Cited by 171Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorTryptophan and brain disorders

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Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRI

Rubia, Katya, Lee, Francis, Cleare, Anthony J., Tunstall, Nigel, Fu, Cynthia H. Y., Brammer, Michael, McGuire, Phillip·2005·Psychopharmacology

DOI 10.1007/s00213-004-2116-z

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Abstract

Rationale and objective In animal and human studies, the neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) has been implicated in mediating impulsiveness and aggression. To test the hypothesis that 5-HT modulates neuro-cognitive brain activation during inhibitory control, we examined the effect of acute tryptophan depletion (ATD), a dietary challenge, which has been shown to decrease 5-HT synthesis in the brain, on functional brain activation during a go/no-go task.Methods Nine healthy, right-handed volunteers performed a rapid, event-related go/no-go task in two functional magnetic resonance imaging (fMRI) scanning sessions, 5 h after either a tryptophan-free or a balanced amino acid drink in a double-blind, sham depletion-controlled, counterbalanced, crossover design. The task required subjects to selectively execute or inhibit a motor response. Tryptophan depletion significantly lowered total plasma tryptophan concentration by 80%, but did not significantly alter inhibitory performance or mood ratings.Results ATD significantly reduced right orbito-inferior prefrontal activation during the no-go condition, and increased activation in superior and medial temporal cortices.Conclusions These findings provide neuro-functional evidence of a serotonergic modulation of right inferior prefrontal during inhibitory motor control. The increased engagement of temporal brain regions may reflect compensatory mechanisms.

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Authors: Rubia, K., Lee, F., Cleare, A. J., Tunstall, N., Fu, C. H. Y., Brammer, M., & McGuire, P.
Affiliations: King's College London (GB)
Corresponding author: Rubia, Katya
ORCID: Rubia, Katya
Cleare, Anthony J.
Fu, Cynthia H. Y.
Brammer, Michael
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2005-01-26
Volume: 179
Issue: 4
Pages: 791-803
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-004-2116-z
OpenAlex: W2137257511
Cited by: 171
References: 114
Citations by year: 2024: 1 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 6 · 2016: 2 · 2015: 13 · 2014: 15 · 2013: 10 · 2012: 12
FWCI: 8.57
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: tryptophan depletion, serotonin, inhibitory control, response inhibition, go/no-go task, orbitofrontal cortex, temporal cortex, impulsivity, aggression, serotonergic modulation, compensatory brain activation
MeSH terms: Adult, Affect, Aggression, Amino Acids, Choice Behavior, Double-Blind Method, Female, Humans, Image Processing, Computer-Assisted, Impulsive Behavior, Functional Laterality, Magnetic Resonance Imaging, Male, Psychomotor Performance, Reaction Time, Tryptophan, Prefrontal Cortex, Cross-Over Studies

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Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRI

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