Reversal of stress-induced anhedonia by the atypical antidepressants, fluoxetine and maprotiline
Abstract
Chronic exposure to mild unpredictable stress has previously been found to depress the consumption of palatable sweet solutions. In the present study this effect was reversed by chronic (9 weeks) treatment with the atypical antidepressants, fluoxetine and maprotiline (5 mg/kg/day); the non-antidepressant chlordiazepoxide was ineffective. Stressed animals were also subsensitive to food reward in the place conditioning procedure; however, fluoxetine and maprotiline treated animals showed normal place preference conditioning. Acute pretreatment with raclopride (100 micrograms/kg) selectively reversed the recovery of sucrose drinking in antidepressant-treated stressed animals. These results extend previous reports of the efficacy of tricyclic antidepressants in this paradigm, and support the hypothesis of a dopaminergic mechanism of antidepressant action.
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Chronic and sequential exposure of rats or mice to a mild stress regimen causes decreases in responsiveness to rewards, including decreased consumption of and preference for sucrose solutions and decreased rewarding properties of pharmacological and natural rewards in the place preference paradigm.
“In particular, Willner and colleagues originally reported that chronic and sequential exposure of rats or mice to a mild stress regimen caused decreases in responsiveness to rewards [190,191], commonly reported as a decrease in the consumption of and preference for sucrose solutions, and a decrease in the rewarding properties of pharmacological and natural rewards in the place preference behavior”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [192]
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Self-citation
- Authors
- Muscat, R., Papp, M., & Willner, P.
- Venue
- Psychopharmacology
- Published
- 1992-12
- Volume
- 109
- Issue
- 4
- Pages
- 433-438
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2085836426
- Cited by
- 237
- References
- 38
- Citations by year
- 2025: 2 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 11 · 2015: 9 · 2014: 14 · 2013: 12 · 2012: 18
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- fluoxetine, maprotiline, atypical antidepressants, unpredictable stress, sucrose intake, food reward, place conditioning, chlordiazepoxide, raclopride, tricyclic antidepressants
- MeSH terms
- Animals, Chlordiazepoxide, Conditioning, Operant, Dopamine, Eating, Feeding Behavior, Fluoxetine, Food, Male, Maprotiline, Reward, Stress, Psychological, Sucrose, Antidepressive Agents, Second-Generation, Rats
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