Changes in plasma and platelet BDNF levels induced by S-citalopram in major depression
Open accessAbstract
Background Neuroplastic processes are thought to be involved in the pathophysiology of major depression. It has been reported that serum brain-derived neurotrophic factor (BDNF) is decreased in depressed patients. Objectives Compare BDNF levels in depressed patients and healthy controls in platelet poor plasma and in washed platelets. Observe the effects of 8- and 24-week treatment with S-citalopram on these levels. Methods We assessed the levels of BDNF in platelet poor plasma and in washed platelets from 18 major depression patients, and compared them with 14 healthy controls. Blood samples were obtained from patients before and during treatment (8 and 24 weeks) with a selective serotonin reuptake inhibitor, S-citalopram. Results A significant decrease in severity of depressive symptoms was observed from the first month of treatment with S-citalopram, and symptoms continued decreasing until the 6th month. Plasma BDNF levels in untreated patients appeared significantly increased (p<0.01) but reached values similar to those of controls at the 24th week. In contrast, levels of platelet BDNF appeared significantly decreased (p<0.05), but treatment also normalized levels so that values obtained were equivalent to those of controls. Conclusions Untreated depressed patients showed increased plasma BDNF levels and decreased platelet BDNF levels, as compared with control subjects, and tend to normalize during treatment with S-citalopram for 24 weeks, with BDNF reaching levels similar to those in healthy controls at the 24th week in both samples. We observed that improvement in depressive symptoms was accompanied by normalization of plasma and platelet BDNF levels.
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In that study, BDNF levels were normalized compared to control with SSRIs treatment.
“In this study, the BDNF levels were normalized compared to control with SSRIs treatment [197].”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [197]
BDNF levels of platelets were significantly decreased compared to controls in patients with MDD.
“Another study showed that BDNF levels of platelet were significantly decreased compared to the controls.”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [197]
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- Authors
- Serra-Millàs, M., López-Vílchez, I., Navarro, V., Galán, A.-M., Escolar, G., Penadés, R., Catalán, R., Fañanás, L., Arias, B., & Gastó, C.
- Affiliations
- Hospital Clínic de Barcelona (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Instituto de Salud Carlos III (ES)
- Venue
- Psychopharmacology
- Published
- 2011-02-11
- Volume
- 216
- Issue
- 1
- Pages
- 1-8
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2017705782
- Cited by
- 67
- References
- 57
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 8 · 2015: 2 · 2014: 7 · 2013: 9 · 2012: 9
- FWCI
- 6.79
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
- Zenodo (CERN European Organization for Nuclear Research)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- brain-derived neurotrophic factor, major depressive disorder, escitalopram, selective serotonin reuptake inhibitors, plasma BDNF, washed platelets, neuroplasticity, antidepressant response, depression severity
- MeSH terms
- Adolescent, Adult, Aged, Blood Platelets, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Longitudinal Studies, Male, Middle Aged, Neuronal Plasticity, Psychiatric Status Rating Scales, Citalopram, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Brain-Derived Neurotrophic Factor, Young Adult
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