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Antiulcerogenic activity of chlorogenic acid in different models of gastric ulcer
Shimoyama, André T., Santin, José Roberto, Machado, Isabel D., de Oliveira e Silva, Ana Mara, de Melo, Illana L. Pereira, Mancini-Filho, Jorge, Farsky, Sandra H. P.·2013·Naunyn-Schmiedeberg's Archives of Pharmacology
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“Chlorogenic acids do not modify gastric acid secretion but inhibit the migration of the neutrophils involved in the immune response and stimulate the protective action of the enzymes of the anti-oxidative cascade.”
From Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update (2022) · cites this paper as [81]
In the citing paper
“The authors suggest that the presence of a high level of chlorogenic acids in coffee could explain the lack of effect of coffee on stomach ulcers [81].”
From Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update (2022) · cites this paper as [81]
In the citing paper
“According to a study in mice, chlorogenic acids could display protective action on gastric mucosa by reducing the surface of the mucosa injured in an experimental ulcer model.”
From Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update (2022) · cites this paper as [81]
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Citations
Cites
Chlorogenic Acid and Caffeic Acid Are Absorbed in Humans
Olthof, M. R., Katan, M. B., & Hollman, P. C. H. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.1.66 · Cited by 975
Chlorogenic Acids from Green Coffee Extract Are Highly Bioavailable in Humans
Farah, A., Monteiro, M., Donangelo, C. M., & Lafay, S. (2008) · The Journal of Nutrition · doi:10.3945/jn.108.095554 · Cited by 578 · cited 1×
“Although CGA is ingested by the oral route and absorbed by gastric and intestinal cells (Farah et al. 2008; Stalmach et al. 2010) and acts as a cytoprotective agent in several disease models (Krakauer 2002; Dos Santos et al.”
BackgroundKempf, K., Herder, C., Erlund, I., Kolb, H., Martin, S., Carstensen, M., Koenig, W., Sundvall, J., Bidel, S., Kuha, S., et al. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28548 · Cited by 364 · cited 1×
“2010) and acts as a cytoprotective agent in several disease models (Krakauer 2002; Dos Santos et al. 2006; Olmos et al. 2007; Zhang et al. 2010; Yonathan et al. 2006; Kempf et al. 2010), no information is currently available on its effects on gastric ulcer.”
BackgroundZhao, Z., Shin, H. S., Satsu, H., Totsuka, M., & Shimizu, M. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf073168d · Cited by 77 · cited 1×
“…Hoelzl et al. 2010), and the proposed mechanism of action involves its reductive and direct radical scavenger activity, in addition to activation of antioxidant enzymes and suppression of the transcription factors induced by reactive by reactive oxygen species (Zhao et al. 2008; Xu et al. 2010).”
Background
Research works printed but not linked: 59
- Aly AM, Al-Alousi L, Salem HA (2005) Licorice: a possible anti-inflammatory and anti-ulcer drug. AAPS Pharm Sci Technol 6:74–82 · DOI
- Andrade-Cetto A, Vázquez RC (2010) Gluconeogenesis inhibition and phytochemical composition of two Cecropia species. J Ethnopharmacol 130:93–97 · DOI
- Barocelli E, Chiavarini M, Ballabeni V, Barlocco D, Vianello P, Dal Piaz V, Impicciatore M (1997) Study of the antisecretory and antiulcer mechanisms of a new indenopirydazinone derivative in rats. Pharmacol Res 35:487–492 · DOI
- Baron JH (1977) Effect of carbenoxolone sodium on human gastric acid secretion. Gut 18:21–722
- Beserra AM, Calegari PI, Souza MD, dos Santos RA, Lima JC, Silva RM, Balogun SO, Martins DT (2011) Gastroprotective and ulcer healing mechanisms of ellagic acid in experimental rats. J Agric Food Chem 13:6957–6965 · DOI
- Beutler E (1975) Red cell metabolism: a manual of biochemical methods, 2nd edn. Grune & Stratton, New York, pp 89–90
- Bonita JS, Mandarano M, Shuta D, Vinson J (2007) Coffee and cardiovascular disease: in vitro, cellular, animal, and human studies. Pharmacol Res 55:187–198 · DOI
- Bradley PP, Priebat DA, Christensen RD, Rothstein G (1982) Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Investig Dermatol 78:206–209 · DOI
- Brzozowski T, Konturek PC, Sliwowski Z, Kwiecie S, Drozdowicz D, Pawlik M, Mach K, Konturek SJ, Pawlik WW (2006) Interaction of nonsteroidal anti-inflammatory drugs (NSAID) with Helicobacter pylori in the stomach of humans and experimental animals. J Physiol Pharmacol 57:67–79
- Chen ZY, Peng C, Jiao R, Wong YM, Yang N, Huang Y (2009) Anti-hypertensive nutraceuticals and functional foods. J Agric Food Chem 57:4485–4499 · DOI
- De Maria CAB, Trugo LC, De Mariz e Miranda LS (1999) The content of individual caffeoylquinic acids in edible vegetables. J Food Compos Anal 12:289–292 · DOI
- De Oliveira RB, de Paula DA, Rocha BA, Franco JJ, Gobbo-Neto L, Uyemura SA, dos Santos WF, Da Costa FB (2011) Renal toxicity caused by oral use of medicinal plants: the yacon example. J Ethnopharmacol 133:434–441 · DOI
- De Souza Almeida ES, Filho VC, Niero R, Clasen BK, Balogun SO, de Oliveira Martins DT (2011) Pharmacological mechanisms underlying the anti-ulcer activity of methanol extract and canthin-6-one of Simaba ferruginea A. St-Hil. in animal models. J Ethnopharmacol 134:630–636 · DOI
- Dos Santos MD, Almeida MC, Lopes NP, de Souza GE (2006) Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid. Biol Pharm Bull 29:2236–2240 · DOI · Paper page
- Dragstedt LR, Woodward ER, Linares CA, Delarosa C (1964) The pathogenesis of gastric ulcer. Ann Surg 160:497–511 · DOI
- Eklund A (1975) Effect of chlorogenic acid in a casein diet for rats. Nutritional and pathological observations. Nutr Metab 18:258–264 · DOI
- Green CE, Pearson DN, Christensen NB, Simon SI (2003) Topographic requirements and dynamics of signaling via l-selectin on neutrophils. Am J Physiol Cell Physiol 284:C705–C717 · DOI
- Green CE, Pearson DN, Camphausen RT, Staunton DE, Simon SI (2004) Shear-dependent capping of l-selectin and P-selectin glycoprotein ligand 1 by E-selectin signals activation of high-avidity beta2-integrin on neutrophils. J Immunol 172:7780–7790 · DOI
- Guslandi M (1987) Effect of ethanol on the gastric mucosa. Dig Dis 5:21–32 · DOI
- Hebeda CB, Bolonheis SM, Nakasato A, Belinati K, Souza PD, Gouvea DR, Lopes NP, Farsky SH (2011) Effects of chlorogenic acid on neutrophil locomotion functions in response to inflammatory stimulus. J Ethnopharmacol 135:261–269 · DOI
- Hoelzl C, Knasmüller S, Wagner KH, Elbling L, Huber W, Kager N, Ferk F, Ehrlich V, Nersesyan A, Neubauer O, Desmarchelier A, Marin-Kuan M, Delatour T, Verguet C, Bezençon C, Besson A, Grathwohl D, Simic T, Kundi M, Schilter B, Cavin C (2010) Instant coffee with high chlorogenic acid levels protects humans against oxidative damage of macromolecules. Mol Nutr Food Res 54:1722–1733 · DOI
- Hwang YP, Yun HJ, Chun HK, Chung YC, Kim HK, Jeong MH, Yoon TR, Jeong HG (2009) Protective mechanisms of 3-caffeoyl, 4-dihydrocaffeoyl quinic acid from Salicornia herbacea against tert-butyl hydroperoxide-induced oxidative damage. Chem Biol Interact 181:366–376 · DOI · Paper page
- Ishida K, Kojima R, Tsuboi M, Tsuda Y, Ito M (2010) Effects of artichoke leaf extract on acute gastric mucosal injury in rats. Biol Pharm Bull 33:223–229 · DOI
- Kim YS, Kim NH, Lee YM, Kim JS (2011) Preventive effect of chlorogenic acid on lens opacity and cytotoxicity in human lens epithelial cells. Biol Pharm Bull 34:925–928 · DOI
- Kirchner T, Aparicio B, Argentieri DC, Lau CY, Ritchie DM (1997) Effects of tepoxalin, a dual inhibitor of cyclooxygenase/5-lipoxygenase, on events associated with NSAID-induced gastrointestinal inflammation. Prostaglandins Leukot Essent Fat Acids 56:417–423 · DOI
- Kitagawa S, Yoshii K, Morita SY, Teraoka R (2011) Efficient topical delivery of chlorogenic acid by an oil-in-water microemulsion to protect skin against UV-induced damage. Chem Pharm Bull (Tokyo) 59:793–796 · DOI
- Klein LC Jr, Gandolfi RB, Santin JR, Lemos M, Cechinel Filho V, de Andrade SF (2010) Antiulcerogenic activity of extract, fractions, and some compounds obtained from Polygala cyparissias St. Hillaire & Moquin (Polygalaceae). Naunyn Schmiedeberg’s Arch Pharmacol 381:121–126 · DOI
- Krakauer T (2002) The polyphenol chlorogenic acid inhibits staphylococcal exotoxin-induced inflammatory cytokines and chemokines. Immunopharmacol Immunotoxicol 24:113–119 · DOI
- Kujbida P, Hatanaka E, Campa A, Curi R, Farsky SHP, Pinto E (2008) Analysis of chemokines and reactive oxygen species formation by rat and human neutrophils induced by microcystin-LA, -YR and -LR. Toxicon 51:1274–1280 · DOI
- Lakshmi V, Singh N, Shrivastva S, Mishra SK, Dharmani P, Mishra V, Palit G (2010) Gedunin and photogedunin of Xylocarpus granatum show significant anti-secretory effects and protect the gastric mucosa of peptic ulcer in rats. Phytomedicine 17:569–574 · DOI
- Lemos M, Santin JR, Júnior LC, Niero R, Andrade SF (2011) Gastroprotective activity of hydroalcoholic extract obtained from the leaves of Brassica oleracea var. acephala DC in different animal models. J Ethnopharmacol 138:503–507 · DOI
- Lockrey G, Lim L (2011) Peptic ulcer disease in older people. J Pharm Pract Res 41:58–61 · DOI
- Malfertheiner P, Chan FKL, McColl KEL (2009) Peptic ulcer disease. Lancet 374:1449–1461 · DOI · Paper page
- Marrassini C, Acevedo C, Miño J, Ferraro G, Gorzalczany S (2010) Evaluation of antinociceptive, anti-inflammatory activities and phytochemical analysis of aerial parts of Urtica urens L. Phytother Res 24:1807–1812 · DOI
- McCord JM, Fridovich I (1969) Superoxide dismutase. An enzyme function for erythrhrocuprein (hemocuprein). J Biol Chem 244:6049–6055 · DOI · Paper page
- Medeiros JV, Gadelha GG, Lima SJ, Garcia JA, Soares PM, Santos AA, Brito GA, Ribeiro RA, Souza MH (2008) Role of the NO/cGMP/K(ATP) pathway in the protective effects of sildenafil against ethanol-induced gastric damage in rats. Br J Pharmacol 153:721–727 · DOI
- Mizui T, Doteuchi M (1983) Effect of polyamines on acidified ethanol-induced gastric lesion in rats. Jpn J Pharmacol 33:939–945 · DOI
- Naik Y, Jayaram S, Nayaka Harish MA, Lakshman, Dharmesh SM (2007) Gastroprotective effect of swallow root (Decalepis hamiltonii) extract: possible involvement of H+-K+-ATPase inhibition and antioxidative mechanism. J Ethnopharmacol 112:173–179 · DOI
- Nanjundaiah SM, Annaiah HN, M Dharmesh S (2009) Gastroprotective effect of ginger rhizome (Zingiber officinale) extract: role of gallic acid and cinnamic acid in H+, K+-ATPase/H. pylori inhibition and anti-oxidative mechanism. Evid Based Complement Alternat Med Jul 1 · DOI
- Nardini M, D'Aquino M, Tomassi G, Gentili V, Di Felice M, Scaccini C (1995) Inhibition of human low-density lipoprotein oxidation by caffeic acid and other hydroxycinnamic acid derivatives. Free Radic Biol Med 19:541–552 · DOI · Paper page
- Ohkawa H, Ohishi N, Yagi K (1979) Assay of lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351–358 · DOI · Paper page
- Olmos A, Giner RM, Recio MC, Rios JL, Cerdá-Nicolás JM, Máñez S (2007) Effects of plant alkylphenols on cytokine production, tyrosine nitration and inflammatory damage in the efferent phase of contact hypersensitivity. Br J Pharmacol 152:366–373 · DOI
- Peters-Golden M, Canetti C, Mancuso P, Coffey MJ (2004) Leukotrienes: underappreciated mediators of innate immune responses. J Immunol 174:589–594 · DOI
- Puangpraphant S, Berhow MA, Vermillion K, Potts G, Gonzalez de Mejia E (2011) Dicaffeoylquinic acids in yerba mate (Ilex paraguariensis St. Hilaire) inhibit NF-κB nucleus translocation in macrophages and induce apoptosis by activating caspases-8 and -3 in human colon cancer cells. Mol Nutr Food Res 55:1509–1522 · DOI
- Rainsford KD (1978) Gastric ulcerogenicity of non-steroidal anti-inflammatory drugs in mice with mucosa sensitized by cholinomimetic treatment. J Pharm Pharmacol 39:669–672 · DOI
- Ribeiro AL, Shimada AL, Hebeda CB, de Oliveira TF, de Melo Loureiro AP, Filho Wdos R, Santos AM, de Lima WT, Farsky SH (2011) In vivo hydroquinone exposure alters circulating neutrophil activities and impairs LPS-induced lung inflammation in mice. Toxicology 288:1–7 · DOI
- Santin JR, Lemos M, Klein-Júnior LC, Machado ID, Costa P, de Oliveira AP, Tilia C, de Souza JP, de Sousa JP, Bastos JK, de Andrade SF (2011) Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal models. Naunyn Schmiedeberg’s Arch Pharmacol 383:149–158 · DOI
- Shan J, Fu J, Zhao Z, Kong X, Huang H, Luo L, Yin Z (2009) Chlorogenic acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 cells through suppressing NF-kappaB and JNK/AP-1 activation. Int Immunopharmacol 9:1042–1048 · DOI
- Shay H, Komarov SA, Fels SS, Meranze D, Gruenstein M, Siplet H (1945) A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology 5:43–61
- Sheen E, Triadafilopoulos G (2011) Adverse effects of long-term proton pump inhibitor therapy. Dig Dis Sci 56:931–950 · DOI · Paper page
- Sies H, Koch OR, Martino E, Boveris A (1979) Increased biliary glutathione disulfide release in chronically ethanol-treated rats. FEBS Lett 103:287–290 · DOI · Paper page
- Stalmach A, Steiling H, Williamson G, Crozier A (2010) Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. Arch Biochem Biophys 501:98–105 · DOI · Paper page
- Szabo S (1987) Mechanisms of mucosal injury in the stomach and duodenum: time-sequence analysis of morphologic, functional, biochemical and histochemical studies. Scand J Gastroenterol Suppl 127:21–28 · DOI
- Tietze F (1969) Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 27:502–522 · DOI
- Wallace JL (2008) Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn’t the stomach digest itself? Physiol Rev 88:1547–1565 · DOI · Paper page
- Xu Y, Chen J, Yu X, Tao W, Jiang F, Yin Z, Liu C (2010) Protective effects of chlorogenic acid on acute hepatotoxicity induced by lipopolysaccharide in mice. Inflamm Res 59:871–877 · DOI
- Yonathan M, Asres K, Assefa A, Bucar F (2006) In vivo anti-inflammatory and anti-nociceptive activities of Cheilanthes farinosa. J Ethnopharmacol 108:462–470 · DOI
- Yun N, Kang JW, Lee SM (2011) Protective effects of chlorogenic acid against ischemia/reperfusion injury in rat liver: molecular evidence of its antioxidant and anti-inflammatory properties. J Nutr Biochem 23(10):1249–1255 · DOI
- Zhang X, Huang H, Yang T, Ye Y, Shan J, Yin Z, Luo L (2010) Chlorogenic acid protects mice against lipopolysaccharide-induced acute lung injury. Injury 41:746–752 · DOI
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Metadata
- Authors
- Shimoyama, A. T., Santin, J. R., Machado, I. D., de Oliveira e Silva, A. M., de Melo, I. L. P., Mancini-Filho, J., & Farsky, S. H. P.
- Venue
- Naunyn-Schmiedeberg's Archives of Pharmacology
- Published
- 2012-11-06
- Volume
- 386
- Issue
- 1
- Pages
- 5-14
- ISSN
- 0028-1298
- 1432-1912
- Cited by
- 90
- References
- 4
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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