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Cited by 221Neurotransmitter Receptor Influence on BehaviorNeuroendocrine regulation and behaviorTryptophan and brain disorders

Serotonergic intervention affects both social dominance and affiliative behaviour

Tse, Wai, Bond, Alyson·2002·Psychopharmacology
DOI 10.1007/s00213-002-1049-7
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Abstract

Rationale Deficiencies in serotonin function have been associated with irritability and aggression but enhancing serotonin has also been shown to promote social status and affiliative behaviour in non-human primates and more recently in humans.Objectives To investigate the effects of citalopram, a selective serotonin reuptake inhibitor (SSRI), on social behaviour with a flatmate and a stranger.Methods Ten pairs of healthy volunteers took part in a randomized double-blind crossover study of 2 weeks treatment with citalopram (20 mg/day) and placebo with a 2-week washout period. In each pair, one person (subject) took the tablets and the other (flatmate) received no treatment. On the last day of each treatment period, the subjects socially interacted with a confederate behaving as a responsive person in a stranger-dyadic social interaction paradigm. After the interaction, subjects played the Mixed-motive game, which measures cooperative behaviour and communication, with the confederate. The flatmates evaluated the social behaviour of the subjects before and at the end of the treatment periods.Results On citalopram, the subjects were rated as significantly less submissive by their flatmates and they showed a dominant pattern of eye contact in the stranger-dyadic social interaction paradigm. They also reduced the number of points they awarded themselves and sent more cooperative messages during the game.Conclusions These results indicate that administration of an SSRI can modify social status in different interactions and increase affiliative behaviour. They implicate a role for serotonin in modulating social aspects of behaviour.

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  • Selective 5-HT manipulations alter identification and neural processing of emotional faces, as well as affiliative behavior.

    “Selective 5-HT manipulations alter identification (Del-Ben et al., 2008) and neural processing of emotional faces (Harmer et al. 2006), as well as affiliative behavior (Tse and Bond, 2002).”

    From Effects of MDMA on sociability and neural response to social threat and social reward (2009) · cites this paper as Tse and Bond, 2002

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Authors
Tse, W., & Bond, A.
Affiliations
King's College London (GB)
ORCID
Tse, Wai
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2002-05-01
Volume
161
Issue
3
Pages
324-330
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/s00213-002-1049-7
OpenAlex
W2165830453
Cited by
221
References
32
Citations by year
2025: 2 · 2024: 7 · 2023: 23 · 2022: 8 · 2021: 16 · 2020: 13 · 2019: 12 · 2018: 5 · 2017: 7 · 2016: 10 · 2015: 12 · 2014: 17 · 2013: 12 · 2012: 9
FWCI
1.86
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
serotonin, citalopram, selective serotonin reuptake inhibitors, social dominance, affiliative behavior, social status, cooperative behavior, mixed-motive games, dyadic social interaction, eye contact, aggression, irritability, human social behavior
MeSH terms
Adult, Analysis of Variance, Behavior, Double-Blind Method, Female, Humans, Male, Personality, Surveys and Questionnaires, Social Behavior, Speech, Citalopram, Selective Serotonin Reuptake Inhibitors, Cross-Over Studies

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