Role of dorsal medial prefrontal cortex dopamine D1-family receptors in relapse to high-fat food seeking induced by the anxiogenic drug yohimbine

Nair, Sunila G; Navarre, Brittany M; Cifani, Carlo; Pickens, Charles L; Bossert, Jennifer M; Shaham, Yavin

doi:10.1038/npp.2010.181

Cited by 85Neurotransmitter Receptor Influence on BehaviorRegulation of Appetite and ObesityEating Disorders and Behaviors

Role of dorsal medial prefrontal cortex dopamine D1-family receptors in relapse to high-fat food seeking induced by the anxiogenic drug yohimbine

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Nair, Sunila G, Navarre, Brittany M, Cifani, Carlo, Pickens, Charles L, Bossert, Jennifer M, Shaham, Yavin·2011·Neuropsychopharmacology

DOI 10.1038/npp.2010.181PMC PMC3005956

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Abstract

In humans, relapse to maladaptive eating habits during dieting is often provoked by stress. In rats, the anxiogenic drug yohimbine, which causes stress-like responses in both humans and nonhumans, reinstates food seeking in a relapse model. In this study, we examined the role of medial prefrontal cortex (mPFC) dopamine D1-family receptors, previously implicated in stress-induced reinstatement of drug seeking, in yohimbine-induced reinstatement of food seeking. We trained food-restricted rats to lever press for 35% high-fat pellets every other day (9-15 sessions, 3 h each); pellet delivery was accompanied by a discrete tone-light cue. We then extinguished operant responding for 10-16 days by removing the pellets. Subsequently, we examined the effect of yohimbine (2 mg/kg, i.p.) on reinstatement of food seeking and Fos (a neuronal activity marker) induction in mPFC. We then examined the effect of systemic injections of the D1-family receptor antagonist SCH23390 (10 μg/kg, s.c.) on yohimbine-induced reinstatement and Fos induction, and that of mPFC SCH23390 (0.5 and 1.0 μg/side) injections on this reinstatement. Yohimbine-induced reinstatement was associated with strong Fos induction in the dorsal mPFC and with weaker Fos induction in the ventral mPFC. Systemic SCH23390 injections blocked both yohimbine-induced reinstatement and mPFC Fos induction. Dorsal, but not ventral, mPFC injections of SCH23390 decreased yohimbine-induced reinstatement of food seeking. In addition, dorsal mPFC SCH23390 injections decreased pellet-priming-induced reinstatement, but had no effect on ongoing high-fat pellet self-administration or discrete-cue-induced reinstatement. Results indicate a critical role of dorsal mPFC dopamine D1-family receptors in stress-induced relapse to palatable food seeking, as well as relapse induced by acute re-exposure to food taste, texture, and smell.

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Elevated D1 on excitatory mPFC projection neurons is associated with increased drug seeking, taking, and drug-cue salience, as well as addiction-related behaviors such as novelty seeking, sexual activity, preferences for sweet taste, and impulsivity.
“Elevated D1 on excitatory mPFC projection neurons is associated with increased drug seeking, taking, and drug-cue salience, as well as addiction-related behaviors such as novelty seeking, sexual activity, preferences for sweet taste, and impulsivity (Freund et al., 2016, Nair et al., 2011, Sanchez et al., 2003, Sonntag et al., 2014).”
From Sensitive periods of substance abuse: Early risk for the transition to dependence (2017) · cites this paper as Nair et al., 2011

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Authors: Nair, S. G., Navarre, B. M., Cifani, C., Pickens, C. L., Bossert, J. M., & Shaham, Y.
Affiliations: United States Department of Health and Human Services (US)
ORCID: Nair, Sunila G
Navarre, Brittany M
Cifani, Carlo
Pickens, Charles L
Bossert, Jennifer M
Shaham, Yavin
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2010-10-20
Volume: 36
Issue: 2
Pages: 497-510
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/npp.2010.181
PMC: PMC3005956
OpenAlex: W2027810813
Cited by: 85
References: 115
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 9 · 2019: 6 · 2018: 1 · 2017: 5 · 2016: 4 · 2015: 9 · 2014: 13 · 2013: 9 · 2012: 6
FWCI: 2.97
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychopharmacology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Unicam Scientific Publications (University of Camerino) (submittedVersion)
Funders: National Institutes of Health
National Institute on Drug Abuse (ZIADA000434)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords: dorsomedial prefrontal cortex, yohimbine, stress-induced relapse, food seeking, high-fat foods, reinstatement, Fos induction, SCH 23390, anxiogenic drugs, dieting, maladaptive eating
MeSH terms: Animals, Anxiety, Appetite Regulation, Hyperphagia, Male, Stress, Psychological, Yohimbine, Prefrontal Cortex, Receptors, Dopamine D1, Rats, Long-Evans, Rats, Secondary Prevention

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Role of dorsal medial prefrontal cortex dopamine D1-family receptors in relapse to high-fat food seeking induced by the anxiogenic drug yohimbine

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