Modulatory functions of neurotransmitters in the striatum: ACh/dopamine/NMDA interactions
Abstract
The striatum is viewed as a structure performing fast neurotransmitter-mediated operations through somatotopically organized projections to medium-size spiny neurons. This view is contrasted with another view that depicts the striatum as a site of diffuse modulatory influences mediated by cholinergic interneurons and by dopamine and N-methyl-D-aspartate receptors. These two operational and organizational modes both contribute, through their mutual interaction, to the function of basal ganglia. Detailed knowledge of the neural mechanisms by which such interactions take place and are expressed into behaviour, can provide new insight into the physiopathology and new clues for therapy of disorders of basal ganglia.
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The striatum is thought to be a region of broad modulatory effects mediated by cholinergic interneurons, dopamine, and NMDA receptors.
“The striatum is thought to be a region of broad modulatory effects mediated by cholinergic interneurons, dopa mine, and N-methyl-D-aspartate (NMDA) receptors (Chiara et al., 1994).”
From Predictive coding in neuropsychiatric disorders: a systematic transdiagnostic review. (2025) · cites this paper as Chiara et al., 1994
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- Authors
- Di Chiara, G., Morelli, M., & Consolo, S.
- Affiliations
- University of Cagliari (IT)
- Mario Negri Institute for Pharmacological Research (IT)
- ORCID
- Morelli, Micaela
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 1994-06
- Volume
- 17
- Issue
- 6
- Pages
- 228-233
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W1990162104
- Semantic Scholar
- 6620d60a424c6c77bf86292e9bd8b24706c6c57f
- Cited by
- 467
- References
- 72
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 6 · 2020: 8 · 2019: 4 · 2018: 8 · 2017: 11 · 2016: 9 · 2015: 6 · 2014: 7 · 2013: 6 · 2012: 13
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- striatum, acetylcholine, dopamine, NMDA receptor, cholinergic interneurons, medium spiny neurons, basal ganglia, neurotransmitter interactions, basal ganglia disorders, neuromodulation
- MeSH terms
- Acetylcholine, Animals, Corpus Striatum, Dopamine, Humans, Synaptic Transmission, Receptors, Dopamine, N-Methylaspartate, Neurotransmitter Agents
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