Effect of dopamine on gastrointestinal motility during critical illness

Dive, A.; Foret, F.; Jamart, J.; Bulpa, P.; Installé, E.

doi:10.1007/s001340051279

Cited by 125Gastrointestinal motility and disordersClinical Nutrition and GastroenterologyIntensive Care Unit Cognitive Disorders

Effect of dopamine on gastrointestinal motility during critical illness

Dive, A., Foret, F., Jamart, J., Bulpa, P., Installé, E.·2000·Intensive Care Medicine

DOI 10.1007/s001340051279

Open this paper in CoChat — free account

Abstract

Objective To document the action of dopamine on gastrointestinal motility in mechanically ventilated patients.Design Crossover, randomized, placebo-controlled study.Setting General intensive care unit (ICU) in a university hospital.Patients Twelve mechanically ventilated patients in a stable hemodynamic condition, with no contraindication to enteral feeding.Interventions Dopamine (4 microg/kg per minute) and placebo were infused over 8 h (4 h fasting, followed immediately by 4 h nasogastric feeding at 100 kcal per hour) on two consecutive days, in a random order. Pressure changes in the gastric antrum (four sites) and in the duodenum (two sites) were recorded by perfused catheter manometry. Each session started with the institution of dopamine or placebo infusion.Measurements and results The migrating motor complex and its three successive phases were identified (phase I, period of quiescence; phase II, period of irregular contractile activity; phase III or activity front, period of high-frequency, regular contractions). Contractions and activity fronts at each site were quantified during fasting and feeding. The mean duration of the fasting migrating motor complex was determined in the duodenum, as well as the contribution of each phase (phases I, II, III) to the length of the complete cycle. The propagation characteristics of each activity front were assessed visually. The number of contractions was lower in the antrum (p = 0.024) and phase III motor activity higher in the duodenum [incidence of activity fronts (p = 0.008); number of phase III contractions (p = 0.009)] during dopamine infusion than with placebo. These modifications observed under dopamine were related to decreased antral contractions during fasting (p = 0.050), increased incidence of activity fronts during feeding (p = 0.031), and increased number of phase III contractions during fasting (p = 0.037). In both groups (placebo and dopamine) activity fronts rarely started in the antrum, and abnormally propagated activity fronts were found in the duodenum in some patients.Conclusions Low-dose dopamine adversely affects gastroduodenal motility in mechanically ventilated critically ill patients.

Integrity signals

Registry

Crossref · 10.1007/s001340051279

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

In critically ill patients, transit time is substantially slowed by various pathophysiological and therapeutic factors.
“In critically ill patients, transit time is substantially slowed by various pathophysiological (glucose and electrolyte disturbances8,9 and endogenous opioid production) and therapeutic (sedatives, opiates, and systemic catecholamines21) factors.”
From The microbiome and critical illness (2016) · cites this paper as [21]

Sorted by citations

Surviving Sepsis Campaign: International guidelines for management of sepsis and septic shock: 2016.
Rhodes, A., Evans, L. E., Alhazzani, W., Levy, M. M., Antonelli, M., Ferrer, R., Kumar, A., Sevransky, J. E., Sprung, C. L., Nunnally, M. E., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4683-6 · Cited by 6,621 · see citing works
Surviving Sepsis Campaign: International guidelines for management of sepsis and septic shock: 2016.
Rhodes, A., Evans, L. E., Alhazzani, W., Levy, M. M., Antonelli, M., Ferrer, R., Kumar, A., Sevransky, J. E., Sprung, C. L., Nunnally, M. E., et al. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002255 · Cited by 3,652 · see citing works
Acute Kidney Injury
Calzavacca, P., Licari, E., & Bellomo, R. (2009) · Springer eBooks · doi:10.1007/978-0-387-77893-8_38 · Cited by 533 · see citing works
Meta-Analysis: Low-Dose Dopamine Increases Urine Output but Does Not Prevent Renal Dysfunction or Death
Friedrich, J. O., Adhikari, N. K. J., Herridge, M. S., & Beyene, J. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-7-200504050-00010 · Cited by 510 · see citing works
The microbiome and critical illness
Dickson, R. P. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00427-0 · Cited by 460 · see citing works
Dopamine, Immunity, and Disease
Channer, B., Matt, S. M., Nickoloff-Bybel, E. A., Pappa, V., Agarwal, Y., Wickman, J. R., & Gaskill, P. J. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000618 · Cited by 319 · see citing works
Vasopressor and inotropic support in septic shock: An evidence-based review
Beale, R. J., Hollenberg, S. M., Vincent, J., & Parrillo, J. E. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000142909.86238.b1 · Cited by 254 · see citing works
“(46) used intestinal manometry to demonstrate that dopamine infused at 4 g·kg (1)·min 1 resulted in impaired gastroduodenal motility.”
Method
Methamphetamine: Effects on the brain, gut and immune system
Prakash, M. D., Tangalakis, K., Antonipillai, J., Stojanovska, L., Nurgali, K., & Apostolopoulos, V. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.03.009 · Cited by 220 · see citing works
“In the gut, dopamine and norepinephrine act on receptors of the enteric nervous system resulting in decreased bowel contractility, intestinal smooth muscle tone and alteration of the migratory motor complex (76-78).”
Use of inotropes and vasopressor agents in critically ill patients
Bangash, M. N., Kong, M., & Pearse, R. M. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01588.x · Cited by 196 · see citing works
“, 1970) and in vivo (Dive et al., 2000).”
Background
Gastrointestinal promotility drugs in the critical care setting: A systematic review of the evidence*
Booth, C. M., Heyland, D. K., & Paterson, W. G. (2002) · Critical Care Medicine · doi:10.1097/00003246-200207000-00005 · Cited by 180 · see citing works
Pathophysiology of the upper gastrointestinal tract in the critically ill patient: Rationale for the therapeutic benefits of acid suppression
Fennerty, M. B. (2002) · Critical Care Medicine · doi:10.1097/00003246-200206001-00002 · Cited by 169 · see citing works
The efficacy and safety of prokinetic agents in critically ill patients receiving enteral nutrition: a systematic review and meta-analysis of randomized trials
Lewis, K., Alqahtani, Z., Mcintyre, L., Almenawer, S., Alshamsi, F., Rhodes, A., Evans, L., Angus, D. C., & Alhazzani, W. (2016) · Critical Care · doi:10.1186/s13054-016-1441-z · Cited by 163 · see citing works
“, narcotics, catecholamines), hyperglycemia, renal dysfunction, mechanical ventilation, or the disease process itself [1–5].”
Background
Tolerability and safety of enteral nutrition in critically ill patients receiving intravenous vasopressor therapy
Mancl, E. E., & Muzevich, K. M. (2013) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607112470460 · Cited by 155 · see citing works
“Although physiologic data vary,(26) dopamine has been associated with increased splanchnic oxygen requirements and decreased gastroduodenal motility.(29,30) In addition, in cardiac surgery patients, administration of dopamine is associated with decreased EN tolerance.”
Bladder and bowel dysfunction in Parkinson’s disease
Sakakibara, R., Uchiyama, T., Yamanishi, T., Shirai, K., & Hattori, T. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-007-0855-9 · Cited by 152 · see citing works
Autonomic dysfunction in parkinsonian disorders: assessment and pathophysiology
Asahina, M., Vichayanrat, E., Low, D. A., Iodice, V., & Mathias, C. J. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-303135 · Cited by 140 · see citing works
Critical Illness, Gastrointestinal Complications, and Medication Therapy during Enteral Feeding in Critically Ill Adult Patients
Btaiche, I. F., Chan, L., Pleva, M. R., & Kraft, M. D. (2010) · Nutrition in Clinical Practice · doi:10.1177/0884533609357565 · Cited by 132 · see citing works
Is There Still a Place for Dopamine in the Modern Intensive Care Unit?
Debaveye, Y. A., & den Berghe, G. V. (2004) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000096188.35789.37 · Cited by 128 · see citing works
“5–5 g · kg 1 · min (1)) was found to be the most significant factor associated with poor gastric emptying (45), and it was clearly shown that LDD adversely affects gastroduodenal motility in mechanically ventilated critically ill patients both during fasting and nasogastric feeding (46).”
Background
Gastrointestinal dysfunction in Parkinson’s disease: Molecular pathology and implications of gut microbiome, probiotics, and fecal microbiota transplantation
Metta, V., Leta, V., Mrudula, K. R., Prashanth, L. K., Goyal, V., Borgohain, R., Chung-Faye, G., & Chaudhuri, K. R. (2022) · Journal of Neurology · doi:10.1007/s00415-021-10567-w · Cited by 130 · see citing works
“For instance, presence of Lewy bodies in grafted neurons (as part of the intra-cerebral transplant program) of PD patients raised the hypothesis that α-synuclein transmitted from the host brain to grafted neurons could occur in a prion-like mechanism with recruitment of endogenous α-synuclein and misfolded aggregates…”
Background
Altered GI Motility in Critically Ill Patients
Ukleja, A. (2010) · Nutrition in Clinical Practice · doi:10.1177/0884533609357568 · Cited by 127 · see citing works
Laxation of critically ill patients with lactulose or polyethylene glycol: A two-center randomized, double-blind, placebo-controlled trial *
van der Spoel, J. I., Straaten, H. M. O., Kuiper, M. A., van Roon, E. N., Zandstra, D. F., & van der Voort, P. H. J. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000287526.08794.29 · Cited by 126 · see citing works
Bad Medicine
Holmes, C. L., & Walley, K. R. (2003) · CHEST Journal · doi:10.1378/chest.123.4.1266 · Cited by 120 · see citing works
Bladder, Bowel, and Sexual Dysfunction in Parkinson's Disease
Sakakibara, R., Kishi, M., Ogawa, E., Tateno, F., Uchiyama, T., Yamamoto, T., & Yamanishi, T. (2011) · Parkinson's Disease · doi:10.4061/2011/924605 · Cited by 118 · see citing works
Intestinal motility disturbances in intensive care patients pathogenesis and clinical impact
Fruhwald, S. M., Holzer, P. D., & Metzler, H. (2006) · Intensive Care Medicine · doi:10.1007/s00134-006-0452-7 · Cited by 118 · see citing works
Factors influencing caspofungin plasma concentrations in patients of a surgical intensive care unit
Nguyen, T. H., Hoppe‐Tichy, T., Geiss, H. K., Rastall, A. C., Swoboda, S., Schmidt, J., & Weigand, M. A. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm125 · Cited by 118 · see citing works
“Haemodynamic response and vital support therapy are also known to influence pharmacokinetic parameters.(2,7,8) For example, wide variabilities in aminoglycoside pharmacokinetic parameters such as clearance, volume of distribution and half-lives have been reported for critically ill trauma patients.”
Background
Antro-pyloro-duodenal motor responses to gastric and duodenal nutrient in critically ill patients
Chapman, M. J., Fraser, R., Vozzo, R., Bryant, L., Tam, W., Nguyen, N., Zacharakis, B., Butler, R., Davidson, G., & Horowitz, M. (2005) · Gut · doi:10.1136/gut.2005.065672 · Cited by 110 · see citing works
Non-Hemodynamic Effects of Catecholamines
Hartmann, C., Radermacher, P., Wepler, M., & Nussbaum, B. L. (2017) · Shock · doi:10.1097/shk.0000000000000879 · Cited by 100 · see citing works
“In mechanically ventilated patients dopamine directly inhibited gastrointestinal motility during fasting and nasogastric feeding (102).”
Background
Influence of severity of illness, medication and selective decontamination on defecation
van der Spoel, J. I., Schultz, M. J., van der Voort, P. H. J., et al. (2006) · Intensive Care Medicine · doi:10.1007/s00134-006-0175-9 · Cited by 89 · see citing works
“vasoactives [3, 4, 5, 6]), neurogenic imbalance [7], hypoperfusion and shock [8], endotoxin [9, 10], nitric oxide overproduction [11, 12], or a combination.”
Standardized concept for the treatment of gastrointestinal dysmotility in critically ill patients—Current status and future options
Herbert, M. K., & Holzer, P. D. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2007.08.001 · Cited by 84 · see citing works
Gastrointestinal motility and prokinetics in the critically ill
Chapman, M. J., Nguyen, N. Q., & Fraser, R. J. (2007) · Current Opinion in Critical Care · doi:10.1097/mcc.0b013e3280523a88 · Cited by 77 · see citing works
Risk Factors for Aspiration
Metheny, N. A. (2002) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860710202600605 · Cited by 78 · see citing works
DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization
Liu, L., Wu, Y., Wang, B., Jiang, Y., Lin, L., Li, X., & Yang, S. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03778-6 · Cited by 59 · see citing works
Effect of gastrointestinal motility and feeding tube site on aspiration risk in critically ill patients: a review
Metheny, N. A., Schallom, M. E., & Edwards, S. J. (2004) · Heart & Lung · doi:10.1016/j.hrtlng.2004.02.001 · Cited by 58 · see citing works
Renal-Dose Dopamine: From Hypothesis to Paradigm to Dogma to Myth and, Finally, Superstition?
Jones, D., & Bellomo, R. (2005) · Journal of Intensive Care Medicine · doi:10.1177/0885066605276963 · Cited by 56 · see citing works
“In a study of critically ill patients, administration of LDD was shown to be the most significant factor associated with poor gastric emptying [94].”
Background
Gastrointestinal Dysmotility: Clinical Consequences and Management of the Critically Ill Patient
Chapman, M. J., Nguyen, N. Q., & Deane, A. M. (2011) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2011.09.003 · Cited by 54 · see citing works
Enteral Nutrition in Critically Ill Children: Are Prescription and Delivery According to Their Energy Requirements?
Iglesias, S., Leite, H. P., Meneses, J. F. S. E., et al. (2007) · Nutrition in Clinical Practice · doi:10.1177/0115426507022002233 · Cited by 54 · see citing works
Gastrointestinal motility in acute illness
Fruhwald, S. M., Holzer, P. D., & Metzler, H. (2008) · Wiener klinische Wochenschrift · doi:10.1007/s00508-007-0920-2 · Cited by 54 · see citing works
“In patients suffering from gastric hypomotility the MMC starts in the duodenum rather than in the antrum [ 28 ].”
Background
Contributions of Gut Bacteria and Diet to Drug Pharmacokinetics in the Treatment of Parkinson's Disease
van Kessel, S. P., & Aidy, S. E. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01087 · Cited by 53 · see citing works
“Similar results were found in terminally ill patients (91).”
BackgroundResult
Provision of enteral nutrition during vasopressor therapy for hemodynamic instability: an evidence-based review.
Wells, D. L. (2012) · Nutrition in clinical practice · doi:10.1177/0884533612448480 · Cited by 49 · see citing works
Altered fecal microbiota composition in individuals who abuse methamphetamine
Yang, Y., Yu, X., Liu, X., Liu, G., Zeng, K., & Wang, G. (2021) · Scientific Reports · doi:10.1038/s41598-021-97548-1 · Cited by 50 · see citing works
Levodopa ameliorated anorectal constipation in de novo Parkinson’s disease: The QL-GAT study
Tateno, F., Sakakibara, R., Yokoi, Y., et al. (2011) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2011.06.002 · Cited by 48 · see citing works
Impact of disease severity on gastric residual volume in critical patients
Hsu, C.-W. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i15.2007 · Cited by 47 · see citing works
Randomized double-blind crossover study to determine the effects of erythromycin on small intestinal nutrient absorption and transit in the critically ill
Deane, A. M., Wong, G. L., Horowitz, M., Zaknic, A. V., Summers, M. J., Bartolomeo, A. E. D., Sim, J. A., Maddox, A. F., Bellon, M., Rayner, C. K., et al. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.035691 · Cited by 46 · see citing works
Risk factors for late defecation and its association with the outcomes of critically ill patients: a retrospective observational study
Fukuda, S., Miyauchi, T., Fujita, M., Oda, Y., Todani, M., Kawamura, Y., Kaneda, K., & Tsuruta, R. (2016) · Journal of Intensive Care · doi:10.1186/s40560-016-0156-1 · Cited by 44 · see citing works
“Previous studies have reported that constipation was attributed to various factors, including immobility [7], neurogenic imbalance [8], hypotension, hypoxemia [3], and the administration of opioids [9] and vasopressors [10].”
Background
Gastric emptying and the organization of antro‐duodenal pressures in the critically ill
Chapman, M. J., Fraser, R. J., Bryant, L. K., Vozzo, R., Nguyen, N. Q., Tam, W., Zacharakis, B., Davidson, G. P., Butler, R., & Horowitz, M. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00984.x · Cited by 43 · see citing works
The implementation of a bowel management protocol in an adult intensive care unit
McPeake, J. M., Gilmour, H., & MacIntosh, G. (2011) · Nursing in Critical Care · doi:10.1111/j.1478-5153.2011.00451.x · Cited by 42 · see citing works
Evidence-Based Guidelines for Nutritional Support of the Critically Ill: Results of a Bi-National Guideline Development Conference
Chairs, M., Doig, G. S., & Simpson, F. O. (2005) · Cited by 40 · see citing works
Gastric Dysmotility in Critically Ill Children
Martinez, E. E., Douglas, K., Nurko, S., & Mehta, N. M. (2015) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000000493 · Cited by 39 · see citing works
“In mechanically ventilated adults, dopamine has been associated with delayed GE and prolonged small bowel transit time by inhibiting phase III activity and decreasing antral contractions, whereas norepinephrine and/ or epinephrine has not been associated with delayed GE (30, 35, 42).”
Background
Parkinson’s Disease Medication Alters Small Intestinal Motility and Microbiota Composition in Healthy Rats
van Kessel, S. P., Bullock, A., van Dijk, G., & El Aidy, S. (2022) · mSystems · doi:10.1128/msystems.01191-21 · Cited by 41 · see citing works
Motility Disorders of the Upper Gastrointestinal Tract in the Intensive Care Unit
Stupak, D., Abdelsayed, G., & Soloway, G. N. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31824e14c1 · Cited by 36 · see citing works
Motility disorders in the ICU: recent therapeutic options and clinical practice
Röhm, K. D., Boldt, J., & Piper, S. N. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32832182c4 · Cited by 31 · see citing works
Cardiac arrest after intravenous metoclopramide – a case of five repeated injections of metoclopramide causing five episodes of cardiac arrest
Bentsen, G., & Stubhaug, A. (2002) · Acta Anaesthesiologica Scandinavica · doi:10.1034/j.1399-6576.2002.460725.x · Cited by 31 · see citing works
“Dopamine is known to decrease gastric tone (14, 15) and may slow down gastric emptying (16).”
Background
Vasopressors and Risk of Acute Mesenteric Ischemia: A Worldwide Pharmacovigilance Analysis and Comprehensive Literature Review
Jozwiak, M., Géri, G., Laghlam, D., Boussion, K., Dolladille, C., & Nguyen, L. S. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.826446 · Cited by 31 · see citing works
“Yet, gastroduodenal motility was found to be adversely impacted by the use of low-dose dopamine (4 μg/kg per minute) as compared to placebo in mechanically ventilated critically ill patients (122).”
Background
Nutrition support and treatment of motility disorders in critically ill patients - Results of a survey on German intensive care units
Röhm, K. D., Schöllhorn, T., Boldt, J., Wolf, M. W., Papsdorf, M., & Piper, S. N. (2007) · European Journal of Anaesthesiology · doi:10.1017/s0265021507002657 · Cited by 28 · see citing works
“Several factors, such as premorbid diagnosis, admission diagnosis, biochemical abnormalities or drug administration, may contribute to the development of motility disorders [25].”
Background
Drug-induced acute liver failure and gastrointestinal complications
Lat, I., Foster, D. R., & Erstad, B. L. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181de0db2 · Cited by 27 · see citing works
“Catecholamine vasopressors can also impair upper GI motility and they are also an independent risk factor for increased gastric aspirate volume during nasogastric feedings (58, 68).”
BackgroundInfluential
Prophylaxis Versus Treatment Use of Laxative for Paralysis of Lower Gastrointestinal Tract in Critically Ill Patients
Guardiola, B., Llompart‐Pou, J. A., Ibáñez, J., et al. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000316 · Cited by 27 · see citing works
“11 In-hospital length of stay (d)w 32 (18-50) 28 (14-46) 0.”
Background
Pharmacologic support of infants and children in septic shock
Irazuzta, J. E., Sullivan, K., Garcia, P. C. R., et al. (2007) · Jornal de Pediatria · doi:10.2223/jped.1623 · Cited by 27 · see citing works
Important Facts About Intestinal Feeding Tube Placement
Ellett, M. L. C. (2006) · Gastroenterology Nursing · doi:10.1097/00001610-200603000-00004 · Cited by 26 · see citing works
Pharmacological therapy of feed intolerance in the critically ills
Nguyen, N. Q. (2014) · World Journal of Gastrointestinal Pharmacology and Therapeutics · doi:10.4292/wjgpt.v5.i3.148 · Cited by 24 · see citing works
Jejunal Feeding Tubes Can Be Efficiently and Independently Placed by Intensive Care Unit Teams
Welpe, P., Frutiger, A., Vanek, P., & Kleger, G. (2010) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607109354781 · Cited by 24 · see citing works
Energy‐Dense Formulae May Slow Gastric Emptying in the Critically Ill
Kar, P., Plummer, M. P., Chapman, M. J., Cousins, C. E., Lange, K. M., Horowitz, M., Jones, K. L., & Deane, A. M. (2015) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607115588333 · Cited by 22 · see citing works
Stress-Related Gastrointestinal Bleeding in Patients with Aneurysmal Subarachnoid Hemorrhage: A Multicenter Retrospective Observational Study
Ali, D. K. S., Barra, M. E., Blunck, J. R., et al. (2020) · Neurocritical Care · doi:10.1007/s12028-020-01137-5 · Cited by 21 · see citing works
Réaction inflammatoire et infection chez le brûlé grave
Carsin, H., Bargues, L., Stéphanazzi, J., Paris, A., Aubert, P. M., & Bever, H. L. (2002) · Pathologie Biologie · doi:10.1016/s0369-8114(01)00272-3 · Cited by 19 · see citing works
An Update on Nutrition Support in the Critically Ill
Gerlach, A. T., & Murphy, C. V. (2010) · Journal of Pharmacy Practice · doi:10.1177/0897190010388142 · Cited by 20 · see citing works
“Dopamine, in particular, has been shown to decrease gastricduodenal motility in mechanically ventilated patients when dosed at 4 mcg/kg per min.(20,26) Four strategies suggested to help optimize delivery and minimize risk of EN are head of bed elevation, small bowel feedings, feeding protocols, and use of promotility…”
Background
DOPAMINE D2 RECEPTOR STIMULATION INHIBITS ANGIOTENSIN II‐INDUCED HYPERTROPHY IN CULTURED NEONATAL RAT VENTRICULAR MYOCYTES
Li, H., Shi, S., Sun, Y., Zhao, Y., Li, Q., Li, H., Wang, R., & Xu, C. (2008) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2008.05064.x · Cited by 20 · see citing works
Physiology of the Aerodigestive System and Aberrations in That System Resulting in Aspiration
DeMeo, M. T., & Bruninga, K. (2002) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860710202600603 · Cited by 20 · see citing works
Methamphetamine-induced paralytic ileus.
Carlson, T. L., Plackett, T. P., Gagliano, R. A., et al. (2012) · PubMed · Cited by 19 · see citing works
Complicaciones gastrointestinales de la nutrición enteral en el paciente crítico
Montejo, J. C., Jiménez, J., Ordóñez, J., Caparrós, T., Garcia, A. J. G., Ortiz, C., & López, J. (2001) · Medicina Intensiva · doi:10.1016/s0210-5691(01)79674-x · Cited by 19 · see citing works
Methamphetamine intoxication in a dog: case report
Pei, Z., & Zhang, X. (2014) · BMC Veterinary Research · doi:10.1186/1746-6148-10-139 · Cited by 17 · see citing works
“The mechanism by which methamphetamine can induce gastrointestinal disorders has been proposed to be by direct affects on cocaine-regulation and upon the amphetamineregulated transcript peptide as well as indirect effects from the release of dopamine and other neurotransmitters [34,35].”
Background
Interrupting Drug Therapy in the Perioperative Period
Noble, D. W., & Webster, J. (2002) · Drug Safety · doi:10.2165/00002018-200225070-00003 · Cited by 17 · see citing works
“[15-22] First, gastric emptying may be impeded, by surgery, by postoperative opioid analgesics as well as by catecholamine drug infusions.”
Background
Getting Critical About Constipation
Parrish, C. R., Vincent, J., & Preiser, J. (2015) · Cited by 15 · see citing works
Low-dose dopamine in the intensive care unit: DNR or DN℞?
Rudis, M. I. (2001) · Critical Care Medicine · doi:10.1097/00003246-200108000-00026 · Cited by 15 · see citing works
Dopamine Use in Intensive Care: Are We Ready to Turn it Down?
Marinosci, G. Z., ROBERTIS, E. D., Benedictis, G. D., et al. (2012) · PubMed · Cited by 14 · see citing works
Future Considerations in Aspiration Pneumonia in the Critically Ill Patient: What Is Not Known, Areas for Future Research, and Experimental Methods
DiSario, J. A. (2002) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860710202600612 · Cited by 14 · see citing works
Levodopa Does Not Worsen Gastric Emptying in Parkinson's Disease
Shiina, S., Sakakibara, R., Doi, H., Tateno, F., Sato, M., Masaka, T., Kishi, M., Tsuyusaki, Y., Ogata, T., Aiba, Y., et al. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13675 · Cited by 11 · see citing works
“In an emergency department, slow gastroduodenal motility with dopamine was found in critically ill individuals.(10) Conversely, the dopamine receptor blocker itopride facilitates gastric motility.”
Background
Metoclopramide nasal spray for management of symptoms of acute and recurrent diabetic gastroparesis in adults
Gajendran, M., Sarosiek, I., & McCallum, R. W. (2021) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2021.1886922 · Cited by 11 · see citing works
“tractions and abnormally propagated duodenal motility when compared to the patients in the placebo group [34].”
Result
Administration of triiodothyronine and dopamine to broiler chicks increases growth, feed conversion and visceral organ mass
Chang, S., Lin, M., Croom, J., et al. (2003) · Poultry Science · doi:10.1093/ps/82.2.285 · Cited by 10 · see citing works
“Dopamine administration has been reported to decrease intestinal contractions and motility in both the chick (Lot 1993) and in the duodenum of critically ill humans (Dive et al., 2000).”
Small intestine neuromuscular dysfunction in a mouse model of dextran sulfate sodium-induced ileitis: Involvement of dopaminergic neurotransmission
Cerantola, S., Faggin, S., Caputi, V., Bosi, A., Banfi, D., Rambaldo, A., Porzionato, A., Liddo, R. D., De, R., Savarino, E. V., et al. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120562 · Cited by 9 · see citing works
Dopamine and Gastrointestinal Motility
Zheng, L., Liu, S., Zhou, L., Zhang, X., Xiao, Y., & Zhu, J. (2021) · Springer eBooks · doi:10.1007/978-981-33-6586-5_5 · Cited by 9 · see citing works
La hemorragia digestiva alta en la Unidad de Cuidados Intensivos
Quevedo, Y. A. F., Peláez, A. J. R., Villa, J. C. M., et al. (2006) · Revista Colombiana de Gastroenterología · Cited by 6 · see citing works
Significant Publications for Pharmacy Nutrition Support Practice in 2013
Dickerson, R. N., Kumpf, V. J., Rollins, C. J., Frankel, E. H., Kraft, M. D., Canada, T. W., & Crill, C. M. (2014) · Hospital Pharmacy · doi:10.1310/hpj4908-717 · Cited by 6 · see citing works
Risk Factors and Management of Stress Ulcers in the Critical Care Unit in a Kenyan Referral Hospital
Kerama, S. K., Okalebo, F., Nyamu, D. G., et al. (2016) · The African Journal of Pharmacology and Therapeutics · doi:10.66563/ats71877 · Cited by 5 · see citing works
“Benzodiazepines could have conferred protection by ameliorating the psychogenic pathways involved in the pathogenesis of stress ulcers (Dive et al, 2000).”
Paralytic Ileus Secondary to Methamphetamine Abuse: A Rare Case
McKelvie, M., & Gerçek, Y. (2017) · Case Reports in Surgery · doi:10.1155/2017/9762803 · Cited by 5 · see citing works
“Studies implicate dopamine in intestinal motility [16], with one study demonstrating how dopamine, acting at the D1 receptor, causes concentration-dependent reduction in mouse ileum muscle tone and markedly reduces small bowel contractility [17].”
Background
Low-Dose Dopamine in the ICU
Holmes, C. L., & Walley, K. R. (2017) · Cited by 5 · see citing works
Peripherally‐active mu‐opioid receptor antagonists for constipation in critically ill patients receiving opioids: A case‐series and a systematic review and meta‐analysis of the literature
Umbrello, M., Venco, R., Palandri, C., Racagni, M., & Muttini, S. (2023) · Neurogastroenterology & Motility · doi:10.1111/nmo.14694 · Cited by 4 · see citing works
Acute heart failure syndromes
(2009) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0346-0022-4_2 · Cited by 4 · see citing works
Therapie des Kreislaufversagens bei Sepsis
Meier‐Hellmann, A. (2004) · Intensivmedizin und Notfallmedizin · doi:10.1007/s00390-004-0514-4 · Cited by 4 · see citing works
Use of creatinine clearances to monitor the effect of low-dose dopamine in critically ill surgical patients
Eachempati, S. R., & Reed, R. L. (2003) · Journal of Surgical Research · doi:10.1016/s0022-4804(03)00151-3 · Cited by 4 · see citing works
Constipation in critically ill adults
Kim, Y., & See, K. C. (2025) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v16.i4.112019 · Cited by 4 · see citing works
Development and validation of a clinical score for early diagnosis of constipation in critically ill children
López, J., Sánchez, C., Fernández, S. N., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-41674-5 · Cited by 3 · see citing works
“The importance of vasoconstrictors could be more related to the hemodynamic and general situation (hypotension, gastrointestinal hypoperfusion and severity of illness) than to the direct effect of these drugs on the bowel motility 1,10,11,13,21 .”
Background
Update on Vasopressors and Inotropes in Septic Shock
Rudis, M. I., & Chant, C. A. (2002) · Journal of Pharmacy Practice · doi:10.1106/jqwy-6udr-1d5q · Cited by 3 · see citing works
Effect of intravenous dopamine infusion on pituitary and thyroid function and on nephroprotection
Kobusiak−Prokopowicz, M., Ściborski, K., & Mysiak, A. (2012) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.1200 · Cited by 3 · see citing works
Pharmacokinetic Alterations of Antimicrobials in the Critically Ill
Cook, A. M. (2005) · Journal of Pharmacy Practice · doi:10.1177/0897190004273568 · Cited by 3 · see citing works
“Catecholamines and overactivation of the sympathetic nervous system can cause impaired gastric emptying, likely by overriding vagal tone.(12,13) Opioids are often used for sedation in critically ill patients.”
Background
Elevated serum dopamine increases while coffee consumption decreases the occurrence of reddish streaks in the intact stomach
Chen, T., & Chang, F. (2013) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12308 · Cited by 2 · see citing works
Upright position mechanical ventilation: An alternative strategy for ALI/ARDS patients?
Zhu, M., Zhang, W., Wang, J., Yan, H., Li, Y., Ai, B., Fu, S.-L., & Fu, X. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2009.03.023 · Cited by 2 · see citing works
“Medications such as dopamine and sedation [21], hyperglycemia [22] or increased intracranial pressure [23] have all been shown to depress the gut activity.”
Background
Therapie des Kreislaufversagens bei Sepsis
Meier‐Hellmann, A. (2007) · Steinkopff eBooks · doi:10.1007/978-3-7985-1729-5_6 · Cited by 2 · see citing works
Vasopressors and Inotropes
Mueller, S. W., & MacLaren, R. (2011) · Springer eBooks · doi:10.1007/978-0-85729-606-1_2 · Cited by 3 · see citing works
Narrative review of constipation in the critically ill child
López, J., Solana, M. J., & López‐Herce, J. (2021) · Pediatric Medicine · doi:10.21037/pm-20-63 · Cited by 2 · see citing works
“In addition, there are multiple and frequent factors in critically ill patients which negatively affect one or several sections of the GI tract: mechanical ventilation, analgesic drugs (opioid or non-opioid) or inotropes, splanchnic hypoperfusion, immobility and delay in the onset of enteral nutrition (EN) (5,7-9,11,1…”
Background
The Microbiome and Antimicrobial Stewardship in Surgical Patients
Creel, J., & Maves, R. C. (2023) · Surgical Infections · doi:10.1089/sur.2022.422 · Cited by 2 · see citing works
“23,24 The dysmotility may favor gut colonization with pathogenic organisms, such as Pseudomonas , and subsequently increase the risk of nosocomial infection related to gastrointestinal tract pathogens.”
Understanding of Pathophysiological Basis of Feeding Intolerance in Critically ill Children
Bağcı, S., Keleş, E., & Müller, A. (2021) · Cam and Sakura Medical Journal · doi:10.4274/csmedj.galenos.2021.2021-11-1 · Cited by 1 · see citing works
“In mechanically ventilated patients with critical illness, Dive et al. (86) demonstrated that continuous intravenous administration of dopamine at a low dose (4 µg/kg per min) decreased the number of contractions in the gastric antrum and induced phase III motor activity in the duodenum both during…”
Background
Use of Gastric Decompression Tubes With Small-Bowel Feeding Tubes
Powers, J. (2014) · Critical Care Nurse · doi:10.4037/ccn2014317 · Cited by 1 · see citing works

Relationships between electrical activities of antrum and duodenum
Allen, G. L., Poole, E. W., & Code, C. F. (1964) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1964.207.4.906 · Cited by 61 · see citing works
Experimental methodology exploration of coordination exercise of stomach and duodenum in body
Kou, G. (2003)
Role of the duodenum in the control of canine gastrointestinal motility
Tanaka, M., & Sarr, M. G. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90232-6 · Cited by 120 · see citing works
FREE-RADICAL OXIDATION AS A PATHOGENETIC FACTOR OF STOMACH AND DUODENAL INJURY IN EARLY POSTOPERATIVE PERIOD AFTER MAXIMALLY PERMISSIBLE LIVER RESECTION
Barskaya, L. O., Khramykh, T. P., Леонидович, П. В., et al. (2017) · Annaly khirurgicheskoy gepatologii = Annals of HPB surgery · doi:10.16931/1995-5464.2017132-39 · Cited by 1 · see citing works
Healing of incisional wounds in stomach and duodenum
Gottrup, F. (1981) · The American Journal of Surgery · doi:10.1016/0002-9610(81)90162-8 · Cited by 34 · see citing works

Authors: Dive, A., Foret, F., Jamart, J., Bulpa, P., & Installé, E.
Affiliations: UCLouvain (BE)
ORCID: Dive, A.
Foret, F.
Jamart, J.
Venue: Intensive Care Medicine
Publisher: Springer Science and Business Media LLC
Published: 2000-07-28
Volume: 26
Issue: 7
Pages: 901-907
ISSN: 0342-4642 (ISSN-L)
1432-1238
DOI: 10.1007/s001340051279
OpenAlex: W2008260145
Cited by: 124
References: 0
Citations by year: 2026: 1 · 2025: 1 · 2023: 3 · 2022: 4 · 2021: 8 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 8 · 2016: 3 · 2015: 7 · 2014: 6 · 2013: 1 · 2012: 10
FWCI: 5.69
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Intensive Care Medicine (publishedVersion)
PubMed (publishedVersion)
Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Keywords: dopamine, gastrointestinal motility, migrating motor complex, gastroduodenal motility, mechanical ventilation, critically ill patients, enteral nutrition, gastric antrum, duodenum
MeSH terms: Adult, Aged, Dopamine, Duodenum, Enteral Nutrition, Female, Gastrointestinal Motility, Humans, Male, Manometry, Middle Aged, Pyloric Antrum, Respiration, Artificial, Vasodilator Agents, Myoelectric Complex, Migrating, Critical Illness, Cross-Over Studies, Statistics, Nonparametric

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effect of dopamine on gastrointestinal motility during critical illness

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cited by

Related

Record

About these checks