The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Morphine-conditioned single-trial place preference: role of nucleus accumbens shell dopamine receptors in acquisition, but not expression
Abstract
Rationale A large body of evidence indicates an involvement of the mesolimbic dopamine (DA) pathway innervating the ventral striatum in the motivational effects of drug abuse.Objective The goal of the study is to clarify the role of DA D1 and D2 receptors of the rat nucleus accumbens (NAc) shell and core in the motivational effects of morphine as studied by conditioned place preference (CPP).Methods The effect of the intracerebral infusion of DA antagonists specific for DA D1 (SCH 39166) and D2 receptors (L-sulpiride) was studied in a single-trial place conditioning paradigm with fixed assignment of the drug to the unpreferred compartment.Results Morphine induced significant CPP at all the doses tested (0.5, 1.0, and 2.0 mg/kg, subcutaneously). A dose of 1.0 mg/kg was selected for further studies. Intra-NAc shell infusion of SCH 39166 and L-sulpiride at doses of 25 and 50 ng/1 microl per side impaired the acquisition of CPP by morphine. No effect was observed at 12.5 ng/1 microl per side. Intra-NAc core infusion of SCH 39166 (12.5, 25, and 50 ng/1 microl per side) did not affect the acquisition of morphine-induced CPP, while L-sulpiride (12.5, 25, and 50 ng/1 microl per side) impaired CPP acquisition only at the dose of 50 ng/1 microl per side. No effect on morphine-induced CPP was observed when the DA antagonists were infused into the NAc shell or core 10 min before the test session.Conclusion These results indicate that DA D1 and D2 receptors in the NAc shell are involved in the acquisition of morphine-induced CPP.
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In the citing paper
“In addition, microinjections of dopaminergic antagonists into the shell, but not the core, disrupt conditioned place preference induced by systemic nicotine or morphine”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Fenu et al., 2006
In the citing paper
“Microinjections of dopamine receptor antagonists into the medial accumbens shell, but not the core, during the acquisition phase disrupt conditioned place preference induced by systemic administration of nicotine or opiates (Fenu et al., 2006; Spina et al., 2006).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Fenu et al., 2006
In the citing paper
“The blockade of dopamine receptors in the medial shell just before preference testing does not change conditioned place preference induced by nicotine or morphine administration, even though the same treatments during the acquisition phase disrupt the acquisition of conditioned place preference (Fenu et al., 2006; Spina et al., 2006).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Fenu et al., 2006
In the citing paper
“SCH 23390 administration into the accumbens core does not disrupt stimulus-outcome association in conditioned place preference procedures (Fenu et al., 2006; Spina et al., 2006).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Fenu et al., 2006
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Nucleus accumbens shell and core dopamine: differential role in behavior and addiction
Di Chiara, G. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00286-3 · Cited by 996
Dopamine and drug addiction: the nucleus accumbens shell connection
Di Chiara, G., Bassareo, V., Fenu, S., De Luca, M. A., Spina, L., Cadoni, C., Acquas, E., Carboni, E., Valentini, V., & Lecca, D. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.032 · Cited by 935
Di Chiara, G., & Imperato, A. (1988) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24578-5 · Cited by 916
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The role of dopamine in drug abuse viewed from the perspective of its role in motivation
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Research works printed but not linked: 3
- Carr GD, Fibiger HC, Phillips AG (1989) Conditioned place preference as a measure of drug reward. In: Liebman JM, Cooper SJ (eds) Oxford reviews in psychopharmacology: neuropharmacological basis of reward. Oxford University Press, New York, pp 264–319
- Robbins TW (2005) Role of cortical and striatal dopamine in cognitive function. In: Dunnett SB, Bentivoglio M, Bjorklund A, Hokfelt T (eds) Dopamine, handbook of chemical neuroanatomy, vol. 21. Elsevier, Amsterdam, pp 395–434
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Étude moléculaire et comportementale de la variabilité de réponse à la cocaïne
Martinez, L. A. A. (2021) · theses.fr (ABES) · doi:10.70675/c394f299z9930z4d9fzb9ecz074185fe9fee
Allichon, M., Espinosa, J., Cole, R. H., Ko, M.-C., Vanhoutte, P., & Joffe, M. E. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1774384 · Cited by 1
Metadata
- Authors
- Fenu, S., Spina, L., Rivas, E., Longoni, R., & Di Chiara, G.
- Affiliations
- University of Cagliari (IT)
- Venue
- Psychopharmacology
- Published
- 2006-05-25
- Volume
- 187
- Issue
- 2
- Pages
- 143-153
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2011492524
- Cited by
- 103
- References
- 64
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 2 · 2022: 5 · 2021: 2 · 2020: 6 · 2019: 1 · 2018: 7 · 2017: 6 · 2016: 5 · 2015: 1 · 2014: 5 · 2013: 7 · 2012: 5
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- morphine, conditioned place preference, nucleus accumbens shell, nucleus accumbens core, dopamine D1 receptor, dopamine D2 receptor, dopamine antagonists, SCH 39166, mesolimbic dopamine system
- MeSH terms
- Animals, Association Learning, Benzazepines, Brain Mapping, Choice Behavior, Conditioning, Classical, Dose-Response Relationship, Drug, Male, Morphine, Narcotics, Nucleus Accumbens, Social Environment, Sulpiride, Rats, Sprague-Dawley, Receptors, Dopamine D1, Receptors, Dopamine D2, Rats, Dopamine D2 Receptor Antagonists
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