Cited by 903Cardiovascular Function and Risk FactorsCardiac Fibrosis and RemodelingCardiomyopathy and Myosin Studies

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Molecular mechanisms of diabetic cardiomyopathy

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Bugger, Heiko, Abel, E. Dale·2014·Diabetologia

DOI 10.1007/s00125-014-3171-6PMC PMC3969857

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Abstract

In recent years, diabetes mellitus has become an epidemic and now represents one of the most prevalent disorders. Cardiovascular complications are the major cause of mortality and morbidity in diabetic patients. While ischaemic events dominate the cardiac complications of diabetes, it is widely recognised that the risk for developing heart failure is also increased in the absence of overt myocardial ischaemia and hypertension or is accelerated in the presence of these comorbidities. These diabetes-associated changes in myocardial structure and function have been called diabetic cardiomyopathy. Numerous molecular mechanisms have been proposed to contribute to the development of diabetic cardiomyopathy following analysis of various animal models of type 1 or type 2 diabetes and in genetically modified mouse models. The steady increase in reports presenting novel mechanistic data on this subject expands the list of potential underlying mechanisms. The current review provides an update on molecular alterations that may contribute to the structural and functional alterations in the diabetic heart.

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2 retracted

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Retracted
Retracted: Advanced glycation endproduct (AGE) accumulation and AGE receptor (RAGE) up‐regulation contribute to the onset of diabetic cardiomyopathy
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Lack of Mitochondrial Anionic Phospholipids Causes an Inhibition of Translation of Protein Components of the Electron Transport Chain
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Abnormal myocardial insulin signalling in type 2 diabetes and left-ventricular dysfunction
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Mitochondrial dysfunction accompanies diastolic dysfunction in diabetic rat heart
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Deficiency of Rac1 Blocks NADPH Oxidase Activation, Inhibits Endoplasmic Reticulum Stress, and Reduces Myocardial Remodeling in a Mouse Model of Type 1 Diabetes
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Increased propensity for cell death in diabetic human heart is mediated by mitochondrial-dependent pathways
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PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation
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Profound Cardioprotection With Chloramphenicol Succinate in the Swine Model of Myocardial Ischemia-Reperfusion Injury
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Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice
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Oxidative Stress-Dependent Impairment of Cardiac-Specific Transcription Factors in Experimental Diabetes
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Diabetes and incident heart failure in hypertensive and normotensive participants of the Strong Heart Study
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Decreased complex II respiration and HNE-modified SDH subunit in diabetic heart
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Cardioprotective and Anti-Inflammatory Effects of Interleukin Converting Enzyme Inhibition in Experimental Diabetic Cardiomyopathy
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Insulin receptor substrate signaling suppresses neonatal autophagy in the heart
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Gene Deletion of the Kinin Receptor B1 Attenuates Cardiac Inflammation and Fibrosis During the Development of Experimental Diabetic Cardiomyopathy
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Myocardial fibrosis and apoptosis, but not inflammation, are present in long-term experimental diabetes
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Involvement of Endoplasmic Reticulum Stress in Myocardial Apoptosis of Streptozocin-Induced Diabetic Rats
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Diabetes‐ and angiotensin II‐induced cardiac endoplasmic reticulum stress and cell death: metallothionein protection
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Advanced glycation end product cross-link breaker attenuates diabetes-induced cardiac dysfunction by improving sarcoplasmic reticulum calcium handling
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The Non-coding RNA gadd7 Is a Regulator of Lipid-induced Oxidative and Endoplasmic Reticulum Stress
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The Heme Oxygenase System Selectively Enhances the Anti-Inflammatory Macrophage-M2 Phenotype, Reduces Pericardial Adiposity, and Ameliorated Cardiac Injury in Diabetic Cardiomyopathy in Zucker Diabetic Fatty Rats
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Renal Failure Increases Cardiac Histone H3 Acetylation, Dimethylation, and Phosphorylation and the Induction of Cardiomyopathy-Related Genes in Type 2 Diabetes
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Dyslipidaemia in type II diabetic mice does not aggravate contractile impairment but increases ventricular stiffness
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α-Lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice
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Antioxidative treatment prevents activation of death-receptor- and mitochondrion-dependent apoptosis in the hearts of diabetic rats
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PARP mediates structural alterations in diabetic cardiomyopathy
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Genetic loss of insulin receptors worsens cardiac efficiency in diabetes
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Diabetes triggers a PARP1 mediated death pathway in the heart through participation of FoxO1
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Insulin suppresses ischemic preconditioning-mediated cardioprotection through Akt-dependent mechanisms
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14-3-3 Protein Protects Against Cardiac Endoplasmic Reticulum Stress (ERS) and ERS-Initiated Apoptosis in Experimental Diabetes
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HATs off to Hop: recruitment of a class I histone deacetylase incriminates a novel transcriptional pathway that opposes cardiac hypertrophy
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Authors: Bugger, H., & Abel, E. D.
Affiliations: University of Freiburg (DE)
University of Iowa (US)
Corresponding author: Abel, E. Dale
ORCID: Bugger, Heiko
Abel, E. Dale
Venue: Diabetologia
Publisher: Springer Science and Business Media LLC
Published: 2014-01-30
Volume: 57
Issue: 4
Pages: 660-671
ISSN: 0012-186X (ISSN-L)
1432-0428
DOI: 10.1007/s00125-014-3171-6
PMC: PMC3969857
OpenAlex: W2006499762
Cited by: 903
References: 153
Citations by year: 2026: 51 · 2025: 76 · 2024: 75 · 2023: 79 · 2022: 95 · 2021: 103 · 2020: 100 · 2019: 66 · 2018: 84 · 2017: 62 · 2016: 54 · 2015: 43 · 2014: 14
FWCI: 9.29
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Diabetologia (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL108379, U01HL087947)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK092065)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
Keywords: diabetic cardiomyopathy, diabetes mellitus, heart failure, myocardial structure and function, type 1 diabetes, type 2 diabetes, animal models of diabetes, genetically engineered mouse models, cardiovascular complications of diabetes
MeSH terms: Animals, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Heart Failure, Humans, Diabetic Cardiomyopathies

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Molecular mechanisms of diabetic cardiomyopathy

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