A preclinical model of binge eating elicited by yo–yo dieting and stressful exposure to food: Effect of sibutramine, fluoxetine, topiramate, and midazolam
Abstract
Rationale Preclinical models are needed to investigate the neurobiology and psychobiology of binge eating and to identify innovative pharmacotherapeutic strategies.Objectives A modification of the model based on the combination of cyclic caloric restrictions and acute stress was developed to further increase its face validity and reliability and, for the first time, to assess its predictive value.Materials and methods Four groups of female rats were employed: group 1 was normally fed and not stressed on the test day (25th); group 2 was fed normally but was exposed to an acute stress on day 25; group 3 was exposed to three cycles (4 days 66% of chow intake + 4 days food ad libitum) of yo-yo dieting but not stressed; and group 4 was exposed to cyclic yo-yo dieting and then stressed. All groups were fed highly palatable food (HPF) for 2 h on days 5-6 and 13-14. Acute stress was elicited by exposing rats to HPF, but preventing them from access to it for 15 min.Results The combination of cyclic food restriction and stressful exposure to food markedly increased HPF intake. Sibutramine and fluoxetine inhibited food intake in all conditions. Topiramate selectively inhibited compulsive HPF intake in rats submitted to caloric restriction and stress. Midazolam increased HPF intake.Conclusions Pharmacological results suggest that this model, in addition to face validity as an isomorphic model of human binge eating, is endowed with good predictive validity.
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Exposure to high-fat diets, yo-yo dieting, and withdrawal from such diets may alter extrahypothalamic CRF pathways involved in stress regulation and disrupt brain reward motivation responses to increase compulsive food seeking and stress-induced highly palatable food seeking.
“exposure to high fats diets, yo–yo dieting and withdrawal from such diets, may alter extrahypothalamic CRF pathways involved in the regulation of stress responses and also disrupt brain reward motivation responses to increase compulsive food seeking and stress-induced HP food seeking”
From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Cifani et al., 2009
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N/OFQ-NOP System in Food Intake
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- Authors
- Cifani, C., Polidori, C., Melotto, S., Ciccocioppo, R., & Massi, M.
- Affiliations
- Università di Camerino (IT)
- Corresponding author
- Massi, Maurizio
- Venue
- Psychopharmacology
- Published
- 2009-01-06
- Volume
- 204
- Issue
- 1
- Pages
- 113-125
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2031082356
- Cited by
- 98
- References
- 58
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 12 · 2019: 8 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 9 · 2013: 3 · 2012: 10
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Unicam Scientific Publications (University of Camerino) (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Keywords
- binge eating, yo-yo dieting, acute stress, highly palatable food, compulsive eating, sibutramine, fluoxetine, topiramate, midazolam, dietary intake, rat model, predictive validity, female rats
- MeSH terms
- Topiramate, Animals, Appetite Depressants, Behavior, Animal, Bulimia, Cyclobutanes, Disease Models, Animal, Eating, Feeding Behavior, Female, Fluoxetine, Food Deprivation, Fructose, Midazolam, Stress, Psychological, Rats, Sprague-Dawley, Rats
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