Cerebral glucose metabolism and D2/D3 receptor availability in young adults with cannabis dependence measured with positron emission tomography
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Introduction Cannabis users have been reported to have decreased regional cerebral glucose metabolism after short periods of abstinence. The purpose of this study was to measure striatal dopamine receptor (D2/D3) availability and cerebral glucose metabolism with positron emission tomography (PET) in young adults who had a prolonged exposure to cannabis and who had been abstinent for a period of at least 12 weeks.Materials and methods Six 18-21-year-old male subjects with cannabis dependence in early full remission and six age- and sex-matched healthy subjects underwent PET scans for D2/D3 receptor availability measured with [C11]-raclopride and glucose metabolism measured with [18F]-FDG. All subjects were sober for at least 12 weeks before PET scan procedures. PET data were analyzed with statistical parametric mapping software (SPM99; uncorrected p < 0.001, corrected p < 0.05 at the cluster level). Toxicology screening was performed prior to the PET scan to confirm the lack of drugs of abuse.Observation and results Striatal D2/D3 receptor availability did not differ significantly between groups. Compared to controls, subjects with cannabis dependence had lower normalized glucose metabolism in the right orbitofrontal cortex, putamen bilaterally, and precuneus. There were no significant correlations between striatal D2/D3 receptor availability and normalized glucose metabolism in any region of the frontal cortex or striatum.Conclusion These findings may reflect both cannabis exposure and adaptive changes that occur after a prolonged period of abstinence. Subsequent studies should address whether metabolic and dopamine receptor effects are associated with either active use or longer-term withdrawal in these relatively young subjects.
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Studies of cannabis abuse have not shown the same decrease in D2 receptor binding.
“Notably, studies of cannabis abuse have not shown this same decrease in D2 receptor binding (Albrecht et al., 2013b; Sevy et al., 2008; Stokes et al., 2012; Urban et al., 2012).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Sevy et al., 2008
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- Authors
- Sevy, S., Smith, G. S., Ma, Y., Dhawan, V., Chaly, T., Kingsley, P. B., Kumra, S., Abdelmessih, S., & Eidelberg, D.
- Affiliations
- Northwell Health (US)
- Centre for Addiction and Mental Health (CA)
- Feinstein Institute for Medical Research (US)
- North Shore University Hospital (US)
- University of Minnesota (US)
- Corresponding author
- Sevy, Serge
- Venue
- Psychopharmacology
- Published
- 2008-02-13
- Volume
- 197
- Issue
- 4
- Pages
- 549-556
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC5646272
- OpenAlex
- W2051075914
- Cited by
- 83
- References
- 43
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 6 · 2017: 1 · 2016: 8 · 2015: 5 · 2014: 9 · 2013: 8 · 2012: 9
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (K02 MH 01621, R01MH064823, MH 64823, K02MH001621)
- National Institute on Drug Abuse (K23DA015541)
- National Center for Research Resources (M01RR000056, M01RR018535)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- cannabis use disorder, brain glucose metabolism, striatum, abstinence, 18F-FDG, orbitofrontal cortex, putamen, precuneus, young adults, cannabis withdrawal
- MeSH terms
- Adolescent, Adult, Blood Glucose, Marijuana Abuse, Corpus Striatum, Dominance, Cerebral, Frontal Lobe, Humans, Male, Parietal Lobe, Reference Values, Receptors, Dopamine D2, Fluorodeoxyglucose F18, Raclopride, Positron-Emission Tomography
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