Nicotine-conditioned single-trial place preference: selective role of nucleus accumbens shell dopamine D1 receptors in acquisition
Abstract
Rationale Experimental evidence indicates that the mesolimbic dopamine (DA) pathway innervating the ventral striatum is critically involved in the motivational effects of drug abuse. However, the role of DA transmission of the two main subdivisions of the nucleus accumbens (NAc), the shell and the core, in the motivational properties of nicotine is unknown.Objectives The aim of this study was to investigate the role of DA D1 and D2 receptors of the rat NAc shell and core in the motivational effects of nicotine using a conditioned place preference (CPP) paradigm.Methods The effect of the intracerebral infusion of DA antagonists specific for DA D1 (SCH 39166) and D2 receptors (L-sulpiride) was studied in a single-trial place-conditioning paradigm with fixed assignment of the drug to the unpreferred compartment.Results Nicotine induced significant CPP at the dose of 0.4 and 0.6 mg/kg subcutaneously (s.c.). Intra-NAc shell infusion of SCH 39166 (6.25, 12.5, 25 and 50 ng bilaterally, 10 min before nicotine administration), impaired in a dose-dependent manner the acquisition of CPP by nicotine (0.4 mg/kg s.c.). SCH 39166 failed to affect nicotine CPP when infused into the NAc core. L-sulpiride (25 and 50 ng bilaterally) had no effect on acquisition after intra-Nac shell infusion. SCH 39166 and L-sulpiride were ineffective after infusion in the NAc shell and core 10 min before the test session.Conclusions The results indicate that dopamine D1 but not D2 receptors of the NAc shell are specifically involved in the acquisition of nicotine-induced CPP.
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Microinjections of dopaminergic antagonists into the shell, but not the core, disrupt conditioned place preference induced by systemic nicotine or morphine.
“In addition, microinjections of dopaminergic antagonists into the shell, but not the core, disrupt conditioned place preference induced by systemic nicotine or morphine”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Spina et al., 2006
Microinjections of dopamine receptor antagonists into the medial accumbens shell, but not the core, during the acquisition phase disrupt conditioned place preference induced by systemic administration of nicotine or opiates.
“Microinjections of dopamine receptor antagonists into the medial accumbens shell, but not the core, during the acquisition phase disrupt conditioned place preference induced by systemic administration of nicotine or opiates (Fenu et al., 2006; Spina et al., 2006).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Spina et al., 2006
Blockade of dopamine receptors in the medial shell just before preference testing does not change conditioned place preference induced by nicotine or morphine administration, even though the same treatments during the acquisition phase disrupt the acquisition of conditioned place preference.
“The blockade of dopamine receptors in the medial shell just before preference testing does not change conditioned place preference induced by nicotine or morphine administration, even though the same treatments during the acquisition phase disrupt the acquisition of conditioned place preference (Fenu et al., 2006; Spina et al., 2006).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Spina et al., 2006
SCH 23390 administration into the accumbens core does not disrupt stimulus-outcome association in conditioned place preference procedures.
“SCH 23390 administration into the accumbens core does not disrupt stimulus-outcome association in conditioned place preference procedures (Fenu et al., 2006; Spina et al., 2006).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Spina et al., 2006
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- Authors
- Spina, L., Fenu, S., Longoni, R., Rivas, E., & Di Chiara, G.
- Affiliations
- University of Cagliari (IT)
- Venue
- Psychopharmacology
- Published
- 2005-12-10
- Volume
- 184
- Issue
- 3-4
- Pages
- 447-455
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2051196507
- Cited by
- 102
- References
- 49
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 9 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 6
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Funders
- Ministero dell'Università e della Ricerca
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- nicotine, conditioned place preference, nucleus accumbens shell, dopamine D1 receptor, dopamine D2 receptor, mesolimbic dopamine system, drug motivation, nicotine dependence, dopamine antagonists, SCH 39166
- MeSH terms
- Animals, Association Learning, Brain Mapping, Choice Behavior, Conditioning, Classical, Dose-Response Relationship, Drug, Injections, Intravenous, Male, Motivation, Nicotine, Nucleus Accumbens, Social Environment, Tobacco Use Disorder, Rats, Sprague-Dawley, Receptors, Dopamine D1, Receptors, Dopamine D2, Rats
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