Cited by 467Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorNeurological disorders and treatments

Modulatory functions of neurotransmitters in the striatum: ACh/dopamine/NMDA interactions

Di Chiara, Gaetano, Morelli, Micaela, Consolo, Silvana·1994·Trends in Neurosciences

Abstract

The striatum is viewed as a structure performing fast neurotransmitter-mediated operations through somatotopically organized projections to medium-size spiny neurons. This view is contrasted with another view that depicts the striatum as a site of diffuse modulatory influences mediated by cholinergic interneurons and by dopamine and N-methyl-D-aspartate receptors. These two operational and organizational modes both contribute, through their mutual interaction, to the function of basal ganglia. Detailed knowledge of the neural mechanisms by which such interactions take place and are expressed into behaviour, can provide new insight into the physiopathology and new clues for therapy of disorders of basal ganglia.

Integrity signals

Registry

Crossref · 10.1016/0166-2236(94)90005-1

Cites

72 of 72 references verified0 citation errors · 0 not checkable

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  • The striatum is thought to be a region of broad modulatory effects mediated by cholinergic interneurons, dopamine, and NMDA receptors.

    “The striatum is thought to be a region of broad modulatory effects mediated by cholinergic interneurons, dopa­ mine, and N-methyl-D-aspartate (NMDA) receptors (Chiara et al., 1994).”

Cites

Flagged first, then by citations

Research works printed but not linked: 17

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  5. Kimura, 1984, 81, 4998
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  7. Jarvie, 1993, Adv. Neurol., 60, 325
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  9. Damsma, 1991, J. Pharmacol. Exp. Ther., 259, 1064
  10. Imperato, 1993, J. Pharmacol. Exp. Ther., 366, 557
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  12. Seeman, 1981, Pharmacol. Rev., 32, 229
  13. Le Moine, 1990, 87, 230
  14. Le Moine, 1991, 88, 4205
  15. Di Chiara G.; Morelli M. Basal Ganglia IV, Proc. IVth Meeting Int. Basal Ganglia Society Percheron G.; McKenzie J.S. Plenum Press (in press.)
  16. Di Chiara, 1993, Adv. Neurol., 60, 102
  17. Riederer, 1993, Adv. Neurol., 60, 626

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Authors
Di Chiara, G., Morelli, M., & Consolo, S.
Affiliations
  • University of Cagliari (IT)
  • Mario Negri Institute for Pharmacological Research (IT)
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
1994-06
Volume
17
Issue
6
Pages
228-233
ISSN
0166-2236 (ISSN-L)
OpenAlex
W1990162104
Cited by
467
References
72
Citations by year
2026: 2 · 2025: 2 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 6 · 2020: 8 · 2019: 4 · 2018: 8 · 2017: 11 · 2016: 9 · 2015: 6 · 2014: 7 · 2013: 6 · 2012: 13
FWCI
4.49
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
striatum, acetylcholine, dopamine, NMDA receptor, cholinergic interneurons, medium spiny neurons, basal ganglia, neurotransmitter interactions, basal ganglia disorders, neuromodulation
MeSH terms
Acetylcholine, Animals, Corpus Striatum, Dopamine, Humans, Synaptic Transmission, Receptors, Dopamine, N-Methylaspartate, Neurotransmitter Agents

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