Cited by 147Stress Responses and CortisolAdrenal Hormones and DisordersHormonal Regulation and Hypertension

The DOI matches its Crossref record; 74 of the 75 references it cites were found in a registry or an index.

Different responses to dexamethasone and prednisolone in the same depressed patients

Juruena, Mario F., Cleare, Anthony J., Papadopoulos, Andrew S., Poon, Lucia, Lightman, Stafford, Pariante, Carmine M.·2006·Psychopharmacology

DOI 10.1007/s00213-006-0555-4

Open this paper in CoChat — free account

Abstract

Rationale Patients with major depression show hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, but the mechanisms underlying this abnormality are still unclear.Objectives We have compared two synthetic glucorticoids, dexamethasone and prednisolone, in their ability to suppress the hypothalamic-pituitary-adrenal (HPA) axis in depressed patients. Dexamethasone probes glucocorticoid receptor (GR) function, while prednisolone probes both GR and mineralocorticoid receptor (MR) function.Materials and methods We used a single-blind, repeated-measure design. We administered placebo, prednisolone (5 mg) or dexamethasone (0.5 mg), at 22:00, to 18 severe, treatment-resistant depressed inpatients (15 of them with a history of childhood trauma) and 14 healthy volunteers. On the following days, we collected salivary cortisol from 9:00 to 22:00.Results Depressed patients had higher salivary cortisol levels compared with controls, at baseline and after both prednisolone and dexamethasone (p<0.001). Consistent with previous studies, depressed inpatients showed impaired suppression by dexamethasone: based on the analysis of the areas under the curve (AUCs), suppression by dexamethasone (0.5 mg) was -85% in controls vs -46% in depressed patients (p=0.018). However, the same depressed patients showed normal suppression by prednisolone (5 mg): suppression was -41% in controls and -36% in depressed patients (p=0.6).Conclusions We suggest that the additional effects of prednisolone on the MR explain the different responses to these glucocorticoids in the same depressed patients.

Integrity signals

Registry

Crossref · 10.1007/s00213-006-0555-4

Cites

74 of 74 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,842
An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032
A rating scale for depression
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
Selective Cortical Undercutting As a Means of Modifying and Studying Frontal Lobe Function in Man
Scoville, W. B. (1949) · Journal of neurosurgery · doi:10.3171/jns.1949.6.1.0065 · Cited by 7,374
Williams Textbook of Endocrinology
Melmed, S., & Polonsky, K. S. (2016) · Elsevier eBooks · doi:10.1016/c2013-0-15980-6 · Cited by 3,715
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614
Salivary cortisol in psychoneuroendocrine research: recent developments and applications
Kirschbaum, C., & Hellhammer, D. H. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90013-2 · Cited by 2,107
Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood
Heim, C. (2000) · JAMA · doi:10.1001/jama.284.5.592 · Cited by 1,968
Williams Textbook of Endocrinology
Stoffer, S. S. (1999) · JAMA · doi:10.1001/jama.281.9.851 · Cited by 1,245
Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
Pariante, C. M., & Miller, A. H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01088-x · Cited by 1,147
Self-citation

Show all 75 references

Sorted by citations

The HPA axis in major depression: classical theories and new developments
Pariante, C. M., & Lightman, S. L. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.06.006 · Cited by 2,009
Self-citation
The Role of Early Life Stress in Adult Psychiatric Disorders: A Systematic Review According to Childhood Trauma Subtypes
Carr, C. P., Martins, C. M. S., Stingel, A. M., Lemgruber, V. B., & Juruena, M. F. (2013) · Journal of Nervous & Mental Disease · doi:10.1097/nmd.0000000000000049 · Cited by 802
Self-citation
The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression
Kim, Y.-K., Na, K.-S., Myint, A.-M., & Leonard, B. E. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.06.008 · Cited by 620
The glucocorticoid receptor: Pivot of depression and of antidepressant treatment?
Anacker, C., Zunszain, P. A., Carvalho, L. A., & Pariante, C. M. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.03.007 · Cited by 592
Self-citation
Glucocorticoids, cytokines and brain abnormalities in depression
Zunszain, P. A., Anacker, C., Cattaneo, A., Carvalho, L. A., & Pariante, C. M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.04.011 · Cited by 554
Self-citation
Relations among posttraumatic stress disorder, comorbid major depression, and HPA function: A systematic review and meta-analysis
Morris, M. C., Compas, B. E., & Garber, J. (2012) · Clinical Psychology Review · doi:10.1016/j.cpr.2012.02.002 · Cited by 466
The Role of Early Life Stress in HPA Axis and Anxiety
Juruena, M. F., Eror, F., Cleare, A. J., & Young, A. H. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9705-0_9 · Cited by 445
Self-citation
Inflammation and depression: a causal or coincidental link to the pathophysiology?
Leonard, B. E. (2018) · Acta Neuropsychiatrica · doi:10.1017/neu.2016.69 · Cited by 409
Atypical depression and non-atypical depression: Is HPA axis function a biomarker? A systematic review
Juruena, M. F., Bocharova, M., Agustini, B., & Young, A. H. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.09.052 · Cited by 365
Self-citation
Salivary cortisol in depressed patients versus control persons: A systematic review and meta-analysis
Knorr, U., Vinberg, M., Kessing, L. V., & Wetterslev, J. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.04.001 · Cited by 317
Abnormal cortisol levels during the day and cortisol awakening response in first-episode psychosis: The role of stress and of antipsychotic treatment
Mondelli, V., Dazzan, P., Hepgul, N., Di Forti, M., Aas, M., D'Albenzio, A., Di Nicola, M., Fisher, H., Handley, R., Marques, T. R., et al. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2009.08.013 · Cited by 278
Self-citation
Cortisol and major depressive disorder-translating findings from humans to animal models and Back
Nandam, L. S., Brazel, M., Zhou, M., & Jhaveri, D. J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00974 · Cited by 265
Early-life stress and HPA axis trigger recurrent adulthood depression
Juruena, M. F. (2013) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2013.10.020 · Cited by 270
Self-citation
The brain mineralocorticoid receptor and stress resilience
ter Heegde, F., De Rijk, R. H., & Vinkers, C. H. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.10.022 · Cited by 187
Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed
Alt, S. R., Turner, J. D., Klok, M. D., Meijer, O. C., Lakke, E. A. J. F., DeRijk, R. H., & Muller, C. P. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.09.001 · Cited by 184
Risk Factors for Development of Depression and Psychosis
Pariante, C. M. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04978.x · Cited by 185
Self-citation
Glucocorticoid Dysregulations and Their Clinical Correlates: From Receptors to Therapeutics
Marques, A. H., Silverman, M. N., & Sternberg, E. M. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04987.x · Cited by 158
Neurobiology of resilience in depression: immune and vascular insights from human and animal studies
Dudek, K., Dion‐Albert, L., Kaufmann, F. N., Tuck, E., Lebel, M., & Ménard, C. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14547 · Cited by 168
Synaptic regulation of the hypothalamic–pituitary–adrenal axis and its modulation by glucocorticoids and stress
Levy, B. H., & Tasker, J. G. (2012) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2012.00024 · Cited by 153
“Inflamed” depression: A review of the interactions between depression and inflammation and current anti-inflammatory strategies for depression
Yin, Y., Ju, T., Zeng, D., Duan, F., Zhu, Y., Liu, J., Li, Y., & Lu, W. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107322 · Cited by 159
Glucocorticoid receptor protein expression in human hippocampus; stability with age
Wang, Q., Van Heerikhuize, J., Aronica, E., Kawata, M., Seress, L., Joels, M., Swaab, D. F., & Lucassen, P. J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.019 · Cited by 144
Association between Glucocorticoid Receptor Methylation and Hippocampal Subfields in Major Depressive Disorder
Na, K., Chang, H. S., Won, E., Han, K., Choi, S., Tae, W., Yoon, H., Kim, Y., Joe, S., Jung, I., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085425 · Cited by 144
Major depression, cognitive dysfunction and Alzheimer's disease: Is there a link?
Sierksma, A. S. R., van den Hove, D. L. A., Steinbusch, H. W. M., & Prickaerts, J. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.10.021 · Cited by 139
Neurobiological Mechanisms of Stress Resilience and Implications for the Aged Population
Faye, C., McGowan, J. C., Denny, C. A., & David, D. J. P. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666170818095105 · Cited by 143
Modulation of the mineralocorticoid receptor as add-on treatment in depression: A randomized, double-blind, placebo-controlled proof-of-concept study
Otte, C., Hinkelmann, K., Moritz, S., Yassouridis, A., Jahn, H., Wiedemann, K., & Kellner, M. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.10.006 · Cited by 129
Whole-blood expression of inflammasome- and glucocorticoid-related mRNAs correctly separates treatment-resistant depressed patients from drug-free and responsive patients in the BIODEP study
Cattaneo, A., Ferrari, C., Turner, L., Mariani, N., Enache, D., Hastings, C. N. M., Kose, M., Lombardo, G., McLaughlin, A. P., Nettis, M. A., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00874-7 · Cited by 120
Self-citation
Prednisolone suppression test in depression: prospective study of the role of HPA axis dysfunction in treatment resistance
Juruena, M. F., Pariante, C. M., Papadopoulos, A. S., Poon, L., Lightman, S. L., & Cleare, A. J. (2009) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.108.050278 · Cited by 112
Self-citation
Neuroimmune and neuroendocrine abnormalities in depression: two sides of the same coin
Horowitz, M. A., & Zunszain, P. A. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12781 · Cited by 118
Glucocorticoid resistance in chronic diseases
Rodriguez, J. M., Monsalves‐Álvarez, M., Henríquez, S., Llanos, M. N., & Troncoso, R. (2016) · Steroids · doi:10.1016/j.steroids.2016.09.010 · Cited by 109
Increased Serum Levels of Cortisol and Inflammatory Cytokines in People With Depression
Jia, Y., Liu, L., Sheng, C.-Q., Cheng, Z., Cui, L., Li, M., Zhao, Y., Shi, T., Yau, T. O., Li, F., et al. (2019) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000000957 · Cited by 108
Long term effects of childhood trauma on cortisol stress reactivity in adulthood and relationship to the occurrence of depression
Suzuki, A., Poon, L., Papadopoulos, A. S., Kumari, V., & Cleare, A. J. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.09.007 · Cited by 102
Self-citation
Examination of peripheral basal and reactive cortisol levels in major depressive disorder and the burnout syndrome: A systematic review
Rothe, N., Steffen, J., Penz, M. S., Kirschbaum, C., & Walther, A. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.024 · Cited by 90
Assessment of the hypothalamic–pituitary–adrenal axis activity: glucocorticoid receptor and mineralocorticoid receptor function in depression with early life stress – a systematic review
Baes, C. V. W., Tofoli, S. M. D. C., Martins, C. M. S., & Juruena, M. F. (2011) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2011.00610.x · Cited by 80
Self-citation
The Serotonin Transporter and Early Life Stress: Translational Perspectives
Houwing, D. J., Buwalda, B., van der Zee, E. A., de Boer, S. F., & Olivier, J. D. A. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00117 · Cited by 83
Epigenetics: A missing link between early life stress and depression
Juruena, M. F., Gadelrab, R., Cleare, A. J., & Young, A. H. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110231 · Cited by 80
Self-citation
Gastrodiae Rhizoma (天麻 tiān má): a review of biological activity and antidepressant mechanisms
Chen, P., & Sheen, L. (2011) · Journal of Traditional and Complementary Medicine · doi:10.1016/s2225-4110(16)30054-2 · Cited by 75
The Role of Saliva Cortisol Measurement in Health and Disease
Karlson, B., Lindfors, P., Riva, R., Theorell, T., Lundberg, U., & Mellner, C. (2012) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/97816080534211120101 · Cited by 74
Early life stress, HPA axis, and depression.
Tofoli, S. M. D. C., Baes, C. V. W., Martins, C. M. S., & Juruena, M. F. (2011) · Psychology & Neuroscience · doi:10.3922/j.psns.2011.2.008 · Cited by 73
Self-citation
Assessment of Depression in a Rodent Model of Spinal Cord Injury
Luedtke, K., Bouchard, S. M., Woller, S. A., Funk, M. K., Aceves, M., & Hook, M. A. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2013.3204 · Cited by 73
Diurnal alterations in circadian genes and peptides in major depressive disorder before and after escitalopram treatment
Li, S., Liu, L.-J., Xu, L., Gao, L., Wang, X., Zhang, J., & Lü, L. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.07.009 · Cited by 71
The role of mineralocorticoid receptor function in treatment-resistant depression
Juruena, M. F., Pariante, C. M., Papadopoulos, A. S., Poon, L., Lightman, S. L., & Cleare, A. J. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113499205 · Cited by 71
Self-citation
Microglia and HPA axis in depression: An overview of participation and relationship
Pereira, G. C., Piton, E., dos Santos, B. M., Ramanzini, L. G., Camargo, L. F. M., da Silva, R. M., & Bochi, G. V. (2021) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2021.1939154 · Cited by 72
In vitromodulation of the glucocorticoid receptor by antidepressants
Carvalho, L. A., & Pariante, C. M. (2008) · Stress · doi:10.1080/10253890701850759 · Cited by 69
Self-citation
Early Life Stress in Depressive Patients: Role of Glucocorticoid and Mineralocorticoid Receptors and of Hypothalamic-Pituitary-Adrenal Axis Activity
Juruena, M. F., Baes, C. V. W., Menezes, I. C., & Graeff, F. G. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666150105125500 · Cited by 69
Self-citation
Animal inflammation-based models of depression and their application to drug discovery
Ma, L., Demin, K. A., Kolesnikova, T. O., Kharsko, S. L., Zhu, X., Yuan, X., Song, C., Мешалкина, Д. А., Leonard, B. E., Tian, L., et al. (2017) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2017.1362385 · Cited by 71
Superposição entre depressão atípica, doença afetiva sazonal e síndrome da fadiga crônica
Juruena, M. F., & Cleare, A. J. (2007) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462007000500005 · Cited by 68
Self-citation
Hypothalamic-Pituitary-Adrenal axis dysfunction by early life stress
Juruena, M. F., Bourne, M., Young, A. H., & Cleare, A. J. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136037 · Cited by 73
Self-citation
Stress induced neural reorganization: A conceptual framework linking depression and Alzheimer's disease
Ross, J. A., Gliebus, G. P., & Bockstaele, E. J. V. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.08.004 · Cited by 63
Towards a “Metabolic” Subtype of Major Depressive Disorder: Shared Pathophysiological Mechanisms May Contribute to Cognitive Dysfunction
Liu, C., Carvalho, A., & McIntyre, R. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130204031 · Cited by 61
Adult Hippocampal Neurogenesis in Depression: Behavioral Implications and Regulation by the Stress System
Anacker, C. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_275 · Cited by 63
Early Life Stress in Depressive Patients: HPA Axis Response to GR and MR Agonist
Baes, C. V. W., Martins, C. M. S., Tofoli, S. M. D. C., & Juruena, M. F. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00002 · Cited by 63
Self-citation
Glucocorticoids prime the inflammatory response of human hippocampal cells through up-regulation of inflammatory pathways
Horowitz, M. A., Cattaneo, A., Cattane, N., Lopizzo, N., Tojo, L. M., Bakunina, N., Musaelyan, K., Borsini, A., Zunszain, P. A., & Pariante, C. M. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.03.012 · Cited by 61
Self-citation
Depressão e estresse: existe um endofenótipo?
Mello, A. F., Juruena, M. F., Pariante, C. M., Tyrka, A. R., Price, L. H., Carpenter, L. L., & Del Porto, J. A. (2007) · Revista Brasileira de Psiquiatria · doi:10.1590/s1516-44462007000500004 · Cited by 56
Self-citation
Characterization of a glucocorticoid receptor gene (GR, NR3C1) promoter polymorphism reveals functionality and extends a haplotype with putative clinical relevance
Kumsta, R., Moser, D., Streit, F., Koper, J. W., Meyer, J., & Wüst, S. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30837 · Cited by 55
Neuroendocrine Stress System in Bipolar Disorder
Juruena, M. F., Cleare, A. J., & Young, A. H. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_184 · Cited by 51
Self-citation
The acute effects of a mineralocorticoid receptor (MR) agonist on nocturnal hypothalamic–adrenal–pituitary (HPA) axis activity in healthy controls
Buckley, T. M., Mullen, B. C., & Schatzberg, A. F. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.05.016 · Cited by 51
Icaritin opposes the development of social aversion after defeat stress via increases of GR mRNA and BDNF mRNA in mice
Wu, X., Wu, J., Xia, S., Li, B., & Dong, J. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.09.034 · Cited by 52
Histories of major depression and premenstrual dysphoric disorder: Evidence for phenotypic differences
Klatzkin, R. R., Lindgren, M. E., Forneris, C. A., & Girdler, S. S. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2010.01.018 · Cited by 54
Antidepressant Outcomes Predicted by Genetic Variation in Corticotropin-Releasing Hormone Binding Protein
O’Connell, C. P., Goldstein‐Piekarski, A. N., Nemeroff, C. B., Schatzberg, A. F., DeBattista, C., Carrillo‐Roa, T., Binder, E. B., Dunlop, B. W., Craighead, W. E., Mayberg, H. S., et al. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.17020172 · Cited by 52
The prednisolone suppression test in depression: Dose–response and changes with antidepressant treatment
Juruena, M. F., Cleare, A. J., Papadopoulos, A. S., Poon, L., Lightman, S. L., & Pariante, C. M. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.04.016 · Cited by 49
Self-citation
The antidepressant desipramine requires the ABCB1 (Mdr1)-type p-glycoprotein to upregulate the glucocorticoid receptor in mice
Yau, J. L. W., Noble, J., Thomas, S., Kerwin, R., Morgan, P. E., Lightman, S., Seckl, J. R., & Pariante, C. M. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301389 · Cited by 46
Self-citation
From feedback loop transitions to biomarkers in the psycho-immune-neuroendocrine network: Detecting the critical transition from health to major depression
Stapelberg, N. J. C., Pratt, R., Neumann, D. L., Shum, D., Brandis, S. J., Muthukkumarasamy, V., Stantić, B., Blumenstein, M., & Headrick, J. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.005 · Cited by 45
Reduced DNA methylation and psychopathology following endogenous hypercortisolism – a genome-wide study
Glad, C. A. M., Andersson‐Assarsson, J. C., Berglund, P., Bergthorsdottir, R., Ragnarsson, Ó., & Johannsson, G. (2017) · Scientific Reports · doi:10.1038/srep44445 · Cited by 48
Posttraumatic stress disorder (PTSD) and depression severity in sexually assaulted women: hypothalamic-pituitary-adrenal (HPA) axis alterations
D'Elia, A. T., Juruena, M. F., Coimbra, B. M., Mello, M. F., & Mello, A. F. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03170-w · Cited by 44
Self-citation
Childhood traumata, Dexamethasone Suppression Test and psychiatric symptoms: a trans-diagnostic approach
Faravelli, C., Amedei, S. G., Rotella, F., Faravelli, L., Palla, A., Consoli, G., Ricca, V., Batini, S., Sauro, C. L., Spiti, A., et al. (2010) · Psychological Medicine · doi:10.1017/s0033291710000115 · Cited by 43
The zebrafish as an in vivo model system for glucocorticoid resistance
Schoonheim, P. J., Chatzopoulou, A., & Schaaf, M. J. M. (2010) · Steroids · doi:10.1016/j.steroids.2010.05.010 · Cited by 44
Hippocampal GR expression is increased in elderly depressed females
Wang, Q., Joëls, M., Swaab, D. F., & Lucassen, P. J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.09.014 · Cited by 48
Convergence of endothelial dysfunction, inflammation and glucocorticoid resistance in depression-related cardiovascular diseases
Hage, Z., Madeira, M. M., Koliatsis, D., & Tsirka, S. E. (2024) · BMC Immunology · doi:10.1186/s12865-024-00653-9 · Cited by 45
Antistress properties of antidepressant drugs and their clinical implications
Calabrese, F., Molteni, R., & Riva, M. A. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.05.007 · Cited by 42
Glucocorticoids, metabolism and brain activity
Jaszczyk, A., & Juszczak, G. R. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.03.007 · Cited by 43
Improved stress response in bipolar affective disorder with adjunctive spironolactone (mineralocorticoid receptor antagonist): case series
Juruena, M., Gama, C., Berk, M., & Belmonte-de-Abreu, P. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881108092121 · Cited by 38
Self-citation
Cognitive correlates of hypothalamic–pituitary–adrenal axis in major depression
Schlosser, N., Wolf, O. T., & Wingenfeld, K. (2011) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.10.79 · Cited by 33
Central glucocorticoid receptor-mediated effects of the antidepressant, citalopram, in humans: a study using EEG and cognitive testing
Pariante, C. M., Alhaj, H. A., Arulnathan, V. E., Gallagher, P., Hanson, A., Massey, E., & McAllister-Williams, R. H. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.08.011 · Cited by 33
Self-citation
Characterization of a Novel Gain of Function Glucocorticoid Receptor Knock-in Mouse
Zhang, J., Ge, R., Matte-Martone, C. C., Goodwin, J. E., Shlomchik, W. D., Mamula, M. J., Kooshkabadi, A., Hardy, M. P., & Geller, D. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807997200 · Cited by 31
Neurovascular glucocorticoid receptors and glucocorticoids: implications in health, neurological disorders and drug therapy
Williams, S., & Ghosh, C. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.09.009 · Cited by 24
Proteomic Profiling as a Diagnostic Biomarker for Discriminating Between Bipolar and Unipolar Depression
Kittel‐Schneider, S., Hahn, T., Haenisch, F., McNeill, R. V., Reif, A., & Bahn, S. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00189 · Cited by 23
Biological outcome measurements for behavioral interventions in multiple sclerosis
Fischer, A., Heesen, C., & Gold, S. M. (2011) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285611405252 · Cited by 23
Neuroendocrine Abnormalities in Major Depression: An Insight Into Glucocorticoids, Cytokines, and the Kynurenine Pathway
Nikkheslat, N., Pariante, C. M., & Zunszain, P. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811073-7.00003-9 · Cited by 23
Self-citation
Differential Diagnosis of Major Depressive Disorder and Bipolar Disorder: Genetic and Hormonal Assessment and the Influence of Early-Life Stress
Menezes, I. C., Baes, C. V. W., Fígaro-Drumond, F. V., Macedo, B. B. D., Bueno, A. C., Lacchini, R., Mello, M. F., de Castro, M., & Juruena, M. F. (2022) · Brain Sciences · doi:10.3390/brainsci12111476 · Cited by 19
Self-citation
Inulae Flos has Anti-Depressive Effects by Suppressing Neuroinflammation and Recovering Dysfunction of HPA-axis
Kim, J. S., Kim, J. H., Eo, H., Ju, I. G., Son, S.-R., Kim, J., Jang, D. S., & Oh, M. S. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04094-8 · Cited by 17
Gene signatures for cancer research: A 25-year retrospective and future avenues
Liu, W., He, H., & Chicco, D. (2024) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1012512 · Cited by 15
Resting-state cerebral blood flow in amygdala is modulated by sex and serotonin transporter genotype
El‐Hage, W., Zelaya, F. O., Raduà, J., Gohier, B., Alsop, D. C., Phillips, M. L., & Surguladze, S. A. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.03.003 · Cited by 14
Effect of the glucocorticoid receptor antagonist Org 34850 on fast and delayed feedback of corticosterone release
Spiga, F., Harrison, L., Wood, S. A., MacSweeney, C. P., THOMSON, F. J., Craighead, M. W., Grassie, M. A., & Lightman, S. L. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0503 · Cited by 14
Self-citation
Modeling inter-sex and inter-individual variability in response to chronopharmacological administration of synthetic glucocorticoids
Scherholz, M. L., Rao, R., & Androulakis, I. P. (2019) · Chronobiology International · doi:10.1080/07420528.2019.1660357 · Cited by 13
Injectable Dexamethasone Sodium Phosphate Administered Orally? A Pharmacokinetic Analysis of a Common Emergency Department Practice
Toledo, A., Amato, C. S., Clarke, N. J., Reitz, R. E., & Salo, D. F. (2015) · The Journal of Pediatric Pharmacology and Therapeutics · doi:10.5863/1551-6776-20.2.105 · Cited by 13
The neuroimmune mechanism of pain induced depression in psoriatic arthritis and future directions
Wang, X., Wu, L., Liu, J., Ma, C., Liu, J., & Zhang, Q. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117802 · Cited by 12
Lactobacillus fermentum ATCC 9338 Supplementation Prevents Depressive-Like Behaviors Through Glucocorticoid Receptor and N-Methyl-D-aspartate2b in Chronic Unpredictable Mild Stress Mouse Model
Tiwari, S., & Paramanik, V. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04738-3 · Cited by 12
Early response to venlafaxine antidepressant correlates with lower ACTH levels prior to pharmacological treatment
Araya, A. V., Rojas, P., Rosemarie Fritsch, M., Rojas, R., Herrera, L., Rojas, G., Gatica, H., Silva, H., & Fiedler, L. (2006) · Endocrine · doi:10.1007/s12020-006-0007-2 · Cited by 11
Major depressive disorder: a possible typisation according to serotonin, inflammation, and metabolic syndrome
Silić, A., Vukojević, J., Peitl, V., Binder, M. D., & Karlović, D. (2021) · Acta Neuropsychiatrica · doi:10.1017/neu.2021.30 · Cited by 10
Aldosterone Action on Brain and Behavior
Murck, H. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00052-3 · Cited by 10
Unipolar depression
Pariante, C. M., & Nemeroff, C. B. (2012) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52002-9.00014-0 · Cited by 10
Self-citation
Mechanisms of Xiong-Pi-Fang in treating coronary heart disease associated with depression: A systematic pharmacology strategy and in vivo pharmacological validation
Deng, F., Li, X., Tang, C., Chen, J., Fan, B., Liang, J., Zhen, X., Tao, R., Zhang, S., Cong, Z., et al. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115631 · Cited by 9
The pathophysiology of major depressive disorder through the lens of systems biology: Network analysis of the psycho-immune-neuroendocrine physiome
Stapelberg, N. J. C., Bui, T. A., Mansour, V., Johnson, S., Branjerdporn, G., Adhikary, S. R., Ashton, K. J., Taylor, N., & Headrick, J. P. (2022) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2022.577959 · Cited by 9
Depression and the hypothalamic-pituitary-adrenal axis: increasing the scope
Andreatini, R. (2012) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2011.00645.x · Cited by 9
The Role of Early Life Stress in HPA Axis and Depression
Juruena, M. F., Cleare, A. J., & Young, A. H. (2017) · Springer eBooks · doi:10.1007/978-981-10-6580-4_5 · Cited by 9
Self-citation
Fresh approaches to antidepressant drug discovery
Anacker, C. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.892071 · Cited by 9
Biological Models of Unipolar Depression
Cleare, A. J. (2004) · Wiley eBooks · doi:10.1002/9780470696385.ch2 · Cited by 8
Self-citation
Early life stress, depression and epigenetics
Juruena, M. F. (2023) · Vitamins and hormones · doi:10.1016/bs.vh.2023.01.004 · Cited by 9
Self-citation
Beta 3‐adrenoceptor agonism ameliorates early‐life stress‐induced visceral hypersensitivity in male rats
Collins, J. M., Hyland, N. P., Clarke, G. A., Fitzgerald, P., Julio‐Pieper, M., Bulmer, D. C., Dinan, T. G., Cryan, J. F., & O’Mahony, S. M. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15804 · Cited by 7
Childhood adversity and the cortisol awakening response in depression: A meta-analysis
Jopling, E. N., & LeMoult, J. (2023) · Journal of Mood and Anxiety Disorders · doi:10.1016/j.xjmad.2023.100014 · Cited by 7

Authors: Juruena, M. F., Cleare, A. J., Papadopoulos, A. S., Poon, L., Lightman, S., & Pariante, C. M.
Affiliations: King's College London (GB)
Bethlem Royal Hospital (GB)
University of Bristol (GB)
Corresponding author: Pariante, Carmine M.
ORCID: Cleare, Anthony J.
Lightman, Stafford
Pariante, Carmine M.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2006-10-03
Volume: 189
Issue: 2
Pages: 225-235
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-006-0555-4
OpenAlex: W2080795205
Cited by: 147
References: 75
Citations by year: 2026: 2 · 2025: 2 · 2024: 9 · 2023: 6 · 2022: 6 · 2021: 9 · 2020: 9 · 2019: 8 · 2018: 4 · 2017: 12 · 2016: 3 · 2015: 10 · 2014: 8 · 2013: 11 · 2012: 7
FWCI: 2.87
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Bristol Research (University of Bristol) (submittedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords: major depressive disorder, dexamethasone suppression test, hypothalamic-pituitary-adrenal axis, HPA axis hyperactivity, glucocorticoid receptor, mineralocorticoid receptor, salivary cortisol, treatment-resistant depression, childhood trauma
MeSH terms: Major Depressive Disorder, Dexamethasone, Female, Glucocorticoids, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Middle Aged, Pituitary-Adrenal System, Prednisolone, Receptors, Glucocorticoid, Saliva, Salivary Glands, Single-Blind Method, Receptors, Mineralocorticoid, Area Under Curve

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Different responses to dexamethasone and prednisolone in the same depressed patients

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks