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Morphine-conditioned single-trial place preference: role of nucleus accumbens shell dopamine receptors in acquisition, but not expression

Fenu, Sandro, Spina, Liliana, Rivas, Emilia, Longoni, Rosanna, Di Chiara, Gaetano·2006·Psychopharmacology

DOI 10.1007/s00213-006-0415-2

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Abstract

Rationale A large body of evidence indicates an involvement of the mesolimbic dopamine (DA) pathway innervating the ventral striatum in the motivational effects of drug abuse.Objective The goal of the study is to clarify the role of DA D1 and D2 receptors of the rat nucleus accumbens (NAc) shell and core in the motivational effects of morphine as studied by conditioned place preference (CPP).Methods The effect of the intracerebral infusion of DA antagonists specific for DA D1 (SCH 39166) and D2 receptors (L-sulpiride) was studied in a single-trial place conditioning paradigm with fixed assignment of the drug to the unpreferred compartment.Results Morphine induced significant CPP at all the doses tested (0.5, 1.0, and 2.0 mg/kg, subcutaneously). A dose of 1.0 mg/kg was selected for further studies. Intra-NAc shell infusion of SCH 39166 and L-sulpiride at doses of 25 and 50 ng/1 microl per side impaired the acquisition of CPP by morphine. No effect was observed at 12.5 ng/1 microl per side. Intra-NAc core infusion of SCH 39166 (12.5, 25, and 50 ng/1 microl per side) did not affect the acquisition of morphine-induced CPP, while L-sulpiride (12.5, 25, and 50 ng/1 microl per side) impaired CPP acquisition only at the dose of 50 ng/1 microl per side. No effect on morphine-induced CPP was observed when the DA antagonists were infused into the NAc shell or core 10 min before the test session.Conclusion These results indicate that DA D1 and D2 receptors in the NAc shell are involved in the acquisition of morphine-induced CPP.

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The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues
Tzschentke, T. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00060-4 · Cited by 1,280
Neuroleptics and operant behavior: The anhedonia hypothesis
Wise, R. A. (1982) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00010372 · Cited by 1,028
Nucleus accumbens shell and core dopamine: differential role in behavior and addiction
Di Chiara, G. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00286-3 · Cited by 996
Dopamine and drug addiction: the nucleus accumbens shell connection
Di Chiara, G., Bassareo, V., Fenu, S., De Luca, M. A., Spina, L., Cadoni, C., Acquas, E., Carboni, E., Valentini, V., & Lecca, D. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.032 · Cited by 935
Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.
Di Chiara, G., & Imperato, A. (1988) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24578-5 · Cited by 916
Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens.
Pontieri, F. E., Tanda, G., & Chiara, G. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.26.12304 · Cited by 868
The role of dopamine in drug abuse viewed from the perspective of its role in motivation
Chiara, G. D. (1995) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(95)01118-i · Cited by 639

Show all 64 references

Research works printed but not linked: 3

Carr GD, Fibiger HC, Phillips AG (1989) Conditioned place preference as a measure of drug reward. In: Liebman JM, Cooper SJ (eds) Oxford reviews in psychopharmacology: neuropharmacological basis of reward. Oxford University Press, New York, pp 264–319
Robbins TW (2005) Role of cortical and striatal dopamine in cognitive function. In: Dunnett SB, Bentivoglio M, Bjorklund A, Hokfelt T (eds) Dopamine, handbook of chemical neuroanatomy, vol. 21. Elsevier, Amsterdam, pp 395–434
Shippenberg TS, Bals-Kubik R, Herz A (1993) Examination of the neurochemical substrates mediating the motivational effects of opioid: role of mesolimbic dopamine system and D1 vs. D2 dopamine receptors. J Pharmacol Exp Ther 265:53–59

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Wickens, R. H., Quartarone, S. E., & Beninger, R. J. (2016) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000283 · Cited by 12
Behavioral and Neurochemical Pharmacology of 5-HT6 Receptors Related to Reward and Reinforcement
Chiara, G. D., Valentini, V., & Fenu, S. (2011) · International review of neurobiology · doi:10.1016/b978-0-12-385902-0.00005-x · Cited by 11
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Runegaard, A. H., Jensen, K. L., Dencker, D., Wörtwein, G., & Gether, U. (2017) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2017.07.010 · Cited by 10
Effects of CCK-8 on the reinstatement of morphine-induced CPP and expression of behavioral sensitization in rats
Wen, D., Zang, G. Y., Sun, D., Yang, S., Yu, F., Li, S., Ma, C., & Cong, B. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.02.057 · Cited by 9
Effects of morphine on place conditioning and ERK1/2 phosphorylation in the nucleus accumbens of psychogenetically selected Roman low- and high-avoidance rats
Rosas, M., Porru, S., Sabariego, M., Piludu, M. A., Giorgi, O., Corda, M. G., & Acquas, E. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4740-4 · Cited by 9
Sexually experienced, but not naïve, female rats show a conditioned object preference (COP) for mating after a single training trial
Piergies, A. M. H., Hicks, M. E., Schwartz, J. P., & Meerts, S. H. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.09.017 · Cited by 9
Conditioned saccharin avoidance and sensitization to drugs of abuse
Fenu, S., Cadoni, C., & Chiara, G. D. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.05.044 · Cited by 7
Recruitment of specific dopamine neuron sub-circuits by opioids
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Can the incentive-sensitization theory of addiction incorporate addiction to opioid drugs?
Robinson, T. E., & Berridge, K. C. (2026) · Psychopharmacology · doi:10.1007/s00213-025-07001-8 · Cited by 6
Morphine-induced place preference affects mRNA expression of G protein α subunits in rat brain
Zelek-Molik, A., Bielawski, A., Kreiner, G., Popik, P., Vetulani, J., & Nalepa, I. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70850-2 · Cited by 6
Involvements of stress hormones in the restraint-induced conditioned place preference
Mei, Y.-Y., & Li, J. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.09.008 · Cited by 6
Interactions of pain and opioids on conditioned place preference in rodents
Barattini, A. E., & Pahng, A. R. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06719-1 · Cited by 5
Intra‐nucleus‐accumbens SKF38393 improved the impaired acquisition of morphine‐conditioned place preference in depression‐like rats
Gao, J., Zhu, N., Feng, M., Meng, X., & Sui, N. (2012) · PsyCh Journal · doi:10.1002/pchj.9 · Cited by 5
In vivo reduction of striatal D1R by RNA interference alters expression of D1R signaling-related proteins and enhances methamphetamine addiction in male rats
Kreisler, A. D., Terranova, M. J., Somkuwar, S. S., Purohit, D. C., Wang, S., Head, B. P., & Mandyam, C. D. (2020) · Brain Structure and Function · doi:10.1007/s00429-020-02059-w · Cited by 5
Nucleus accumbens sub-regions experience distinct dopamine release responses following acute and chronic morphine exposurePreprint
Gooding, S. W., Lewis, E., Chau, C., Sandhu, S., Glienke, J., & Whistler, J. L. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.28.601282 · Cited by 6
Knockout of Dopamine D3 Receptor Gene Blocked Methamphetamine-Induced Distinct Changes of Dopaminergic and Glutamatergic Synapse in the Nucleus Accumbens Shell of Mice
Wang, S., Li, M., Su, L., Wang, Y., Ma, D., Wang, H., Zhu, J., & Chen, T. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.893190 · Cited by 4
Differential effects of amphetamine on ultrasonic vocalizations and locomotor activity in a rat model of endogenous depression
Banjac, A., Elersič, K., Živin, M., & Zorović, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-27298-x · Cited by 2
Alcohol inhibits morphine/cocaine reward memory acquisition and reconsolidation in rats
Zhu, S., Chen, P., Chen, M., Ruan, J., Ren, W., Zhang, X., Gao, Y., & Li, Y. (2020) · Psychopharmacology · doi:10.1007/s00213-019-05433-7 · Cited by 2
The role of mesolimbic circuitry in aversive signaling and opioid dependence
Branco, P., Cox, J., Wu, Y., Morison, S. L., Parker, J. G., Lerner, T. N., Martina, M., Awatramani, R. B., Surmeier, D. J., & Apkarian, A. V. (2025) · Neuron · doi:10.1016/j.neuron.2025.08.019 · Cited by 1
Molecular chaperone heat shock protein 70 inhibitors suppress conditioned place preference induced by morphine exposure in male rats
Wei, S., Li, Y., Gong, Q. H., Liang, H., Bernardi, R. E., & Liang, J. (2022) · Addiction Biology · doi:10.1111/adb.13163 · Cited by 1
Molecular mechanisms underlying the actions of psychoactive drugs in the basal ganglia : Focus on cannabinoids and morphine
Borgkvist, A. (2008) · Figshare
Behavioral and neurobiological consequences of intermittent exposure to addictive drugs.
Rothwell, P. E. (2010) · University of Minnesota Digital Conservancy (University of Minnesota)
Neural Mechanisms of Anxiety during Opiate Withdrawal: Role of the Ventral Tegmental Area and Extended Amygdala
Radke, A. K. (2011) · University of Minnesota Digital Conservancy (University of Minnesota)
142948A on 3,4-methylenedioxymethamphetamine-induced behaviours in mice.
Cynthia Marie-claire, A., Palminteri, S., Romualdi, P., & Noble, F. (2008)
Effect of Glycogen Synthase Kinase 3-β on the Acquisition & Expression of Intra-Accumbal Amphetamine-Induced Conditioned Place Preference in Rats
Quartarone, S. E. (2014) · QSpace (Queen's University Library)
Dopamine D1 and D3 Receptor Polypharmacology in Cocaine Reward and Cocaine Seeking
Galaj, E. (2017) · CUNY Academic Works (City University of New York)
Approach and Avoidance Processing: Investigating a Rostrocaudal Gradient in the Nucleus Accumbens Core
Hamel, L. (2014) · TSpace (University of Toronto)
Hippocampal Lesions in Male Rats Produce Retrograde Memory Loss for Over‐Trained Spatial Memory but Do Not Impact Appetitive‐Contextual Memory: Implications for Theories of Memory Organization in the Mammalian Brain
Hong, N. S., Lee, J. Q., Bonifacio, C. J. T., Gibb, M. J., Kent, M., Nixon, A., Panjwani, M., Robinson, D., Rusnak, V., Trudel, T., et al. (2025) · Journal of Neuroscience Research · doi:10.1002/jnr.70013
Dopamine, γ-aminobutyric acid, and glutamate balance in the nucleus accumbens shell: Differential effects of cannabinoid 1 receptor agonists Δ9-Tetrahydrocannabinol, AM11101, and AM8936
Smith, E. C., Iliopoulos‐Tsoutsouvas, C., Georgiadis, M., Nikas, S. P., Brijlall, K., Makriyannis, A., & Desai, R. I. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.110891

Authors: Fenu, S., Spina, L., Rivas, E., Longoni, R., & Di Chiara, G.
Affiliations: University of Cagliari (IT)
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2006-05-25
Volume: 187
Issue: 2
Pages: 143-153
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-006-0415-2
OpenAlex: W2011492524
Cited by: 103
References: 64
Citations by year: 2026: 3 · 2025: 5 · 2024: 2 · 2022: 5 · 2021: 2 · 2020: 6 · 2019: 1 · 2018: 7 · 2017: 6 · 2016: 5 · 2015: 1 · 2014: 5 · 2013: 7 · 2012: 5
FWCI: 3.80
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: morphine, conditioned place preference, nucleus accumbens shell, nucleus accumbens core, dopamine D1 receptor, dopamine D2 receptor, dopamine antagonists, SCH 39166, mesolimbic dopamine system
MeSH terms: Animals, Association Learning, Benzazepines, Brain Mapping, Choice Behavior, Conditioning, Classical, Dose-Response Relationship, Drug, Male, Morphine, Narcotics, Nucleus Accumbens, Social Environment, Sulpiride, Rats, Sprague-Dawley, Receptors, Dopamine D1, Receptors, Dopamine D2, Rats, Dopamine D2 Receptor Antagonists

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Morphine-conditioned single-trial place preference: role of nucleus accumbens shell dopamine receptors in acquisition, but not expression

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