Parkinson’s Disease Medication Alters Small Intestinal Motility and Microbiota Composition in Healthy Rats
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Abstract
Parkinson’s disease (PD) is the second most common neurodegenerative disorder and is known to be associated with altered gastrointestinal function and microbiota composition. We previously showed that the gut bacteria harboring tyrosine decarboxylase enzymes interfere with levodopa, the main treatment for PD (S. P. van Kessel, A. K. Frye, A. O. El-Gendy, M. Castejon, A. Keshavarzian, G. van Dijk, and S. El Aidy, Nat Commun 10:310, 2019).
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Treatment with dopamine agonists was associated with reduced intestinal motility and small intestinal bacterial overgrowth in rats.
“treatment with dopamine agonists was associated with reduced intestinal motility and small intestinal bacteria overgrowth (SIBO; a kind of dysbiosis that frequently occurs in PD patients) in rats [191]”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [191]
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- Authors
- van Kessel, S. P., Bullock, A., van Dijk, G., & El Aidy, S.
- Affiliations
- Host-Microbe Interactions, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands
- University of Groningen (NL)
- Department of Behavioral Neuroscience, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands
- Venue
- mSystems
- Publisher
- American Society for Microbiology
- Published
- 2022-02-22
- Volume
- 7
- Issue
- 1
- Pages
- e0119121-e0119121
- ISSN
- 2379-5077 (ISSN-L)
- PMC
- PMC8788331
- OpenAlex
- W4206996485
- Cited by
- 41
- References
- 80
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 10 · 2023: 10 · 2022: 3
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mSystems (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- SSRN Electronic Journal (acceptedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by)
- Funders
- Weston Brain Institute
- European Commission
- Rijksuniversiteit Groningen
- Ministerie van Economische Zaken
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (2016.000.RUG)
- Center for Information Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Parkinson's disease, levodopa, small intestine motility, gut microbiota, small intestinal bacterial overgrowth, tyrosine decarboxylase, levodopa bioavailability, gastrointestinal function, gut-brain axis, microbiome biomarkers
- MeSH terms
- Gastrointestinal Microbiome, Animals, Bacteria, Carbidopa, Cross-Sectional Studies, Gastrointestinal Motility, Humans, Levodopa, Parkinson Disease, Tyrosine Decarboxylase, Rats
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