The DOI matches its Crossref record; 113 of the 114 references it cites were found in a registry or an index.
Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRI
Abstract
Rationale and objective In animal and human studies, the neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) has been implicated in mediating impulsiveness and aggression. To test the hypothesis that 5-HT modulates neuro-cognitive brain activation during inhibitory control, we examined the effect of acute tryptophan depletion (ATD), a dietary challenge, which has been shown to decrease 5-HT synthesis in the brain, on functional brain activation during a go/no-go task.Methods Nine healthy, right-handed volunteers performed a rapid, event-related go/no-go task in two functional magnetic resonance imaging (fMRI) scanning sessions, 5 h after either a tryptophan-free or a balanced amino acid drink in a double-blind, sham depletion-controlled, counterbalanced, crossover design. The task required subjects to selectively execute or inhibit a motor response. Tryptophan depletion significantly lowered total plasma tryptophan concentration by 80%, but did not significantly alter inhibitory performance or mood ratings.Results ATD significantly reduced right orbito-inferior prefrontal activation during the no-go condition, and increased activation in superior and medial temporal cortices.Conclusions These findings provide neuro-functional evidence of a serotonergic modulation of right inferior prefrontal during inhibitory motor control. The increased engagement of temporal brain regions may reflect compensatory mechanisms.
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“Serotonin depletion has been shown to decrease activation of the IFG during inhibition and decreases activation of the medial prefrontal lobe during error monitoring in the Go/No Go task (Rubia et al., 2005a; Evers et al., 2006).”
From Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders (2014) · cites this paper as Rubia et al., 2005a
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“Many of the studies reporting RIFC involvement during Go/No-go tasks used a direct contrast of No-go and Go trials”
From Meta-analysis of Go/No-go tasks demonstrating that fMRI activation associated with response inhibition is task-dependent (2008) · cites this paper as Rubia et al., 2005
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Self-citation
Metadata
- Authors
- Rubia, K., Lee, F., Cleare, A. J., Tunstall, N., Fu, C. H. Y., Brammer, M., & McGuire, P.
- Affiliations
- King's College London (GB)
- Corresponding author
- Rubia, Katya
- Venue
- Psychopharmacology
- Published
- 2005-01-26
- Volume
- 179
- Issue
- 4
- Pages
- 791-803
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2137257511
- Cited by
- 171
- References
- 114
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 6 · 2016: 2 · 2015: 13 · 2014: 15 · 2013: 10 · 2012: 12
- FWCI
- 8.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- tryptophan depletion, serotonin, inhibitory control, response inhibition, go/no-go task, orbitofrontal cortex, temporal cortex, impulsivity, aggression, serotonergic modulation, compensatory brain activation
- MeSH terms
- Adult, Affect, Aggression, Amino Acids, Choice Behavior, Double-Blind Method, Female, Humans, Image Processing, Computer-Assisted, Impulsive Behavior, Functional Laterality, Magnetic Resonance Imaging, Male, Psychomotor Performance, Reaction Time, Tryptophan, Prefrontal Cortex, Cross-Over Studies
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