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Cited by 21Bone health and osteoporosis researchGrowth Hormone and Insulin-like Growth FactorsPituitary Gland Disorders and Treatments

Quantitative Ultrasound of the Heel and Some Parameters of Bone Turnover in Patients with Acromegaly

Bolanowski, M., Jędrzejuk, D., Milewicz, A., Arkowska, A.·2002·Osteoporosis International
DOI 10.1007/s001980200030
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Abstract

Acromegaly caused by growth hormone (GH) hypersecretion is characterized by enhanced skeletal growth and soft tissue enlargement. Insulin-like growth factor-1 (IGF-1) is the main peripheral mediator of GH action and it has a crucial role in the maintenance of a normal bone mass. However, in some patients with acromegaly, secondary osteoporosis is observed, despite the strong anabolic effect of GH and IGF-1 in bones. It is thought to be due to hypogonadism. The bone changes are accompanied by increased turnover. The aim of this study was to assess bone properties by ultrasound and turnover in patients with acromegaly. The study was carried out in 26 patients (13 men, 13 women): 14 with active acromegaly and 12 cured by surgery who had non-active disease. Speed of sound (SOS), broadband ultrasound attenuation (BUA) and their combination Stiffness Index (SI) by quantitative ultrasound (QUS) of the heel, hormonal status, serum osteocalcin (OC) concentration and the urinary excretion of pyridinoline collagen crosslinks (PYR) were all studied. Controls were 20 age- and sex-matched healthy persons. We observed statistically significantly lower QUS values in patients with active disease than in those whose disease was cured. The differences were more pronounced in men. QUS values were lower in the entire group of patients compared with the controls; however, the differences were not statistically significant. Serum OC concentrations and urinary PYR excretion were higher in active dis…

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Crossref · 10.1007/s001980200030

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  • GH and IGF-1 stimulate proliferation, differentiation, and extracellular matrix production in osteoblastic cells, and also promote osteoclast recruitment and bone resorption activity.

    “GH and its main peripheral mediator insulin-like growth factor-1 (IGF-1) stimulate proliferation, differentiation, and extracellular matrix production in osteoblastic cells. GH and IGF-1 also promote osteoclast recruitment and bone resorption activity [27–30].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [28]

  • Conflicting data on bone mineral density in acromegaly might be related to gonadal status, different skeletal sites measured, various techniques employed, subject's gender, age, and activity of the disease.

    “Conflicting data on bone mineral density might be related to gonadal status, different skeletal sites being measured, various techniques employed, subject's gender, age, and activity of the disease [28, 36, 38].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [28]

  • Indicators of bone resorption such as urinary hydroxyproline/creatinine, urinary type I collagen cross-linked N-telopeptide, and serum C-terminal collagen type I cross-links are in higher concentrations in acromegaly than in controls.

    “Indicators of bone resorption such as urinary hydroxyproline/creatinine, urinary type I collagen cross-linked N-telopeptide, and serum C-terminal collagen type I cross-links are in higher concentrations than in controls [28, 29, 35, 40, 43].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [28]

  • Impaired gonadal status including hypogonadism and hyperprolactinemia is thought to be a cause of BMD decline in acromegaly.

    “Impaired gonadal status including hypogonadism and hyperprolactinemia is thought to be a cause of BMD decline [28, 34].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [28]

  • Osteocalcin, a specific marker of bone formation, is elevated in subjects with active acromegaly.

    “A specific marker of bone formation, osteocalcin, is elevated in subjects with active disease [28, 29, 35, 40, 43].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [28]

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Authors
Bolanowski, M., Jędrzejuk, D., Milewicz, A., & Arkowska, A.
Affiliations
Wroclaw Medical University (PL)
ORCID
Venue
Osteoporosis International
Publisher
Springer Science and Business Media LLC
Published
2002-04
Volume
13
Issue
4
Pages
303-308
ISSN
  • 0937-941X (ISSN-L)
  • 1433-2965
DOI
10.1007/s001980200030
OpenAlex
W2074498121
Cited by
21
References
23
Citations by year
2026: 1 · 2024: 3 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
FWCI
1.02
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Osteoporosis International (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords
quantitative ultrasound, calcaneus, bone turnover, secondary osteoporosis, growth hormone, insulin-like growth factor I, osteocalcin, pyridinoline, bone stiffness, bone mineral density, sex differences, hypogonadism, bone quality, sound velocity, broadband ultrasound attenuation, stiffness index, surgical cure
MeSH terms
Acromegaly, Adult, Aged, Amino Acids, Bone Resorption, Calcaneus, Collagen, Female, Humans, Insulin-Like Growth Factor I, Male, Middle Aged, Growth Hormone, Ultrasonography, Biomarkers, Osteocalcin, Case-Control Studies

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