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Cited by 103Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.

Morphine-conditioned single-trial place preference: role of nucleus accumbens shell dopamine receptors in acquisition, but not expression

Fenu, Sandro, Spina, Liliana, Rivas, Emilia, Longoni, Rosanna, Di Chiara, Gaetano·2006·Psychopharmacology
DOI 10.1007/s00213-006-0415-2
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Abstract

Rationale A large body of evidence indicates an involvement of the mesolimbic dopamine (DA) pathway innervating the ventral striatum in the motivational effects of drug abuse.Objective The goal of the study is to clarify the role of DA D1 and D2 receptors of the rat nucleus accumbens (NAc) shell and core in the motivational effects of morphine as studied by conditioned place preference (CPP).Methods The effect of the intracerebral infusion of DA antagonists specific for DA D1 (SCH 39166) and D2 receptors (L-sulpiride) was studied in a single-trial place conditioning paradigm with fixed assignment of the drug to the unpreferred compartment.Results Morphine induced significant CPP at all the doses tested (0.5, 1.0, and 2.0 mg/kg, subcutaneously). A dose of 1.0 mg/kg was selected for further studies. Intra-NAc shell infusion of SCH 39166 and L-sulpiride at doses of 25 and 50 ng/1 microl per side impaired the acquisition of CPP by morphine. No effect was observed at 12.5 ng/1 microl per side. Intra-NAc core infusion of SCH 39166 (12.5, 25, and 50 ng/1 microl per side) did not affect the acquisition of morphine-induced CPP, while L-sulpiride (12.5, 25, and 50 ng/1 microl per side) impaired CPP acquisition only at the dose of 50 ng/1 microl per side. No effect on morphine-induced CPP was observed when the DA antagonists were infused into the NAc shell or core 10 min before the test session.Conclusion These results indicate that DA D1 and D2 receptors in the NAc shell are involved in the acquisition of morphine-induced CPP.

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Research works printed but not linked: 3

  1. Carr GD, Fibiger HC, Phillips AG (1989) Conditioned place preference as a measure of drug reward. In: Liebman JM, Cooper SJ (eds) Oxford reviews in psychopharmacology: neuropharmacological basis of reward. Oxford University Press, New York, pp 264–319
  2. Robbins TW (2005) Role of cortical and striatal dopamine in cognitive function. In: Dunnett SB, Bentivoglio M, Bjorklund A, Hokfelt T (eds) Dopamine, handbook of chemical neuroanatomy, vol. 21. Elsevier, Amsterdam, pp 395–434
  3. Shippenberg TS, Bals-Kubik R, Herz A (1993) Examination of the neurochemical substrates mediating the motivational effects of opioid: role of mesolimbic dopamine system and D1 vs. D2 dopamine receptors. J Pharmacol Exp Ther 265:53–59

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Metadata

Authors
Fenu, S., Spina, L., Rivas, E., Longoni, R., & Di Chiara, G.
Affiliations
University of Cagliari (IT)
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2006-05-25
Volume
187
Issue
2
Pages
143-153
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/s00213-006-0415-2
OpenAlex
W2011492524
Cited by
103
References
64
Citations by year
2026: 3 · 2025: 5 · 2024: 2 · 2022: 5 · 2021: 2 · 2020: 6 · 2019: 1 · 2018: 7 · 2017: 6 · 2016: 5 · 2015: 1 · 2014: 5 · 2013: 7 · 2012: 5
FWCI
3.80
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
morphine, conditioned place preference, nucleus accumbens shell, nucleus accumbens core, dopamine D1 receptor, dopamine D2 receptor, dopamine antagonists, SCH 39166, mesolimbic dopamine system
MeSH terms
Animals, Association Learning, Benzazepines, Brain Mapping, Choice Behavior, Conditioning, Classical, Dose-Response Relationship, Drug, Male, Morphine, Narcotics, Nucleus Accumbens, Social Environment, Sulpiride, Rats, Sprague-Dawley, Receptors, Dopamine D1, Receptors, Dopamine D2, Rats, Dopamine D2 Receptor Antagonists

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