Stress resilience and subsequent risk of type 2 diabetes in 1.5 million young men
Open accessAbstract
Aims/hypothesisPsychosocial stress in adulthood is associated with a higher risk of type 2 diabetes, possibly mediated by behavioural and physiological factors. However, it is unknown whether low stress resilience earlier in life is related to subsequent development of type 2 diabetes. We examined whether low stress resilience in late adolescence is associated with an increased risk of type 2 diabetes in adulthood.MethodsWe conducted a national cohort study of all 1,534,425 military conscripts in Sweden during 1969–1997 (97–98% of all 18-year-old men nationwide each year) without prior diagnosis of diabetes, who underwent standardised psychological assessment for stress resilience (on a scale of 1–9) and were followed up for type 2 diabetes identified from outpatient and inpatient diagnoses during 1987–2012 (maximum attained age 62 years).ResultsThere were 34,008 men diagnosed with type 2 diabetes in 39.4 million person-years of follow-up. Low stress resilience was associated with an increased risk of developing type 2 diabetes after adjusting for BMI, family history of diabetes, and individual and neighbourhood socioeconomic factors (HR for lowest vs highest quintile: 1.51; 95% CI 1.46, 1.57; p < 0.0001), including a strong linear trend across the full range of stress resilience (ptrend < 0.0001). This association did not vary by BMI level, family history of diabetes or socioeconomic factors.Conclusions/interpretationThese findings suggest that low stress resilience may play an important long-term role in aetiological pathways for type 2 diabetes. Further elucidation of the underlying causal factors may help inform more effective preventive interventions across the lifespan.
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Low stress resilience predicts development of T2DM in Swedish military recruits.
“One interesting study of 1.5 million Swedish military recruits with a 25.7 years of follow-up reported that low stress resilience (as assessed by semi-structured interview) was a predictor of the development of T2DM 88”
From Type 2 diabetes mellitus and psychological stress — a modifiable risk factor (2017) · cites this paper as [88]
The association between low stress resilience and T2DM was robust to adjustment for a range of risk factors for T2DM.
“This association was robust to adjustment for a range of risk factors for T2DM.”
From Type 2 diabetes mellitus and psychological stress — a modifiable risk factor (2017) · cites this paper as [88]
In Swedish male military conscripts (n=1.5 million; average mean follow-up 25.7 years), low stress resilience assessed by semi-structured interview was associated with incident diabetes mellitus (HR 1.51, 95% CI 1.46-1.57).
“Swedish male military conscripts ( n = 1.5 million; average mean follow-up 25.7 years) | Low stress resilience assessed by semi- structured interview | *HR 1.51 (95% CI 1.46-1.57).”
From Type 2 diabetes mellitus and psychological stress — a modifiable risk factor (2017) · cites this paper as Crump (2016) 82
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Cites
Multiple Imputation for Nonresponse in Surveys
Rubin, D. B. (1987) · Wiley Series in Probability and Statistics · doi:10.1002/9780470316696 · Cited by 20,701 · see citing works
Depression and Type 2 Diabetes Over the Lifespan
Mezuk, B., Eaton, W. W., Albrecht, S., & Golden, S. H. (2008) · Diabetes Care · doi:10.2337/dc08-0985 · Cited by 1,558 · see citing works
Inflammation and Activated Innate Immunity in the Pathogenesis of Type 2 Diabetes
Pickup, J. C. (2004) · Diabetes Care · doi:10.2337/diacare.27.3.813 · Cited by 1,414 · see citing works
Boyle, J. P., Thompson, T. J., Gregg, E. W., Barker, L. E., & Williamson, D. F. (2010) · Population Health Metrics · doi:10.1186/1478-7954-8-29 · Cited by 1,309 · see citing works
Do stress reactions cause abdominal obesity and comorbidities?
Björntorp, P. A. (2001) · Obesity Reviews · doi:10.1046/j.1467-789x.2001.00027.x · Cited by 1,141 · see citing works
Geiss, L. S., Wang, J., Cheng, Y. J., Thompson, T. J., Barker, L. E., Li, Y., Albright, A. L., & Gregg, E. W. (2014) · JAMA · doi:10.1001/jama.2014.11494 · Cited by 668 · see citing works
Changes in terminology for childhood overweight and obesity.
Ogden, C. L., & Flegal, K. M. (2010) · PubMed · Cited by 485 · see citing works
Bonnet, F., Irving, K., Terra, J., Nony, P., Berthézène, F., & Moulin, P. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.08.035 · Cited by 438 · see citing works
The InterAct Consortium (614230) (2012) · Diabetologia · doi:10.1007/s00125-012-2715-x · Cited by 355 · see citing works
The role of depression and anxiety in onset of diabetes in a large population-based study
Engum, A. (2007) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2006.07.009 · Cited by 330 · see citing works
Job Strain as a Risk Factor for Type 2 Diabetes: A Pooled Analysis of 124,808 Men and Women
Nyberg, S. T., Fransson, E. I., Heikkilä, K., Ahola, K., Alfredsson, L., Bjorner, J. B., Borritz, M., Burr, H., Dragano, N., Goldberg, M., et al. (2014) · Diabetes Care · doi:10.2337/dc13-2936 · Cited by 249 · see citing works
Ganz, M. L., Wintfeld, N., Li, Q., Alas, V., Langer, J., & Hammer, M. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-50 · Cited by 242 · see citing works
Rod, N. H., Grønbæk, M., Schnohr, P., Prescott, E., & Kristensen, T. (2009) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2009.02124.x · Cited by 222 · see citing works
Depressive Symptoms and Change in Abdominal Obesity in Older Persons
Vogelzangs, N., Kritchevsky, S. B., Beekman, A. T. F., Newman, A. B., Satterfield, S., Simonsick, E. M., Yaffe, K., Harris, T. B., & Penninx, B. W. J. H. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.12.1386 · Cited by 200 · see citing works
Mooy, J. M., de Vries, H., Grootenhuis, P. A., Bouter, L. M., & Heine, R. J. (2000) · Diabetes Care · doi:10.2337/diacare.23.2.197 · Cited by 177 · see citing works
Schulz, A. J., Zenk, S. N., Israel, B. A., Mentz, G. B., Stokes, C., & Galea, S. (2008) · Journal of Urban Health · doi:10.1007/s11524-008-9288-5 · Cited by 105 · see citing works
Sundquist, K., Eriksson, U., Mezuk, B., & Ohlsson, H. (2015) · Health & Place · doi:10.1016/j.healthplace.2014.10.011 · Cited by 98 · see citing works
Self-citationCrump, C., Sundquist, K., Sundquist, J., & Winkleby, M. A. (2011) · Annals of Epidemiology · doi:10.1016/j.annepidem.2011.01.005 · Cited by 80 · see citing works
Self-citationBergh, C., Udumyan, R., Fall, K., Almroth, H., & Montgomery, S. (2015) · Heart · doi:10.1136/heartjnl-2014-306703 · Cited by 71 · see citing works
Stress resilience in male adolescents and subsequent stroke risk: cohort study
Bergh, C., Udumyan, R., Fall, K., Nilsagård, Y. E., Appelros, P., & Montgomery, S. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-307485 · Cited by 61 · see citing works
Golden, S. H., Williams, J. E., Ford, D. E., Yeh, H.-C., Sanford, C. P., Nieto, F. J., & Brancati, F. L. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.08.008 · Cited by 55 · see citing works
Zhang, J., NIAURA, R. S., Dyer, J. R., Shen, B., Todaro, J. F., McCaffery, J. M., Spiro, A., & Ward, K. D. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000228343.89466.11 · Cited by 44 · see citing works
Genetic vulnerability to diabetes and obesity: Does education offset the risk?
Liu, S. Y., Walter, S., Marden, J. R., Rehkopf, D. H., Kubzansky, L. D., Nguyen, T. T., & Glymour, M. M. (2014) · Social Science & Medicine · doi:10.1016/j.socscimed.2014.09.009 · Cited by 41 · see citing works
Melinder, C., Udumyan, R., Hiyoshi, A., Brummer, R. J., & Montgomery, S. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13168 · Cited by 33 · see citing works
Falkstedt, D., Sorjonen, K., Hemmingsson, T., Deary, I. J., & Melin, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082031 · Cited by 18 · see citing works
Genetic Vulnerability to Diabetes and Obesity: Does Education Offset the Risk?
Liu, S. Y., Walter, S., Marden, J. R., Rehkopf, D. H., Kubzansky, L. D., Xuan, T. T., & Glymour, M. M. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv096.525 · Cited by 3 · see citing works
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Delamater, A. M., de Wit, M., McDarby, V., Malik, J. A., Hilliard, M. E., Northam, E., & Acerini, C. L. (2018) · Pediatric Diabetes · doi:10.1111/pedi.12736 · Cited by 279 · see citing works
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- Authors
- Crump, C., Sundquist, J., Winkleby, M. A., & Sundquist, K.
- Affiliations
- Stanford Medicine (US)
- Lund University (SE)
- Stanford University (US)
- Corresponding author
- Crump, Casey
- Venue
- Diabetologia
- Published
- 2016-01-13
- Volume
- 59
- Issue
- 4
- Pages
- 728-733
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- PMC
- PMC4779396
- OpenAlex
- W2237749469
- Semantic Scholar
- 05375cbd7b9b39c0263fb3a3e3372a2251284783
- Cited by
- 65
- References
- 26
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 7 · 2023: 4 · 2022: 14 · 2021: 5 · 2020: 1 · 2019: 7 · 2018: 6 · 2017: 8 · 2016: 7
- FWCI
- 12.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Lund University Publications (Lund University) (submittedVersion, other-oa)
- Funders
- National Institutes of Health (R01 HL116381)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- stress resilience, type 2 diabetes, psychosocial stress, late adolescence, young men, conscripts, diabetes risk, diabetes prevention
- MeSH terms
- Adolescent, Diabetes Mellitus, Type 2, Humans, Male, Risk Factors, Stress, Psychological, Sweden, Cohort Studies, Body Mass Index
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