The 5-HT7 receptor and disorders of the nervous system: an overview

Major depressive disorder

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Assessing antidepressant activity in rodents: recent developments and future needs

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Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review

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The ascent of mouse: advances in modelling human depression and anxiety

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Chronic mild stress-induced anhedonia: A realistic animal model of depression

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Aripiprazole, A Novel Atypical Antipsychotic Drug with a Unique and Robust Pharmacology

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A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms

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Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.

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Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.

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Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors

Choudhary, M. S., Craigo, S. C., Sibley, D. R., Roth, B. L., Monsma, F. J., Shen, Y., Uluer, A., & Meltzer, H. Y. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/74zp-ze10 · Cited by 592 · see citing works

Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase.

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8-hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, a potent and selective simplified ergot congener with central 5-HT-receptor stimulating activity

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Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.

Shen, Y., Monsma, F. J., Metcalf, M. A., José, P. A., Hamblin, M. W., & Sibley, D. R. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46830-x · Cited by 508 · see citing works

Sleep Disturbances in Patients with Schizophrenia: Impact and Effect of Antipsychotics

Cohrs, S. (2008) · CNS Drugs · doi:10.2165/00023210-200822110-00004 · Cited by 433 · see citing works

Interactions of the Novel Antipsychotic Aripiprazole (OPC-14597) with Dopamine and Serotonin Receptor Subtypes

Lawler, C. P. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00099-2 · Cited by 409 · see citing works

Functional, molecular and pharmacological advances in 5-HT receptor research

Hedlund, P. B., & Sutcliffe, J. G. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.07.002 · Cited by 350 · see citing works

Characterization of SB‐269970‐A, a selective 5‐HT7 receptor antagonist

Hagan, J. J., Price, G. W., Jeffrey, P., Deeks, N. J., Stean, T. O., Piper, D. C., Smith, M. I., Upton, N., Medhurst, A. D., Middlemiss, D. N., et al. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703357 · Cited by 288 · see citing works

Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo

Abbas, A. I., Hedlund, P. B., Huang, X., Tran, T. B., Meltzer, H. Y., & Roth, B. L. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1521-8 · Cited by 286 · see citing works

5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern

Hedlund, P. B., Huitron-Resendiz, S., Henriksen, S. J., & Sutcliffe, J. G. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.012 · Cited by 281 · see citing works

Aripiprazole Augmentation in Major Depressive Disorder: <i>A Double-Blind, Placebo-Controlled Study in Patients with Inadequate Response to Antidepressants</i>

Berman, R. M., Fava, M., Thase, M. E., Trivedi, M. H., Swanink, R., McQuade, R. D., Carson, W. H., Adson, D., Taylor, L., Hazel, J., et al. (2009) · CNS Spectrums · doi:10.1017/s1092852900020216 · Cited by 260 · see citing works

A Novel, Potent, and Selective 5-HT7Antagonist: (R)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)

Lovell, P. J., Bromidge, S. M., Dabbs, S., Duckworth, D. M., Forbes, I. T., Jennings, A. J., King, F. D., Middlemiss, D. N., Rahman, S. K., Saunders, D. V., et al. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm991151j · Cited by 252 · see citing works

A combined marble burying–locomotor activity test in mice: A practical screening test with sensitivity to different classes of anxiolytics and antidepressants

Nicolas, L. B., Kolb, Y., & Prinssen, E. P. M. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.07.015 · Cited by 234 · see citing works

Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression

Wesołowska, A., Nikiforuk, A., Stachowicz, K., & Tatarczynska, E. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.04.017 · Cited by 230 · see citing works

Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression

Guscott, M. R., Bristow, L. J., Hadingham, K. L., Rosahl, T. W., Beer, M. S., Stanton, J. A., Bromidge, F. A., Owens, A. P., Huscroft, I. T., Myers, J., et al. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.11.015 · Cited by 229 · see citing works

Differential mediation of descending pain facilitation and inhibition by spinal 5HT-3 and 5HT-7 receptors

Dogrul, A. B., Ossipov, M. H., & Porreca, F. (2009) · Brain Research · doi:10.1016/j.brainres.2009.05.001 · Cited by 229 · see citing works

BindingDB Entry 4895: Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.

BindingDB (2011) · PubMed · doi:10.7270/q2154fjq · Cited by 224 · see citing works

Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.

Roth, B. L., Craigo, S. C., Choudhary, M. S., Uluer, A., Monsma, F. J., Shen, Y., Meltzer, H. Y., & Sibley, D. R. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38596-4 · Cited by 214 · see citing works

8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents

Hedlund, P. B., Kelly, L., Mazur, C., Lovenberg, T. W., Sutcliffe, J. G., & Bonaventure, P. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.01.031 · Cited by 192 · see citing works

5-HT7 Receptors

Thomas, D. W., & Hagan, J. J. (2004) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007043482633 · Cited by 184 · see citing works

No hypothermic response to serotonin in 5-HT 7 receptor knockout mice

Hedlund, P. B., Danielson, P. E., Thomas, E. A., Slanina, K. A., Carson, M. J., & Sutcliffe, J. G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337340100 · Cited by 182 · see citing works

Obsessive-compulsive disorder

Heyman, I. (2006) · BMJ · doi:10.1136/bmj.333.7565.424 · Cited by 180 · see citing works

Midbrain Raphe Modulation of Nonphotic Circadian Clock Resetting and 5-HT Release in the Mammalian Suprachiasmatic Nucleus

Glass, J. D., Grossman, G. H., Farnbauch, L. A., & DiNardo, L. A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-20-07451.2003 · Cited by 176 · see citing works

Elucidation of the neurobiology of depression: insights from a novel genetic animal model

Yadid, G., Nakash, R., Roth‐Deri, I., Tamar, G., Kinor, N., Gispan, I. H., & Zangen, A. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00018-6 · Cited by 171 · see citing works

Selective Blockade of 5-Hydroxytryptamine (5-HT)7 Receptors Enhances 5-HT Transmission, Antidepressant-Like Behavior, and Rapid Eye Movement Sleep Suppression Induced by Citalopram in Rodents

Bonaventure, P., Kelly, L., Aluisio, L. E., Shelton, J. E., Lord, B., Galici, R., Miller, K. L., Atack, J. R., Lovenberg, T. W., & Dugovic, C. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.119404 · Cited by 170 · see citing works

Effects of Antidepressants on 5-HT7 Receptor Regulation in the Rat Hypothalamus

Mullins, U. L. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00041-x · Cited by 166 · see citing works

Mice lacking 5‐HT7 receptors show specific impairments in contextual learning

Roberts, A. J., Krucker, T., Levy, C. L., Slanina, K. A., Sutcliffe, J. G., & Hedlund, P. B. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03288.x · Cited by 149 · see citing works

Studies on the neuroendocrine role of serotonin.

Jørgensen, H. S. (2007) · PubMed · Cited by 144 · see citing works

5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice

Brenchat, A., Romero, L. I., Garcı́a, M., Pujol, M., Burgueño, J., Torrens, A., Hamon, M., Baeyens, J. M., Buschmann, H., Zamanillo, D., et al. (2009) · Pain · doi:10.1016/j.pain.2008.11.009 · Cited by 142 · see citing works

<i>In Vivo</i>Resetting of the Hamster Circadian Clock by 5-HT₇Receptors in the Suprachiasmatic Nucleus

Ehlen, J. C., Grossman, G. H., & Glass, J. D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05351.2001 · Cited by 139 · see citing works

8-OH-DPAT as a 5-HT7 agonist: phase shifts of the circadian biological clock through increases in cAMP production

Sprouse, J. S., Reynolds, L. S., Li, X., Braselton, J. P., & Schmidt, A. W. (2003) · Neuropharmacology · doi:10.1016/j.neuropharm.2003.08.007 · Cited by 137 · see citing works

5-HT1-like receptor agonists and the pathophysiology of migraine

Saxena, P. R., & Ferrari, M. D. (1989) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(89)90238-1 · Cited by 134 · see citing works

Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats

Li, Y., Wang, F., Pan, Y., Qiang, L.-Q., Cheng, G. S., Zhang, W., & Kong, L. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.01.006 · Cited by 134 · see citing works

5-HT7 receptors mediate serotonergic effects on light-sensitive suprachiasmatic nucleus neurons

Ying, S.-W., & Rusak, B. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00102-9 · Cited by 131 · see citing works

Methylphenidate Administration to Adolescent Rats Determines Plastic Changes on Reward-Related Behavior and Striatal Gene Expression

Adriani, W., Leo, D., Greco, D., Rea, M., di Porzio, U., Laviola, G., & Perrone‐Capano, C. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300962 · Cited by 130 · see citing works

Pre- and postsynaptic localization of the 5-HT7 receptor in rat dorsal spinal cord: Immunocytochemical evidence

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SB‐656104‐A, a novel selective 5‐HT7 receptor antagonist, modulates REM sleep in rats

Thomas, D. R., Melotto, S., Massagrande, M., Gribble, A. D., Jeffrey, P. D., Stevens, A. J., Deeks, N. J., Eddershaw, P. J., Fenwick, S. H., Riley, G. J., et al. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705290 · Cited by 127 · see citing works

The 5-HT7 receptor is involved in allocentric spatial memory information processing

Sarkisyan, G., & Hedlund, P. B. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.011 · Cited by 126 · see citing works

Serotonin pharmacology in the gastrointestinal tract: a review

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Effects of the 5-HT7 receptor antagonist SB-258741 in animal models for schizophrenia

Pouzet, B., Didriksen, M., & Arnt, J. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00744-4 · Cited by 120 · see citing works

Amisulpride versus imipramine and placebo in dysthymia and major depression

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Tetrahydrobenzindoles: Selective Antagonists of the 5-HT7Receptor

Kikuchi, C., Nagaso, H., Hiranuma, T., & Koyama, M. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm980519u · Cited by 118 · see citing works

Enhancement of the anti-immobility action of antidepressants by a selective 5-HT7 receptor antagonist in the forced swimming test in mice

Wesołowska, A., Tatarczynska, E., Nikiforuk, A., & Chojnacka-Wójcik, E. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.10.001 · Cited by 115 · see citing works

Potential anxiolytic and antidepressant effects of the selective 5-HT7 receptor antagonist SB 269970 after intrahippocampal administration to rats

Wesołowska, A., Nikiforuk, A., & Stachowicz, K. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.09.064 · Cited by 112 · see citing works

Amisulpride versus fluoxetine in patients with dysthymia or major depression in partial remission A double-blind, comparative study

Smeraldi, E. (1998) · Journal of Affective Disorders · doi:10.1016/s0165-0327(97)00139-0 · Cited by 104 · see citing works

Pronociceptive role of peripheral and spinal 5-HT7 receptors in the formalin test

Rocha-­González, H. I., Meneses, A., Carlton, S. M., & Granados‐Soto, V. (2005) · Pain · doi:10.1016/j.pain.2005.06.011 · Cited by 99 · see citing works

Systemic morphine produce antinociception mediated by spinal 5‐HT7, but not 5‐HT1A and 5‐HT2 receptors in the spinal cord

Dogrul, A. B., & Seyrek, M. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706854 · Cited by 98 · see citing works

Pharmacological evidence for the 5‐HT7 receptor mediating smooth muscle relaxation in canine cerebral arteries

Terrón, J. A., & Falcón‐Neri, A. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702580 · Cited by 90 · see citing works

Selective 5-HT1A and 5-HT7 antagonists decrease epileptic activity in the WAG/Rij rat model of absence epilepsy

Gráf, M., Jakus, R., Kántor, S., Lévay, G. I., & Bagdy, G. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.01.072 · Cited by 89 · see citing works

Effect of 5-HT7 antagonist SB-269970 in the modulation of working and reference memory in the rat

Gasbarri, A., Cifariello, A., Pompili, A., & Meneses, A. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.12.020 · Cited by 87 · see citing works

The 5-HT7 receptor influences stereotypic behavior in a model of obsessive-compulsive disorder

Hedlund, P. B., & Sutcliffe, J. G. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2006.12.054 · Cited by 84 · see citing works

Response of the Mouse Circadian System to Serotonin 1A/2/7 Agonists in vivo: Surprisingly Little

Antle, M. C., Ogilvie, M. D., Pickard, G. E., & Mistlberger, R. E. (2003) · Journal of Biological Rhythms · doi:10.1177/0748730403251805 · Cited by 82 · see citing works

The 5-HT7 receptor: Role in novel object discrimination and relation to novelty-seeking behavior

Ballaz, S., Akil, H., & Watson, S. J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.07.043 · Cited by 80 · see citing works

Analysis of 5-HT6 and 5-HT7 receptor gene expression in rats showing differences in novelty-seeking behavior

Ballaz, S., Akil, H., & Watson, S. J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.04.024 · Cited by 68 · see citing works

5-HT7 receptor stimulation by 8-OH-DPAT counteracts the impairing effect of 5-HT1A receptor stimulation on contextual learning in mice

Eriksson, T. M., Golkar, A., Ekstrom, J. C., Svenningsson, P., & Ögren, S. O. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.08.026 · Cited by 68 · see citing works

Mediation of 5‐HT‐induced external carotid vasodilatation in GR 127935‐pretreated vagosympathectomized dogs by the putative 5‐HT7 receptor

Villalón, C. M., Centurión, D., Estrada, M. L., Terrón, J. A., & Sánchez‐López, A. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701020 · Cited by 68 · see citing works

New light on the serotonergic paradox in the rat circadian system

Cuesta, M., Clesse, D., Pévet, P., & Challet, E. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06128.x · Cited by 67 · see citing works

Methylphenidate to adolescent rats drives enduring changes of accumbal Htr7 expression: implications for impulsive behavior and neuronal morphology

Leo, D., Adriani, W., Cavaliere, C., Cirillo, G., Marco, E. M., Romano, E., di Porzio, U., Papa, M., Perrone‐Capano, C., & Giovanni Laviola, A. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00486.x · Cited by 66 · see citing works

Positive Association of the Serotonin 5-HT7 Receptor Gene with Schizophrenia in a Japanese Population

Ikeda, M., Iwata, N., Kitajima, T., Suzuki, T., Yamanouchi, Y., Kinoshita, Y., & Ozaki, N. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300901 · Cited by 65 · see citing works

Effects of SB-269970, a 5-HT7 receptor antagonist, in mouse models predictive of antipsychotic-like activity

Galici, R., Boggs, J. D., Miller, K. L., Bonaventure, P., & Atack, J. R. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282f62d8c · Cited by 64 · see citing works

Radioligand binding analysis of knockout mice reveals 5-hydroxytryptamine7 receptor distribution and uncovers 8-hydroxy-2-(di-n-propylamino)tetralin interaction with α2 adrenergic receptors

Bonaventure, P., Nepomuceno, D. H., Hein, L., Sutcliffe, J. G., Lovenberg, T. W., & Hedlund, P. B. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.01.014 · Cited by 64 · see citing works

Influence of serotonin 5-HT(7) receptor blockade on the behavioral and neurochemical effects of imipramine in rats.

Wesołowska, A., & Kowalska, M. (2008) · PubMed · Cited by 60 · see citing works

An RT-PCR study of 5-HT6 and 5-HT7 receptor mRNAs in the hippocampal formation and prefrontal cortex in schizophrenia

East, S. Z., Burnet, P. W. J., Kerwin, R. W., & Harrison, P. J. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00323-1 · Cited by 60 · see citing works

Evidence for the involvement of central 5‐HT7 receptors in the micturition reflex in anaesthetized female rats

Read, K. E., Sanger, G. J., & Ramage, A. G. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705399 · Cited by 58 · see citing works

Activation of 5-HT1A and 5-HT7 receptors in the parafascicular nucleus suppresses the affective reaction of rats to noxious stimulation

Harte, S. E., Kender, R. G., & Borszcz, G. S. (2004) · Pain · doi:10.1016/j.pain.2004.11.023 · Cited by 55 · see citing works

Aging and SB-269970-A, a selective 5-HT7 receptor antagonist, attenuate circadian phase advances induced by microinjections of serotonergic drugs in the hamster dorsal raphe nucleus

Duncan, M. J., Grear, K. E., & Hoskins, M. A. (2004) · Brain Research · doi:10.1016/j.brainres.2004.02.025 · Cited by 54 · see citing works

Correlation between 5-HT7 receptor affinity and protection against sound-induced seizures in DBA/2J mice

Bourson, A., Kapps, V., Zwingelstein, C., Rudler, A., Boess, F., & Sleight, A. J. (1997) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/pl00005123 · Cited by 53 · see citing works

Inactivation of the 5-HT7 Receptor Partially Blocks Phencyclidine-Induced Disruption of Prepulse Inhibition

Semenova, S., Geyer, M. A., Sutcliffe, J. G., Markou, A., & Hedlund, P. B. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.12.011 · Cited by 53 · see citing works

Circadian Rhythm Phenotype of 5-HT₇ Receptor Knockout Mice: 5-HT and 8-OH-DPAT-Induced Phase Advances of SCN Neuronal Firing

Sprouse, J. S., Li, X., Stock, J. L., McNeish, J. D., & Reynolds, L. S. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730404273432 · Cited by 50 · see citing works

Constitutive deletion of the serotonin-7 (5-HT7) receptor decreases electrical and chemical seizure thresholds

Witkin, J. M., Baez, M., Yu, J., Barton, M. E., & Shannon, H. E. (2007) · Epilepsy Research · doi:10.1016/j.eplepsyres.2007.03.017 · Cited by 49 · see citing works

5-HT1A/1B, 5-HT6, and 5-HT7 serotonergic receptors recruitment in tonic-clonic seizure-induced antinociception: Role of dorsal raphe nucleus

de Freitas, R. L., Ferreira, C. M. D. R., Urbina, M., Marino, A., Carvalho, A. D., Butera, G., de Oliveira, A. M., & Coimbra, N. C. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.01.003 · Cited by 40 · see citing works

Presence of a 5-HT7Receptor Positively Coupled to Adenylate Cyclase Activation in Human Granulosa-Lutein Cells1

Graveleau, C., Paust, H., Schmidt-Grimminger, D., & Mukhopadhyay, A. K. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.3.6448 · Cited by 38 · see citing works

5-HT7 receptor-mediated dilatation in the middle meningeal artery of anesthetized rats

Terrón, J. A., & Martínez-García, E. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.01.019 · Cited by 36 · see citing works

5‐hydroxytryptamine induced relaxation in the pig urinary bladder neck

Recio, P., Barahona, M. V., Orensanz, L. M., Bustamante, S., Martı́nez, A. C., Benedito, S., García‐Sacristán, A., Prieto, D., & Hernández, M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00144.x · Cited by 35 · see citing works

Serotonin 5-HT7receptors mediate relaxation of porcine pial veins

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Antagonism of 5‐HT1Areceptors uncovers an excitatory effect of SSRIs on 5‐HT neuronal activity, an action probably mediated by 5‐HT7receptors

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Tokarski, K., Kusek, M., & Hess, G. (2011) · PubMed · Cited by 45 · see citing works

Selective blockade of 5-HT7 receptors facilitates attentional set-shifting in stressed and control rats

Nikiforuk, A. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.09.006 · Cited by 44 · see citing works

Serotonin receptor 5-HT7 regulates morphology and migratory properties of dendritic cells

Holst, K., Guseva, D., Schindler, S., Sixt, M., Braun, A. C., Chopra, H., Pabst, O., & Ponimaskin, E. G. (2015) · Journal of Cell Science · doi:10.1242/jcs.167999 · Cited by 44 · see citing works

Amisulpride promotes cognitive flexibility in rats: The role of 5-HT7 receptors

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Inflammation and peripheral 5-HT7 receptors: The role of 5-HT7 receptors in carrageenan induced inflammation in rats

Albayrak, A., Halıcı, Z., Çadırcı, E., Polat, B., Karakuş, E., Bayır, Y., Ünal, D., Atasoy, M., & Dogrul, A. B. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.05.010 · Cited by 43 · see citing works

S100B interacts with the serotonin 5-HT7 receptor to regulate a depressive-like behavior

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Differential distribution of serotonin receptor subtypes in BNSTALG neurons: Modulation by unpredictable shock stress

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Efficacy of vortioxetine on the physical symptoms of major depressive disorder

Christensen, M. C., Florea, I., Lindstén, A., & Baldwin, D. S. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881118788826 · Cited by 42 · see citing works

5-HT7 receptor activation attenuates thermal hyperalgesia in streptozocin-induced diabetic mice

Ulugöl, A., Oltulu, Ç., Gündüz, Ö., Citak, C., Carrara, R., Shaqaqi, M. R., Sanchez, A. M., & Dogrul, A. B. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.05.006 · Cited by 40 · see citing works

Involvement of 5-HT7 receptors in vortioxetine's modulation of circadian rhythms and episodic memory in rodents

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Effects of 5-HT-7 receptor ligands on memory and cognition

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Pharmaco-EEG Studies in Animals: A History-Based Introduction to Contemporary Translational Applications

Drinkenburg, W. H. I. M., Ahnaou, A., & Ruigt, G. S. F. (2015) · Neuropsychobiology · doi:10.1159/000443175 · Cited by 37 · see citing works

The critical role of spinal 5-HT7 receptors in opioid and non-opioid type stress-induced analgesia

Yeşilyurt, Ö., Seyrek, M., Taşdemir, S., Kahraman, S., Deveci, M. S., Karakuş, E., Halıcı, Z., & Dogrul, A. B. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.04.020 · Cited by 38 · see citing works

Arene- and quinoline-sulfonamides as novel 5-HT7 receptor ligands

Zajdel, P., Marciniec, K., Maślankiewicz, A., Paluchowska, M. H., Satała, G., Partyka, A., Jastrzębska‐Więsek, M., Wróbel‐Biedrawa, D., Wesołowska, A., Duszyńska, B., et al. (2011) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2011.09.044 · Cited by 37 · see citing works

Persistent modification of forebrain networks and metabolism in rats following adolescent exposure to a 5-HT7 receptor agonist

Canese, R., Zoratto, F., Altabella, L., Porcari, P., Mercurio, L., de Pasquale, F., Butti, E., Martino, G., Lacivita, E., Leopoldo, M., et al. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3639-6 · Cited by 36 · see citing works

Comparison of 4 Radiolabeled Antagonists for Serotonin 5-HT7Receptor Neuroimaging: Toward the First PET Radiotracer

Lemoine, L., Andriès, J., Bars, D. L., Billard, T., & Zimmer, L. (2011) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.089185 · Cited by 36 · see citing works

Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers

Hogendorf, A. S., Hogendorf, A., Popiołek-Barczyk, K., Ciechanowska, A., Mika, J., Satała, G., Walczak, M., Latacz, G., Handzlik, J., Kieć‐Kononowicz, K., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.03.017 · Cited by 36 · see citing works

The Serotonin-7 Receptor as a Novel Therapeutic Target

Stahl, S. M. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.10bs06601gry · Cited by 35 · see citing works

5-HT7 receptor modulates GABAergic transmission in the rat dorsal raphe nucleus and controls cortical release of serotonin

Kusek, M., Sowa, J., Kamińska, K., Gołembiowska, K., Tokarski, K., & Hess, G. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00324 · Cited by 33 · see citing works

Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder

Vigli, D., Rusconi, L., Valenti, D., Montanara, P. L., Cosentino, L., Lacivita, E., Leopoldo, M., Amendola, E., Gross, C. T., Landsberger, N., et al. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.10.018 · Cited by 33 · see citing works

Receptor mechanisms of antipsychotic drug action in bipolar disorder – focus on asenapine

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Search for a 5-CT alternative. In vitro and in vivo evaluation of novel pharmacological tools: 3-(1-alkyl-1 H -imidazol-5-yl)-1 H -indole-5-carboxamides, low-basicity 5-HT 7 receptor agonists

Latacz, G., Hogendorf, A. S., Hogendorf, A., Lubelska, A., Wierońska, J. M., Woźniak, M., Cieślik, P., Kieć‐Kononowicz, K., Handzlik, J., & Bojarski, A. J. (2018) · MedChemComm · doi:10.1039/c8md00313k · Cited by 32 · see citing works

Therapeutic potential of serotonin 4 receptor for chronic depression and its associated comorbidity in the gut

Agrawal, L., Korkutata, M., Vimal, S. K., Yadav, M. K., Bhattacharyya, S., & Shiga, T. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.107969 · Cited by 31 · see citing works

Estradiol modulation of cortical, striatal and raphe nucleus 5-HT1A and 5-HT2A receptors of female hemiparkinsonian monkeys after long-term ovariectomy

Sanchez, M. G. D. B., Estrada-Camarena, E. M., Bélanger, N., Morissette, M., & Paolo, T. D. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.11.024 · Cited by 31 · see citing works

Evidence of an inverse correlation between serotonergic activity and spreading depression propagation in the rat cortex

Guedes, R. C. A., de Araújo, M. D. G. R., Verçosa, T. C., Bion, F. M., de Sá, A. L., Pereira, A., & Abadie‐Guedes, R. (2017) · Brain Research · doi:10.1016/j.brainres.2017.07.011 · Cited by 30 · see citing works

The 5-HT7 receptor system as a treatment target for mood and anxiety disorders: A systematic review

Gottlieb, N., Li, T.-Y., Young, A. H., & Stokes, P. R. A. (2023) · Journal of Psychopharmacology · doi:10.1177/02698811231211228 · Cited by 32 · see citing works

Evaluation of 5-HT7 receptor antagonism for the treatment of anxiety, depression, and schizophrenia through the use of receptor-deficient mice

Balcer, O. M., Seager, M. A., Gleason, S. D., Li, X., Rasmussen, K., Maxwell, J. K., Nomikos, G. G., Degroot, A., & Witkin, J. M. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.12.019 · Cited by 29 · see citing works

C.16.03 The importance of serotonin (5-HT) and noradrenaline (NA) in anxiety

Blier, P. (2006) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(06)70858-6

Targeting the Serotonin 5-HT7 Receptor in the Search for Treatments for CNS Disorders: Rationale and Progress to Date

Nikiforuk, A. (2015) · CNS Drugs · doi:10.1007/s40263-015-0236-0 · Cited by 136 · see citing works

Therapeutic Potential of 5-HT7 Receptors in Mood Disorders

Mnie‐Filali, O., Lambás‐Señas, L., Scarna, H., & Haddjeri, N. (2009) · Current Drug Targets · doi:10.2174/138945009789735129 · Cited by 37 · see citing works