The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance
Open accessAbstract
Aims/hypothesis The role of IL-6 in the development of obesity and hepatic insulin resistance is unclear and still the subject of controversy. We aimed to determine whether global deletion of Il6 in mice (Il6 (-/-)) results in standard chow-induced and high-fat diet (HFD)-induced obesity, hepatosteatosis, inflammation and insulin resistance.Methods Male, 8-week-old Il6 (-/-) and littermate control mice were fed a standard chow or HFD for 12 weeks and phenotyped accordingly.Results Il6 (-/-) mice displayed obesity, hepatosteatosis, liver inflammation and insulin resistance when compared with control mice on a standard chow diet. When fed a HFD, the Il6 (-/-) and control mice had marked, equivalent gains in body weight, fat mass and ectopic lipid deposition in the liver relative to chow-fed animals. Despite this normalisation, the greater liver inflammation, damage and insulin resistance observed in chow-fed Il6 (-/-) mice relative to control persisted when both were fed the HFD. Microarray analysis from livers of mice fed a HFD revealed that genes associated with oxidative phosphorylation, the electron transport chain and tricarboxylic acid cycle were uniformly decreased in Il6 (-/-) relative to control mice. This coincided with reduced maximal activity of the mitochondrial enzyme β-hydroxyacyl-CoA-dehydrogenase and decreased levels of mitochondrial respiratory chain proteins.Conclusions/interpretation Our data suggest that IL-6 deficiency exacerbates HFD-induced hepatic insulin resistance and inflammation, a process that appears to be related to defects in mitochondrial metabolism.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The anti-inflammatory properties of IL-6 are illustrated by IL-6−/− mice, which exhibit hepatosteatosis, insulin resistance, and liver inflammation (44).”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [44]
In the citing paper
“On the other hand, in these same contexts, others have shown that IL6 induces insulin sensitivity (Carey et al., 2006; Findeisen et al., 2019; Matthews et al., 2010; Mauer et al., 2014; Steensberg et al., 2003; Timper et al., 2017), while IL6 has been shown to be insulin sensitizing in exercise (Benrick et al., 2012).”
From Origin and function of stress-induced IL-6 in murine models (2020) · cites this paper as Matthews et al., 2010
Citations
Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Ghrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107
Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952
Cited by
Sorted by citations
Items 101–200 of 332
Lam, Y. Y., Hatzinikolas, G., Weir, J. M., Janovská, A., McAinch, A. J., Game, P. A., Meikle, P. J., & Wittert, G. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.04.011 · Cited by 60
Schéle, E., Benrick, A., Grahnemo, L., Egecioglu, E., Anesten, F., Pálsdóttir, V., & Jansson, J. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12033 · Cited by 61
Gavaldà‐Navarro, A., Moreno‐Navarrete, J. M., Quesada‐López, T., Cairó, M., Giralt, M., Fernández‐Real, J. M., & Villarroya, F. (2016) · Diabetologia · doi:10.1007/s00125-016-4028-y · Cited by 56
Different roles of interleukin 6 and interleukin 11 in the liver: implications for therapy
Widjaja, A. A., Chothani, S. P., & Cook, S. A. (2020) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2020.1761203 · Cited by 55
Adult-onset obesity is triggered by impaired mitochondrial gene expression
Perks, K. L., Ferreira, N., Richman, T. R., Ermer, J. A., Kuznetsova, I., Shearwood, A.-M. J., Lee, R. G., Viola, H. M., Johnstone, V., Matthews, V. B., et al. (2017) · Science Advances · doi:10.1126/sciadv.1700677 · Cited by 56
Prestwood, T. R., Asgariroozbehani, R., Wu, S., Agarwal, S. M., Logan, R. W., Ballon, J. S., Hahn, M., & Freyberg, Z. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113101 · Cited by 67
Nonalcoholic fatty liver disease: molecular pathways and therapeutic strategies
Huang, Y. Y., Gusdon, A. M., & Qu, S. (2013) · Lipids in Health and Disease · doi:10.1186/1476-511x-12-171 · Cited by 55
The role of gp130 receptor cytokines in the regulation of metabolic homeostasis
Cron, L., Allen, T. L., & Febbraio, M. A. (2016) · Journal of Experimental Biology · doi:10.1242/jeb.129213 · Cited by 53
The impact of bariatric surgery on inflammation: quenching the fire of obesity?
Hafida, S., Mirshahi, T., & Nikolajczyk, B. S. (2016) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000277 · Cited by 53
A Rodent Model of Human-Dose-Equivalent 5-Fluorouracil: Toxicity in the Liver, Kidneys, and Lungs
da Silva, M. C., Fabiano, L. C., Salomão, K. C. D. C., de Freitas, P. L. Z., Neves, C. Q., Borges, S. C., Carvalho, M. D. G. D. S., Breithaupt‐Faloppa, A. C., de Thomaz, A. A., dos Santos, A. M., et al. (2023) · Antioxidants · doi:10.3390/antiox12051005 · Cited by 52
Aniszewska, A., Chlodzinska, N., Bartkowska, K., Winnicka, M., Turlejski, K., & Djavadian, R. (2015) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2015.05.001 · Cited by 54
Jordy, A. B., Kraakman, M. J., Gardner, T., Estévez, E., Kammoun, H. L., Weir, J. M., Kiens, B., Meikle, P. J., Febbraio, M. A., & Henstridge, D. C. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00547.2014 · Cited by 51
Bruce, C. R., Risis, S., Babb, J. R., Yang, C., Lee, R. S., Henstridge, D. C., & Febbraio, M. A. (2012) · Endocrinology · doi:10.1210/en.2012-1847 · Cited by 55
Singh, H., Sidhu, S., Chopra, K., & Khan, M. M. U. (2016) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2016-0071 · Cited by 51
The IL-6-neutralizing sIL-6R/sgp130 buffer system is disturbed in patients with type 2 diabetes.
Aparicio-Siegmund, S., Garbers, Y., Flynn, C. M., Waetzig, G. H., Gouni-Berthold, I., Krone, W., Berthold, H., Laudes, M., Rose-John, S., & Garbers, C. (2019) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00166.2019 · Cited by 45
Vida, M., Gavito, A., Pavón, F. J., Bautista, D., Serrano, A., Suárez, J., Arrabal, S., Decara, J. M., Cuevas, M. R., de Fonseca, F. R., et al. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.019166 · Cited by 53
Bovbjerg, K. K. L., Jørgensen, N. B., Just, R., Heegaard, P. M. H., & Madsbad, S. (2015) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-015-0012-9 · Cited by 50
Skeletal muscle – A bystander or influencer of metabolic syndrome?
Richter-Stretton, G. L., Fenning, A. S., & Vella, R. K. (2020) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2020.06.006 · Cited by 52
Interleukin-6 mediates exercise-induced increase in insulin sensitivity in mice
Benrick, A., Wallenius, V., & Asterholm, I. W. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2012.065508 · Cited by 49
Müller, S. A., Shmueli, M. D., Feng, X. M., Tüshaus, J., Schumacher, N., Clark, R., Smith, B. E., Chi, A., Rose‐John, S., Kennedy, M. E., et al. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00596-6 · Cited by 51
Breuillard, C., Bonhomme, S., Couderc, R., Cynober, L., & Bandt, J. P. D. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514002086 · Cited by 48
(2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2019.07.012 · Cited by 46
Mutation in MRPS34 Compromises Protein Synthesis and Causes Mitochondrial Dysfunction
Richman, T. R., Ermer, J. A., Davies, S. M. K., Perks, K. L., Viola, H. M., Shearwood, A.-M. J., Hool, L. C., Rackham, O., & Filipovska, A. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005089 · Cited by 46
Lourido, F., Quenti, D., Salgado-Canales, D., & Tobar, N. (2021) · Scientific Reports · doi:10.1038/s41598-021-82944-4 · Cited by 48
Eye on the horizon: The metabolic landscape of the RPE in aging and disease
Hansman, D., Du, J., Casson, R. J., & Peet, D. J. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101306 · Cited by 50
Townsend, L. K., Medak, K. D., Peppler, W. T., Meers, G. M.-E., Rector, R. S., LeBlanc, P. J., & Wright, D. C. (2019) · Journal of Lipid Research · doi:10.1194/jlr.m092510 · Cited by 44
Wu, L. H., Huang, C., Adhikarakunnathu, S., Mateo, L. R. S., Duffy, K. E., Rafferty, P., Bugelski, P. J., Raymond, H. A., Deutsch, H., Picha, K. M., et al. (2012) · Metabolism · doi:10.1016/j.metabol.2012.04.015 · Cited by 44
Yang, M., Qiu, S., He, Y., Li, L., Wu, T., Ding, N., Li, F., Zhao, A. Z., & Yang, G. (2021) · Diabetologia · doi:10.1007/s00125-021-05384-9 · Cited by 44
IL-6: A Potential Role in Cardiac Metabolic Homeostasis
Xu, Y., Zhang, Y., & Ye, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092474 · Cited by 42
Hematological and acute-phase responses to diet-induced obesity in IL-6 KO mice
Pini, M., Rhodes, D., & Fantuzzi, G. (2011) · Cytokine · doi:10.1016/j.cyto.2011.09.015 · Cited by 42
Patin, F., Baranek, T., Vourc’h, P., Nadal‐Desbarats, L., Goossens, J., Marouillat, S., Dessein, A., Descat, A., Hounoum, B. M., Bruno, C., et al. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0461-3 · Cited by 41
Collotta, D., Hull, W. M., Mastrocola, R., Chiazza, F., Cento, A. S., Murphy, C., Verta, R., Alves, G. F., Gaudioso, G., Fava, F., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101009 · Cited by 41
Dynamic Interplay Between Metabolic Syndrome and Immunity
Paragh, G., Seres, I., Harangi, M., & Fülöp, P. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-07320-0_13 · Cited by 40
Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC
Boslem, E., Reibe, S., Carlessi, R., Smeuninx, B., Tegegne, S., Egan, C. L., McLennan, E., Terry, L. V., Nobis, M., Mu, A., et al. (2023) · Science Advances · doi:10.1126/sciadv.adh0831 · Cited by 39
Self-citationNajjar, S. M., & Russo, L. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0407-3 · Cited by 40
Chen, F., Chen, D., Zhao, X., Yang, S., Li, Z., Sanchı́s, D., Jin, L., Qiang, X., Wang, K., Xu, Y., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.08.022 · Cited by 40
Peripheral IL-6/STAT3 signaling promotes beiging of white fat
Li, H., Dong, M., Liu, W., Gao, C., Jia, Y., Zhang, X., Xiao, X., Liu, Q., & Lin, H. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2021.119080 · Cited by 40
Selective blockade of interleukin 6 trans-signaling depresses atrial fibrillation
Li, X., Wu, X. O., Chen, X., Peng, S., Chen, S., Zhou, G., Wei, Y., Lu, X., Zhou, C., Ye, Y., et al. (2023) · Heart Rhythm · doi:10.1016/j.hrthm.2023.08.026 · Cited by 39
Marchesin, J. D. C., Celiberto, L. S., Orlando, A. B., de Medeiros, A. I., Pinto, R. A., Zuanon, J. A. S., Spolidório, L. C., Santos, A., Taranto, M. P., & Cavallini, D. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.07.010 · Cited by 39
Boeta‐Lopez, K., Durán, J. A., Elizondo, D. M., Gonzales, E., Rentfro, A. R., Schwarzbach, A. E., & Nair, S. (2017) · Obesity Science & Practice · doi:10.1002/osp4.138 · Cited by 37
Modeling progressive non-alcoholic fatty liver disease in the laboratory mouse
Riordan, J. D., & Nadeau, J. H. (2014) · Mammalian Genome · doi:10.1007/s00335-014-9521-3 · Cited by 36
Amouzou, C., Breuker, C., Fabre, O., Bourret, A., Lambert, K., Birot, O., Fédou, C., Dupuy, A., Cristol, J., Sutra, T., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154119 · Cited by 39
McGillicuddy, F. C., Reynolds, C. M., Finucane, O., Coleman, E., Harford, K. A., Grant, C., Sergi, D., Williams, L. M., Mills, K. H. G., & Roche, H. M. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00297.2013 · Cited by 36
An Easy, Convenient Cell and Tissue Extraction Protocol for Nuclear Magnetic Resonance Metabolomics
Mathéus, N., Hansen, S., Rozet, E., Peixoto, P., Maquoi, E., Lambert, V., Noël, A., Frédérich, M., Mottet, D., & Tullio, P. D. (2014) · Phytochemical Analysis · doi:10.1002/pca.2498 · Cited by 36
Effect of a trans fatty acid-enriched diet on biochemical and inflammatory parameters in Wistar rats
Longhi, R., Almeida, R. F., Machado, L. D. S., Duarte, M. M. M. F., de Souza, D. G., Machado, P. P., de Assis, A. M., Quincozes‐Santos, A., & Souza, D. O. (2016) · European Journal of Nutrition · doi:10.1007/s00394-015-1148-y · Cited by 35
Role of muscle IL-6 in gender-specific metabolism in mice
Molinero, A., Fernández-Pérez, A., Barcons, A. M., Giralt, M., Comes, G., Fernández‐Gayol, O., Vallejo, M., & Hidalgo, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173675 · Cited by 36
Increased levels of inflammatory plasma markers and obesity risk in a mouse model of Down syndrome
Fructuoso, M., Rachdi, L., Philippe, E., Denis, R., Magnan, C., Stunff, H. L., Janel, N., & Dierssen, M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.09.021 · Cited by 35
Rodrigues, D. F., Henriques, M. C. D. C., Oliveira, M. C., Garcia, Z. M., Marques, P. E., de Souza, D. D. G., Menezes, G. B., Teixeira, M. M., & Ferreira, A. V. M. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.11.012 · Cited by 36
Nerstedt, A., Cansby, E., Amrutkar, M., Smith, U., & Mahlapuu, M. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.05.013 · Cited by 36
Why do anti-inflammatory therapies fail to improve insulin sensitivity?
Gao, Z., & Ye, J. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.131 · Cited by 35
Targeting gp130 to prevent inflammation and promote insulin action
Kraakman, M. J., Allen, T. L., Whitham, M., Iliades, P., Kammoun, H. L., Estévez, E., Lancaster, G. I., & Febbraio, M. A. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12170 · Cited by 35
Shriki, A., Lanton, T., Sonnenblick, A., Levkovitch-Siany, O., Eidelshtein, D., Abramovitch, R., Rosenberg, N., Pappo, O., Elgavish, S., Nevo, Y., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0321 · Cited by 34
Karbalaei, R., Piran, M., Rezaei–Tavirani, M., Asadzadeh‐Aghdaei, H., & Heidari, M. H. (2017) · Gastroenterology and hepatology from bed to bench. · Cited by 31
Colorectal Cancer Microenvironment: Among Nutrition, Gut Microbiota, Inflammation and Epigenetics
Garagnani, P., Pirazzini, C., & Franceschi, C. (2012) · Current Pharmaceutical Design · doi:10.2174/1381612811306040765 · Cited by 38
Loss of P2X7 receptor function dampens whole body energy expenditure and fatty acid oxidation
Giacovazzo, G., Apolloni, S., & Coccurello, R. (2018) · Purinergic Signalling · doi:10.1007/s11302-018-9610-y · Cited by 34
Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling
Luan, D., Dadpey, B., Zaid, J., Bridge-Comer, P. E., DeLuca, J. H., Xia, W., Castle, J., & Reilly, S. M. (2022) · Diabetes · doi:10.2337/db22-0444 · Cited by 35
Interleukin‑6 signaling blockade treatment for cytokine release syndrome in COVID‑19 (Review)
Chen, J., Zhang, L., Hou, H., Xu, L., & Ji, K. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.9456 · Cited by 30
Akama, T., & Chun, T. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.000456 · Cited by 31
The diverse roles of macrophages in metabolic inflammation and its resolution
Ray, A. G., Odum, O., Wiseman, D., & Weinstock, A. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1147434 · Cited by 31
Vachliotis, I. D., & Pοlyzos, S. A. (2025) · Current Obesity Reports · doi:10.1007/s13679-025-00657-5 · Cited by 31
de Souza, R. M., de Souza, L., Machado, A. E., Alves, A. C. D. B., Rodrigues, F. S., Aguiar, A. S., Santos, A. R. S., Bem, A. F. D., & Moreira, E. L. G. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.09.022 · Cited by 27
Gavito, A., Bautista, D., Suárez, J., Badran, S., Arco, R., Pavón, F. J., Serrano, A., Rivera, P., Decara, J. M., Cuesta, A. L., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157956 · Cited by 28
IL-6 Is Not Necessary for the Regulation of Adipose Tissue Mitochondrial Content
Wan, Z., Perry, C. G. R., MacDonald, T. L., Chan, C. B., Holloway, G. P., & Wright, D. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051233 · Cited by 29
Pazos, P., Lima, L., Casanueva, F. F., Diéguez, C., & García, M. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072339 · Cited by 30
Kruse, M., Kemper, M., Gancheva, S., Osterhoff, M. A., Dannenberger, D., Markgraf, D. F., Machann, J., Hierholzer, J., Roden, M., & Pfeiffer, A. F. H. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000419 · Cited by 27
Paula, V. G., Sinzato, Y. K., Moraes-Souza, R. Q., Soares, T. S., Gallego, F. Q., Karki, B., Paes, A. M. D. A., Corrente, J. E., Damasceno, D. C., & Volpato, G. T. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab195 · Cited by 27
Whitham, M., Pál, M., Petzold, T., Hjorth, M., Egan, C. L., Brunner, J. S., Estévez, E., Iliades, P., Zivanovic, B., Reibe, S., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00206.2019 · Cited by 29
Huang, D., Gao, J., Li, C., Nong, C., Huang, W., Zheng, X., Li, S., & Peng, Y. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05878-9 · Cited by 26
Ferraccioli, G., & Gremese, E. (2011) · Swiss Medical Weekly · doi:10.4414/smw.2011.13211 · Cited by 26
Garcia, M. D. C., Pazos, P., Lima, L., & Diéguez, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092569 · Cited by 27
Unravelling the broader complexity of IL-6 involvement in health and disease
Jenkins, R. L., Hughes, S. T. O., Figueras, A. C., & Jones, S. A. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155684 · Cited by 25
Anesten, F., Holt, M. K., Schéle, E., Pálsdóttir, V., Reimann, F. M., Gribble, F. M., Safari, C., Skibicka, K. P., Trapp, S., & Jansson, J. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00383.2015 · Cited by 25
Body Composition and Metabolic Caging Analysis in High Fat Fed Mice
Lancaster, G. I., & Henstridge, D. C. (2018) · Journal of Visualized Experiments · doi:10.3791/57280 · Cited by 25
Link between plasma trans-fatty acid and fatty liver is moderated by adiposity
Mazidi, M., Katsiki, N., Mikhailidis, D. P., & Banach, M. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.07.061 · Cited by 25
Adipokines: A Rainbow of Proteins with Metabolic and Endocrine Functions
Parrettini, S., Cavallo, M., Gaggia, F., Calafiore, R., & Luca, G. (2020) · Protein and Peptide Letters · doi:10.2174/0929866527666200505214555 · Cited by 26
Skeletal muscle IL-6 and regulation of liver metabolism during high-fat diet and exercise training
Knudsen, J. G., Joensen, E., Bertholdt, L., Jessen, H., van Hauen, L., Hidalgo, J., & Pilegaard, H. (2016) · Physiological Reports · doi:10.14814/phy2.12788 · Cited by 24
Metformin induces the AP-1 transcription factor network in normal dermal fibroblasts
Gillespie, Z. E., Wang, C., Vadan, F., Yu, T. Y., Ausió, J., KUSALIK, A. J., & Eskiw, C. H. (2019) · Scientific Reports · doi:10.1038/s41598-019-41839-1 · Cited by 28
Li, X., Qiu, W., Li, N., Da, X., Ma, Q., Hou, Y., Wang, T., Song, M., & Chen, J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00557 · Cited by 22
Smad3 Phospho-Isoform Signaling in Nonalcoholic Steatohepatitis
Yamaguchi, T., Yoshida, K., Murata, M., Suwa, K., Tsuneyama, K., Matsuzaki, K., & Naganuma, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116270 · Cited by 25
Copp, S. W., Stone, A. J., Li, J., & Kaufman, M. P. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00195.2015 · Cited by 24
MacPherson, R. E. K., Gamu, D., Frendo‐Cumbo, S., Castellani, L. N., Kwon, F., Tupling, A. R., & Wright, D. C. (2016) · Obesity · doi:10.1002/oby.21521 · Cited by 23
Exocrine pancreas regeneration modifies original pancreas to alleviate diabetes in mouse models
Kou, X., Liu, J., Wang, D., Yu, M., Li, C., Lu, L., Chen, C., Liu, D., Yu, W., Yu, T., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abg9170 · Cited by 22
Chew, G.-S., Myers, S., Shu‐Chien, A. C., & Muhammad, T. S. T. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1896-z · Cited by 22
Oliveira, M. C., Garcia, Z. M., Arifa, R. D. D. N., de Paula, T. P., Andrade, J. M. O., Santos, S. H. S., Menezes, G. B., de Souza, D. D. G., Teixeira, M. M., & Ferreira, A. V. M. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.04.004 · Cited by 22
In immune defense: redefining the role of the immune system in chronic disease
Rubinow, K. B., & Rubinow, D. R. (2017) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2017.19.1/drubinow · Cited by 22
Paternal high‐fat diet transgenerationally impacts hepatic immunometabolism
Barbosa, T. D. C., Alm, P. S., Krook, A., Barrès, R., & Zierath, J. R. (2019) · The FASEB Journal · doi:10.1096/fj.201801879rr · Cited by 21
Thyfault, J. P., & Wright, D. C. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0122 · Cited by 23
The Role of Interleukin-6 and Interleukin-8 Gene Polymorphisms in Non-Alcoholic Steatohepatitis
Cengiz, M., Yaşar, D. G., Ergün, M. A., Akyol, G., & Özeni̇rler, S. (2014) · Hepatitis Monthly · doi:10.5812/hepatmon.24635 · Cited by 21
Saunders, B. M., Rudnicka, C., Filipovska, A., Davies, S. M. K., Ward, N. C., Hricová, J., Schlaich, M. P., & Matthews, V. B. (2017) · Immunology and Cell Biology · doi:10.1111/imcb.1002 · Cited by 21
Huhtala, M. S., Tertti, K., Juhila, J., Sorsa, T. A., & Rönnemaa, T. (2020) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-020-03077-6 · Cited by 21
IL-6 is not essential for exercise-induced increases in glucose uptake
O’Neill, H. M., Palanivel, R., Wright, D. C., MacDonald, T. L., Lally, J., Schertzer, J. D., & Steinberg, G. R. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00946.2012 · Cited by 20
Reduction of IL‐6 gene expression in human adipose tissue after sleeve gastrectomy surgery
Casimiro, I., Hanlon, E. C., White, J., Leon, A. A. D., Ross, R., Moise, K., Piron, M. J., & Brady, M. (2019) · Obesity Science & Practice · doi:10.1002/osp4.396 · Cited by 21
Santamarina, A. B., de Moraes, R. C. M., Filho, V. N., Murata, G. M., de Freitas, J. A., de Miranda, D. A., Cerqueira, A., Costa, S. K. P., Ferreira, A. F. F., Britto, L. R., et al. (2022) · Antioxidants · doi:10.3390/antiox11030447 · Cited by 20
Su, T., He, Y., Huang, Y., Ye, M., Guo, Q., Xiao, Y., Cai, G., Chen, L., Li, C., Zhou, H., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-43787-x · Cited by 22
Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice
Gaur, V., Connor, T., Venardos, K. M., Henstridge, D. C., Martin, S. D., Swinton, C., Morrison, S., Aston‐Mourney, K., Gehrig, S. M., van Ewijk, R., et al. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12896 · Cited by 18
Ma, D., Wang, Y., Zhou, G., Wang, Y., & Li, X. (2019) · Inflammation · doi:10.1007/s10753-019-00959-6 · Cited by 19
Lehrskov, L. L., Christensen, R. H., Wedell‐Neergaard, A., Legaard, G. E., Dorph, E., Larsen, M. K., Henneberg, M., Launbo, N., Fagerlind, S. R., Seide, S. K., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01249 · Cited by 19
Farhadi, S., Ghias, J. S., Hasanpur, K., Mohammadi, S. A., & Ebrahimie, E. (2021) · Archives animal breeding/Archiv für Tierzucht · doi:10.5194/aab-64-53-2021 · Cited by 19
Khudhair, Z., Al-Hallaf, R., Eichenberger, R. M., Field, M. A., Krause, L., Sotillo, J., & Loukas, A. C. (2022) · Biomolecules · doi:10.3390/biom12050637 · Cited by 19
High serum level of interleukin‑6 is linked with dyslipidemia in oral lichen planus
Toader, M. P., Ţăranu, T., Constantin, M. M., Temelie-Olinici, D., Mocanu, M., Costan, V. V., & Toader, Ș. V. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10419 · Cited by 18
Metadata
- Authors
- Matthews, V. B., Allen, T. L., Risis, S., Chan, M. H. S., Henstridge, D. C., Watson, N., Zaffino, L. A., Babb, J. R., Boon, J., Meikle, P. J., Jowett, J. B., Watt, M. J., Jansson, J.-O., Bruce, C. R., & Febbraio, M. A.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- Monash University (AU)
- University of Gothenburg (SE)
- Corresponding author
- Febbraio, M. A.
- ORCID
- Venue
- Diabetologia
- Published
- 2010-08-11
- Volume
- 53
- Issue
- 11
- Pages
- 2431-2441
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2089567564
- Cited by
- 334
- References
- 50
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 12 · 2023: 15 · 2022: 23 · 2021: 21 · 2020: 26 · 2019: 27 · 2018: 21 · 2017: 29 · 2016: 26 · 2015: 22 · 2014: 20 · 2013: 31 · 2012: 25
- FWCI
- 18.39
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- RMIT Research Repository (RMIT University Library) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Figshare (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- interleukin-6, hepatic insulin resistance, liver inflammation, obesity, high-fat diet, hepatic steatosis, mitochondrial metabolism, oxidative phosphorylation, beta-hydroxyacyl-CoA dehydrogenase, mitochondrial respiratory chain, liver fat deposition
- MeSH terms
- Animals, Body Composition, Calorimetry, Indirect, Diglycerides, Fatty Liver, Female, Inflammation, Insulin Resistance, Liver, Male, Mice, Inbred C57BL, Obesity, Triglycerides, Interleukin-6, Adipocytes, Mice, Knockout, Cell Size, Adiposity, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
