Variation in saliva cotinine as a function of self-reported attempts to reduce cigarette consumption
Abstract
Rationale Cotinine is an accurate objective marker of nicotine intake. There is very little information on its stability over time or as a function of self-reported attempts at smoking reduction.Objectives This study aimed to assess the stability of saliva cotinine concentrations over a 3-month period, as a function of self-reported attempts to reduce cigarette consumption, using data from a general population sample of English smokers.Methods Six-hundred and ninety-one smokers from a population sample of English smokers provided saliva samples for cotinine analysis on two occasions 3 months apart. Data on cigarette consumption, whether smokers reported that they were attempting to cut down consumption and concurrent use of nicotine replacement therapy (NRT), were also collected on both occasions.Results The 'test-retest' measure of cotinine stability was 0.76, and the simple correlation was 0.73. Smokers not using NRT who reported cutting down on one occasion but not the other showed a small reduction in cigarette consumption at the time they were cutting down (1.1 cig per day, p = 0.013) but no significant difference in saliva cotinine concentrations (mean reduction = 13.4 ng/ml, p = 0.39).Conclusions Saliva cotinine concentrations show moderate-to-high stability within subjects over a 3-month period. Smokers' reports of attempting to cut down their smoking are associated with small daily cigarette consumption decreases but no detectable change in nicotine intake.
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Concurrent use of NRT among smokers did not appear to increase their nicotine intake.
“Moreover, confirming previous research, 67,112 the concurrent use of NRT among smokers did not appear to increase their nicotine intake.”
From Evaluating Long-term Outcomes of NHS Stop Smoking Services (ELONS): a prospective cohort study (2015) · cites this paper as [112]
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- Authors
- Fidler, J. A., Stapleton, J. A., & West, R.
- Affiliations
- University College London (GB)
- Corresponding author
- Fidler, Jennifer A.
- ORCID
- West, Robert
- Venue
- Psychopharmacology
- Published
- 2011-05-10
- Volume
- 217
- Issue
- 4
- Pages
- 587-593
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2029401380
- Cited by
- 14
- References
- 22
- Citations by year
- 2019: 2 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 1
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Funders
- GlaxoSmithKline
- Cancer Research UK
- National Institute for Health and Care Research
- Johnson and Johnson
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- saliva cotinine, nicotine use, smoking reduction, test-retest stability, nicotine replacement therapy, cigarette consumption, biomarker validity, smokers
- MeSH terms
- Adult, Cotinine, Data Interpretation, Statistical, Female, Humans, Male, Middle Aged, Saliva, Smoking, Biomarkers, Smoking Cessation, Behavior, Addictive, Self Report
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