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Cited by 147Stress Responses and CortisolAdrenal Hormones and DisordersHormonal Regulation and Hypertension

The DOI matches its Crossref record; 74 of the 75 references it cites were found in a registry or an index.

Different responses to dexamethasone and prednisolone in the same depressed patients

Juruena, Mario F., Cleare, Anthony J., Papadopoulos, Andrew S., Poon, Lucia, Lightman, Stafford, Pariante, Carmine M.·2006·Psychopharmacology
DOI 10.1007/s00213-006-0555-4
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Abstract

Rationale Patients with major depression show hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, but the mechanisms underlying this abnormality are still unclear.Objectives We have compared two synthetic glucorticoids, dexamethasone and prednisolone, in their ability to suppress the hypothalamic-pituitary-adrenal (HPA) axis in depressed patients. Dexamethasone probes glucocorticoid receptor (GR) function, while prednisolone probes both GR and mineralocorticoid receptor (MR) function.Materials and methods We used a single-blind, repeated-measure design. We administered placebo, prednisolone (5 mg) or dexamethasone (0.5 mg), at 22:00, to 18 severe, treatment-resistant depressed inpatients (15 of them with a history of childhood trauma) and 14 healthy volunteers. On the following days, we collected salivary cortisol from 9:00 to 22:00.Results Depressed patients had higher salivary cortisol levels compared with controls, at baseline and after both prednisolone and dexamethasone (p<0.001). Consistent with previous studies, depressed inpatients showed impaired suppression by dexamethasone: based on the analysis of the areas under the curve (AUCs), suppression by dexamethasone (0.5 mg) was -85% in controls vs -46% in depressed patients (p=0.018). However, the same depressed patients showed normal suppression by prednisolone (5 mg): suppression was -41% in controls and -36% in depressed patients (p=0.6).Conclusions We suggest that the additional effects of prednisolone on the MR explain the different responses to these glucocorticoids in the same depressed patients.

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Metadata

Authors
Juruena, M. F., Cleare, A. J., Papadopoulos, A. S., Poon, L., Lightman, S., & Pariante, C. M.
Affiliations
  • King's College London (GB)
  • Bethlem Royal Hospital (GB)
  • University of Bristol (GB)
Corresponding author
Pariante, Carmine M.
ORCID
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2006-10-03
Volume
189
Issue
2
Pages
225-235
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/s00213-006-0555-4
OpenAlex
W2080795205
Cited by
147
References
75
Citations by year
2026: 2 · 2025: 2 · 2024: 9 · 2023: 6 · 2022: 6 · 2021: 9 · 2020: 9 · 2019: 8 · 2018: 4 · 2017: 12 · 2016: 3 · 2015: 10 · 2014: 8 · 2013: 11 · 2012: 7
FWCI
2.87
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
  • Bristol Research (University of Bristol) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords
major depressive disorder, dexamethasone suppression test, hypothalamic-pituitary-adrenal axis, HPA axis hyperactivity, glucocorticoid receptor, mineralocorticoid receptor, salivary cortisol, treatment-resistant depression, childhood trauma
MeSH terms
Major Depressive Disorder, Dexamethasone, Female, Glucocorticoids, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Middle Aged, Pituitary-Adrenal System, Prednisolone, Receptors, Glucocorticoid, Saliva, Salivary Glands, Single-Blind Method, Receptors, Mineralocorticoid, Area Under Curve

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