Cited by 903Cardiovascular Function and Risk FactorsCardiac Fibrosis and RemodelingCardiomyopathy and Myosin Studies

The DOI matches its Crossref record; 152 of the 153 references it cites were found in a registry or an index.

Molecular mechanisms of diabetic cardiomyopathy

Open access

Bugger, Heiko, Abel, E. Dale·2014·Diabetologia

DOI 10.1007/s00125-014-3171-6PMC PMC3969857

Open this paper in CoChat — free account Open PDF

Abstract

In recent years, diabetes mellitus has become an epidemic and now represents one of the most prevalent disorders. Cardiovascular complications are the major cause of mortality and morbidity in diabetic patients. While ischaemic events dominate the cardiac complications of diabetes, it is widely recognised that the risk for developing heart failure is also increased in the absence of overt myocardial ischaemia and hypertension or is accelerated in the presence of these comorbidities. These diabetes-associated changes in myocardial structure and function have been called diabetic cardiomyopathy. Numerous molecular mechanisms have been proposed to contribute to the development of diabetic cardiomyopathy following analysis of various animal models of type 1 or type 2 diabetes and in genetically modified mouse models. The steady increase in reports presenting novel mechanistic data on this subject expands the list of potential underlying mechanisms. The current review provides an update on molecular alterations that may contribute to the structural and functional alterations in the diabetic heart.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s00125-014-3171-6

Cites

152 of 152 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

2 retracted

MicroRNA miR-133 Represses HERG K+ Channel Expression Contributing to QT Prolongation in Diabetic Hearts
Xiao, J., Luo, X., Lin, H., Zhang, Y., Lu, Y., Wang, N., Zhang, Y., Yang, B., & Wang, Z. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c700015200 · Cited by 233
Retracted
Retracted: Advanced glycation endproduct (AGE) accumulation and AGE receptor (RAGE) up‐regulation contribute to the onset of diabetic cardiomyopathy
Ma, H., Li, S., Xu, P., Babcock, S. A., Dolence, E. K., Brownlee, M., Li, J., & Ren, J. T. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00547.x · Cited by 154
Retracted
Most mammalian mRNAs are conserved targets of microRNAs
Friedman, R. C., Farh, K. K.-H., Burge, C. B., & Bartel, D. P. (2009) · Genome Research · doi:10.1101/gr.082701.108 · Cited by 8,462
Development by Self-Digestion
Levine, B., & Klionsky, D. J. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00099-1 · Cited by 3,728
Diabetes and Cardiovascular Disease: The Framingham Study
Kannel, W. B. (1979) · JAMA · doi:10.1001/jama.1979.03290450033020 · Cited by 2,936
Advanced Glycation End Products: Sparking the Development of Diabetic Vascular Injury
Goldin, A., Beckman, J. A., Schmidt, A. M., & Creager, M. A. (2006) · Circulation · doi:10.1161/circulationaha.106.621854 · Cited by 2,261
The Framingham Study
Dawber, T. R. (1980) · Harvard University Press eBooks · doi:10.4159/harvard.9780674492097 · Cited by 1,965
Identification of hundreds of conserved and nonconserved human microRNAs
Bentwich, I., Avniel, A., Karov, Y., Aharonov, R., Gilad, S., Barad, O., Barzilai, A., Einat, P., Einav, U., Meiri, E., et al. (2005) · Nature Genetics · doi:10.1038/ng1590 · Cited by 1,841
New type of cardiomyopathy associated with diabetic glomerulosclerosis
Rubler, S., Dlugash, J., Yuceoglu, Y. Z., Kumral, T., Branwood, A. W., & Grishman, A. (1972) · The American Journal of Cardiology · doi:10.1016/0002-9149(72)90595-4 · Cited by 1,835
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress
Nakai, A., Yamaguchi, O., Takeda, T., Higuchi, Y., Hikoso, S., Taniike, M., Omiya, S., Mizote, I., Matsumura, Y., Asahi, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1574 · Cited by 1,520

Show all 153 references

Sorted by citations

Items 701–800 of 903

Heart Failure and Diabetes: Perspective of a Dangerous Association
Favaloro, L. E., Ratto, R., & Musso, C. (2021) · Current Hypertension Reviews · doi:10.2174/1573402117666210406111927 · Cited by 3
Changes in microRNA Expression Profiles in Diabetic Cardiomyopathy Rats Following H3 Relaxin Treatment
Zhang, X., Liu, M., Yang, K., Chi, J., Chen, W., Shi, Z., Liu, W., Ma, X., & Yin, X. (2022) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001211 · Cited by 3
MicroRNAs Targeting Critical Molecular Pathways in Diabetic Cardiomyopathy Emerging Valuable for Therapy
Mathur, P., Saxena, S., Saxena, B., & Rani, V. (2024) · Cardiovascular & Hematological Agents in Medicinal Chemistry · doi:10.2174/0118715257265947231129074526 · Cited by 3
Correlations of Serum Lipid Parameters and Atherogenic Indices With Left Ventricular Diastolic Dysfunction Among Apparently Healthy Patients With Type 2 Diabetes Mellitus: A Multicenter In‐Hospital Cross‐Sectional Study
Mayambu, Y. D., On'kin, J. B. K. L., Nkodila, A. N., Lubenga, Y. N., Mvunzi, T. S., M’Buyamba-Kabangu, J.-R., Longo‐Mbenza, B., & Phanzu, B. K. (2024) · Journal of Diabetes Research · doi:10.1155/2024/4078281 · Cited by 3
Remodeling of the cardiac striatin interactome and its dynamics in the diabetic heart
Chacar, S., Abdrabou, W. S., Hageh, C. A., Ali, L., Venkatachalam, T., Zalloua, P., Suleiman, M. S., Howarth, F. C., Khraibi, A. A., & Nader, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-91098-6 · Cited by 3
Spirulina platensis Alleviates the Liver, Brain and Heart Oxidative Stress in Type 1 Diabetic Rats
Garcia, F. A. D. O., Yuen, V. G., Sales‐Campos, H., Turatti, E., Viana, G. S. D. B., Oliveira, C. J. F., & McNeill, J. H. (2018) · Food and Nutrition Sciences · doi:10.4236/fns.2018.96056 · Cited by 3
Diabetic cardiomyopathy: a review of literature on clinical status and meta-analysis of tissue doppler diagnostic method and the clinical value of intensive glycemic control
Albakri, A. (2018) · Medical and Clinical Archives · doi:10.15761/mca.1000139 · Cited by 3
VEGF-B: friend or foe to the heart in times of nutrient excess?
Rowe, G. C., & Young, M. E. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00158.2017 · Cited by 3
Subclinical Right Ventricular Dysfunction in Type 2 Diabetes Mellitus: An Echocardiographic Strain/Strain Rate Study
YASER R. MOHAMMED, M. D. W. R. H., ANWAR, M. D. S. H. N. A. M., & EL-HAMID, M. D. A. T. E.-D. A. E.-H. I. (2018) · The Medical Journal of Cairo University/The Medical Journal of Cairo University · doi:10.21608/mjcu.2018.55054 · Cited by 3
Alpha-lipoic acid and vitamin B complex slow down the changes in mice diabetic cardiomyopathy
Târtea, G. C., Hădăreanu, D.-R., Mihailovici, A. R., Donoiu, I., & Istrătoaie, O. (2020) · Romanian Journal of Morphology and Embryology · doi:10.47162/rjme.61.2.22 · Cited by 3
Diabetic Cardiomyopathy and Heart Failure
Jorge, A. J. L., & de Carvalho, M. R. M. (2023) · ABC Heart Failure & Cardiomyopathy · doi:10.36660/abchf.20230021 · Cited by 2
Multimodal imaging reveals distinct cardiac benefits of dulaglutide versus dapagliflozin in a mouse model of glucotoxic cardiomyopathy
Joubert, M., Ducheix, S., Prieur, X., Cariou, B., & Manrique, A. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.70012 · Cited by 2
A related mechanism for USP18 regulating diabetic cardiomyopathy procession: promoting activity of AKT signaling pathway by improving Notch1 stability
Cheng, Y., Liu, G., Yu, L., Li, H., Liu, Y., Yang, H., & Zhang, P. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152626 · Cited by 2
METTL14 aggravates pyroptosis in diabetic cardiomyopathy by promoting m6A modification of NLRP3
Hua, Z., Zhong, F., Xu, C., & Liang, S. (2025) · Immunologic Research · doi:10.1007/s12026-025-09702-w · Cited by 2
Diffuse Myocardial Injury With Diabetes-Related Advanced Glycation End Product Accumulation in Dilated Cardiomyopathy: Pathological Insights From an Autopsy Case
Kitazawa, S., & Kitazawa, R. (2026) · Cureus · doi:10.7759/cureus.101298 · Cited by 2
TyG index and MAFLD severity are associated with subclinical LV dysfunction in T2DM patients: a cross−sectional study
Hu, X., Chen, H., Wang, Z., Deng, Y., Huang, L., Zhang, C., Guo, L., Liu, S., & Liao, L. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1749989 · Cited by 2
(Pro)renin receptor (PRR) exacerbates diabetic cardiomyopathy by suppressing LRRK2-Mediated mitophagy and promoting senescence
Deng, L., Wang, B., Jie, H., Liu, M., Yu, L., Wu, S., Wang, L., Li, S., Hu, X., Yu, Y., et al. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.01.036 · Cited by 2
Diabetes-induced right ventricular remodeling precedes left ventricular remodeling and occurs via a distinct fatty acid uptake pathway
Satyanarayana, S. B., Campbell, J. S., Schmitt, M. P., Júnior, J. E. C., Shukla, R., Smith, D. F., Nair, S., & Bruns, D. R. (2026) · Cardiovascular Diabetology – Endocrinology Reports · doi:10.1186/s40842-026-00287-3 · Cited by 2
Diabetes as a Predictor of In-Hospital and One-Year Outcomes After Decompensated Heart Failure
Fairman, E. B., Delfino, F. A., Mauro, V. M., Charask, A. A., Costa, Y. C., Raffaeli, A., Rojo, L., Rowain, V. R., Cáceres, L., & Barrero, C. (2020) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2020.100579 · Cited by 2
The Effect of Glycemic Control on Left Ventricular Function in Clinical and Experimental Diabetes
Lavine, S. J., & Prcevski, P. (2023) · CJC Open · doi:10.1016/j.cjco.2023.06.007 · Cited by 2
Pulmonary hypertension and metabolic disorders
Shchelkova, G. V., Yarovoy, S. Y., Олеговна, Д. Е., & Chazova, I. E. (2024) · Systemic Hypertension · doi:10.38109/2075-082x-2024-1-37-46 · Cited by 2
Oral edaravone ameliorates myocardial fibrosis in type 2 diabetic rats by TGF-β1/Smad signaling pathway
Zhang, X., Xu, Y., Xue, S.-Q., Zeng, Y.-Q., Gu, J.-H., Zhou, X., Luo, H., & Pu, L. (2025) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2025.108976 · Cited by 2
Glycemic Influences on Hypertrophic Cardiomyopathy Myocardium: Insights From Cardiac MRI Feature Tracking
Peng, X., Huo, H., Gao, J., Jiang, X., & Yuan, Y. (2025) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.70031 · Cited by 2
Диабетическая кардиомиопатия: классификация, инструментальные методы диагностики
Serhiyenko, A. A., & Serhiyenko, V. A. (2020) · INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) · doi:10.22141/2224-0721.16.7.2020.219012 · Cited by 2
The Comparison of the effect of High Intensity Interval and Progressive Resistance Training on Activated Transcription Factor 3 myocardial gene expression in male Diabetic Rats
Manesh, S. S., Khaledi, N., Rajabi, H., & Askari, H. G. (2021) · Journal of Sport and Exercise Physiology · doi:10.52547/joeppa.14.2.67 · Cited by 2
A hypothesis: Glucagon-like peptide-1 may play a protective role in diabetic cardiomyopathy
Fan, Z., Yang, C., & Yang, J. M. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.06.108 · Cited by 2
Resveratrol protects against early cardiomyopathic changes-induced by Type-1 diabetes through a heme-oxygenase-1 dependent mechanism
Hammad, A. S. A., Ahmed, A. F., Heeba, G. H., & Taye, A. (2018) · Journal of advanced Biomedical and Pharmaceutical Sciences · doi:10.21608/jabps.2018.5175.1022 · Cited by 2
Acute high-intensity aerobic exercise increases gene expression of calcium-related proteins and activates endoplasmic reticulum stress responses in diabetic hearts
Ness, H. O., Ljones, K., Pinho, M., & Høydal, M. A. (2020) · Comparative Exercise Physiology · doi:10.3920/cep200022 · Cited by 2
Diabetic Cardiomyopathy: An Update on Its Pathophysiology With Specific Emphasis on Epigenetics Modifications Besides Treatment – A Systematic Review
Kaur, K. K., Allahbadia, G., & Singh, M. (2022) · doi:10.54646/bijrdpm.001 · Cited by 4
Impact of Prenatal Exposure to Maternal Diabetes and High-Fat Diet on Postnatal Myocardial Ketone Body Metabolism in Rats
Ayyappan, P., Larsen, T. D., Gandy, T. C. T., Louwagie, E. J., & Baack, M. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043684 · Cited by 2
Non-Invasive Myocardial Work Indices in Infants Born to Mothers With Diabetes in Pregnancy
Iwashima, S., Yanase, Y., Takahashi, K., Murakami, Y., Tanaka, A., & Hiyoshi, Y. (2023) · Circulation Journal · doi:10.1253/circj.cj-22-0804 · Cited by 2
Nicorandil alleviates inflammation and oxidation in diabetic cardiomyopathy
Tao, Y., Zhou, B. R., Zou, J., Yu, Y., Zhao, J., Xu, N., & Wang, Q. (2022) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v21i2.9 · Cited by 2
Epigenetics of diabetes in humans
Kowluru, R. A., & Kowluru, A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-18661-5.00009-9 · Cited by 2
Diabetic state of human coronary artery endothelial cells results in altered effects of bone mesenchymal stem cell‐derived extracellular vesicles
Xu, C., Karbasiafshar, C., Teixeira, R. B., Broadwin, M., Sellke, F. W., & Abid, M. R. (2023) · Physiological Reports · doi:10.14814/phy2.15866 · Cited by 1
Potential Role of SGLT2 Inhibitors in the Treatment and Prevention of Diabetic Cardiomyopathy
Nandave, M. (2024) · Springer eBooks · doi:10.1007/978-981-97-7568-2_5 · Cited by 2
An Inhibition Effect on Diabetic Cardiomyopathy Fibrosis of db/db Mice through Reduction of Myocardial Protein N-glycosylation by Crude 1-DNJ Extract from Homemade Bombyx Batryticatus mori.LPreprint
Zhao, Q. J., Jia, T. Z., Cao, Q. C., Tian, F., & Ying, W. T. (2018) · Preprints.org · doi:10.20944/preprints201803.0030.v1 · Cited by 2
Nomogram based on multimodal echocardiography for assessing the evolution of diabetic cardiomyopathy in diabetic patients with normal cardiac function
Liu, Y., Lu, H., Zhang, Y., Cai, M., Guo, J., & Ruan, X. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1002509 · Cited by 1
Targeted delivery of isoliquiritigenin by ultrasonic microbubbles attenuate myocardial injury via suppressing inflammation and oxidative stress and activating AMPK/SIRT1/eNOS signaling pathway in rats
Liang, S., Zhang, L., & Liang, S. (2023) · Applied Biological Chemistry · doi:10.1186/s13765-023-00805-2 · Cited by 1
Sport and type 1 diabetes - a great value but also a challenge. Review of the literature and guidelines
Błaszczak, K., Kruszewski, A., Paduszyńska, N., Dąbrowska, A., Przybysz, P., Szyszka, M., & Kucharska, M. (2024) · Quality in Sport · doi:10.12775/qs.2024.17.52978 · Cited by 2
Phasic electrical remodeling of ventricular myocardium affects arrhythmogenesis in rats with type 1 diabetes mellitus
Sedyakina, E. N., Tsvetkova, A., Gonotkov, M., Durkina, A., Bernikova, O. G., Azarov, J. E., & Ovechkin, A. O. (2025) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2025.153887 · Cited by 1
Intrahospital Prevalence of Diabetes and Prediabetes in Medical Departments in Upper Austria
Heinzl, M. W., Resl, M., Kellermair, J., Steinwender, C., Mayr, B. M., Obereder, J., Fellner-Färber, R., Klammer, C., Hartl, S., Brandner, J., et al. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14113668 · Cited by 1
Exercise Empowerment: A Multifaceted Anatomy in Managing Diabetic Myocardial Disorder
Chen, C., Xu, L., Wang, K., & Wang, T. (2025) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-025-10630-1 · Cited by 1
Transient Increase in Cardiomyocyte Protein O‐GlcNAcylation Enhances Susceptibility to Pressure Overload‐Induced Cardiac Remodeling
Chang, S. F., Ha, C., Brahma, M. K., Potter, L., Reddy, M. S., Bakshi, S., Preuß, K., Rahman, M. S., Fischer, J. K., Harrell, C. A., et al. (2026) · Journal of the American Heart Association · doi:10.1161/jaha.125.044089 · Cited by 1
Exploring the role of immune cell traits and circulating inflammatory cytokines in the development of diabetic neuropathy
Guo, N., Li, Q., Wang, H., & Li, P. (2025) · Cytokine · doi:10.1016/j.cyto.2025.156985 · Cited by 2
Role of membrane microdomains in cardiac protection: strategies for diabetic cardiomyopathy
Zemljic‐Harpf, A. E., Bonds, J. A., Zuniga-Hertz, J. P., & Patel, H. H. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00139.2025 · Cited by 1
Targeting the miR-493-5p/OTUB1 axis to mitigate mitochondrial dysfunction in diabetic cardiomyopathy
Zhong, X., Li, Y., Xie, Y., Zhang, Y., Wang, M., Jiang, H., Liu, Z., Dai, L., Li, L., Wang, H., et al. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177956 · Cited by 1
From the gut to the heart: probiotic therapy with Saccharomyces boulardii and its potential role on diabetic cardiomyopathy in a murine model
Brandão, A. B. P., de Albuquerque, R. C. M. F., de Abreu, I. C. M. E., Ferreira, F. G., dos Santos, L. B., Jensen, L., de Souza, L. E., Ferreira, S., de Souza, L. B., Arisawa, E. Â. L. S., et al. (2025) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2025.2539188 · Cited by 1
Culinary Medicine in Type II Diabetes Mellitus Management: A Narrative Review of Randomized Clinical Trials on Dietary Interventions (Nutritional Profiles of Meals and Snacks, Timing, Preparation and Key Considerations)
Dimopoulou, M., Androutsos, O., Kipouros, M., Bargiota, Α., & Gortzi, O. (2025) · Diabetology · doi:10.3390/diabetology6080072 · Cited by 1
Anthocephalus indicus and Terminalia arjuna Combination Ameliorates Hematological and Histopathological Changes in a Rat Model of Metabolic Syndrome
Patel, V. R., Gupta, A. K., Dwivedi, J., Lal, N., Abidi, A., & Misra, A. (2025) · Cureus · doi:10.7759/cureus.93523 · Cited by 1
Isorhamnetin as a promising agent for reducing diabetes-induced cardiac damage: insights into antioxidant and enzyme regulatory mechanisms
Qnais, E. Y., Alqudah, A. M., Gammoh, O., Bseiso, Y., Wedyan, M. A., Alotaibi, B. S., Aljabali, A. A. A., & Hatahet, T. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10941-1 · Cited by 1
Functions of exosomal microRNAs from adipose tissue in diabetes mellitus and related cardiovascular pathologies
Li, Y., Zhang, Y., & Li, X. (2025) · Cell Cycle · doi:10.1080/15384101.2025.2590058 · Cited by 2
Diabetic Cardiomyopathy: Unraveling the Molecular Architecture beyond Hyperglycemia – A Narrative Review
Alluri, J. V., Sontakke, T. R., Acharya, S., Bardiya, N. A., & Rode, A. C. (2025) · Journal of the Practice of Cardiovascular Sciences · doi:10.4103/jpcs.jpcs_57_25 · Cited by 2
Proteomic Signatures of Cardiac Dysfunction Among People With Diabetes: The Atherosclerosis Risk in Communities Study
Echouffo-Tcheugui, J. B., Ndumele, C. E., CHEN, J., Rooney, M. R., Walker, K. A., Schlosser, P., Matsushita, K., Grams, M. E., Ballantyne, C. M., Hoogeveen, R. C., et al. (2026) · Circulation Heart Failure · doi:10.1161/circheartfailure.125.013171 · Cited by 1
Effects of exercise training on oxidative phosphorylation-related genes in a diabetic heart via microarray analysis
Shah, I. A., Ishaq, S., Lee, S., & Wu, B.-T. (2026) · BMC Cardiovascular Disorders · doi:10.1186/s12872-025-05496-9 · Cited by 1
Gene Therapy for Heart Failure
Wang, H., Määttä, A., & Yla-Herttuala, S. (2026) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-025-10736-6 · Cited by 1
Type 2 diabetes disrupts T-tubule and RyR2 organization in male but not in female rat ventricular muscle
Rahmani, M., Taberner, A. J., Tran, K., Crossman, D. J., & Han, J. (2026) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00664.2025 · Cited by 1
Multifaceted therapeutic potential of saponins in type 2 diabetes mellitus: mechanisms targeting insulin resistance and diabetic complications
Yuan, Y., Shou, K.-Y., Wu, S., Zhao, J., Liu, Y., Wang, Y., Luo, H.-S., & Dai, W. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1793697 · Cited by 1
Mechanobiology of the diabetic cardiomyocyte: insulin signaling, titin elasticity, and multiscale mechanical dysfunction
Kacmaz, M., Halupka, E., Sultana, I., Delalat, S., El‐Battrawy, I., Khan, M., van Heerebeek, L., & Hamdani, N. (2026) · Biophysical Reviews · doi:10.1007/s12551-026-01444-9 · Cited by 1
Multi-omics analysis of genetic drivers linking aortic stenosis and left ventricular diastolic dysfunction in heart failure
Ahmed, Z., Govindareddy, P., Mathew, J., Yanamala, N. V. K., & Sengupta, P. P. (2026) · BioData Mining · doi:10.1186/s13040-026-00564-y · Cited by 1
Diabetic Cardiomyopathy: Distinct Clinical Entity or Manifestation of Metabolic Heart Disease?
D’Elia, S., Franzese, R., Luisi, E., Morello, M., Titolo, G., Serpico, C., Solimene, A., Granata, M., Acampora, B., Loffredo, F. S., et al. (2026) · Diabetology · doi:10.3390/diabetology7080160 · Cited by 1
Advanced glycation end products and RAGE signaling in diabetic cardiomyopathy: distinct mechanisms, human evidence, and translational barriers
Wang, Z., Shi, Q., Li, X., Zhang, Z., & Li, M. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1846184 · Cited by 1
Diabetic Cardiomyopathy: Distinct and Preventable Entity or Inevitable Consequence?
Schilling, J. D., & Mann, D. L. (2014) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-014-0417-2 · Cited by 1
Protease Cathepsins in Cardiomyopathy: From Mechanism to Intervention
Guo, R., & Nair, S. (2017) · Springer eBooks · doi:10.1007/978-981-10-3162-5_21 · Cited by 1
A Protective Mechanism of Glucogon-like Peptide-1 on AGEs-Induced H9C2 Cardiomyocytes Injury through Inhibiting ROS-Autophagy Pathway
Gu, X. Q., Zhang, J., Xia, W., Zhang, P., Yin, C.-C., Guana, G.-P., & Huang, L. (2017) · Cardiology and Cardiovascular Medicine · doi:10.26502/fccm.92920021
Contemporary Advances in Myocardial Metabolic Imaging and Their Impact on Clinical Care: a Focus on Positron Emission Tomography (PET)
Bois, J. P., Gropler, R. J., & Peterson, L. R. (2018) · Current Cardiovascular Imaging Reports · doi:10.1007/s12410-018-9444-6 · Cited by 1
Adrenal Secretome and Epicardial Adipose Tissue
Petramala, L., Concistrè, A., Iannucci, G., & Letizia, C. (2020) · Contemporary cardiology · doi:10.1007/978-3-030-40570-0_14 · Cited by 1
Effect of advanced glycation end products on autophagic ability in osteoblasts.
Luo, D., Hu, Y., Tang, Y., Ding, X., Li, C., & Zheng, L. (2021) · PubMed Central · doi:10.11817/j.issn.1672-7347.2021.190401 · Cited by 1
Comparative analysis of the transcriptome of T2DM Bama mini-pigs with T2DM patients
Yan, X., Si, J., Zhong, F., Wu, Y., Jiang, Q., Guo, Y., Yang, X., Liang, J., & Lan, G. (2021) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-021-00981-1 · Cited by 1
Physalin A alleviates inflammation and oxidative stress in mouse infantile pneumonia by inhibiting JAK/STAT3 and NF κB pathways
Ling, Z., & Zhao, J. (2022) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v22i2.9 · Cited by 1
Heart Involvement in Diabetes mellitus Patients
Shkala, L. V. (2022) · Family Medicine · doi:10.30841/2307-5112.1-2.2022.260509 · Cited by 1
In vitro effects of low-intensity infrared laser irradiation on oxidative stress biomarkers in blood samples from diabetes mellitus patients
Tkaczenko, H., Tomin, V. I., Osmólska, U., & Kurhaluk, N. (2023) · Optics & Laser Technology · doi:10.1016/j.optlastec.2023.110116 · Cited by 2
Growth factors reviews
Li, X. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15793-6.00001-9 · Cited by 1
Trimetazidine: An Antianginal Drug and Not Only!
Alrouhayyah, R. (2024) · Medicinal & Analytical Chemistry International · doi:10.23880/macij-16000194 · Cited by 1
Study on Left Heart Systolic Dysfunction in Type 2 Diabetes Mellitus Exhibition
王, 宏. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.1482409 · Cited by 1
Enhanced negative modulation of urotensin II on cardiac function and [Ca2+]i regulation in a diabetic rat model: Insights into molecular and cellular mechanisms
Zhang, X., Chen, Z., Cao, J., Peng, Z., Zhang, Z., Sun, X., Liu, Y., Li, T., Cheng, H.-J., & Cheng, C. P. (2025) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2025.103594 · Cited by 1
Left ventricular systolic dysfunction predicts long-term major microvascular complication outcomes in type 1 diabetes. The Pittsburgh Epidemiology of Diabetes Complications (EDC) study of childhood onset diabetes
Guo, J. S., Miller, R. G., Costacou, T., Follansbee, W. P., & Orchard, T. J. (2017) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2017.12.004 · Cited by 1
Role of Hemodynamic and Metabolic Factors in the Development and Progression of Chronic Heart Failure in Patients with Ischaemic Heart Disease and Type 2 Diabetes Mellitus
Gorb, Y. G., Strona, V. I., & Tkachenko, O. V. (2020) · Ukraïnsʹkij žurnal medicini bìologìï ta sportu · doi:10.26693/jmbs05.04.026 · Cited by 1
Emerging Role of Natriuretic Peptides in Diabetes Mellitus
Berezin, A. Е., & Berezin, A. A. (2020) · Heart and Mind · doi:10.4103/hm.hm_3_20 · Cited by 1
Pengaruh Probiotik Dalam Menurunkan Kadar Gula Darah Pada Penderita Diabetes Melitus Tipe 2
Jainata, D., Utama, B. I., & Desmawati, D. (2022) · Jurnal Ilmu Kesehatan Indonesia · doi:10.25077/jikesi.v2i4.487 · Cited by 1
Next Generation of Spontaneously Diabetic Model of ZDSD Rats with Intact Leptin Signaling Develop Cardiac Dysfunction and Compromised Cardiac ReservePreprint
Sun, G., Zhang, G., Jackson, V., & Wang, J. J. (2018) · Preprints.org · doi:10.20944/preprints201805.0082.v1 · Cited by 1
Assessment of the subclinical myocardial dysfunction with preserved left ventricle ejection fraction in type 2 diabetes mellitus patients with global myocardial workPreprint
Wang, T., Huang, J., Yan, Z.-N., & Fan, L. (2021) · Research Square · doi:10.21203/rs.3.rs-210151/v1 · Cited by 1
The Effects of Low-dose Empagliflozin on Cardiac Function in a Rat Model of Streptozotocin-induced DiabetesPreprint
Yesilyurt, Z. E., Karaömerlioğlu, İ., Erdoğan, B. R., Ozturk, G., Michel, M. C., & Arioglu‐Inan, E. (2021) · Research Square · doi:10.21203/rs.3.rs-526255/v1 · Cited by 1
Congestive Heart Failure
Norhammar, A., Johansson, I., Thrainsdottir, I. S., & Rydén, L. (2016) · Wiley eBooks · doi:10.1002/9781118924853.ch45 · Cited by 1
Diabetes Mellitus and Exercise Physiology in the Presence of Diabetic Comorbidities
Schauer, I. E., Huebschmann, A. G., & Regensteiner, J. G. (2017) · Contemporary diabetes · doi:10.1007/978-3-319-61013-9_18 · Cited by 1
Does the Duration of Diabetes Matter When Evaluating the Risk of Heart Failure?
Echouffo-Tcheugui, J. B. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac761 · Cited by 1
Why the Diabetic Heart Is Fatty
Yang, Y., & Arany, Z. P. (2025) · Circulation Research · doi:10.1161/circresaha.125.326677 · Cited by 1
Glucose Uptake and Its Consequence on Cardiomyocyte Function
Bertrand, L., Horman, S., & Beauloye, C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-800093-9.00012-0 · Cited by 1
Lifestyle and cardio-metabolic health
Cassidy, S. (2016)
Diabetic Cardiomyopathy: Cause or Consequence of Diabetes Mellitus?
Albarracin, M. L. G., & Chaparro, P. (2017) · Cardiology and Cardiovascular Medicine · doi:10.26502/fccm.92920020
A szolubilis guanilát-cikláz aktivátor cinaciguat megelőzi a kardiális diszfunkció kialakulását 1-es típusú cukorbetegség patkánymodelljében
Mátyás, C., Barta, B. A., Németh, B. T., Oláh, A., Hidi, L., Birtalan, E., Kellermayer, D., Ruppert, M., Korkmaz‐Icöz, S., Kökény, G., et al. (2017) · Cardiologia Hungarica · doi:10.26430/chungarica.2017.47.1.34
Cardiotoxicidad del estado de tolerancia a la glucosa alterada
Sommese, L. M. (2018) · doi:10.35537/10915/66305
Cardiomyopathie du diabète : nouvelles données physiopathologiques
Joubert, M. (2018) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(18)30175-5
Resveratrol Combined with Pioglitazone Ameliorates Cardiovascular Complications in db/db Diabetic Mice
Duarte‐Vázquez, M. A., Gómez‐Solís, A., Reyes-Esparza, J. A., Rosad, J. L., & Fragoso, L. R. (2018) · Journal of Metabolic Syndrome · doi:10.4172/2167-0943.1000243
Pathogenetic Mechanisms and Ways of Preventing Cardiovascular Complications of Diabetes Mellitus Type 2
Gorb, Y. G., Strona, V. I., & Komir, I. (2019) · Ukraïnsʹkij žurnal medicini bìologìï ta sportu · doi:10.26693/jmbs04.01.008
Catecholamine metabolism via monoamine oxidase (MAO) within myocardium of individuals with type 2 diabetes
Nelson, M. A. M. (2019) · The Scholarship East Carolina University's Institutional Repository (East Carolina University)
Az antidiabetikumok hatása a kardiovaszkuláris biztonságosságra és a szívelégtelenségre – ahogy a kardiológus látja
Rábai, M., & Habon, T. (2017) · Diabetologia Hungarica · doi:10.24121/dh.2017.33
Cardiomyopathie du diabétique, dépistage et épidémiologie
Cohen, A. A., & Angoulvant, D. (2019) · Archives of Cardiovascular Diseases Supplements · doi:10.1016/s1878-6480(19)30963-2
Is Diabetes Associated With “Twistolic” Dysfunction? Mechanisms of Exercise Intolerance in Patients With Diabetes
Evans, M. C., & Litwin, S. E. (2020) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2020.01.022
Функціональний стан міокарда у хворих на ішемічну хворобу серця, цукровий діабет 2-го типу та серцеву недостатність
Gorb, Y. G., Strona, V. I., & Komir, I. (2020) · Lviv clinical bulletin · doi:10.25040/lkv2020.01.052
Anti-inflammatory and anti-fibrotic effects of ursodeoxycholic acid in streptozocin-induced diabetic rats
Canbolat, İ. P., Yiğittürk, G., & Erbaş, O. (2020) · Kocaeli Medical Journal · doi:10.5505/ktd.2020.64507

Authors: Bugger, H., & Abel, E. D.
Affiliations: University of Freiburg (DE)
University of Iowa (US)
Corresponding author: Abel, E. Dale
ORCID: Bugger, Heiko
Abel, E. Dale
Venue: Diabetologia
Publisher: Springer Science and Business Media LLC
Published: 2014-01-30
Volume: 57
Issue: 4
Pages: 660-671
ISSN: 0012-186X (ISSN-L)
1432-0428
DOI: 10.1007/s00125-014-3171-6
PMC: PMC3969857
OpenAlex: W2006499762
Cited by: 903
References: 153
Citations by year: 2026: 51 · 2025: 76 · 2024: 75 · 2023: 79 · 2022: 95 · 2021: 103 · 2020: 100 · 2019: 66 · 2018: 84 · 2017: 62 · 2016: 54 · 2015: 43 · 2014: 14
FWCI: 9.29
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Diabetologia (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL108379, U01HL087947)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK092065)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
Keywords: diabetic cardiomyopathy, diabetes mellitus, heart failure, myocardial structure and function, type 1 diabetes, type 2 diabetes, animal models of diabetes, genetically engineered mouse models, cardiovascular complications of diabetes
MeSH terms: Animals, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Heart Failure, Humans, Diabetic Cardiomyopathies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Molecular mechanisms of diabetic cardiomyopathy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks