Impairment of social and moral behavior related to early damage in human prefrontal cortex
Abstract
The long-term consequences of early prefrontal cortex lesions occurring before 16 months were investigated in two adults. As is the case when such damage occurs in adulthood, the two early-onset patients had severely impaired social behavior despite normal basic cognitive abilities, and showed insensitivity to future consequences of decisions, defective autonomic responses to punishment contingencies and failure to respond to behavioral interventions. Unlike adult-onset patients, however, the two patients had defective social and moral reasoning, suggesting that the acquisition of complex social conventions and moral rules had been impaired. Thus early-onset prefrontal damage resulted in a syndrome resembling psychopathy.
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Damage to MPFC regions causes disturbances in moral behavior and moral reasoning.
“Convergent evidence from neuropsy- chological studies suggests that damage to these regions causes disturbances in moral behavior and moral reasoning (33–35).”
From The neural basis of the interaction between theory of mind and moral judgment (2007) · cites this paper as [33]
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Insensitivity to future consequences following damage to human prefrontal cortex
Bechara, A., Damasio, A. R., Damasio, H., & Anderson, S. W. (1994) · Cognition · doi:10.1016/0010-0277(94)90018-3 · Cited by 6,128 · see citing works
Self-citationDeciding advantageously before knowing the advantageous strategy
Bechara, A., Damasio, H., Tranel, D., & Damasio, A. R. (1997) · Science · doi:10.1126/science.275.5304.1293 · Cited by 3,547 · see citing works
Self-citationNeuropsychological assessment.
Lisa Cipolotti, A., & Warrington, E. K. (1995) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.58.6.655 · Cited by 3,234 · see citing works
The somatic marker hypothesis and the possible functions of the prefrontal cortex
Damasio, A. R. (1996) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1996.0125 · Cited by 2,847 · see citing works
Self-citationStuss, D. T., & Benson, D. F. (1986) · Raven Press eBooks · Cited by 2,102 · see citing works
DEFICITS IN STRATEGY APPLICATION FOLLOWING FRONTAL LOBE DAMAGE IN MAN
SHALLICE, T., & BURGESS, P. W. (1991) · Brain · doi:10.1093/brain/114.2.727 · Cited by 2,017 · see citing works
Frontal Lobe Function and Dysfunction
(1991) · doi:10.1093/oso/9780195062847.001.0001 · Cited by 1,238 · see citing works
Bechara, A., Tranel, D., Damasio, H., & Damasio, A. R. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.2.215 · Cited by 1,179 · see citing works
Self-citationThe measurement of moral judgment
Colby, A. (1987) · Cited by 703 · see citing works
Somatic Markers and the Guidance of Behavior: Theory and Preliminary Testing
Damásio, A. R., Tranel, D., & Damásio, H. (1991) · doi:10.1093/oso/9780195062847.003.0011 · Cited by 671 · see citing works
Self-citationClinical neuropsychology: 1960-1990
Benton, A. L. (1992) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/01688639208407616 · Cited by 640 · see citing works
Saver, J. L., & Damásio, A. R. (1991) · Neuropsychologia · doi:10.1016/0028-3932(91)90037-9 · Cited by 521 · see citing works
The Measurement of Moral Judgment
Thackrey, M. (1988) · JAMA · doi:10.1001/jama.1988.03410130176050 · Cited by 420 · see citing works
Moral reasoning and the child with psychopathic tendencies
Blair, J. (1997) · Personality and Individual Differences · doi:10.1016/s0191-8869(96)00249-8 · Cited by 328 · see citing works
Structure and Functions of the Human Prefrontal Cortex
Grafman, J. H., Holyoak, K. J., & Boller, F. (1996) · Medical Entomology and Zoology · Cited by 308 · see citing works
PSYCHOPHYSIOLOGY OF ANGER AND VIOLENT BEHAVIOR
Scarpa, A., & Raine, A. (1997) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70318-x · Cited by 284 · see citing works
Brainvox: An Interactive, Multimodal Visualization and Analysis System for Neuroanatomical Imaging
Frank, R. J., Damasio, H., & Grabowski, T. J. (1997) · NeuroImage · doi:10.1006/nimg.1996.0250 · Cited by 273 · see citing works
Self-citationThree-dimensional In Vivo Mapping of Brain Lesions in Humans
Damasio, H., & Frank, R. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530260037016 · Cited by 240 · see citing works
Self-citationTHE COMPORTMENTAL LEARNING DISABILITIES OF EARLY FRONTAL LOBE DAMAGE
Price, B. H., Daffner, K. R., Stowe, R., & Mesulam, M. M. (1990) · Brain · doi:10.1093/brain/113.5.1383 · Cited by 238 · see citing works
Report of case of bilateral frontal lobe defect.
Ackerly, S., & Benton, A. L. (1948) · PubMed · Cited by 166 · see citing works
Prefrontal glucose deficits in murderers lacking psychosocial deprivation.
Raine, A., Phil, D. L. E., Stoddard, J., Bihrle, S., & Buchsbaum, M. S. (1998) · PubMed · Cited by 152 · see citing works
Single Photon Emission Computerised Tomography in Chronic Alcoholism
Kuruoğlu, A., Arıkan, Z., Uçmak, G., Karataş, M., Araç, M., & Işık, E. (1996) · The British Journal of Psychiatry · doi:10.1192/bjp.169.3.348 · Cited by 104 · see citing works
Moral judgment in sociopathic and normal children.
Campagna, A. F., & Harter, S. (1975) · Journal of Personality and Social Psychology · doi:10.1037/h0076318 · Cited by 83 · see citing works
Newman, J. D., & Bachevalier, J. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00212-6 · Cited by 34 · see citing works
WISC-III and KAIT results in adolescent delinquent males
Law, J. G., & Faison, L. (1996) · Journal of Clinical Psychology · doi:10.1002/(sici)1097-4679(199611)52:6 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The emotional dog and its rational tail: A social intuitionist approach to moral judgment.
Haidt, J. (2001) · Psychological Review · doi:10.1037/0033-295x.108.4.814 · Cited by 8,048 · see citing works
Empathy: its ultimate and proximate bases
Preston, S. D., & de Waal, F. B. M. (2002) · Behavioral and Brain Sciences · doi:10.1017/s0140525x02000018 · Cited by 4,126 · see citing works
Emotion, Decision Making and the Orbitofrontal Cortex
Bechara, A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.295 · Cited by 3,589 · see citing works
Self-citationFunctional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI
Phan, K. L., Wager, T., Taylor, S. F., & Liberzon, I. (2002) · NeuroImage · doi:10.1006/nimg.2002.1087 · Cited by 3,502 · see citing works
The functional architecture of human empathy
Decety, J., & Jackson, P. L. (2004) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582304267187 · Cited by 3,407 · see citing works
The amygdala: vigilance and emotion
Davis, M., & Whalen, P. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000812 · Cited by 2,882 · see citing works
Assessment and Development of Executive Function (EF) During Childhood
Anderson, P. (2002) · Child Neuropsychology · doi:10.1076/chin.8.2.71.8724 · Cited by 2,218 · see citing works
The human orbitofrontal cortex: linking reward to hedonic experience
Kringelbach, M. L. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1747 · Cited by 2,180 · see citing works
Abstract reward and punishment representations in the human orbitofrontal cortex
O'Doherty, J., Kringelbach, M. L., Rolls, E. T., Hornak, J., & Andrews, C. (2001) · Nature Neuroscience · doi:10.1038/82959 · Cited by 2,003 · see citing works
The somatic marker hypothesis: A neural theory of economic decision
Bechara, A., & Damasio, A. R. (2005) · Games and Economic Behavior · doi:10.1016/j.geb.2004.06.010 · Cited by 1,986 · see citing works
Self-citationKRINGELBACH, M. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.03.006 · Cited by 1,977 · see citing works
Emotion, cognition, and behavior
Dolan, R. J. (2002) · Science · doi:10.1126/science.1076358 · Cited by 1,979 · see citing works
How (and where) does moral judgment work?
Greene, J., & Haidt, J. (2002) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(02)02011-9 · Cited by 1,945 · see citing works
The social brain in adolescence
Blakemore, S.-J. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2353 · Cited by 1,896 · see citing works
Behavioral Ethics in Organizations: A Review
Treviño, L. K., Weaver, G. R., & Reynolds, S. J. (2006) · Journal of Management · doi:10.1177/0149206306294258 · Cited by 1,837 · see citing works
The Social Brain: Neural Basis of Social Knowledge
Adolphs, R. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.60.110707.163514 · Cited by 1,827 · see citing works
Cognitive neuroscience of human social behaviour
Adolphs, R. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1056 · Cited by 1,657 · see citing works
The neurobiology of social cognition
Adolphs, R. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00202-6 · Cited by 1,432 · see citing works
McLaughlin, K. A., Sheridan, M. A., & Lambert, H. K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.012 · Cited by 1,389 · see citing works
“he neural changes we argue to be a result of deprivation expoure – including age-specific reductions in cortical thickness, poor erformance on complex cognitive tasks, and inefficient neural ecruitment during such tasks – have also been linked to exteralizing disorders in numerous studies (Anderson et al., 1999; ursto…”
ResultBlair, R. J. R. (2005) · Consciousness and Cognition · doi:10.1016/j.concog.2005.06.004 · Cited by 1,365 · see citing works
Mapping brain maturation and cognitive development during adolescence
Paus, T. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.12.008 · Cited by 1,348 · see citing works
NELSON, E. E., LEIBENLUFT, E., McCLURE, E. B., & PINE, D. S. (2005) · Psychological Medicine · doi:10.1017/s0033291704003915 · Cited by 1,075 · see citing works
Shared representations between self and other: a social cognitive neuroscience view
Decety, J., & Sommerville, J. A. (2003) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2003.10.004 · Cited by 996 · see citing works
Neurobiology of Executive Functions: Catecholamine Influences on Prefrontal Cortical Functions
Arnsten, A. F. T., & Li, B.-M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.08.019 · Cited by 948 · see citing works
The neural basis of human moral cognition
Moll, J., Zahn, R., de Oliveira-Souza, R., Krueger, F., & Grafman, J. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1768 · Cited by 930 · see citing works
The somatic marker hypothesis: A critical evaluation
Dunn, B. D., Dalgleish, T., & Lawrence, A. D. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.07.001 · Cited by 894 · see citing works
Executive Function in Typical and Atypical Development
Zelazo, P. D., & Müller, U. (2010) · The Wiley‐Blackwell Handbook of Childhood Cognitive Development · doi:10.1002/9781444325485.ch22 · Cited by 784 · see citing works
The amygdala and ventromedial prefrontal cortex in morality and psychopathy
Blair, R. J. R. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.07.003 · Cited by 742 · see citing works
Moll, J., de Oliveira-Souza, R., Eslinger, P. J., Bramati, I. E., Mourão-Miranda, J., Andreiuolo, P. A., & Pessoa, L. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02730.2002 · Cited by 721 · see citing works
Hongwanishkul, D., Happaney, K. R., Lee, W. S. C., & Zelazo, P. D. (2005) · Developmental Neuropsychology · doi:10.1207/s15326942dn2802_4 · Cited by 654 · see citing works
Bzdok, D., Schilbach, L., Vogeley, K., Schneider, K., Laird, A. R., Langner, R., & Eickhoff, S. B. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0380-y · Cited by 653 · see citing works
The neural basis of the interaction between theory of mind and moral judgment
Young, L., Cushman, F., Hauser, M., & Saxe, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701408104 · Cited by 625 · see citing works
Thinking of the future and past: the roles of the frontal pole and the medial temporal lobes
Okuda, J., Fujii, T., Ohtake, H., Tsukiura, T., Tanji, K., Suzuki, K., Kawashima, R., Fukuda, H., Itoh, M., & Yamadori, A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00179-4 · Cited by 607 · see citing works
The Anterior Cingulate Gyrus and Social Cognition: Tracking the Motivation of Others
Apps, M. A. J., Rushworth, M. F. S., & Chang, S. W. C. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.018 · Cited by 559 · see citing works
An additional antecedent of empathic concern: Valuing the welfare of the person in need.
Batson, C. D., Eklund, J. H., Chermok, V. L., Hoyt, J. L., & Ortiz, B. G. (2007) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.93.1.65 · Cited by 587 · see citing works
The default-mode, ego-functions and free-energy: a neurobiological account of Freudian ideas
Carhart-Harris, R. L., & Friston, K. J. (2010) · Brain · doi:10.1093/brain/awq010 · Cited by 574 · see citing works
Brower, M. C. (2001) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.71.6.720 · Cited by 567 · see citing works
Seo, D., Patrick, C. J., & Kennealy, P. J. (2008) · Aggression and Violent Behavior · doi:10.1016/j.avb.2008.06.003 · Cited by 520 · see citing works
Structural anatomy of empathy in neurodegenerative disease
Rankin, K. P., Gorno-Tempini, M. L., Allison, S. C., Stanley, C. M., Glenn, S., Weiner, M. W., & Miller, B. L. (2006) · Brain · doi:10.1093/brain/awl254 · Cited by 504 · see citing works
The role of the hippocampus in flexible cognition and social behavior
Rubin, R. D., Watson, P. D., Duff, M. C., & Cohen, N. J. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00742 · Cited by 489 · see citing works
Functional Networks in Emotional Moral and Nonmoral Social Judgments
Moll, J., de Oliveira-Souza, R., Bramati, I. E., & Grafman, J. (2002) · NeuroImage · doi:10.1006/nimg.2002.1118 · Cited by 497 · see citing works
Decety, J., & Moriguchi, Y. (2007) · BioPsychoSocial Medicine · doi:10.1186/1751-0759-1-22 · Cited by 497 · see citing works
The contribution of emotion and cognition to moral sensitivity: A neurodevelopmental study
Decety, J., Michalska, K. J., & Kinzler, K. D. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr111 · Cited by 482 · see citing works
Age differences in affective decision making as indexed by performance on the Iowa gambling task
Cauffman, E., Shulman, E. P., Steinberg, L., Claus, E., Banich, M. T., Graham, S., & Woolard, J. (2010) · Developmental Psychology · doi:10.1037/a0016128 · Cited by 488 · see citing works
Stimulants: Therapeutic Actions in ADHD
Arnsten, A. F. T. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301164 · Cited by 473 · see citing works
Construct validity of the iowa gambling task
Buelow, M. T., & Suhr, J. A. (2009) · Neuropsychology Review · doi:10.1007/s11065-009-9083-4 · Cited by 464 · see citing works
Halperin, J. M., & Schulz, K. P. (2006) · Psychological Bulletin · doi:10.1037/0033-2909.132.4.560 · Cited by 446 · see citing works
The neuropsychology of ventral prefrontal cortex: Decision-making and reversal learning
Clark, L., Cools, R., & Robbins, T. W. (2004) · Brain and Cognition · doi:10.1016/s0278-2626(03)00284-7 · Cited by 439 · see citing works
Selective deficit in personal moral judgment following damage to ventromedial prefrontal cortex
Ciaramelli, E., Muccioli, M., Làdavas, E., & di Pellegrino, G. (2007) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsm001 · Cited by 436 · see citing works
An evaluation of dual-process theories of reasoning
Osman, M. (2004) · Psychonomic Bulletin & Review · doi:10.3758/bf03196730 · Cited by 444 · see citing works
Shamay-Tsoory, S. G., Harari, H., Aharon-Peretz, J., & Levkovitz, Y. (2010) · Cortex · doi:10.1016/j.cortex.2009.04.008 · Cited by 432 · see citing works
Emotion, motivation, and the brain: Reflex foundations in animal and human research
Lang, P. J., & Davis, M. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)56001-7 · Cited by 410 · see citing works
The orbitofrontal-amygdala circuit and self-regulation of social-emotional behavior in autism
Bachevalier, J., & Loveland, K. A. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.07.002 · Cited by 402 · see citing works
Brain, conscious experience and the observing self
Baars, B. J., Ramsøy, T. Z., & Laureys, S. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.09.015 · Cited by 404 · see citing works
Psychopaths know right from wrong but don’t care
Cima, M., Tonnaer, F., & Hauser, M. D. (2010) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsp051 · Cited by 362 · see citing works
fMRI during affect discrimination in bipolar affective disorder
Yurgelun‐Todd, D. A., Gruber, S. A., Kanayama, G., Killgore, W. D., Baird, A. A., & Young, A. D. (2000) · Bipolar Disorders · doi:10.1034/j.1399-5618.2000.20304.x · Cited by 359 · see citing works
Brain activation associated with evaluative processes of guilt and embarrassment: an fMRI study
Takahashi, H., Yahata, N., Koeda, M., Matsuda, T., Asai, K., & Okubo, Y. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.054 · Cited by 354 · see citing works
Reduced sensitivity to others' fearful expressions in psychopathic individuals
Blair, R. J. R., Mitchell, D. G. V., Peschardt, K. S., Colledge, E., Leonard, R. A., Shine, J. H., Murray, L. K., & Perrett, D. I. (2004) · Personality and Individual Differences · doi:10.1016/j.paid.2003.10.008 · Cited by 344 · see citing works
Zhou, Y., Kaiser, T., Monteiro, P., Zhang, X., Van der Goes, M. S., Wang, D., Barak, B., Zeng, M., Li, C., Lu, C., et al. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.023 · Cited by 325 · see citing works
Harshaw, C. (2015) · Psychological Bulletin · doi:10.1037/a0038101 · Cited by 302 · see citing works
Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators
Duffney, L. J., Zhong, P., Wei, J., Matas, E., Cheng, J., Qin, L., Ma, K., Dietz, D. M., Kajiwara, Y., Buxbaum, J. D., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.064 · Cited by 281 · see citing works
Clan mentality: evidence that the medial prefrontal cortex responds to close others
Krienen, F. M., Tu, P.-C., & Buckner, R. L. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2180-10.2010 · Cited by 256 · see citing works
“…and behavioral interactions (Glees et al., 1950; Eslinger and Damasio, 1985; Damasio et al., 1990; Rolls et al., 1994; Stone et al., 1998; Anderson et al., 1999; Hadland et al., 2003; Mah et al., 2005; Rudebeck et al., 2006, 2007) [for review, see Damasio et al. (1996), Stuss (2002), and…”
BackgroundThe neural code of reward anticipation in human orbitofrontal cortex
Kahnt, T., Heinzle, J., Park, S. Q., & Haynes, J.-D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912838107 · Cited by 274 · see citing works
An fMRI study of simple ethical decision-making
Heekeren, H. R., Wartenburger, I., Schmidt, H., Schwintowski, H.-P., & Villringer, A. (2003) · NeuroReport · doi:10.1097/00001756-200307010-00005 · Cited by 263 · see citing works
Rest Is Not Idleness: Implications of the Brain’s Default Mode for Human Development and Education
Immordino-Yang, M. H., Christodoulou, J. A., & Singh, V. (2012) · Perspectives on Psychological Science · doi:10.1177/1745691612447308 · Cited by 245 · see citing works
Siegel, D. J. (2007) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsm034 · Cited by 245 · see citing works
Morphometric Brain Abnormalities in Boys With Conduct Disorder
HUEBNER, T., VLOET, T. D., MARX, I., KONRAD, K., FINK, G. R., HERPERTZ, S. C., & HERPERTZ-DAHLMANN, B. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3181676545 · Cited by 239 · see citing works
Neural circuitry underlying affective response to peer feedback in adolescence
Guyer, A. E., Choate, V. R., Pine, D. S., & Nelson, E. E. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr043 · Cited by 236 · see citing works
Food for thought: hedonic experience beyond homeostasis in the human brain
Kringelbach, M. L. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.04.035 · Cited by 236 · see citing works
The effects of 53 hours of sleep deprivation on moral judgment
Killgore, W. D. S., Killgore, D. B., Day, L. M., Li, C., Kamimori, G. H., & Balkin, T. J. (2007) · SLEEP · doi:10.1093/sleep/30.3.345 · Cited by 225 · see citing works
Social cognitive neuroscience: where are we heading?
Blakemore, S.-J., Winston, J., & Frith, U. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.03.012 · Cited by 224 · see citing works
ADHD and the Prefrontal Cortex
Arnsten, A. F. T. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.01.018 · Cited by 220 · see citing works
Do low levels of stress reactivity signal poor states of health?
Lovallo, W. R. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2010.01.006 · Cited by 208 · see citing works
The development of the ventral prefrontal cortex and social flexibility
Nelson, E. E., & Guyer, A. E. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.01.002 · Cited by 201 · see citing works
Tian, Y., Baek, J., Lee, S., & Jang, C. (2010) · Synapse · doi:10.1002/syn.20746 · Cited by 197 · see citing works
The neural basis of implicit moral attitude—An IAT study using event-related fMRI
Luo, Q., Nakic, M., Wheatley, T., Richell, R., Martin, A., & Blair, R. J. R. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.11.005 · Cited by 191 · see citing works
The emotional modulation of cognitive processing: an fMRI study
Simpson, J. R., Öngür, D., Akbudak, E., Conturo, T. E., Ollinger, J. M., Snyder, A. Z., Gusnard, D. A., & Raichle, M. E. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/089892900564019 · Cited by 190 · see citing works
A neurobiological mapping of theory of mind
Abu-Akel, A. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00190-5 · Cited by 189 · see citing works
Neural basis of emotional self-regulation in childhood
Lévesque, J., Joanette, Y., Mensour, B., Beaudoin, G., Leroux, J.-M., Bourgouin, P., & Beauregard, M. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.07.032 · Cited by 184 · see citing works
A Psychophysiological Investigation of Moral Judgment after Ventromedial Prefrontal Damage
Moretto, G., Làdavas, E., Mattioli, F., & di Pellegrino, G. (2010) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21367 · Cited by 182 · see citing works
Impact of early adversity on glucocorticoid regulation and later mental disorders
Strüber, N., Strüber, D., & Roth, G. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.10.015 · Cited by 173 · see citing works
Kurczek, J., Wechsler, E., Ahuja, S., Jensen, U., Cohen, N. J., Tranel, D., & Duff, M. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.05.002 · Cited by 157 · see citing works
Self-citationRubia, K., Lee, F., Cleare, A. J., Tunstall, N., Fu, C. H. Y., Brammer, M., & McGuire, P. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2116-z · Cited by 171 · see citing works
Different neural systems adjust motor behavior in response to reward and punishment
Wrase, J., Kahnt, T., Schlagenhauf, F., Beck, A., Cohen, M. X., Knutson, B., & Heinz, A. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.04.001 · Cited by 172 · see citing works
Self-Representation in Nervous Systems.
Churchland, P. S. (2002) · Science · doi:10.1126/science.1070564 · Cited by 160 · see citing works
Appetitive motivation predicts the neural response to facial signals of aggression.
Beaver, J. D., Lawrence, A. D., Passamonti, L., & Calder, A. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0033-08.2008 · Cited by 152 · see citing works
Irritability in pediatric mania and other childhood psychopathology
LEIBENLUFT, E., BLAIR, R. J. R., CHARNEY, D. S., & PINE, D. S. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1301.022 · Cited by 145 · see citing works
De Gregorio, D., Popic, J., Enns, J. P., Inserra, A., Skalecka, A., Markopoulos, A., Posa, L., Lopez-Canul, M., He, Q., Lafferty, C. K., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2020705118 · Cited by 139 · see citing works
The role of the microbiome in the neurobiology of social behaviour
Sarkar, A., Harty, S., Johnson, K. V. ‐., Moeller, A. H., Carmody, R. N., Lehto, S. M., Erdman, S. E., Dunbar, R. I. M., & Burnet, P. W. J. (2020) · Biological Reviews · doi:10.1111/brv.12603 · Cited by 135 · see citing works
The structural and functional brain networks that support human social networks
Noonan, M. P., Mars, R. B., Sallet, J., Dunbar, R. I. M., & Fellows, L. K. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.02.019 · Cited by 131 · see citing works
Sex differences in social interaction in rats: role of the immediate-early gene Zif268
Stack, A., Carrier, N., Dietz, D., Hollis, F., Sorenson, J., & Kabbaj, M. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.163 · Cited by 113 · see citing works
Smidts, D. P., Jacobs, R., & Anderson, V. (2004) · Developmental Neuropsychology · doi:10.1207/s15326942dn2601_2 · Cited by 111 · see citing works
Hermes, G., Li, N., Duman, C., & Duman, R. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.12.019 · Cited by 111 · see citing works
Iowa gambling task performance in currently depressed suicide attempters
Gorlyn, M., Keilp, J. G., Oquendo, M. A., Burke, A. K., & John Mann, J. (2013) · Psychiatry Research · doi:10.1016/j.psychres.2013.01.030 · Cited by 94 · see citing works
Saunders, B., Farag, N., Vincent, A. S., Collins, F. L., Sorocco, K. H., & Lovallo, W. R. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00648.x · Cited by 92 · see citing works
Neural correlates of risk prediction error during reinforcement learning in humans
d'Acremont, M., Lu, Z.-L., Li, X., Van der Linden, M., & Bechara, A. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.04.096 · Cited by 94 · see citing works
Self-citationRegard, M., Knoch, D., Gütling, E., & Landis, T. (2003) · Cognitive and Behavioral Neurology · doi:10.1097/00146965-200303000-00006 · Cited by 75 · see citing works
Hamilton, D. A., Barto, D., Rodriguez, C. I., Magcalas, C. M., Fink, B. C., Rice, J. P., Bird, C. W., Davies, S., & Savage, D. D. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.04.029 · Cited by 73 · see citing works
Bridging Intimate Partner Violence and the Human Brain: A Literature Review
Wong, J. Y.-H., Fong, D. Y.-T., Lai, V., & Tiwari, A. (2014) · Trauma, Violence, & Abuse · doi:10.1177/1524838013496333 · Cited by 69 · see citing works
Kukekova, A. V., Johnson, J. L., Teiling, C., Li, L., Oskina, I. N., Kharlamova, A. V., Gulevich, R. G., Padte, R., Dubreuil, M. M., Vladimirova, A. V., et al. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-482 · Cited by 57 · see citing works
- Authors
- Anderson, S. W., Bechara, A., Damasio, H., Tranel, D., & Damasio, A. R.
- Affiliations
- University of Iowa (US)
- Venue
- Nature Neuroscience
- Published
- 1999-11
- Volume
- 2
- Issue
- 11
- Pages
- 1032-1037
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1500891748
- Cited by
- 1,539
- References
- 26
- Citations by year
- 2026: 21 · 2025: 17 · 2024: 28 · 2023: 44 · 2022: 26 · 2021: 39 · 2020: 73 · 2019: 56 · 2018: 56 · 2017: 52 · 2016: 52 · 2015: 58 · 2014: 69 · 2013: 63 · 2012: 76
- FWCI
- 19.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- DigitalGeorgetown (Georgetown University Library) (submittedVersion)
- Funders
- G. Harold and Leila Y. Mathers Foundation
- National Institute of Neurological Disorders and Stroke (P01NS019632)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Life Sciences › Neuroscience › Cognitive Neuroscience › Psychology of Moral and Emotional Judgment
- Keywords
- prefrontal cortex, social behavior impairment, moral reasoning, psychopathy, social conventions, punishment sensitivity, autonomic responses, decision-making, behavioral interventions
- MeSH terms
- Adult, Brain Damage, Chronic, Brain Neoplasms, Female, Humans, Infant, Infant, Newborn, Male, Morals, Social Behavior, Prefrontal Cortex
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