Phospholipase A2 activation as a therapeutic approach for cognitive enhancement in early-stage Alzheimer disease
Abstract
Rationale Alzheimer disease (AD) is the leading cause of dementia in the elderly and has no known cure. Evidence suggests that reduced activity of specific subtypes of intracellular phospholipases A2 (cPLA2 and iPLA2) is an early event in AD and may contribute to memory impairment and neuropathology in the disease.Objective The objective of this study was to review the literature focusing on the therapeutic role of PLA2 stimulation by cognitive training and positive modulators, or of supplementation with arachidonic acid (PLA2 product) in facilitating memory function and synaptic transmission and plasticity in either research animals or human subjects.Methods MEDLINE database was searched (no date restrictions) for published articles using the keywords Alzheimer disease (mild, moderate, severe), mild cognitive impairment, healthy elderly, rats, mice, phospholipase A(2), phospholipid metabolism, phosphatidylcholine, arachidonic acid, cognitive training, learning, memory, long-term potentiation, protein kinases, dietary lipid compounds, cell proliferation, neurogenesis, and neuritogenesis. Reference lists of the identified articles were checked to select additional studies of interest.Results Overall, the data suggest that PLA2 activation is induced in the healthy brain during learning and memory. Furthermore, learning seems to regulate endogenous neurogenesis, which has been observed in AD brains. Finally, PLA2 appears to be implicated in homeostatic processes related to neurite outgrowth and differentiation in both neurodevelopmental processes and response to neuronal injury.Conclusion The use of positive modulators of PLA2 (especially of cPLA2 and iPLA2) or supplementation with dietary lipid compounds (e.g., arachidonic acid) in combination with cognitive training could be a valuable therapeutic strategy for cognitive enhancement in early-stage AD.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There is reason to believe that non-pharmacological approaches based on these novel findings might be beneficial to ameliorate Alzheimer's disease symptoms.
“there is also reason to believe that non-pharmacological approaches based on these novel findings might be beneficial to ameliorate AD symptoms (Schaeffer et al., 2009).”
From The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease (2011) · cites this paper as Schaeffer et al., 2009
Cites
Current concepts in mild cognitive impairment
Petersen, R. C., Doody, R., Kurz, A., Mohs, R. C., Morris, J. C., Rabins, P. V., Ritchie, K., Rossor, M., Thal, L., & Winblad, B. (2001) · Archives of Neurology · doi:10.1001/archneur.58.12.1985 · Cited by 4,781 · see citing works
More hippocampal neurons in adult mice living in an enriched environment
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,513 · see citing works
Learning enhances adult neurogenesis in the hippocampal formation
Gould, E., Beylin, A., Tanapat, P., Reeves, A., & Shors, T. J. (1999) · Nature Neuroscience · doi:10.1038/6365 · Cited by 2,157 · see citing works
Petersen, R. C., Stevens, J. C., Ganguli, M., Tangalos, E. G., Cummings, J. L., & DeKosky, S. T. (2001) · Neurology · doi:10.1212/wnl.56.9.1133 · Cited by 2,065 · see citing works
cPLA2 is phosphorylated and activated by MAP kinase
Lin, L., Wartmann, M., Lin, A. Y., Knopf, J. L., Seth, A., & Davis, R. J. (1993) · Cell · doi:10.1016/0092-8674(93)90666-e · Cited by 1,851 · see citing works
Diversity of group types, regulation, and function of phospholipase A2.
Dennis, E. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36794-7 · Cited by 1,435 · see citing works
The expanding superfamily of phospholipase A2 enzymes: classification and characterization
Six, D. A., & Dennis, E. A. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00105-0 · Cited by 1,359 · see citing works
Neurogenesis in the Neocortex of Adult Primates
Gould, E., Reeves, A. J., Graziano, M. S. A., & Gross, C. G. (1999) · Science · doi:10.1126/science.286.5439.548 · Cited by 1,262 · see citing works
Experience-Induced Neurogenesis in the Senescent Dentate Gyrus
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03206.1998 · Cited by 1,150 · see citing works
Prostaglandins stimulate calcium-dependent glutamate release in astrocytes
Bezzi, P., Carmignoto, G., Pasti, L., Vesce, S., Rossi, D., Rizzini, B. L., Pozzan, T., & Volterra, A. (1998) · Nature · doi:10.1038/34651 · Cited by 1,143 · see citing works
Jin, K., Minami, M., Lan, J., Mao, X., Batteur, S., Simon, R., & Greenberg, D. A. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.081011098 · Cited by 1,117 · see citing works
Increased hippocampal neurogenesis in Alzheimer's disease
Jin, K., Peel, A. L., Mao, X. O., Xie, L., Cottrell, B. A., Henshall, D. C., & Greenberg, D. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2634794100 · Cited by 971 · see citing works
The growing phospholipase A2 superfamily of signal transduction enzymes
Dennis, E. A. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)20031-3 · Cited by 807 · see citing works
The C2 domain calcium‐binding motif: Structural and functional diversity
Nalefski, E. A., & Falke, J. (1996) · Protein Science · doi:10.1002/pro.5560051201 · Cited by 802 · see citing works
Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures
Bengzon, J., Kokaia, Z., Elmér, E., Nanobashvili, A., Kokaia, M., & Lindvall, O. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.19.10432 · Cited by 782 · see citing works
Kudo, I., & Murakami, M. (2002) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(02)00020-5 · Cited by 757 · see citing works
Zhang, R. L., Zhang, Z. G., Zhang, L., & Chopp, M. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00117-8 · Cited by 576 · see citing works
Conquer, J. A., Tierney, M. C., Zecevic, J., Bettger, W. J., & Fisher, R. H. (2000) · Lipids · doi:10.1007/s11745-000-0646-3 · Cited by 523 · see citing works
Nemenoff, R. A., Winitz, S., Qian, N. X., Putten, V. V., Johnson, G. L., & Heasley, L. E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53948-x · Cited by 522 · see citing works
Colangelo, V., Schurr, J., Ball, M. J., Pelaez, R. P., Bazan, N. G., & Lukiw, W. J. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10351 · Cited by 517 · see citing works
Regional metabolic patterns in mild cognitive impairment and Alzheimer’s disease
Kantarci, K., Jack, C. R., Xu, Y., Campeau, N. G., O’Brien, P. C., Smith, G. E., Ivnik, R. J., Boeve, B. F., Kokmen, E., Tangalos, E. G., et al. (2000) · Neurology · doi:10.1212/wnl.55.2.210 · Cited by 460 · see citing works
Neurogenesis in adulthood: a possible role in learning
Gould, E. (1999) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(99)01310-8 · Cited by 430 · see citing works
Belleville, S., Gilbert, B., Fontaine, F. S., Gagnon, L., Ménard, É., & Gauthier, S. G. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000096316 · Cited by 417 · see citing works
Lesion-induced proliferation of neuronal progenitors in the dentate gyrus of the adult rat
Gould, E. A., & Tanapat, P. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00127-9 · Cited by 406 · see citing works
Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons
Dupret, D., Fabre, A., Döbrössy, M. D., Panatier, A., Rodriguez, J. J., Lamarque, S., Lemaire, V., Oliet, S. H. R., Piazza, P., & Abrous, D. N. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050214 · Cited by 387 · see citing works
Kempermann, G., Brandon, E. P., & Gage, F. H. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00377-6 · Cited by 385 · see citing works
Cameron, H. A., Tanapat, P., & Gould, E. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00303-5 · Cited by 381 · see citing works
Arachidonic acid induces a prolonged inhibition of glutamate uptake into glial cells
Barbour, B., Szatkowski, M. S., Ingledew, N., & Attwell, D. (1989) · Nature · doi:10.1038/342918a0 · Cited by 373 · see citing works
In vivo 1H MRS choline: Correlation with in vitro chemistry/histology
Miller, B. L., Changl, L., Booth, R. A., Ernst, T., Cornford, M. E., Nikas, D. L., McBride, D. Q., & Jenden, D. J. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00182-8 · Cited by 368 · see citing works
Gray, W. P., & Sundström, L. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00030-4 · Cited by 348 · see citing works
Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein.
Caporaso, G. L., Gandy, S., Buxbaum, J. D., Ramabhadran, T. V., & Greengard, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.3055 · Cited by 338 · see citing works
Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction
Kotani, S., Sakaguchi, E., Warashina, S., Matsukawa, N., Ishikura, Y., Kiso, Y., Sakakibara, M., Yoshimoto, T., Guo, J., & Yamashima, T. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.06.010 · Cited by 321 · see citing works
Phospholipase A₂-Generated Lipid Mediators in the Brain: The Good, the Bad, and the Ugly
Farooqui, A. A., & Horrocks, L. A. (2006) · The Neuroscientist · doi:10.1177/1073858405285923 · Cited by 273 · see citing works
Calcium-independent phospholipase A2: structure and function
Winstead, M. V., Balsinde, J., & Dennis, E. A. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00107-4 · Cited by 248 · see citing works
Cortical Neurogenesis in Adult Rats After Transient Middle Cerebral Artery Occlusion
Jiang, W., Gu, W., Brännström, T., Rosqvist, R., & Wester, P. O. (2001) · Stroke · doi:10.1161/01.str.32.5.1201 · Cited by 248 · see citing works
Enhanced neurogenesis after transient global ischemia in the dentate gyrus of the rat
Kee, N., Preston, E., & Wojtowicz, J. M. (2001) · Experimental Brain Research · doi:10.1007/s002210000591 · Cited by 244 · see citing works
Memory enhancement training for older adults with mild cognitive impairment: A preliminary study
Rapp, S. R., Brenes, G. A., & Marsh, A. P. (2002) · Aging & Mental Health · doi:10.1080/13607860120101077 · Cited by 237 · see citing works
Rozzini, L., Costardi, D., Chilovi, B. V., Franzoni, S., Trabucchi, M., & Padovani, A. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1681 · Cited by 233 · see citing works
Nagy, Z., Esiri, M. M., & Smith, A. D. (1997) · Acta Neuropathologica · doi:10.1007/s004010050617 · Cited by 225 · see citing works
Underwood, K. W., Song, C., Kriz, R., Chang, X. J., Knopf, J. L., & Lin, L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.34.21926 · Cited by 224 · see citing works
Chen, J., Engle, S. J., Seilhamer, J. J., & Tischfield, J. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41952-1 · Cited by 221 · see citing works
Cytosolic Phospholipase A2(cPLA2) Immunoreactivity Is Elevated in Alzheimer's Disease Brain
Stephenson, D. T., Lemere, C. A., Selkoe, D. J., & Clemens, J. A. (1996) · Neurobiology of Disease · doi:10.1006/nbdi.1996.0005 · Cited by 220 · see citing works
Larsson, P., Claesson, H., & Kennedy, B. P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.207 · Cited by 216 · see citing works
Spatial learning affects immature granule cell survival in adult rat dentate gyrus
Ambrogini, P., Cuppini, R., Cuppini, C., Ciaroni, S., Cecchini, T., Ferri, P., Sartini, S., & Grande, P. D. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01074-0 · Cited by 212 · see citing works
Mancuso, D. J., Jenkins, C. M., & Gross, R. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.9937 · Cited by 211 · see citing works
Molecular Cloning of Two New Human Paralogs of 85-kDa Cytosolic Phospholipase A2
Pickard, R. T., Strifler, B. A., Kramer, R. M., & Sharp, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8823 · Cited by 203 · see citing works
PI3 kinase signaling is required for retrieval and extinction of contextual memory
Chen, X., Garelick, M. G., Wang, H., Li, V., Athos, J., & Storm, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1482 · Cited by 188 · see citing works
Volterra, A., Trotti, D., Cassutti, P., Tromba, C., SALVAGGIO, A., Melcangi, R. C., & Racagni, G. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09411.x · Cited by 185 · see citing works
Relearning face-name associations in early Alzheimer's disease.
Clare, L., Wilson, B. A., Carter, G., Roth, I., & Hodges, J. R. (2002) · Neuropsychology · doi:10.1037/0894-4105.16.4.538 · Cited by 185 · see citing works
Alterations of cerebral metabolism in probable Alzheimer's disease: A preliminary study
Pettegrew, J. W., Panchalingam, K., Klunk, W. E., McClure, R. J., & Muenz, L. R. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)90152-x · Cited by 183 · see citing works
Phospholipase A2 isoforms: a perspective
Chakraborti, S. (2003) · Cellular Signalling · doi:10.1016/s0898-6568(02)00144-4 · Cited by 181 · see citing works
Increased Neurogenesis in Young Transgenic Mice Overexpressing Human APPSw,Ind
López-Toledano, M. A., & Shelanski, M. L. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-12304 · Cited by 177 · see citing works
Epp, J. R., Spritzer, M. D., & Galea, L. A. M. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.07.046 · Cited by 176 · see citing works
Jessen, F., Block, W., Träber, F., Keller, E., Flacke, S., Papassotiropoulos, A., Lamerichs, R. M. J. N., Heun, R., & Schild, H. H. (2000) · Neurology · doi:10.1212/wnl.55.5.684 · Cited by 174 · see citing works
Suzuki, N., Ishizaki, J., Yokota, Y., Higashino, K., Ono, T., Ikeda, M., Fujii, N., Kawamoto, K., & Hanasaki, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.8.5785 · Cited by 168 · see citing works
Relearning face-name associations in early Alzheimer's disease.
Clare, L., Wilson, B. A., Carter, G., Roth, I., & Hodges, J. R. (2002) · Neuropsychology · doi:10.1037//0894-4105.16.4.538 · Cited by 166 · see citing works
Increased platelet phospholipase A2 activity in schizophrenia
Gattaz, W. F. (1995) · Schizophrenia Research · doi:10.1016/0920-9964(94)00060-l · Cited by 164 · see citing works
Self-citationShinzawa, K., Sumi, H., Ikawa, M., Matsuoka, Y., Okabe, M., Sakoda, S., & Tsujimoto, Y. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4354-07.2008 · Cited by 163 · see citing works
Cloning and Recombinant Expression of a Structurally Novel Human Secreted Phospholipase A2
Gelb, M. H., Valentin, E. D., Ghomashchi, F., Lazdunski, M., & Lambeau, G. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000671200 · Cited by 161 · see citing works
Characterisation of the second messenger pathway underlying neurite outgrowth stimulated by FGF
Williams, E. J., Furness, J., Walsh, F. S., & Doherty, P. (1994) · Development · doi:10.1242/dev.120.6.1685 · Cited by 161 · see citing works
In vivo 31 P NMR profiles of Alzheimer's disease and multiple subcortical infarct dementia
Brown, G. G., Levine, S. R., Gorell, J. M., Pettegrew, J. W., Gdowski, J. W., Bueri, J. A., Helpern, J. A., & Welch, K. M. A. (1989) · Neurology · doi:10.1212/wnl.39.11.1423 · Cited by 157 · see citing works
Pettegrew, J. W., Kopp, S. J., Minshew, N. J., Glonek, T., Feliksik, J. M., Tow, J. P., & Cohen, M. M. (1987) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198707000-00002 · Cited by 156 · see citing works
Sanfeliu, C., Hunt, A., & Patel, A. J. (1990) · Brain Research · doi:10.1016/0006-8993(90)91228-9 · Cited by 154 · see citing works
Stephenson, D. T., Rash, K. S., Smalstig, B., Roberts, E. F., Johnstone, E., Sharp, J., Panetta, J., Little, S. P., Kramer, R. M., & Clemens, J. A. (1999) · Glia · doi:10.1002/(sici)1098-1136(199908)27:2 · Cited by 152 · see citing works
Yu, A., Chan, P. H., & Fishman, R. A. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb00738.x · Cited by 152 · see citing works
31P Nuclear Magnetic Resonance Study of the Brain in Alzheimerʼs Disease
Pettegrew, J. W., Moossy, J. J., Withers, G., McKeag, D., & Panchalingam, K. (1988) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198805000-00004 · Cited by 150 · see citing works
Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease
Pettegrew, J. W., Klunk, W. E., Panchalingam, K., Kanfer, J. N., & McClure, R. J. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)80001-8 · Cited by 148 · see citing works
Blusztajn, J. K., Liscovitch, M., & Richardson, U. I. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.15.5474 · Cited by 148 · see citing works
Post-Training Cyclooxygenase-2 (COX-2) Inhibition Impairs Memory ConsolidationPreprint
Teather, L. A., Packard, M. G., & Bazan, N. G. (2002) · Learning & Memory · doi:10.1101/lm.43602 · Cited by 148 · see citing works
Williams, E. J., Walsh, F. S., & Doherty, P. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62031231.x · Cited by 145 · see citing works
Memory training alters hippocampal neurochemistry in healthy elderly
Valenzuela, M., Jones, M., Rae, W. W. C., Rae, C., Graham, S., Shnier, R., & Sachdev, P. S. (2003) · Neuroreport · doi:10.1097/01.wnr.0000077548.91466.05 · Cited by 143 · see citing works
Cammarota, M., Bernabeu, R., de Stein, M. L., Izquierdo, I., & Medina, J. H. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00254.x · Cited by 141 · see citing works
Secretory PLA2-IIA: a new inflammatory factor for Alzheimer's disease
Moses, G. S. D., Jensen, M. D., Lue, L., Walker, D. G., Sun, A. Y., Simonyi, Á., & Sun, G. Y. (2006) · Journal of Neuroinflammation · doi:10.1186/1742-2094-3-28 · Cited by 136 · see citing works
Ohto‐Nakanishi, T., Uozumi, N., Hirabayashi, T., & Shimizu, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413711200 · Cited by 135 · see citing works
Wijkander, J., & Sundler, R. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb16445.x · Cited by 134 · see citing works
The human calcium‐independent phospholipase A2 gene
Forsell, P. K. A. L., Kennedy, B. P., & Claesson, H. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00418.x · Cited by 133 · see citing works
Kantarci, K., Reynolds, G., Petersen, R. C., Boeve, B. F., Knopman, D. S., Edland, S. D., Smith, G. E., Ivnik, R. J., Tangalos, E. G., & Jack, C. R. (2003) · PubMed Central · Cited by 122 · see citing works
Yang, H., Mosior, M. K., Ni, B., & Dennis, E. A. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731278.x · Cited by 122 · see citing works
Brain phospholipases A2: a perspective on the history
Farooqui, A. A., & Horrocks, L. A. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2004.03.004 · Cited by 120 · see citing works
Molecular Characterization of Cytosolic Phospholipase A2-β
Song, C., Chang, X. J., Bean, K. M., Proia, M. S., Knopf, J. L., & Kriz, R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17063 · Cited by 119 · see citing works
Ross, B. M., Moszczyńska, A., Erlich, J. C., & Kish, S. J. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70020786.x · Cited by 118 · see citing works
Arachidonic acid preserves hippocampal neuron membrane fluidity in senescent rats
Fukaya, T., Gondaira, T., Kashiyae, Y., Kotani, S., Ishikura, Y., Fujikawa, S., Kiso, Y., & Sakakibara, M. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.05.023 · Cited by 116 · see citing works
Nalefski, E. A., McDonagh, T., Somers, W., Seehra, J., Falke, J., & Clark, J. D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.3.1365 · Cited by 115 · see citing works
A non‐amyloidogenic function of BACE‐2 in the secretory pathway
Fluhrer, R., Capell, A., Westmeyer, G. G., Willem, M., Hartung, B., Condron, M. M., Teplow, D. B., Haass, C., & Walter, J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00908.x · Cited by 113 · see citing works
Decreased phospholipase A2 activity in Alzheimer brains
Gattaz, W. F., Maras, A., Cairns, N. J., Levy, R., & Förstl, H. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(94)00123-k · Cited by 108 · see citing works
Self-citationMulder, M. T., Ravid, R., Swaab, D. F., de Kloet, E. R., Haasdijk, E. D., Julk, J., van der Boom, J., & Havekes, L. M. (1998) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199809000-00012 · Cited by 107 · see citing works
Genes encoding multiple forms of phospholipase A2 are expressed in rat brain
Molloy, G. Y., Rattray, M., & Williams, R. J. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00838-6 · Cited by 105 · see citing works
Muthalif, M. M., Hefner, Y., Canaan, S., Harper, J. L., Zhou, H., Parmentier, J., Aebersold, R. H., Gelb, M. H., & Malik, K. U. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103136200 · Cited by 101 · see citing works
Wenisch, É., Cantegreil, I., de Rotrou, J., Garrigue, P., Moulin, F., Batouche, F., Richard, A. G., de Sant’Anna, M., & Rigaud, A.-S. (2007) · Aging Clinical and Experimental Research · doi:10.1007/bf03324708 · Cited by 99 · see citing works
Schaeffer, E. L., & Gattaz, W. F. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1092-0 · Cited by 98 · see citing works
Self-citationEffect of lysophosphatidylcholine on transmembrane signal transduction.
Prokazova, N. V., Zvezdina, N. D., & Коротаева, А. А. (1998) · PubMed · Cited by 96 · see citing works
Akiba, S., Mizunaga, S., Kume, K., Hayama, M., & Sato, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19906 · Cited by 95 · see citing works
Chantal, S., Labelle, M., Bouchard, R. W., Braun, C. M. J., & Boulanger, Y. (2002) · Archives of Neurology · doi:10.1001/archneur.59.6.955 · Cited by 95 · see citing works
Adult neurogenesis is functionally associated with AD-like neurodegeneration
Chen, Q., Nakajima, A., Choi, S. H., Xiong, X., Sisodia, S. S., & Tang, Y. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.09.005 · Cited by 94 · see citing works
Lim, S., & Suzuki, H. (2000) · Journal of Nutrition · doi:10.1093/jn/130.6.1629 · Cited by 91 · see citing works
Localization of cytosolic phospholipase A2 messenger RNA mainly in neurons in the rat brain
Kishimoto, K., Matsumura, K., Kataoka, Y., Morii, H., & Watanabe, Y. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00051-2 · Cited by 90 · see citing works
A Novel Intracellular Membrane-Bound Calcium-Independent Phospholipase A2
Tanaka, H., Takeya, R., & Sumimoto, H. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2776 · Cited by 88 · see citing works
Intrahippocampal infusion of a cyclooxygenase-2 inhibitor attenuates memory acquisition in rats
Rall, J., Mach, S. A., & Dash, P. K. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02248-0 · Cited by 87 · see citing works
In Vitro31P NMR Spectroscopy Detects Altered Phospholipid Metabolism in Alzheimer's Disease
Miatto, O., González, R. G., Buonanno, F. S., & Growdon, J. H. (1986) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100037276 · Cited by 86 · see citing works
Nitsch, R. M., Deng, A., Wurtman, R. J., & Growdon, J. H. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69020704.x · Cited by 84 · see citing works
Gattaz, W. F., Förstl, H., Braus, D. F., Maras, A., Cairns, N. J., & Levy, R. (1996) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02189113 · Cited by 84 · see citing works
Self-citationMaire, J. C., & Wurtman, R. J. (1985) · PubMed · Cited by 81 · see citing works
Stella, N., Pellerin, L., & Magistretti, P. J. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03307.1995 · Cited by 80 · see citing works
Phospholipase A2 Activation Influences the Processing and Secretion of the Amyloid Precursor Protein
Emmerling, M. R., Moore, C. J., Doyle, P. D., Carroll, R. T., & Davis, R. E. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2474 · Cited by 78 · see citing works
Stewart, M. G., Bourne, R. C., & Steele, R. J. (1992) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1992.tb00120.x · Cited by 78 · see citing works
Gan, L., Qiao, S., Lan, X., Chi, L., Luo, C., Lien, L., Liu, Q. Y., & Liu, R. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.08.002 · Cited by 75 · see citing works
Clements, M., Bliss, T. V. P., & Lynch, M. A. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90235-g · Cited by 75 · see citing works
Release of arachidonic acid by NMDA-receptor activation in the rat hippocampus
Pellerin, L., & Wolfe, L. S. (1991) · Neurochemical Research · doi:10.1007/bf00965841 · Cited by 73 · see citing works
Synaptic plasticity preserved with arachidonic acid diet in aged rats
Kotani, S., Nakazawa, H. K., Tokimasa, T., Akimoto, K., Kawashima, H., Toyoda‐Ono, Y., Kiso, Y., Okaichi, H., & Sakakibara, M. (2003) · Neuroscience Research · doi:10.1016/s0168-0102(03)00123-8 · Cited by 73 · see citing works
Owada, Y., Tominaga, T., Yoshimoto, T., & Kondo, H. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90174-0 · Cited by 73 · see citing works
Ávila, R., Bottino, C. M. C., de Carvalho, I. A. M., dos Santos, C. B., Seral, C., & Miotto, E. C. (2004) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2004001100018 · Cited by 73 · see citing works
Dalla, C., Bangasser, D. A., Edgecomb, C., & Shors, T. J. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.02.003 · Cited by 70 · see citing works
Alonso, M., Viola, H., Izquierdo, I., & Medina, J. H. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2000.4000 · Cited by 69 · see citing works
Talbot, K., Young, R., Jolly-Tornetta, C., Lee, V. M. ‐., Trojanowski, J. Q., & Wolf, B. A. (2000) · Neurochemistry International · doi:10.1016/s0197-0186(00)00006-1 · Cited by 69 · see citing works
Phosphatidylcholine as a precursor of choline for acetylcholine synthesis.
Blusztajn, J. K., Liscovitch, M., Mauron, C., Richardson, U. I., & Wurtman, R. J. (1987) · PubMed · Cited by 69 · see citing works
Neuronal Expression and Neuritogenic Action of Group X Secreted Phospholipase A2
Masuda, S., Murakami, M., Takanezawa, Y., Aoki, J., Arai, H., Ishikawa, Y., Ishii, T., Arioka, M., & Kudo, I. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500985200 · Cited by 66 · see citing works
Arachidonic acid improves aged rats' spatial cognition
Okaichi, Y., Ishikura, Y., AKIMOTO, K., Kawashima, H., Toyoda‐Ono, Y., Kiso, Y., & Okaichi, H. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.02.008 · Cited by 66 · see citing works
Bernabeu, R., Cammarota, M., Izquierdo, I., & Medina, J. H. (1997) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x1997000800008 · Cited by 66 · see citing works
Smalheiser, N. R., Dissanayake, S., & Kapil, A. (1996) · Brain Research · doi:10.1016/0006-8993(96)00134-5 · Cited by 65 · see citing works
Ikeno, Y., Konno, N., Cheon, S.-H., Bolchi, A., Ottonello, S., Kitamoto, K., & Arioka, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503343200 · Cited by 65 · see citing works
Cammarota, M., Paratcha, G., de Stein, M. L., Bernabeu, R., Izquierdo, I., & Medina, J. H. (1997) · Neurochemical Research · doi:10.1023/a:1027324214060 · Cited by 62 · see citing works
Sharifzadeh, M. S., Naghdi, N., Khosrovani, S., Ostad, S. N., Sharifzadeh, K., & Roghani, A. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.01.041 · Cited by 61 · see citing works
Platelet phospholipase A 2 activity in Alzheimer?s disease and mild cognitive impairment
Gattaz, W. F., Forlenza, O. V., Talib, L. L., Barbosa, N. R., & Bottino, C. M. C. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0142-y · Cited by 61 · see citing works
Self-citationErk1/2- and p38 MAP kinase-dependent phosphorylation and activation of cPLA2by m3 and m2 receptors
Zhou, H., Das, S. P., & Murthy, K. S. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00345.2002 · Cited by 61 · see citing works
Schaeffer, E. L., & Gattaz, W. F. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2256-9 · Cited by 60 · see citing works
Self-citationMassicotte, G., & Baudry, M. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90638-p · Cited by 59 · see citing works
Massicotte, G., Vanderklish, P. W., LYNCH, G. S., & Baudry, M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.5.1893 · Cited by 58 · see citing works
Human group III secreted phospholipase A2 promotes neuronal outgrowth and survival
Masuda, S., Yamamoto, K., Hirabayashi, T., Ishikawa, Y., Ishii, T., Kudo, I., & Murakami, M. (2007) · Biochemical Journal · doi:10.1042/bj20070844 · Cited by 58 · see citing works
Rapid and Transient Learning-Associated Increase in NMDA NR1 Subunit in the Rat Hippocampus
Cammarota, M., de Stein, M. L., Paratcha, G., Bevilaqua, L. R., Izquierdo, I., & Medina, J. H. (2000) · Neurochemical Research · doi:10.1023/a:1007590415556 · Cited by 57 · see citing works
Bosetti, F., & Weerasinghe, G. R. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02118.x · Cited by 57 · see citing works
Gaudreault, S. B., Chabot, C., Gratton, J., & Poirier, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304777200 · Cited by 56 · see citing works
Łazarewicz, J. W., Wroblewski, J. T., & Salińska, E. (1992) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-3426-6_7 · Cited by 56 · see citing works
Cammarota, M., Izquierdo, I., Wolfman, C., DESTEIN, M. L., Bernabeu, R., Jerusalinsky, D. A., & Medina, J. H. (1995) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1995.0008 · Cited by 54 · see citing works
Reduced phospholipid breakdown in Alzheimer’s brains: a 31P spectroscopy study
Forlenza, O. V., Wacker, P., Nunes, P. V., Yacubian, J., de Castro, C. C., Otaduy, M. C. G., & Gattaz, W. F. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2168-8 · Cited by 54 · see citing works
Self-citationBernabeu, R., Izquierdo, I., Cammarota, M., Jerusalinsky, D. A., & Medina, J. H. (1995) · Brain Research · doi:10.1016/0006-8993(95)00310-m · Cited by 52 · see citing works
Paratcha, G., Furman, M., Bevilaqua, L. R., Cammarota, M., Vianna, M. R. M. R., de Stein, M. L., Izquierdo, I., & Medina, J. H. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02323-9 · Cited by 51 · see citing works
Adult Hippocampal Neurogenesis in Rodents and Primates: Endogenous, Enhanced, and Engrafted
Yamashima, T., Tonchev, A. B., & Yukie, M. (2007) · Reviews in the Neurosciences · doi:10.1515/revneuro.2007.18.1.67 · Cited by 50 · see citing works
Young, E., Ceseña, T. I., Meiri, K. F., & Perrone‐Bizzozero, N. I. (2002) · Hippocampus · doi:10.1002/hipo.10015 · Cited by 49 · see citing works
Vázquez, A., & de Ortı́z, S. P. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.03.011 · Cited by 48 · see citing works
Phospholipid Abnormalities in Early Alzheimer's Disease
Cuénod, C. A. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540250097018 · Cited by 47 · see citing works
Bernard, J., Lahsaïni, A., & Massicotte, G. (1994) · Hippocampus · doi:10.1002/hipo.450040407 · Cited by 47 · see citing works
Inhibitors of Cyclooxygenases produce Amnesia for a Passive Avoidance Task in the Chick
Hölscher, C. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01127.x · Cited by 46 · see citing works
Lim, S., & Suzuki, H. (2000) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.70.5.251 · Cited by 44 · see citing works
Reversible Changes in Hippocampal3H-AMPA Binding Following Inhibitory Avoidance Training in the Rat
Cammarota, M., Bernabeu, R., Izquierdo, I., & Medina, J. H. (1996) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.0046 · Cited by 43 · see citing works
Inhibition of phospholipase A2 reduces neurite outgrowth and neuronal viability
Forlenza, O. V., Mendes, C. T., Marie, S. K. N., & Gattaz, W. F. (2006) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2006.10.002 · Cited by 41 · see citing works
Self-citationWharton, S., Williams, G., Stoeber, K., Gelsthorpe, C. H., Baxter, L., Johnson, A., & Ince, P. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.04.019 · Cited by 40 · see citing works
Inhibitors of phospholipase A2 produce amnesia for a passive avoidance task in the chick
Hölscher, C., & Rose, S. P. R. (1994) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(05)80005-6 · Cited by 39 · see citing works
31P magnetic resonance spectroscopy in alzheimer's and pick's disease
Smith, C. D., Gallenstein, L. G., Layton, W. J., Kryscio, R. J., & Markesbery, W. R. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90026-8 · Cited by 37 · see citing works
"Autocannibalism" of membrane choline-phospholipids: physiology and pathology.
Blusztajn, J. K., Holbrook, P. G., Lakher, M., Liscovitch, M., Maire, J. C., Mauron, C., Richardson, U. I., Tacconi, M. T., & Wurtman, R. J. (1986) · PubMed · Cited by 36 · see citing works
Cytosolic PLA2: mRNA levels and potential for transcriptional regulation.
Sharp, J., & White, D. L. (1993) · PubMed · Cited by 36 · see citing works
Catania, M. V., Hollingsworth, Z. R., Penney, J. B., & Young, A. B. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb05843.x · Cited by 34 · see citing works
Memory formation requires p38MAPK activity in the rat hippocampus
Alonso, M., Bevilaqua, L. R., Izquierdo, I., Medina, J. H., & Cammarota, M. (2003) · Neuroreport · doi:10.1097/00001756-200310270-00022 · Cited by 34 · see citing works
Requirement of hippocampal phospholipase A2 activity for long-term memory retrieval in rats
Schaeffer, E. L., & Gattaz, W. F. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0585-4 · Cited by 33 · see citing works
Self-citationQuantitative In Vivo 31P Magnetic Resonance Spectroscopy of Alzheimer Disease
Gonz??lez, R. G., Guimarães, A. R., Moore, G. J., Crawley, A. P., Cupples, L. A., & Growdon, J. H. (1996) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199601010-00008 · Cited by 33 · see citing works
Ca2+-Independent Phospholipase A2 Inhibiror Impairs Spatial Memory of Mice.
Fujita, S., Ikegaya, Y., Nishiyama, N., & Matsuki, N. (2000) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.83.277 · Cited by 32 · see citing works
Cognitive training increases platelet PLA2 activity in healthy elderly subjects
Talib, L. L., Yassuda, M. S., Diniz, B. S., Forlenza, O. V., & Gattaz, W. F. (2008) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2008.03.002 · Cited by 30 · see citing works
Self-citationKadoyama, K., Takahashi, Y., Higashida, H., Tanabe, T., & Yoshimoto, T. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4357 · Cited by 30 · see citing works
Inhibitors of PLA2 and NO synthase cooperate in producing amnesia of a spatial task
Hölscher, C., Canevari, L., & Richter‐Levin, G. (1995) · Neuroreport · doi:10.1097/00001756-199503270-00006 · Cited by 29 · see citing works
Lautens, L. L., Chiou, X. G., Sharp, J., Young, W. S., Sprague, D. L., Ross, L. S., & Felder, C. C. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00806-3 · Cited by 27 · see citing works
A longitudial study of a neuropsychological rehabilitation program in Alzheimer's disease
Abrisqueta‐Gomez, J., Canali, F., Vieira, V. L. D., Aguiar, A. C. P. D. O., Ponce, C., Brucki, S. M. D., & Bueno, O. F. A. (2004) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2004000500007 · Cited by 26 · see citing works
Fukushima, D., Konishi, M., Maruyama, K., Miyamoto, T., Ishiura, S., & Suzuki, K. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1804 · Cited by 25 · see citing works
Cloning and Expression of Cytosolic Phospholipase A2 (cPLA2) and a Naturally Occurring Variant
Gordon, R. D., Leighton, I. A., Campbell, D. G., Cohen, P., Creaney, A., Wilton, D. C., Masters, D. J., Ritchie, G. A. F., Mott, R., Taylor, I. W. F., et al. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0690w.x · Cited by 24 · see citing works
Yu, A. C. H., Chan, P. H., & Fishman, R. A. (1987) · Journal of Neuroscience Research · doi:10.1002/jnr.490170414 · Cited by 24 · see citing works
A novel neurotrophic role of secretory phospholipases A2 for cerebellar granule neurons
Arioka, M., Cheon, S.-H., Ikeno, Y., Nakashima, S., & Kitamoto, K. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.03.092 · Cited by 23 · see citing works
Cho, H.-W., Kim, J. H., Choi, S., & Kim, H.-J. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.12.014 · Cited by 23 · see citing works
Prospective Study of Risk Factors for Alzheimer’s Disease: Results at 7.5 Years
Zubenko, G. S., Winwood, E., Jacobs, B., Teply, I., Stiffler, J. S., Hughes, H. B., Huff, F. J., Sunderland, T., & Martinez, A. J. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.1.50 · Cited by 23 · see citing works
Opposite effects of phospholipase A2 on [3H]AMPA binding in adult and neonatal membranes
Baudry, M., Massicotte, G., & Hauge, S. (1991) · Developmental Brain Research · doi:10.1016/0165-3806(91)90140-e · Cited by 22 · see citing works
Melittin increases AMPA receptor affinity in rat brain synaptoneurosomes.
Bernard, J., Chabot, C., Gagné, J., Baudry, M., & Massicotte, G. (1995) · Brain Research · doi:10.1016/0006-8993(94)01313-7 · Cited by 21 · see citing works
Prostaglandins play a role in memory consolidation in the chick
Hölscher, C. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00541-2 · Cited by 21 · see citing works
Phospholipase A-induced changes in AMPA receptor: An autoradiographic study
Tocco, G., Massicotte, G., Standley, S., Thompson, R. F., & Baudry, M. (1992) · Neuroreport · doi:10.1097/00001756-199206000-00015 · Cited by 21 · see citing works
Martel, M., Patenaude, C., Ménard, C., Alaux‐Cantin, S., Cummings, B. S., & Massicotte, G. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04565.x · Cited by 19 · see citing works
Sato, T., Ishida, T., Irifune, M., Tanaka, K., Hirate, K., Nakamura, N., & Nishikawa, T. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.01.011 · Cited by 19 · see citing works
The Role of Arachidonic Acid in the Secretion of the Amyloid Precursor Protein (APP)a
Emmerling, M. R., Dudley, D. T., Dyer, R. D., Carroll, R. T., DOYLE, P. D., & Davis, R. E. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb34438.x · Cited by 19 · see citing works
Long-lasting enhancement of ACh receptor currents by lysophospholipids
Ikeuchi, Y., Nishizaki, T., Matsuoka, T., & Sumikawa, K. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00292-6 · Cited by 16 · see citing works
Lim, S., & Suzuki, H. (2002) · Annals of Nutrition and Metabolism · doi:10.1159/000065410 · Cited by 14 · see citing works
Clements, M., & Rose, S. P. R. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67031317.x · Cited by 13 · see citing works
Bernard, J., Lahsaïni, A., Baudry, M., & Massicotte, G. (1993) · Brain Research · doi:10.1016/0006-8993(93)90977-u · Cited by 9 · see citing works
Nilsson (1999) · doi:10.1002/(sici)1097-4695(19990615)39:4
Episodic memory, semantic memory, and amnesia
Squire, L. R., & Zola, S. M. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1998)8:3
Flagged first, then by citations
Cited by
Sorted by citations
Dennis, E. A., Cao, J., Hsu, Y., Magrioti, V., & Kokotos, G. (2011) · Chemical Reviews · doi:10.1021/cr200085w · Cited by 1,213 · see citing works
Therapeutics of Alzheimer's disease: Past, present and future
Anand, R., Gill, K. D., & Mahdi, A. A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.07.004 · Cited by 748 · see citing works
The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease
Ferreira, S. T., & Klein, W. L. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.08.003 · Cited by 442 · see citing works
Docosahexaenoic acid (DHA): An essential nutrient and a nutraceutical for brain health and diseases
Sun, G. Y., Simonyi, Á., Fritsche, K. L., Chuang, D. Y., Hannink, M., Gu, Z., Greenlief, C. M., Yao, J. K., Lee, J. C., & Beversdorf, D. Q. (2017) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2017.03.006 · Cited by 311 · see citing works
Agis-Torres, A., Sollhuber, M., Fernandez, M., & Sanchez-Montero, J. M. (2014) · Current Neuropharmacology · doi:10.2174/1570159x113116660047 · Cited by 202 · see citing works
Phospholipases A2 and Inflammatory Responses in the Central Nervous System
Sun, G. Y., Shelat, P. B., Jensen, M. B., He, Y., Sun, A. Y., & Simonyi, Á. (2009) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8092-z · Cited by 197 · see citing works
Calcium-independent phospholipases A2 and their roles in biological processes and diseases
Ramanadham, S., Ali, T., Ashley, J. W., Bone, R. N., Hancock, W. D., & Lei, X. (2015) · Journal of Lipid Research · doi:10.1194/jlr.r058701 · Cited by 195 · see citing works
Omega-3 fatty acids: potential role in the management of early Alzheimer’s disease
Jicha, G. A. (2010) · Clinical Interventions in Aging · doi:10.2147/cia.s5231 · Cited by 153 · see citing works
Alzheimer's disease–like pathology has transient effects on the brain and blood metabolome
Pan, X., Nasaruddin, M. L., Elliott, C. T., McGuinness, B., Passmore, A. P., Kehoe, P. G., Hölscher, C., McClean, P. L., Graham, S. F., & Green, B. D. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.11.014 · Cited by 115 · see citing works
Sun, G. Y., Chuang, D. Y., Zong, Y., Jiang, J., Lee, J. C., Gu, Z., & Simonyi, Á. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8662-4 · Cited by 99 · see citing works
Cunnane, S. C., Chouinard‐Watkins, R., Castellano, C., & Barberger‐Gateau, P. (2012) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2012.04.006 · Cited by 92 · see citing works
Kline, A., Leary, J. B., Radabaugh, H. L., Cheng, J. P., & Bondi, C. (2016) · Progress in neurobiology · doi:10.1016/j.pneurobio.2016.05.002 · Cited by 79 · see citing works
Chouinard‐Watkins, R., Rioux‐Perreault, C., Fortier, M., Tremblay‐Mercier, J., Zhang, Y., Lawrence, P., Vohl, M., Perron, P., Lorrain, D., Brenna, J. T., et al. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513001268 · Cited by 86 · see citing works
Docosahexaenoic acid and synaptic protection in Alzheimer's disease mice
Oster, T., & Pillot, T. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.02.011 · Cited by 74 · see citing works
Exercise facilitates the action of dietary DHA on functional recovery after brain trauma
Wu, A. D., Ying, Z., & Gómez‐Pinilla, F. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.06.041 · Cited by 69 · see citing works
Colucci, L., Bosco, Amenta, Fasanaro, Ziello, & Rea, R. (2012) · Journal of Experimental Pharmacology · doi:10.2147/jep.s35326 · Cited by 67 · see citing works
Dynamic Role of Phospholipases A2 in Health and Diseases in the Central Nervous System
Sun, G. Y., Geng, X. H., Teng, T., Yang, B., Appenteng, M. K., Greenlief, C. M., & Lee, J. C. (2021) · Cells · doi:10.3390/cells10112963 · Cited by 64 · see citing works
Sheikh, A. M., Michikawa, M., Kim, S. U., & Nagai, A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.02.034 · Cited by 53 · see citing works
Hermann, P. M., Watson, S. N., & Wildering, W. C. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00419 · Cited by 53 · see citing works
Group VIA Ca2+-independent phospholipase A2 (iPLA2β) and its role in β-cell programmed cell death
Lei, X., Barbour, S. E., & Ramanadham, S. (2010) · Biochimie · doi:10.1016/j.biochi.2010.01.005 · Cited by 52 · see citing works
Alterations in erythrocyte fatty acid composition in preclinical Alzheimer’s disease
Goozee, K. G., Chatterjee, P., JAMES, I. R., Shen, K., Sohrabi, H. R., Asih, P. R., Dave, P., Ball, B., ManYan, C., Taddei, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00751-2 · Cited by 48 · see citing works
Sun, G. Y., He, Y., Chuang, D. Y., Lee, J. C., Gu, Z., Simonyi, Á., & Sun, A. Y. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8261-1 · Cited by 44 · see citing works
Peichoto, M. E., Tavares, F. L., DeKrey, G. K., & Mackessy, S. P. (2011) · Toxicon · doi:10.1016/j.toxicon.2011.04.018 · Cited by 38 · see citing works
Huang, J., Wang, X., Xie, L., Wu, M., Zhao, W., Zhang, Y., Wang, Q., Yao, L., & Li, W. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112673 · Cited by 37 · see citing works
Saeedi, M., & Mehranfar, F. (2022) · Recent Patents on Biotechnology · doi:10.2174/1872208316666220302115901 · Cited by 35 · see citing works
Interactions Between Ferroptosis and Oxidative Stress in Ischemic Stroke
Liu, D., Yang, S., & Yu, S. (2024) · Antioxidants · doi:10.3390/antiox13111329 · Cited by 36 · see citing works
Gattaz, W. F., Talib, L. L., Schaeffer, E. L., Diniz, B. S., & Forlenza, O. V. (2013) · Journal of Neural Transmission · doi:10.1007/s00702-013-1088-8 · Cited by 32 · see citing works
Self-citationAliev, A. M., & Магомедович, А. И. (2016) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2016.08.021 · Cited by 31 · see citing works
Gatta, V., Drago, D., Fincati, K., Valenti, M. T., Carbonare, L. D., Sensi, S. L., & Zatta, P. F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015965 · Cited by 30 · see citing works
Maintenance of Synaptic Stability Requires Calcium-Independent Phospholipase A2Activity
Allyson, J., Bi, X., Baudry, M., & Massicotte, G. (2012) · Neural Plasticity · doi:10.1155/2012/569149 · Cited by 25 · see citing works
Therapeutic Strategies Aimed at Improving Neuroplasticity in Alzheimer Disease
Colavitta, M. F., & Barrantes, F. J. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15082052 · Cited by 25 · see citing works
Plasma lipids metabolism in mild cognitive impairment and Alzheimer’s disease
Costa, A. C., Joaquim, H. P. G., Forlenza, O. V., Talib, L. L., & Gattaz, W. F. (2017) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2017.1369566 · Cited by 23 · see citing works
Self-citationIn vitro 6-hydroxydopamine-induced neurotoxicity: New insights on NFκB modulation
González, P. A. I., Conde, M. A., Pardo, V. G., Uranga, R. M., & Salvador, G. A. (2019) · Toxicology in Vitro · doi:10.1016/j.tiv.2019.06.019 · Cited by 22 · see citing works
Kim, H.-J., Kim, B., Kim, H.-S., & Cho, J. (2020) · Molecular Brain · doi:10.1186/s13041-020-0565-x · Cited by 21 · see citing works
Talib, L. L., Hototian, S. R., Joaquim, H. P. G., Forlenza, O. V., & Gattaz, W. F. (2015) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-015-0600-6 · Cited by 20 · see citing works
Self-citationBalietti, M., Giuli, C., Fattoretti, P., Fabbietti, P., Postacchini, D., & Conti, F. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150714 · Cited by 20 · see citing works
Devyatkin, V. A., Redina, O. E., Kolosova, N. G., & Muraleva, N. A. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-190956 · Cited by 19 · see citing works
Naik, B., Maurya, V. K., Kumar, V., Kumar, V., Upadhyay, S., & Gupta, S. K. (2020) · Current Nutrition & Food Science · doi:10.2174/1573401316999200614162834 · Cited by 18 · see citing works
Martínez-Iglesias, O. A., Naidoo, V., Carrera, I., Corzo, L., & Cacabelos, R. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14112447 · Cited by 18 · see citing works
Recent Preclinical Insights Into the Treatment of Chronic Traumatic Encephalopathy
Breen, P., & Krishnan, V. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00616 · Cited by 19 · see citing works
Mohibbullah, M., Hannan, M. A., Park, I.-S., Moon, I. S., & Hong, Y.-K. (2016) · Journal of Medicinal Food · doi:10.1089/jmf.2016.3694 · Cited by 17 · see citing works
Donepezil effects on cholesterol and oxysterol plasma levels of Alzheimer’s disease patients
Costa, A. C., Joaquim, H. P. G., Nunes, V. S., Kerr, D. S., Ferreira, G. S., Forlenza, O. V., Gattaz, W. F., & Talib, L. L. (2017) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-017-0838-2 · Cited by 16 · see citing works
Self-citationMohibbullah, M., Choi, J., Bhuiyan, M. M. H., Haque, M. N., Rahman, M. K., Moon, I. S., & Hong, Y. (2018) · Journal of Medicinal Food · doi:10.1089/jmf.2017.4026 · Cited by 15 · see citing works
Emerging cognitive enhancing drugs
Buccafusco, J. J. (2009) · Expert Opinion on Emerging Drugs · doi:10.1517/14728210903257796 · Cited by 14 · see citing works
Mury, F. B., da Silva, W. C. F. N., Barbosa, N. R., Mendes, C. T., Bonini, J. S., Sarkis, J. E. D. S., Cammarota, M., Izquierdo, I., Gattaz, W. F., & Dias‐Neto, E. (2015) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-015-0665-2 · Cited by 13 · see citing works
Self-citationMa, M.-T., Yeo, J.-F., Farooqui, A. A., & Ong, W. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0340-y · Cited by 12 · see citing works
Gao, Y., Li, C., Kang, L., Hang, B., Yan, M., Li, S., Jin, H., Lee, A. W., & Cho, S. S. (2014) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2014.10.009 · Cited by 10 · see citing works
Nagata, T., Shinagawa, S., Nukariya, K., Nakayama, R., Nakayama, K., & Yamada, H. (2011) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000335355 · Cited by 10 · see citing works
Gattaz, W. F., Talib, L. L., Shaeffer, E., Diniz, B. S., & Forlenza, O. V. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.05.647 · Cited by 7 · see citing works
Self-citationLei, Z., Wan, J., Han, J.-J., Zhang, C., Wang, H., Zhou, D., Chen, Y., & Huang, H. (2024) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x241261949 · Cited by 6 · see citing works
Chew, W.-S., Shalini, S.-M., Torta, F. T., Wenk, M. R., Stohler, C. S., Yeo, J.-F., Herr, D. R., & Ong, W. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.10.037 · Cited by 6 · see citing works
Chew, W.-S., & Ong, W. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-9026-9 · Cited by 4 · see citing works
Drozd, A., Szczuko, M., Bohatyrewicz, A., Jurewicz, A., & Kotlęga, D. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11092652 · Cited by 4 · see citing works
Neuroprotective Effects of Macrovipera lebetina Snake Venom in the Model of Alzheimer’s Disease
Ghazaryan, N. A., Սիմոնյան, Կ. Վ., Danielyan, M., Zakaryan, N. A., Ghulikyan, L. A., Kirakosyan, G. R., Chavushyan, V. A., & Ayvazyan, N. M. (2017) · Neurophysiology · doi:10.1007/s11062-018-9704-8 · Cited by 4 · see citing works
Therapeutics of Alzheimer’s Disease
Herrera-Rivero, M., & Emiliano, G. (2011) · InTech eBooks · doi:10.5772/27990 · Cited by 3 · see citing works
Leong, V., & Fonteh, A. N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-21800-2.00022-1 · Cited by 2 · see citing works
Molecular Cloning and Characterization of a Venom Phospholipase A2 from Apis mellifera spp.
Hou, C., Guo, L., You, L., Wang, J., Lin, J., Wu, W., Wu, C., & Wang, T. (2014) · Cited by 2 · see citing works
Role of Calcium-Independent Phospholipase A2 VIA in Mediating Neurological Disorder and Cancer
Chung, C. Y., Shi, Y., Surendranath, A. R., Jalal, N., Pathak, J. L., & Subramaniyam, S. (2016) · Transactions of Tianjin University · doi:10.1007/s12209-016-0025-y · Cited by 2 · see citing works
Alzheimer’s Disease, Schizophrenia and Depression
Das, U. N. (2011) · Springer eBooks · doi:10.1007/978-94-007-0495-4_12 · Cited by 2 · see citing works
Afnan, U., Khan, M. S., Swaliha, C. A., Manzoor, U., Mumtaz, I., Dar, M. J., & Maqbool, T. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15177-4.00002-9 · Cited by 1 · see citing works
Lin, J. (2014) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.13102/sociobiology.v59i3.558 · Cited by 1 · see citing works
Atividade da fosfolipase A2 no transtorno bipolar
Ikenaga, E. H. (2013) · doi:10.11606/d.5.2013.tde-14082013-101930
Khan, M. N. A., Kang, J.-Y., Park, N.-G., Choi, J., Cho, I.-S., & Hong, Y. (2012) · Fisheries and aquatic sciences · doi:10.5657/fas.2012.0163
Group VIA Ca 2þ -independent phospholipase A2 (iPLA2b) and its role in b-cell programmed cell death
Lei, X., Barbour, S. E., & Ramanadham, S. (2010)
A bioenergética do músculo esquelético na Doença de Alzheimer
Alexandra, M., & de Castro, T. (2012) · Repository of UTAD (Universidad De Tras-os Montes e Alto Douro)
Current awareness in human psychopharmacology
(2009) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.976
Current awareness in geriatric psychiatry
(2009) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2118
Role of phospholipase A2 and glutamate in Alzheimer's disease
Samant, N. P., & Gupta, G. L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-21800-2.00011-7
Delayed niacin skin flush response identifies cognitive impairment in late-life depression
Chen, Y., Wu, Y., Wang, D., Yang, Y., Guo, Q., Qiu, Q., Wan, C., & Li, X. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.03.095
- Authors
- Schaeffer, E. L., Forlenza, O. V., & Gattaz, W. F.
- Affiliations
- Universidade de São Paulo (BR)
- Corresponding author
- Schaeffer, Evelin L.
- Venue
- Psychopharmacology
- Published
- 2008-10-14
- Volume
- 202
- Issue
- 1-3
- Pages
- 37-51
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2017563414
- Cited by
- 71
- References
- 179
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 6 · 2015: 5 · 2014: 7 · 2013: 6 · 2012: 6
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, phospholipase A2, calcium-dependent phospholipase A2, arachidonic acid, cognitive training, memory enhancement, synaptic plasticity, long-term potentiation, neurogenesis, neurite outgrowth, phospholipid metabolism, phosphatidylcholine, mild cognitive impairment, dietary fat supplementation, cognitive enhancement therapy
- MeSH terms
- Aged, Alzheimer Disease, Animals, Brain, Cells, Cultured, Cognition, Dietary Fats, Enzyme Activation, Humans, Learning, Memory Disorders, Neuronal Plasticity, Neurons, Amyloid beta-Peptides, Nootropic Agents, Cell Proliferation, Phospholipases A2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review