Factors associated with favourable 5 year outcomes in islet transplant alone recipients with type 1 diabetes complicated by severe hypoglycaemia in the Collaborative Islet Transplant Registry
Open accessAbstract
Aims/hypothesis Islet transplantation has been studied in small cohorts of recipients with type 1 diabetes complicated by severe hypoglycaemic events (SHEs). We determined factors associated with favourable outcomes in a large cohort of recipients reported to the Collaborative Islet Transplant Registry (CITR). Methods In 398 non-uraemic islet transplant alone (ITA) recipients with type 1 diabetes and SHEs, transplanted between 1999 and 2015 and with at least 1 year follow-up, we analysed specified favourable outcomes against each of all available characteristics of pancreas donors, islet grafts, recipients and immunosuppressive regimens, as well as immunosuppression and procedure-related serious adverse events (SAEs). Results Four factors were associated with the highest rates of favourable outcomes: recipient age ≥35 years; total infused islets ≥325,000 islet equivalents; induction immunosuppression with T cell depletion and/or TNF-α inhibition; and maintenance with both mechanistic target of rapamycin (mTOR) and calcineurin inhibitors. At 5 years after the last islet infusion, of the recipients meeting these four common favourable factors (4CFF; N=126), 95% were free of SHEs, 76% had HbA 1c <53 mmol/mol (7.0%), 73% had HbA 1c <53 mmol/mol (7.0%) and absence of SHEs, and 53% were insulin independent, significantly higher rates than in the remaining recipients (<4CFF; N=272). The incidence of procedural and immunosuppression-related SAEs per recipient that resulted in sequelae, disability or death was low in both the 4CFF (0.056 per person) and <4CFF (0.074 per person) groups. Conclusions/interpretation In recipients with type 1 diabetes complicated by SHEs, islet transplantation meeting 4CFF protected 95% from SHEs at 5 years after the last islet infusion and exerted a large and significant benefit on glycaemic control, with an acceptable safety profile for this subgroup of type 1 diabetes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Graft success increases when a high number of islets are transplanted, often resulting in the need for multiple donor pancreases.
“In particular, graft success increases when a high number of islets are transplanted, often resulting in the need for multiple donor pancreases. 15,20,24”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [24]
The Results (‘The common favourable factors’; page unavailable) associate at least 325,000 infused islet equivalents with more favourable outcomes in the studied recipients. The Introduction says 74% received at least two islet infusions, but does not establish that achieving a high islet dose often requires multiple donor pancreases; the observational association also does not establish causation. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Shapiro, A. M. J., Lakey, J. R. T., Ryan, E. A., Korbutt, G. S., Toth, E., Warnock, G. L., Kneteman, N. M., & Rajotte, R. V. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007273430401 · Cited by 5,237 · see citing works
International trial of the Edmonton protocol for islet transplantation
Shapiro, A. M. J., Ricordi, C., Hering, B. J., Auchincloss, H., Lindblad, R., Robertson, R. P., Secchi, A., Brendel, M. D., Berney, T., Brennan, D. C., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061267 · Cited by 1,942 · see citing works
Self-citationHypoglycemia in the Diabetes Control and Complications Trial
The Diabetes Control and Complications Trial Research Group (1997) · Diabetes · doi:10.2337/diab.46.2.271 · Cited by 746 · see citing works
Improvement in outcomes of clinical islet transplantation: 1999–2010
Barton, F. B., Rickels, M. R., Alejandro, R., Hering, B. J., Wease, S., Naziruddin, B., Oberholzer, J., Odorico, J. S., Garfinkel, M. R., Levy, M., et al. (2012) · Diabetes Care · doi:10.2337/dc12-0063 · Cited by 725 · see citing works
Self-citationHering, B. J., Clarke, W. R., Bridges, N. D., Eggerman, T. L., Alejandro, R., Bellin, M. D., Chaloner, K., Czarniecki, C. W., Goldstein, J. S., Hunsicker, L. G., et al. (2016) · Diabetes Care · doi:10.2337/dc15-1988 · Cited by 645 · see citing works
Self-citationSingle-donor, marginal-dose islet transplantation in patients with type 1 diabetes.
Hering, B., Kandaswamy, R., Ansite, J., Eckman, P., Nakano, M., Sawada, T., Matsumoto, I., Ihm, S., Zhang, H.-J., Parkey, J., et al. (2005) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.293.7.830 · Cited by 580 · see citing works
Self-citationHeinemann, L., Freckmann, G., Ehrmann, D., Faber-Heinemann, G., Guerra, S., Waldenmaier, D., & Hermanns, N. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30297-6 · Cited by 522 · see citing works
Bellin, M. D., Barton, F. B., Heitman, A., Harmon, J. V., Kandaswamy, R., Balamurugan, A. N., Sutherland, D. E. R., Alejandro, R., & Hering, B. J. (2012) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2011.03977.x · Cited by 350 · see citing works
Self-citationPancreatic Islet Transplantation in Humans: Recent Progress and Future Directions
Rickels, M. R., & Robertson, R. P. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00154 · Cited by 329 · see citing works
Self-citationChoudhary, P., Rickels, M. R., Senior, P. A., Vantyghem, M.-C., Maffi, P., Kay, T. W., Keymeulen, B., Inagaki, N., Saudek, F., Lehmann, R., et al. (2015) · Diabetes Care · doi:10.2337/dc15-0090 · Cited by 233 · see citing works
Self-citationWarnock, G. L., Kneteman, N. M., Ryan, E. A., Rabinovitch, A., & Rajotte, R. V. (1992) · Diabetologia · doi:10.1007/bf00400857 · Cited by 213 · see citing works
Lablanche, S., Vantyghem, M.-C., Kessler, L., Wojtusciszyn, A., Borot, S., Thivolet, C., Girerd, S., Bosco, D., Bosson, J.-L., Colin, C., et al. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30078-0 · Cited by 200 · see citing works
SCHARP, D. W., Lacy, P. E., Santiago, J. V., McCullough, C. S., Weide, L. G., BOYLE, P. J., Falqui, L., Marchetti, P., RICORDI, C., Gingerich, R. L., et al. (1991) · Transplantation · doi:10.1097/00007890-199101000-00012 · Cited by 194 · see citing works
High Risk of Sensitization After Failed Islet Transplantation
Campbell, P. M., Senior, P. A., Salam, A., LaBranche, K., Bigam, D. L., Kneteman, N. M., Imes, S., Halpin, A., Ryan, E. A., & Shapiro, A. M. J. (2007) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2007.01923.x · Cited by 173 · see citing works
Villiger, P., Ryan, E. A., Owen, R. J., O’Kelly, K., Oberholzer, J., Saif, F. A., Kin, T., Wang, H., Larsen, I. M., Blitz, S., et al. (2005) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2005.01108.x · Cited by 162 · see citing works
Yeoh, E., Choudhary, P., Nwokolo, M., Ayis, S., & Amiel, S. A. (2015) · Diabetes Care · doi:10.2337/dc15-0102 · Cited by 154 · see citing works
Multicenter Australian Trial of Islet Transplantation: Improving Accessibility and Outcomes
O’Connell, P. J., Holmes-Walker, D. J., Goodman, D., Hawthorne, W. J., Loudovaris, T., Gunton, J. E., Thomas, H. E., Grey, S. T., Drogemuller, C., Ward, G. M., et al. (2013) · American Journal of Transplantation · doi:10.1111/ajt.12250 · Cited by 113 · see citing works
Phase 3 trial of human islet-after-kidney transplantation in type 1 diabetes
Markmann, J. F., Rickels, M. R., Eggerman, T. L., Bridges, N. D., Lafontant, D.-E., Qidwai, J. C., Foster, E., Clarke, W. R., Kamoun, M., Alejandro, R., et al. (2020) · American Journal of Transplantation · doi:10.1111/ajt.16174 · Cited by 111 · see citing works
Self-citationVantyghem, M.-C., Raverdy, V., Balavoine, A.-S., Defrance, F., Caiazzo, R., Arnalsteen, L., Gmyr, V., Hazzan, M., Noël, C., Kerr-Conte, J., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2115 · Cited by 103 · see citing works
Pedersen‐Bjergaard, U., Kristensen, P. L., Beck‐Nielsen, H., Nørgaard, K., Perrild, H., Christiansen, J. S., Jensen, T. J., Hougaard, P., Parving, H., Thorsteinsson, B., et al. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70073-7 · Cited by 94 · see citing works
Little, S. A., Speight, J., Leelarathna, L., Walkinshaw, E., Tan, H. K., Bowes, A., Lubina-Solomon, A., Chadwick, T. J., Stocken, D. D., Brennand, C., et al. (2018) · Diabetes Care · doi:10.2337/dc17-2682 · Cited by 86 · see citing works
Allosensitization of Islet Allograft Recipients
Cardani, R., Pileggi, A., Ricordi, C., Gomez, C. I., Baidal, D., Ponte, G., Mineo, D., Faradji, R., Froud, T., Ciancio, G., et al. (2007) · Transplantation · doi:10.1097/01.tp.0000290388.70019.6e · Cited by 73 · see citing works
Self-citationRestoration of Glucose Counterregulation by Islet Transplantation in Long-standing Type 1 Diabetes
Rickels, M. R., Fuller, C. S., DALTON-BAKES, C. V., Markmann, E., Palanjian, M., Cullison, K., Tiao, J., Kapoor, S. C., Liu, C., Naji, A., et al. (2014) · Diabetes · doi:10.2337/db14-1620 · Cited by 66 · see citing works
Self-citationBrooks, A. M., Walker, N., Aldibbiat, A. M., Hughes, S. J., JONES, G. L., de Havilland, J., Choudhary, P., Huang, G. C., PARROTT, N. R., McGowan, N. W. A., et al. (2013) · American Journal of Transplantation · doi:10.1111/ajt.12469 · Cited by 59 · see citing works
Naziruddin, B., Wease, S., Stablein, D., Barton, F. B., Berney, T., Rickels, M. R., & Alejandro, R. (2011) · Cell Transplantation · doi:10.3727/096368911x612468 · Cited by 51 · see citing works
Self-citationPouliquen, É., Baltzinger, P., Lemle, A., Chen, C., Parissiadis, A., Borot, S., Frimat, L., Girerd, S., Berney, T., Lablanche, S., et al. (2016) · American Journal of Transplantation · doi:10.1111/ajt.13936 · Cited by 39 · see citing works
Lucidi, P., Porcellati, F., Bolli, G. B., & Fanelli, C. G. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1065-6 · Cited by 38 · see citing works
Gómez, A. M., Carrillo, L. F. M., Múñoz, Ó., Rondón, M., Correa, C. M. A., Garzón, E. M., Diaz, M. C. C., & Henao, D. C. (2016) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2016.0332 · Cited by 32 · see citing works
Gerber, P. A., Locher, R., Zuellig, R. A., Tschopp, O., Ajdler-Schaeffler, E., Kron, P., Oberkofler, C. E., Brändle, M., Spinas, G. A., & Lehmann, R. (2015) · Transplantation · doi:10.1097/tp.0000000000000720 · Cited by 23 · see citing works
Bellin, M. D., Sutherland, D. E. R., & Robertson, R. P. (2012) · Hospital Practice · doi:10.3810/hp.2012.08.992 · Cited by 22 · see citing works
Self-citationByrne, M., Hopkins, D., Littlejohn, W., Beckford, R., Srinivasan, P., Heaton, N. D., Amiel, S. A., & Choudhary, P. (2014) · Hormone and Metabolic Research · doi:10.1055/s-0034-1394455 · Cited by 20 · see citing works
Andrès, A., Livingstone, S., Kin, T., Campbell, P. M., Senior, P. A., Kneteman, N. M., Bigam, D. L., & Shapiro, A. M. J. (2015) · Islets · doi:10.1080/19382014.2015.1126036 · Cited by 13 · see citing works
Long-term Persistence of Allosensitization After Islet Allograft Failure
Ríos, P., Baidal, D. A., Lemos, J. R. N., Camhi, S. S., Infante, M., Padilla, N., Gil, A. M. A., Fuenmayor, V., Ambut, J., Qasmi, F. A., et al. (2021) · Transplantation · doi:10.1097/tp.0000000000003635 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
1 of the 34 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes
Hogrebe, N. J., Ishahak, M., & Millman, J. R. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.04.002 · Cited by 210 · see citing works
Grattoni, A., Korbutt, G., Tomei, A. A., García, A. J., Pepper, A. R., Stabler, C., Brehm, M., Papas, K., Citro, A., Shirwan, H., et al. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01029-0 · Cited by 92 · see citing works
Chetboun, M., Drumez, E., Ballou, C., Maanaoui, M., Payne, E., Barton, F., Kerr-Conte, J., Vantyghem, M.-C., Piemonti, L., Rickels, M. R., et al. (2023) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(23)00082-7 · Cited by 64 · see citing works
Self-citationPancreatic islet transplantation: current advances and challenges
Wang, Q., Huang, Y.-X., Liu, L., Zhao, X.-H., Sun, Y., Mao, X.-L., & Li, S.-W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1391504 · Cited by 63 · see citing works
Renard, É., Joubert, M., Villard, O., Dreves, B., Reznik, Y., Farret, A., Place, J., Breton, M. D., & Kovatchev, B. P. (2023) · Diabetes Care · doi:10.2337/dc23-0685 · Cited by 52 · see citing works
Advances in Cell Replacement Therapies for Diabetes
Hering, B. J., Rickels, M. R., Bellin, M. D., Millman, J. R., Tomei, A. A., Garcı́a, A. J., Shirwan, H., Stabler, C. L., Ma, M., Peng, Y., et al. (2025) · Diabetes · doi:10.2337/db25-0037 · Cited by 49 · see citing works
Self-citationThe Current Status of Allogenic Islet Cell Transplantation
Czarnecka, Z., Dadheech, N., Razavy, H., Pawlick, R., & Shapiro, A. M. J. (2023) · Cells · doi:10.3390/cells12202423 · Cited by 29 · see citing works
A spectacular year for islet and stem cell transplantation
Shapiro, A. M. J., & Verhoeff, K. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00790-4 · Cited by 32 · see citing works
Catarinella, D., Melzi, R., Mercalli, A., Magistretti, P., Tentori, S., Gremizzi, C., Paloschi, V., de Cobelli, F., Esposto, G., Costa, S., et al. (2025) · The Lancet Diabetes and Endocrinology · doi:10.1016/s2213-8587(24)00341-3 · Cited by 20 · see citing works
Immunoprotection of cellular transplants for autoimmune type 1 diabetes through local drug delivery
Lansberry, T. R., & Stabler, C. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115179 · Cited by 19 · see citing works
Pham, T. T., Tran, P. L., Tempelman, L. A., Stone, S. G., Piccirillo, C., Li, A., Flanders, J. A., & Ma, M. (2025) · Nature Communications · doi:10.1038/s41467-025-62271-2 · Cited by 17 · see citing works
Legal and regulatory challenges for emerging regenerative medicine solutions for Diabetes
Thom, R. L., Cronin, A. J., & the VANGUARD Consortium (2024) · Transplantation · doi:10.1097/tp.0000000000004797 · Cited by 12 · see citing works
Witkowski, P., Eaton, A. A., Porter, S., Abu‐El‐Haija, M. A., Ahmad, S. A., Mokshagundam, S. P., Wijkstrom, M. N., Naziruddin, B., Trikudanathan, G., Singh, V. K., et al. (2025) · Diabetes Care · doi:10.2337/dc25-0620 · Cited by 8 · see citing works
Self-citationAdvances in Islet Transplantation and the Future of Stem Cell–Derived Islets to Treat Diabetes
Kieffer, T. J., Hoesli, C. A., & Shapiro, A. M. J. (2025) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041624 · Cited by 7 · see citing works
Regulating islet stress responses through CD47 activation
Kale, A., Azar, M., Cheng, V., Robertson, H., Coulter, S., Mehta, P. M., Julovi, S., Patrick, E., Ghimire, K., & Rogers, N. M. (2025) · Diabetologia · doi:10.1007/s00125-025-06409-3 · Cited by 5 · see citing works
Identifying Promising Immunomodulators for Type 1 Diabetes (T1D) and Islet Transplantation
Ajmal, N., Bogart, M. C., Khan, P., Max-Harry, I. M., Healy, A. M., & Nunemaker, C. S. (2024) · Journal of Diabetes Research · doi:10.1155/jdr/5151171 · Cited by 7 · see citing works
Recreating the Endocrine Niche: Advances in Bioengineering the Pancreas
Fonseca, L. M., Krause, N., Lebreton, F., & Berishvili, E. (2025) · Artificial Organs · doi:10.1111/aor.14950 · Cited by 7 · see citing works
HLA-B Matching Prolongs Allograft Survival in Islet Cell Transplantation
Lemos, J., Baidal, D., Poggioli, R., Fuenmayor, V., Chávez, C., Alvarez, A., Ricordi, C., & Alejandro, R. (2023) · Cell Transplantation · doi:10.1177/09636897231166529 · Cited by 6 · see citing works
Self-citationPark, H.-S., Lee, E., You, Y., Rhee, M., Kim, J.-M., Hwang, S.-S., & Lee, P.-Y. (2024) · Journal of Diabetes Investigation · doi:10.1111/jdi.14216 · Cited by 6 · see citing works
Pilz, J., Gloddek, N., Lindheimer, F., Lindner, M., Puhr-Westerheide, D., Ümütlü, M., Cyran, C., Seidensticker, M., Lindner, R. J., Kraetzl, M., et al. (2024) · American Journal of Transplantation · doi:10.1016/j.ajt.2024.02.026 · Cited by 5 · see citing works
Current Challenges in Pancreas and Islet Transplantation: A Scoping Review
Altabas, V., & Bulum, T. (2024) · Biomedicines · doi:10.3390/biomedicines12122853 · Cited by 5 · see citing works
Long-term outcomes and challenges of islet transplantation in type 1 diabetes
Chetboun, M., & Pattou, F. N. (2025) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(25)00003-8 · Cited by 6 · see citing works
Clinical Trials with Stem Cell-Derived Insulin-Producing Cells
Lei, J., & Markmann, J. F. (2023) · Springer eBooks · doi:10.1007/978-3-031-41943-0_23 · Cited by 5 · see citing works
Anazawa, T., Marubashi, S., Kodama, S., Goto, M., Maruyama, M., Eguchi, H., Shimoda, M., Noguchi, H., Yamaguchi, T., Ito, T., et al. (2025) · Transplantation Direct · doi:10.1097/txd.0000000000001765 · Cited by 2 · see citing works
O'Brien, S. M., Li, C., Trana, R., Hoesli, C. A., & Moraes, C. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c00372 · Cited by 3 · see citing works
Lee, E. Y., & Yoon, K. (2024) · Journal of Diabetes Investigation · doi:10.1111/jdi.14140 · Cited by 3 · see citing works
A differentiation protocol for generating pancreatic delta cells from human pluripotent stem cells
Zhang, T., Wang, N., Liao, Z., Chen, J., Meng, H., Lin, H., Xu, T., Chen, L., Zhu, L., & Liu, H. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1490040 · Cited by 3 · see citing works
Orr, C., Hacker-Stratton, J., El-Shahawy, M. A., Forouhar, E., Peng, A., Singh, G. P., Omori, K., Qi, M., & Kandeel, F. F. (2025) · Cell Transplantation · doi:10.1177/09636897241309412 · Cited by 3 · see citing works
Self-citationHypothermia-induced on-demand drug delivery at a subcutaneous islet transplantation site
Waduthanthri, K. D., Kuppan, P., Korbutt, G. S., Pepper, A. R., & Unsworth, L. D. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.168418 · Cited by 2 · see citing works
Islet transplantation in kidney transplant recipients with type 1 diabetes
Forbes, S., & Kay, T. W. H. (2024) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(24)00274-2 · Cited by 2 · see citing works
β-Cell Benchmarks: Defining Predictive Outcomes in Islet Transplantation
Forbes, S. (2025) · Diabetes · doi:10.2337/dbi24-0054 · Cited by 2 · see citing works
Engineering Strategies of Islet Product for Endocrine Regeneration
Cheng, Y., & Zhao, G. (2023) · Engineered Regeneration · doi:10.1016/j.engreg.2023.01.003 · Cited by 2 · see citing works
An unmet need: Pancreatic beta cell replacement.
Mohamed, F., Adams, C., & Mansfield, B. (2024) · South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde · doi:10.7196/samj.2024.v114i3b.1249 · Cited by 2 · see citing works
Wu, Q., Yuan, Y., Yang, H., & Fu, Q. (2025) · Transplantation Reviews · doi:10.1016/j.trre.2025.100962 · Cited by 1 · see citing works
Siracusano, G., Deambrogio, F., Sordi, V., Malnati, M., Piemonti, L., & Chimienti, R. (2025) · Transplant International · doi:10.3389/ti.2025.15433 · Cited by 1 · see citing works
Basok, Y. B., Ponomareva, A. S., Baranova, N. V., Grudinin, N. V., Kruglov, D., Кирсанова, Л. А., Kuznetsova, E. G., Skaletskaya, G. N., Belova, A. D., Guseva, E. A., et al. (2026) · Russian Journal of Transplantology and Artificial Organs · doi:10.15825/1995-1191-2026-1-197-205 · Cited by 1 · see citing works
Forbes, S. (2023) · The Lancet Diabetes and Endocrinology · doi:10.1016/s2213-8587(23)00090-6 · Cited by 1 · see citing works
Islet Macroencapsulation: Strategies to Boost Islet Graft Oxygenation
Ludwig, B., Heller, C., Sarangova, V., & Welzel, P. B. (2023) · Springer eBooks · doi:10.1007/978-3-031-41943-0_12 · Cited by 1 · see citing works
The Adrenal Gland and Pancreatic Islets – A Beneficial Endocrine Alliance
Schubert, U., Lehmann, S., Schmid, J., Morawietz, H., Bornstein, S. R., & Ludwig, B. (2024) · Hormone and Metabolic Research · doi:10.1055/a-2256-6344 · Cited by 1 · see citing works
Extracellular matrix biomimetics for pancreatic tissue engineering
Ponomareva, A. S., Baranova, N. V., Basok, Y. B., & Sevastianov, V. I. (2025) · Russian Journal of Transplantology and Artificial Organs · doi:10.15825/1995-1191-2025-3-146-159 · Cited by 1 · see citing works
Rickels, M. R. (2025) · Diabetes Care · doi:10.2337/dci25-0064 · Cited by 1 · see citing works
Self-citationIslet Transplantation: How Much Have We Advanced and How to Keep Moving Forward?
Marfil‐Garza, B. A., & Kin, T. (2022) · OBM Transplantation · doi:10.21926/obm.transplant.2204171
Considerations Pertaining to Implant Sites for Cell-Based Insulin Replacement Therapies
Marfil‐Garza, B. A., Cuesta‐Gomez, N., & Shapiro, A. M. J. (2023) · Springer eBooks · doi:10.1007/978-3-031-41943-0_16 · Cited by 1 · see citing works
Teo, A. K. S., Tan, K. S. M., Koh, Y. X., Koh, A., & Teo, A. K. K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-824465-4.00143-5
Lei, Y., Guo, S., Chen, M., Zhao, H., Lan, H., Huang, Z., Wang, J., Huang, B., Zhuang, B., Xie, X., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-6245373/v1
Advances in Islet Function Replacing Strategies After Total Pancreatectomy
Peng, S., Zhao, B., Yi, X., Li, X., Zhang, J., Wang, J., & Li, R. (2025) · Endocrine Practice · doi:10.1016/j.eprac.2025.07.012
He, D.-W., Zhang, F., Zhang, H.-X., Xiao, S.-Y., Bi, X.-Y., Wang, Y.-M., Wang, R.-L., Lu, Y.-X., Yin, H., & Li, T. (2026) · World Journal of Diabetes · doi:10.4239/wjd.119760
Abreu, P., Kadri, H., Zaragoza, S. S. A., Guerra, G., Ortigosa‐Goggins, M., Nguyen, M. C., Khan, A. S., Eltemamy, M., Riella, J., Figueiro, J., et al. (2026) · BMC Surgery · doi:10.1186/s12893-026-03860-w
Microscale strategies in engineering the pancreas: Toward clinical translation.
Billaud, M., Campbell, B. E., Zhu, X., Ling, S.-D., Movasat, H., Li, C., Prezelj, D., Vdovenko, D., Shakiba, N., Hoesli, C. A., et al. (2026) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2026.115919
Tawhari, I., Yamani, F., Alotaibi, M., Aldosari, M., Hennawy, H. E. E., & Tawhari, M. H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1909238
Chen, L., Hu, X.-H., Zheng, C., Huang, Q., Xu, J.-N., You, X.-B., & Wang, C.-F. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1981945
- Authors
- Hering, B. J., Ballou, C. M., Bellin, M. D., Payne, E. H., Kandeel, F., Witkowski, P., Alejandro, R., Rickels, M. R., & Barton, F. B.
- Affiliations
- University of Minnesota (US)
- Emmes (United States) (US)
- City Of Hope National Medical Center (US)
- University of Chicago (US)
- University of Miami (US)
- University of Pennsylvania (US)
- Corresponding author
- Hering, Bernhard J.
- Ballou, Cassandra M.
- ORCID
- Venue
- Diabetologia
- Published
- 2022-10-06
- Volume
- 66
- Issue
- 1
- Pages
- 163-173
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- PMC
- PMC10355148
- OpenAlex
- W4302288336
- Cited by
- 51
- References
- 34
- Citations by year
- 2026: 6 · 2025: 19 · 2024: 13 · 2023: 11 · 2022: 2
- FWCI
- 10.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eli Lilly and Company
- University of Miami
- University of Pennsylvania
- Emory University
- Northwestern University
- University of Minnesota
- Vertex Pharmaceuticals
- Insulet Corporation
- Dexcom
- University of Alberta
- Hôpitaux Universitaires de Genève
- Centre hospitalier régional universitaire de Lille
- National Institutes of Health (5r01dk091331-10)
- University of Illinois at Urbana-Champaign
- Weill Cornell Medical College
- University of California, San Francisco
- National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK-091331, UC4DK114839, UC4DK098086, U01DK133709, P30DK020595)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- islet transplantation, type 1 diabetes, severe hypoglycemia, T cell depletion, anti-TNF therapy, mTOR inhibitors, calcineurin inhibitors, immunosuppression, glycemic control, insulin independence, serious adverse events
- MeSH terms
- Adult, Diabetes Mellitus, Type 1, Humans, Islets of Langerhans Transplantation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
