The effect of tryptophan depletion on brain activation measured by functional magnetic resonance imaging during the Stroop test in healthy subjects
Open accessAbstract
We investigated the role of serotonin in cognitive activation of the frontal cortex. The serotonergic system was affected by the administration of an amino acids mixture without tryptophan (tryptophan depletion). In a placebo-controlled double-blind cross-over study with 20 healthy volunteers, we tested the hypothesis that a tryptophan (serotonin) decrease affects the activation of prefrontal cortex by the Stroop test. Cognitive brain activation was evaluated by functional magnetic resonance imaging (fMRI). Tryptophan depletion decreased the plasma tryptophan level up to 90 % for five hours after the tryptophan-free drink had been consumed when compared with the same mixture with tryptophan (p?0.0001). Tryptophan depletion did not affect the Stroop test performance. We compared fMRI activation in both conditions (tryptophan depletion and placebo) with plasma tryptophan levels as the covariates. The tryptophan depletion increased the activation (fMRI signal) in the bilateral mediofrontal cortex, anterior cingulate and left dorsolateral prefrontal cortex. The present findings allow the postulate that serotonergic medial forebrain and cingulum bundle pathways play a role in the activity of cortical structures involved in Stroop test processing.
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Increased activation of the DLPFC and ACC is observed during performance of a Stroop task after serotonin depletion.
“Increased activation of the DLPFC and ACC was observed during performance of a Stroop task after serotonin depletion (Horacek et al., 2005).”
From Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders (2014) · cites this paper as Horacek et al., 2005
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WITHDRAWN: Is acute tryptophan depletion a valid method to assess central serotonergic function?
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- Authors
- Horáček, J., Závěšická, L., Tintěra, J., Dockery, C., Platilová, V, Kopeček, M., Španiel, F., Bubeníková, V, & Höschl, C.
- Affiliations
- Charles University (CZ)
- National Institute of Mental Health (CZ)
- Institute of Clinical and Experimental Medicine (CZ)
- Venue
- Physiological Research
- Published
- 2005
- Volume
- 54
- Issue
- 2
- Pages
- 235-244
- ISSN
- 0862-8408 (ISSN-L)
- 1802-9973
- OpenAlex
- W2184103870
- Cited by
- 34
- References
- 57
- Citations by year
- 2020: 2 · 2019: 1 · 2015: 1 · 2014: 3 · 2013: 2
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Physiological Research (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Ministerstvo Školství, Mládeže a Tělovýchovy (LN00B122, 1M0002375201)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- tryptophan depletion, serotonin, Stroop task, prefrontal cortex activation, anterior cingulate cortex, dorsolateral prefrontal cortex, plasma tryptophan, serotonergic pathways, cognitive activation, executive function
- MeSH terms
- Adult, Brain, Double-Blind Method, Female, Humans, Magnetic Resonance Imaging, Male, Psychomotor Performance, Tryptophan, Cross-Over Studies, Statistics, Nonparametric
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