Cited by 473Stress Responses and CortisolMaternal Mental Health During Pregnancy and PostpartumBirth, Development, and Health

Prenatal Stress and Risk for Psychopathology: Specific Effects or Induction of General Susceptibility?

Huizink, Anja C., Mulder, Edu J. H., Buitelaar, Jan K.·2004·Psychological Bulletin

Abstract

This review focuses on prenatal stress as a risk factor for psychopathology. Evidence from animal studies is summarized, and the relevance of prenatal stress models in animals for human studies is discussed. In the offspring of prenatally stressed animals, overactivity and impaired negative feedback regulation of the hypothalamic-pituitary-adrenal axis are consistent findings and may reflect a pathophysiological mechanism involved in the development of psychopathology. Reduced activity of the opioid GABA/benzodiazepine, serotonin, and dopamine systems and increased activity of the sympathico-adrenal system have been found as well. These alterations have been linked to a diverse spectrum of psychopathology. Therefore, the evidence supports the view that exposure to prenatal stress may result in a general susceptibility to psychopathology, rather than exerting a direct effect on a specific form of psychopathology.

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Crossref · 10.1037/0033-2909.130.1.115

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Authors
Huizink, A. C., Mulder, E. J. H., & Buitelaar, J. K.
Affiliations
University Medical Center Utrecht (NL)
Venue
Psychological Bulletin
Published
2004
Volume
130
Issue
1
Pages
115-142
ISSN
  • 0033-2909 (ISSN-L)
  • 1939-1455
OpenAlex
W2164438435
Cited by
473
References
263
Citations by year
2026: 1 · 2025: 5 · 2024: 5 · 2023: 10 · 2022: 12 · 2021: 11 · 2020: 18 · 2019: 17 · 2018: 22 · 2017: 24 · 2016: 28 · 2015: 34 · 2014: 33 · 2013: 22 · 2012: 26
FWCI
2.27
Type
journal article
Language
en
Open access
closed
Locations
  • Psychological Bulletin (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
  • VU Research Portal (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
prenatal stress, psychopathology, risk factors, hypothalamic-pituitary-adrenal axis, negative feedback regulation, opioid system, serotonin, dopamine, sympathoadrenal system, animal models of stress
MeSH terms
Animals, Arousal, Mental Disorders, Female, Humans, Hypothalamo-Hypophyseal System, Infant, Newborn, Pituitary-Adrenal System, Pregnancy, Prenatal Exposure Delayed Effects, Psychopathology, Risk, Stress, Psychological, Receptors, Neurotransmitter

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