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Global vitamin D status and determinants of hypovitaminosis D
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Unlabelled This review describes the vitamin D status in different regions of the world with the objective of understanding the scope of hypovitaminosis D and the factors related to its prevalence that may contribute to the pathogenesis of osteoporosis and fragility fractures.Introduction Vitamin D status has been linked to the pathogenesis of hip fractures as well as other skeletal and non-skeletal disorders. The purpose of this review is to provide a global perspective of vitamin D status across different regions of the world and to identify the common and significant determinants of hypovitaminosis D.Methods Six regions of the world were reviewed-Asia, Europe, Middle East and Africa, Latin America, North America, and Oceania-through a survey of published literature.Results The definition of vitamin D insufficiency and deficiency, as well as assay methodology for 25-hydroxyvitamin D or 25(OH)D, vary between studies. However, serum 25(OH)D levels below 75 nmol/L are prevalent in every region studied whilst levels below 25 nmol/L are most common in regions such as South Asia and the Middle East. Older age, female sex, higher latitude, winter season, darker skin pigmentation, less sunlight exposure, dietary habits, and absence of vitamin D fortification are the main factors that are significantly associated with lower 25(OH)D levels.Conclusion Reports from across the world indicate that hypovitaminosis D is widespread and is re-emerging as a major health problem globally.
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“Congruent with previous meta-analyses (58,59), and a RCT study (23), our study found a significant reduction in depressive symptoms after 3 months vitamin D supplementation.”
From Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial (2020) · cites this paper as [58]
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Time for an Adolescent Health Surveillance System in Saudi Arabia: Findings From “Jeeluna”
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“Vitamin D deficiency is most prevalent in South Asia and the Middle East [30].”
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Serum 25-hydroxyvitamin D levels and the risk of depression: A systematic review and meta-analysis
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Annual high-dose vitamin D3and mental well-being: randomised controlled trial
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“Vitamin D deficiency is common in the US and throughout the world, even in 32 areas near the equator where sun exposure is presumed to be high.(1) In addition to 33 known effects on calcium homeostasis, vitamin D has a variety of functions including 34 immunomodulatory and anti-inflammatory effects.”
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Metadata
- Authors
- on behalf of the IOF Committee of Scientific Advisors (CSA) Nutrition Working Group, Mithal, A., Wahl, D. A., Bonjour, J.-P., Burckhardt, P., Dawson-Hughes, B., Eisman, J. A., El-Hajj Fuleihan, G., Josse, R. G., Lips, P., & Morales-Torres, J.
- Affiliations
- Indraprastha Apollo Hospitals (IN)
- International Osteoporosis Foundation (CH)
- University of Geneva (CH)
- Hirslanden Clinique Bois-Cerf (CH)
- Garvan Institute of Medical Research (AU)
- St. Michael's Hospital (CA)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Mithal, A.
- Venue
- Osteoporosis International
- Published
- 2009-06-19
- Volume
- 20
- Issue
- 11
- Pages
- 1807-1820
- ISSN
- 0937-941X (ISSN-L)
- 1433-2965
- OpenAlex
- W2106647095
- Cited by
- 1,472
- References
- 156
- Citations by year
- 2026: 31 · 2025: 49 · 2024: 63 · 2023: 67 · 2022: 87 · 2021: 97 · 2020: 103 · 2019: 93 · 2018: 99 · 2017: 103 · 2016: 100 · 2015: 116 · 2014: 121 · 2013: 123 · 2012: 94
- FWCI
- 8.67
- Type
- journal article
- Language
- en
- Open access
- green
- research.vumc.nl
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Osteoporosis International (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (submittedVersion, other-oa)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- International Osteoporosis Foundation
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
- Keywords
- vitamin D status, vitamin D deficiency, 25-hydroxyvitamin D, osteoporosis, fragility fractures, hip fracture, risk factors, sun exposure, skin pigmentation, latitude, seasonal variation, dietary habits, vitamin D fortification, global prevalence
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Child, Child, Preschool, Cross-Cultural Comparison, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Risk Factors, Sex Factors, Vitamin D, Vitamin D Deficiency, Global Health, Prevalence, Genetic Predisposition to Disease, Young Adult
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