with the designer cytokine IC7Fc
Findeisen, M., Allen, T. L., Henstridge, D. C., Kammoun, H., Brandon, A. E., Baggio, L. L., Watt, K. I., Pal, M., Cron, L., Estevez, E., et al. (2019) · Nature · doi:10.1038/s41586-019-1601-9 · Cited by 86
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Reilly, S. M., Ahmadian, M., Zamarron, B. F., Chang, L. C., Uhm, M., Poirier, B., Peng, X., Krause, D., Korytnaya, E., Neidert, A., et al. (2015) · Nature Communications · doi:10.1038/ncomms7047 · Cited by 89
Li, C. C. Y., Young, P. E., Maloney, C., Eaton, S. A., Cowley, M. J., Buckland, M. E., Preiß, T., Henstridge, D. C., Cooney, G. J., Febbraio, M. A., et al. (2013) · Epigenetics · doi:10.4161/epi.24656 · Cited by 83
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Bunn, R. C., Cockrell, G. E., Ou, Y., Thrailkill, K. M., Lumpkin, C. K., & Fowlkes, J. L. (2010) · Cardiovascular Diabetology · doi:10.1186/1475-2840-9-73 · Cited by 86
Tarantino, G. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i40.6735 · Cited by 81
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Nicholls, H. T., Kowalski, G. M., Kennedy, D. J., Risis, S., Zaffino, L. A., Watson, N., Kanellakis, P., Watt, M. J., Bobik, A., Bonen, A., et al. (2011) · Diabetes · doi:10.2337/db10-1353 · Cited by 79
Pimentel, G. D., Lira, F. S., Neto, J. C. R., Caris, A. V., Pinheiro, F., Ribeiro, E. B., do Nascimento, C. M. O., & Oyama, L. M. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.04.016 · Cited by 78
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Metadata
- Authors
- Matthews, V. B., Allen, T. L., Risis, S., Chan, M. H. S., Henstridge, D. C., Watson, N., Zaffino, L. A., Babb, J. R., Boon, J., Meikle, P. J., Jowett, J. B., Watt, M. J., Jansson, J.-O., Bruce, C. R., & Febbraio, M. A.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- Monash University (AU)
- University of Gothenburg (SE)
- Corresponding author
- Febbraio, M. A.
- ORCID
- Venue
- Diabetologia
- Published
- 2010-08-11
- Volume
- 53
- Issue
- 11
- Pages
- 2431-2441
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2089567564
- Cited by
- 334
- References
- 50
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 12 · 2023: 15 · 2022: 23 · 2021: 21 · 2020: 26 · 2019: 27 · 2018: 21 · 2017: 29 · 2016: 26 · 2015: 22 · 2014: 20 · 2013: 31 · 2012: 25
- FWCI
- 18.39
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- RMIT Research Repository (RMIT University Library) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Figshare (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- interleukin-6, hepatic insulin resistance, liver inflammation, obesity, high-fat diet, hepatic steatosis, mitochondrial metabolism, oxidative phosphorylation, beta-hydroxyacyl-CoA dehydrogenase, mitochondrial respiratory chain, liver fat deposition
- MeSH terms
- Animals, Body Composition, Calorimetry, Indirect, Diglycerides, Fatty Liver, Female, Inflammation, Insulin Resistance, Liver, Male, Mice, Inbred C57BL, Obesity, Triglycerides, Interleukin-6, Adipocytes, Mice, Knockout, Cell Size, Adiposity, Mice
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