Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear
Abstract
Rationale The post-extinction exposure of rats to a sub-conditioning procedure (SCP; i.e., retraining with a shock intensity that is too weak to induce by itself significant fear conditioning) has been reported to provoke the reemergence of extinguished fear. This phenomenon can be prevented by chronic fluoxetine treatment.Objectives We sought to examine another potential inducer of fear reemergence, acute stress, in rats and determine whether fluoxetine prevents this phenomenon.Methods Because in previous studies fluoxetine was administered before extinction, we first analyzed its effect on the SCP-associated reemergence of auditory-cued conditioned fear in rats injected after extinction to avoid any interaction between fluoxetine and extinction learning. Next, we used the same protocol but replaced the SCP with acute stress.Results We found that the SCP and acute stress, which were carried out 3 weeks after fear extinction, similarly provoked the reemergence of extinguished fear in rats injected with vehicle during the 3-week period. In contrast, the animals treated with fluoxetine during this period behaved similarly to those not exposed to an inducer of fear reemergence.Conclusions Our data establish acute stress as an inducer of fear reemergence. The results provide further support for the hypothesis that fluoxetine interfered with mechanisms that reactivated extinguished fear, even when administered after fear extinction.
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Pre-clinical rodent studies have shown that venlafaxine and fluoxetine can prevent reinstatement of conditioned fear.
“Pre-clinical rodent studies have shown that monoaminergic specific antidepressants such as venlafaxine (serotonin–norepinephrine reuptake inhibitor; SNRI) and fluoxetine (serotonin specific reuptake inhibitor; SSRI) can facilitate between-session extinction (79, 80) and prevent reinstatement of conditioned fear (80, 81).”
From Conditioned fear associated phenotypes as robust, translational indices of trauma-, stressor-, and anxiety-related behaviors (2014) · cites this paper as [81]
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- Authors
- Deschaux, O., Zheng, X., Lavigne, J., Nachon, O., Cleren, C., Moreau, J.-L., & Garcia, R.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Chinese Academy of Sciences (CN)
- F. Hoffmann-La Roche AG (CH)
- Corresponding author
- Deschaux, Olivier
- Venue
- Psychopharmacology
- Published
- 2012-07-24
- Volume
- 225
- Issue
- 1
- Pages
- 209-216
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2100035918
- Cited by
- 62
- References
- 38
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 7 · 2017: 2 · 2016: 5 · 2015: 10 · 2014: 10 · 2013: 12
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repository of Institute of Psychology, Chinese Academy of Sciences (Institute of Psychology, Chinese Academy of Sciences) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- fear extinction, fluoxetine, acute stress
- MeSH terms
- Animals, Disease Models, Animal, Extinction, Psychological, Fear, Fluoxetine, Male, Stress, Psychological, Rats, Sprague-Dawley, Selective Serotonin Reuptake Inhibitors, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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