The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Effects of caffeine on performance and mood depend on the level of caffeine abstinence
Open accessAbstract
Rationale Most studies of the effects of caffeine on performance have used regular caffeine consumers who are deprived at test. Thus the reported effects of caffeine could be explained through reversal of caffeine withdrawal.Objectives To test how preloading deprived caffeine consumers with 0, 1 or 2 mg/kg caffeine altered the subsequent ability of caffeine to modify mood and performance.Methods Thirty moderate caffeine consumers were given a drink containing 0, 1 or 2 mg/kg caffeine at breakfast followed 60 min later by a second drink containing either 0 or 1 mg/kg caffeine. Performance on a measure of sustained attention and mood were measured before and after each drink.Results Administration of both 1 and 2 mg/kg caffeine at breakfast decreased reaction time and 1 mg/kg caffeine also increased performance accuracy on the sustained attention (RVIP) task relative to placebo. Both breakfast doses of caffeine also improved rated mental alertness. Similarly, 1 mg/kg caffeine administered 60 min after breakfast decreased reaction time and increased rated mental alertness in the group who had not been given caffeine at breakfast. However, this second dose of caffeine had no effect on subsequent performance or mood in the two groups who had received caffeine at breakfast.Conclusions Caffeine reliably improved performance on a sustained attention task, and increased rated mental alertness, in moderate caffeine consumers who were tested when caffeine-deprived. However, caffeine had no such effects when consumers were no longer caffeine deprived. These data are consistent with the view that reversal of caffeine withdrawal is a major component of the effects of caffeine on mood and performance.
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“The impact of caffeine appears to be greater under conditions that would negatively impact performance, such as acute caffeine withdrawal (74–76) or sleep deprivation (71, 77).”
From The Safety of Ingested Caffeine: A Comprehensive Review (2017) · cites this paper as [75]
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Cites
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The effects of low doses of caffeine on human performance and mood
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Self-citationBreakfast, blood glucose, and cognition
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Acute and chronic effects of caffeine on performance, mood, headache, and sleep
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Self-citationEffects of caffeine on cognition and mood without caffeine abstinence
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Juliano, L. M., & Griffiths, R. R. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2000-x · Cited by 613
The Safety of Ingested Caffeine: A Comprehensive Review
Temple, J. L., Bernard, C., Lipshultz, S. E., Czachor, J. D., Westphal, J. A., & Mestre, M. A. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00080 · Cited by 557
Effects of caffeine on performance and mood: withdrawal reversal is the most plausible explanation
James, J. E., & Rogers, P. J. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0084-6 · Cited by 231
Self-citationCaffeine, Mental Health, and Psychiatric Disorders
Lara, D. R. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1378 · Cited by 245
Caffeine as an Attention Enhancer: Reviewing Existing Assumptions
Einöther, S. J. L., & Giesbrecht, T. (2013) · Psychopharmacology · doi:10.1007/s00213-012-2917-4 · Cited by 215
Metadata
- Authors
- Yeomans, M., Ripley, T., Davies, L., Rusted, J., & Rogers, P.
- Affiliations
- University of Sussex (GB)
- University of Bristol (GB)
- Corresponding author
- Yeomans, Martin
- Venue
- Psychopharmacology
- Published
- 2002-11-01
- Volume
- 164
- Issue
- 3
- Pages
- 241-249
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2151484680
- Cited by
- 130
- References
- 47
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 6 · 2015: 3 · 2014: 7 · 2013: 6 · 2012: 11
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Explore Bristol Research (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
- Keywords
- caffeine, caffeine withdrawal, caffeine abstinence, sustained attention, reaction time, mental alertness, mood
- MeSH terms
- Adult, Affect, Central Nervous System Stimulants, Attention, Caffeine, Coffee, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Female, Humans, Male, Placebos, Psychomotor Performance, Surveys and Questionnaires, Reaction Time, Time Factors
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