Rethinking psychopharmacotherapy: the role of treatment context and brain plasticity in antidepressant and antipsychotic interventions.
Open accessAbstract
Emerging evidence indicates that treatment context profoundly affects psychopharmacological interventions. We review the evidence for the interaction between drug application and the context in which the drug is given both in human and animal research. We found evidence for this interaction in the placebo response in clinical trials, in our evolving knowledge of pharmacological and environmental effects on neural plasticity, and in animal studies analyzing environmental influences on psychotropic drug effects. Experimental placebo research has revealed neurobiological trajectories of mechanisms such as patients' treatment expectations and prior treatment experiences. Animal research confirmed that "enriched environments" support positive drug effects, while unfavorable environments (low sensory stimulation, low rates of social contacts) can even reverse the intended treatment outcome. Finally we provide recommendations for context conditions under which psychotropic drugs should be applied. Drug action should be steered by positive expectations, physical activity, and helpful social and physical environmental stimulation. Future drug trials should focus on fully controlling and optimizing such drug×environment interactions to improve trial sensitivity and treatment outcome.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Neither antipsychotics nor antidepressants have been consistently shown to induce any lasting neuroplastic changes in the brain.
“Neither antipsychotics nor antidepressants have been consistently shown to induce any lasting neuroplastic changes in the brain (Rief et al., 2015).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Rief et al., 2015
The efficacy of both antidepressant and antipsychotic medications could be improved if more attention were afforded to relevant lifestyle factors such as AE engagement.
“The efficacy of both antidepressant and antipsychotic medications could be improved should more attention be afforded to relevant lifestyle factors such as AE engagement (Rief et al., 2015).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Rief et al., 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444 · see citing works
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321 · see citing works
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111 · see citing works
Selective publication of antidepressant trials and its influence on apparent efficacy
Turner, E. H., Matthews, A. M., Linardatos, E., Tell, R. A., & Rosenthal, R. (2008) · New England Journal of Medicine · doi:10.1056/nejmsa065779 · Cited by 2,435 · see citing works
Maximizing exposure therapy: An inhibitory learning approach
Craske, M. G., Treanor, M., Conway, C. C., Zbozinek, T., & Vervliet, B. (2014) · Behaviour Research and Therapy · doi:10.1016/j.brat.2014.04.006 · Cited by 2,339 · see citing works
Critical period plasticity in local cortical circuits
Hensch, T. K. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1787 · Cited by 2,323 · see citing works
Cooney, G. M., Dwan, K., Greig, C. A., Lawlor, D. A., Rimer, J., Waugh, F. R., McMurdo, M., & Mead, G. E. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004366.pub6 · Cited by 1,834 · see citing works
Plasticity in gray and white: neuroimaging changes in brain structure during learning
Zatorre, R. J., Fields, R. D., & Johansen-Berg, H. (2012) · Nature Neuroscience · doi:10.1038/nn.3045 · Cited by 1,685 · see citing works
Synaptic Dysfunction in Depression: Potential Therapeutic Targets
Duman, R. S., & Aghajanian, G. K. (2012) · Science · doi:10.1126/science.1222939 · Cited by 1,651 · see citing works
Plasticity of ocular dominance columns in monkey striate cortex
Hubel, D. H., Wiesel, T. N., LeVay, S., Barlow, H. B., & Gaze, R. M. (1977) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1977.0050 · Cited by 1,642 · see citing works
The contextual brain: implications for fear conditioning, extinction and psychopathology
Maren, S., Phan, K. L., & Liberzon, I. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3492 · Cited by 1,547 · see citing works
(1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.7.979 · Cited by 1,485 · see citing works
Identification of a Common Neurobiological Substrate for Mental Illness
Goodkind, M., Eickhoff, S. B., Oathes, D. J., Jiang, Y., Chang, A., Jones-Hagata, L. B., Ortega, B. N., Zaiko, Y. V., Roach, E. L., Korgaonkar, M. S., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2206 · Cited by 1,404 · see citing works
Placebo Response in Studies of Major Depression: Variable, Substantial, and Growing
Walsh, B. T., Seidman, S. N., Sysko, R., & Gould, M. (2002) · JAMA · doi:10.1001/jama.287.14.1840 · Cited by 1,109 · see citing works
Eye tracking of attention in the affective disorders: a meta-analytic review and synthesis
Armstrong, T., & Olatunji, B. O. (2012) · Clinical Psychology Review · doi:10.1016/j.cpr.2012.09.004 · Cited by 1,049 · see citing works
Expectation and Dopamine Release: Mechanism of the Placebo Effect in Parkinson's Disease
de la Fuente‐Fernández, R., Ruth, T. J., Sossi, V., Schulzer, M., Calne, D. B., & Stoessl, A. J. (2001) · Science · doi:10.1126/science.1060937 · Cited by 991 · see citing works
Long-term Antipsychotic Treatment and Brain Volumes
Ho, B., Andreasen, N. C., Ziebell, S., Pierson, R. K., & Magnotta, V. A. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.199 · Cited by 975 · see citing works
De Hert, M., Dekker, J. M., Wood, D., Kahl, K. G., Holt, R. I. G., & Möller, H.-J. (2009) · European Psychiatry · doi:10.1016/j.eurpsy.2009.01.005 · Cited by 951 · see citing works
Cooney, G. M., Dwan, K., Greig, C. A., Lawlor, D. A., Rimer, J., Waugh, F. R., McMurdo, M., & Mead, G. E. (2014) · Advances in Psychiatric Treatment · doi:10.1192/apt.20.1.2 · Cited by 895 · see citing works
The antidepressant fluoxetine restores plasticity in the adult visual cortex
Vetencourt, J. F. M., Sale, A., Viegi, A., Baroncelli, L., De Pasquale, R., F. O'Leary, O., Castrén, E., & Maffei, L. (2008) · Science · doi:10.1126/science.1150516 · Cited by 890 · see citing works
Expectation in perceptual decision making: neural and computational mechanisms
Summerfield, C., & de Lange, F. P. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3838 · Cited by 832 · see citing works
Early-Life Blockade of the 5-HT Transporter Alters Emotional Behavior in Adult Mice
Ansorge, M. S., Zhou, M., Lira, A., Hen, R., & Gingrich, J. A. (2004) · Science · doi:10.1126/science.1101678 · Cited by 817 · see citing works
Walker, D. L., Ressler, K. J., Lu, K.-T., & Davis, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02343.2002 · Cited by 815 · see citing works
Malberg, J. E., & Duman, R. S. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300234 · Cited by 815 · see citing works
Neurobiological Mechanisms of the Placebo Effect
Benedetti, F., Mayberg, H., Wager, T., Stohler, C., & Zubieta, J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3458-05.2005 · Cited by 771 · see citing works
Perineuronal Nets Protect Fear Memories from Erasure
Gogolla, N., Caroni, P., Lüthi, A., & Herry, C. (2009) · Science · doi:10.1126/science.1174146 · Cited by 760 · see citing works
The Functional Neuroanatomy of the Placebo Effect
Mayberg, H. S., Silva, J. A., Brannan, S., Tekell, J. L., Mahurin, R. K., McGinnis, S. M., & Jerabek, P. A. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.5.728 · Cited by 718 · see citing works
Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety
Thomas, A., Burant, A., Bui, N., Graham, D., Yuva-Paylor, L. A., & Paylor, R. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1466-y · Cited by 698 · see citing works
The placebo response in medicine: minimize, maximize or personalize?
Enck, P., Bingel, U., Schedlowski, M., & Rief, W. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3923 · Cited by 671 · see citing works
Self-citationA meta-analysis of the magnitude of biased attention in depression
Peckham, A. D., McHugh, R. K., & Otto, M. W. (2010) · Depression and Anxiety · doi:10.1002/da.20755 · Cited by 647 · see citing works
Linking Molecules to Mood: New Insight Into the Biology of Depression
Krishnan, V., & Nestler, E. J. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.10030434 · Cited by 643 · see citing works
Twenty-five year mortality of a community cohort with schizophrenia
Brown, S., Kim, M., Mitchell, C., & Inskip, H. (2010) · British Journal of Psychiatry · doi:10.1192/bjp.bp.109.067512 · Cited by 601 · see citing works
Eyding, D., Lelgemann, M., Grouven, U., Härter, M. C., Kromp, M., Kaiser, T., Kerekeş, M., Gerken, M., & Wieseler, B. (2010) · BMJ · doi:10.1136/bmj.c4737 · Cited by 591 · see citing works
Castrén, E. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1629 · Cited by 563 · see citing works
BDNF in schizophrenia, depression and corresponding animal models
Angelucci, F., Brené, S., & Mathé, A. A. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001637 · Cited by 548 · see citing works
Fusar-Poli, P., Smieskova, R., Kempton, M. J., Ho, B. C., Andreasen, N. C., & Borgwardt, S. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.06.001 · Cited by 512 · see citing works
Listening to Prozac but hearing placebo: A meta-analysis of antidepressant medication.
Kirsch, I., & Sapirstein, G. (1998) · Prevention & Treatment · doi:10.1037/1522-3736.1.1.12a · Cited by 509 · see citing works
Leucht, S., Arbter, D., Engel, R. R., Kissling, W., & Davis, J. M. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002136 · Cited by 489 · see citing works
Mechanism of Action of Atypical Antipsychotic Drugs and the Neurobiology of Schizophrenia
Horáček, J., Bubeníková‐Valešová, V., Kopeček, M., Páleníček, T., Dockery, C. A., Mohr, P., & Höschl, C. (2006) · CNS Drugs · doi:10.2165/00023210-200620050-00004 · Cited by 462 · see citing works
Induction of Fear Extinction with Hippocampal-Infralimbic BDNF
Peters, J., Dieppa-Perea, L. M., Melendez, L. M., & Quirk, G. J. (2010) · Science · doi:10.1126/science.1186909 · Cited by 462 · see citing works
Petrovic, P., Dietrich, T., Fransson, P., Andersson, J., Carlsson, K., & Ingvar, M. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.023 · Cited by 437 · see citing works
Krogsbøll, L. T., Hróbjartsson, A., & Gøtzsche, P. C. (2009) · BMC Medical Research Methodology · doi:10.1186/1471-2288-9-1 · Cited by 435 · see citing works
Overgeneral autobiographical memory as a predictor of the course of depression: A meta-analysis
Sumner, J. A., Griffith, J. W., & Mineka, S. (2010) · Behaviour Research and Therapy · doi:10.1016/j.brat.2010.03.013 · Cited by 414 · see citing works
Czéh, B., Keuker, J. I. H., Ryguła, R., Abumaria, N., Hiemke, C., Domenici, E., & Fuchs, E. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301275 · Cited by 397 · see citing works
Changes in Brain Function of Depressed Subjects During Treatment With Placebo
Leuchter, A. F., Cook, I. A., Witte, E. A., Morgan, M. L., & Abrams, M. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.1.122 · Cited by 394 · see citing works
Kodama, M., Fujioka, T., & Duman, R. S. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.07.008 · Cited by 387 · see citing works
Fear erasure in mice requires synergy between antidepressant drugs and extinction training
Karpova, N. N., Pickenhagen, A., Lindholm, J., Tiraboschi, E., Kulesskaya, N., Ágústsdóttir, A., Antila, H., Popova, D., Akamine, Y., Sullivan, R., et al. (2011) · Science · doi:10.1126/science.1214592 · Cited by 382 · see citing works
Antidepressants versus placebo for depression in primary care
Arroll, B., Elley, C. R., Fishman, T., Goodyear‐Smith, F., Kenealy, T. W., Blashki, G. A., Kerse, N. M., & MacGillivray, S. A. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007954 · Cited by 353 · see citing works
Meta-analysis of the placebo response in antidepressant trials.
Rief, W., Nestoriuc, Y., Weiss, S., Welzel, E., Barsky, A. J., & Hofmann, S. G. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.01.029 · Cited by 346 · see citing works
Self-citationNeural mechanisms of social risk for psychiatric disorders
Meyer‐Lindenberg, A., & Tost, H. (2012) · Nature Neuroscience · doi:10.1038/nn.3083 · Cited by 342 · see citing works
Active placebos versus antidepressants for depression
Moncrieff, J., Wessely, S., & Hardy, R. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003012.pub2 · Cited by 342 · see citing works
Antipsychotic Treatment and Functional Connectivity of the Striatum in First-Episode Schizophrenia
Sarpal, D. K., Robinson, D. G., Lencz, T., Árgyelán, M., Ikuta, T., Karlsgodt, K. H., Gallego, J. A., Kane, J. M., Szeszko, P. R., & Malhotra, A. K. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1734 · Cited by 328 · see citing works
Yau, S. Y., Li, A., Hoo, R. L. C., Ching, Y. P., Christie, B. R., Lee, T. M. C., Xu, A., & So, K.-F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415219111 · Cited by 326 · see citing works
Waltz, J. A., Frank, M. J., Robinson, B. M., & Gold, J. M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.042 · Cited by 326 · see citing works
Adult neuroplasticity: more than 40 years of research
Fuchs, E., & Flügge, G. (2014) · Neural Plasticity · doi:10.1155/2014/541870 · Cited by 325 · see citing works
Schedlowski, M., Enck, P., Rief, W., & Bingel, U. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009423 · Cited by 323 · see citing works
Self-citationAgomelatine, a new antidepressant, induces regional changes in hippocampal neurogenesis
Banasr, M., Soumier, A., Hery, M., Mocaër, E., & Daszuta, A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.025 · Cited by 318 · see citing works
Adult Neurogenesis: Beyond Learning and Memory
Cameron, H. A., & Glover, L. R. (2014) · Annual Review of Psychology · doi:10.1146/annurev-psych-010814-015006 · Cited by 302 · see citing works
Maintenance treatment with antipsychotic drugs for schizophrenia
Leucht, S., Tardy, M., Komossa, K., Heres, S., Kissling, W., & Davis, J. M. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008016.pub2 · Cited by 287 · see citing works
Ross, L. E., Grigoriadis, S., Mamisashvili, L., VonderPorten, E. H., Roerecke, M., Rehm, J., Dennis, C.-L., Koren, G., Steiner, M., Mousmanis, P., et al. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.684 · Cited by 268 · see citing works
Zoladz, J. A., & Pilc, A. (2010) · PubMed · Cited by 268 · see citing works
A Model of Placebo Response in Antidepressant Clinical Trials
Rutherford, B. R., & Roose, S. P. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12040474 · Cited by 268 · see citing works
New perspectives on the neurodevelopmental effects of SSRIs
Homberg, J. R., Schubert, D., & Gaspar, P. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.11.003 · Cited by 266 · see citing works
Wöhr, M., Orduz, D., Gregory, P., Moreno, H., Khan, U., Vörckel, K. J., Wolfer, D. P., Welzl, H., Gall, D., Schiffmann, S. N., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.19 · Cited by 258 · see citing works
Self-citationLong-Term Plasticity of Visually Evoked Potentials in Humans is Altered in Major Depression
Normann, C., Schmitz, D., Fürmaier, A., Döing, C., & Bach, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.10.006 · Cited by 243 · see citing works
Petrik, D., Lagace, D. C., & Eisch, A. J. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.09.003 · Cited by 241 · see citing works
Expectancies as core features of mental disorders
Rief, W., Glombiewski, J. A., Gollwitzer, M., Schubö, A., Schwarting, R. K. W., & Thorwart, A. (2015) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000184 · Cited by 235 · see citing works
Self-citationAtypical neuroleptics stimulate neurogenesis in adult rat brain
Wakade, C. G., Mahadik, S. P., Waller, J. L., & Chiu, F. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10281 · Cited by 230 · see citing works
Placebo effects in psychiatry: mediators and moderators
Weimer, K., Colloca, L., & Enck, P. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(14)00092-3 · Cited by 222 · see citing works
Reversal of hippocampal neuronal maturation by serotonergic antidepressants
Kobayashi, K., Ikeda, Y., Sakai, A., Yamasaki, N., Haneda, E., Miyakawa, T., & Suzuki, H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912690107 · Cited by 212 · see citing works
Becker, C., Zeau, B., Rivat, C., Blugeot, A., Hamon, M., & Benoliel, J. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002097 · Cited by 211 · see citing works
Furmark, T., Appel, L., Henningsson, S., Åhs, F., Faria, V., Linnman, C., Pissiota, A., Frans, Ö., Bani, M., Bettica, P., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2534-08.2008 · Cited by 210 · see citing works
Rief, W., Nestoriuc, Y., von Lilienfeld-Toal, A., Dogan, I., Schreiber, F., Hofmann, S. G., Barsky, A. J., & Avorn, J. (2009) · Drug Safety · doi:10.2165/11316580-000000000-00000 · Cited by 202 · see citing works
Self-citationWeikum, W., Oberlander, T. F., Hensch, T. K., & Werker, J. F. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121263109 · Cited by 201 · see citing works
Neuronal network plasticity and recovery from depression
Castrén, E. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.1 · Cited by 190 · see citing works
Sinyor, M., LEVITT, A. J., Cheung, A. H., Schaffer, A., Kiss, A., Dowlati, Y., & Lanctôt, K. L. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08r04516blu · Cited by 189 · see citing works
Effects of Chronic Haloperidol and Clozapine Treatment on Neurogenesis in the Adult Rat Hippocampus
Halim, N. D., Weickert, C. S., McClintock, B., Weinberger, D. R., & Lipska, B. K. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300422 · Cited by 189 · see citing works
Schneier, F. R., Neria, Y., Pavlicová, M., Hembree, E. A., Suh, E. J., Amsel, L., & Marshall, R. D. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11020321 · Cited by 187 · see citing works
Pang, T., & Hannan, A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.029 · Cited by 182 · see citing works
Vernon, A. C., Natesan, S., Modo, M., & Kapur, S. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.11.010 · Cited by 173 · see citing works
Glucocorticoids Orchestrate Divergent Effects on Mood through Adult Neurogenesis
Lehmann, M. L., Brachman, R. A., Martinowich, K., Schloesser, R. J., & Herkenham, M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3878-12.2013 · Cited by 168 · see citing works
Cooney, G., Dwan, K., & Mead, G. (2014) · JAMA · doi:10.1001/jama.2014.4930 · Cited by 168 · see citing works
Sustained and “Sleeper” Effects of Group Metacognitive Training for Schizophrenia
Moritz, S., Veckenstedt, R., Andreou, C., Bohn, F., Hottenrott, B., Leighton, L., Köther, U., Woodward, T. S., Treszl, A., Menon, M., et al. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1038 · Cited by 165 · see citing works
Effects of Antipsychotic Drugs on Neurogenesis in the Forebrain of the Adult Rat
Wang, H.-D., Dunnavant, F. D., Jarman, T., & Deutch, A. Y. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300449 · Cited by 162 · see citing works
Effects of working memory training on functional connectivity and cerebral blood flow during rest
Takeuchi, H., Taki, Y., Nouchi, R., Hashizume, H., Sekiguchi, A., Kotozaki, Y., Nakagawa, S., Miyauchi, C. M., Sassa, Y., & Kawashima, R. (2013) · Cortex · doi:10.1016/j.cortex.2012.09.007 · Cited by 162 · see citing works
Barber, J. P., Barrett, M. S., Gallop, R., Rynn, M. A., & Rickels, K. (2012) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.11m06831 · Cited by 157 · see citing works
Haloperidol versus placebo for schizophrenia
Adams, C. E., Bergman, H., Irving, C. B., & Lawrie, S. M. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003082.pub3 · Cited by 157 · see citing works
Placebo Response in Antipsychotic Clinical Trials
Rutherford, B. R., Pott, E., Tandler, J. M., Wall, M. M., Roose, S. P., & Lieberman, J. A. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1319 · Cited by 152 · see citing works
Association Between Placebo-Activated Neural Systems and Antidepressant Responses
Peciña, M., Bohnert, A. M., Sikora, M., Avery, E. T., Langenecker, S. A., Mickey, B. J., & Zubieta, J. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.1335 · Cited by 152 · see citing works
Steinert, C., Hofmann, M., Kruse, J., & Leichsenring, F. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.10.017 · Cited by 148 · see citing works
Zou, K., Deng, W., Li, T., Zhang, B., Jiang, L., Huang, C., Sun, X., & Sun, X. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.014 · Cited by 141 · see citing works
Wichers, M. C., Barge-Schaapveld, D. Q. C. M., Nicolson, N. A., Peeters, F., de Vries, M., Mengelers, R., & van Os, J. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.66 · Cited by 139 · see citing works
Hernández‐Rabaza, V., Llorens-Martı́n, M., Velázquez-Sánchez, C., Ferragud, A., Arcusa, A., Gumus, H. G., Gómez‐Pinedo, U., Pérez‐Villalba, A., Roselló, J., Trejo, J. L., et al. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.11.054 · Cited by 138 · see citing works
Mechanisms Involved in Placebo and Nocebo Responses and Implications for Drug Trials
Rief, W., Bingel, U., Schedlowski, M., & Enck, P. (2011) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2011.204 · Cited by 133 · see citing works
Self-citationNeuroplasticity in Depressed Individuals Compared with Healthy Controls
Player, M. J., Taylor, J. L., Weickert, C. S., Alonzo, A., Sachdev, P., Martin, D., Mitchell, P. B., & Loo, C. K. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.126 · Cited by 127 · see citing works
Utilizing placebo mechanisms for dose reduction in pharmacotherapy
Doering, B. K., & Rief, W. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.12.001 · Cited by 125 · see citing works
Self-citationActive placebos versus antidepressants for depression (Review)
Moncrieff, J., Wessely, S. C., & Hardy, R. (2004) · UCL Discovery (University College London) · Cited by 125 · see citing works
Vernon, A. C., Natesan, S., Crum, W. R., Cooper, J. D., Modo, M., Williams, S., & Kapur, S. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.004 · Cited by 124 · see citing works
Leuchter, A. F., McCracken, J. T., Hunter, A. M., Cook, I. A., & Alpert, J. E. (2009) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181ac4aaf · Cited by 122 · see citing works
Modeling Social Influences on Human Health
Karelina, K., & DeVries, A. C. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182002116 · Cited by 115 · see citing works
Quetiapine reverses the suppression of hippocampal neurogenesis caused by repeated restraint stress
Luo, C., Xu, H., & Li, X. (2005) · Brain Research · doi:10.1016/j.brainres.2005.09.043 · Cited by 114 · see citing works
Trajectories of Depression Severity in Clinical Trials of Duloxetine
Gueorguieva, R. V. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.132 · Cited by 114 · see citing works
Andersson, E., Hedman‐Lagerlöf, E., Enander, J., Djurfeldt, D. R., Ljótsson, B., Červenka, S., Isung, J., Svanborg, C., Mataix‐Cols, D., Kaldo, V., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.0546 · Cited by 109 · see citing works
Stress coping stimulates hippocampal neurogenesis in adult monkeys
Lyons, D. M., Buckmaster, P. S., Lee, A. G., Wu, C., Mitra, R., Duffey, L. M., Buckmaster, C. L., Her, S., Patel, P. D., & Schatzberg, A. F. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914568107 · Cited by 109 · see citing works
Andersson, C. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00287-7 · Cited by 105 · see citing works
Honey, G. D., Corlett, P. R., Absalom, A. R., Lee, M., Pomarol‐Clotet, E., Murray, G. K., McKenna, P. J., Bullmore, E. T., Menon, D. K., & Fletcher, P. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0910-08.2008 · Cited by 102 · see citing works
Branchi, I., Santarelli, S., Capoccia, S., Poggini, S., D’Andrea, I., Cirulli, F., & Alleva, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062226 · Cited by 102 · see citing works
Camp, M., MacPherson, K. P., Lederle, L. I., Graybeal, C., Gaburro, S., DeBrouse, L., Ihne, J. L., Bravo, J. A., O’Connor, R. M., Ciocchi, S., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.340 · Cited by 101 · see citing works
Striatal enlargement in rats chronically treated with neuroleptic
Chakos, M., Shirakawa, O., Lieberman, J. A., Lee, H., Bilder, R. M., & Tamminga, C. A. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00029-8 · Cited by 100 · see citing works
The hidden effects of blinded, placebo-controlled randomized trials: An experimental investigation
Rief, W., & Glombiewski, J. A. (2012) · Pain · doi:10.1016/j.pain.2012.09.007 · Cited by 98 · see citing works
Self-citationLincoln, T. M., Ziegler, M., Mehl, S., Kesting, M.-L., Lüllmann, E., Westermann, S., & Rief, W. (2012) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0028665 · Cited by 97 · see citing works
Self-citationCentonze, D., Usiello, A., Costa, C., Picconi, B., Erbs, E., Bernardi, G., Borrelli, E., & Calabresi, P. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1274-04.2004 · Cited by 96 · see citing works
LAUGHREN, T. P. (2001) · European Psychiatry · doi:10.1016/s0924-9338(01)00600-9 · Cited by 93 · see citing works
Leuchter, A. F., Hunter, A. M., Tartter, M. A., & Cook, I. A. (2014) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.113.140343 · Cited by 87 · see citing works
Heidbreder, C. A., Foxton, R. H., Cilia, J., Hughes, Z. A., Shah, A. J., Atkins, A. R., Hunter, J. A., Hagan, J. J., & Jones, D. N. C. (2001) · Psychopharmacology · doi:10.1007/s002130100760 · Cited by 84 · see citing works
Mind matters: placebo enhances reward learning in Parkinson's disease
Schmidt, L., Braun, E. K., Wager, T. D., & Shohamy, D. (2014) · Nature Neuroscience · doi:10.1038/nn.3842 · Cited by 84 · see citing works
Hendriksen, H., Prins, J., Olivier, B., & Oosting, R. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011943 · Cited by 77 · see citing works
Luoni, A., Berry, A., Calabrese, F., Capoccia, S., Bellisario, V., Gass, P., Cirulli, F., & Riva, M. A. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.12.010 · Cited by 74 · see citing works
Uranova, N. A., Orlovskaya, D. D., Apel, K., et al. (1991) · Synapse · doi:10.1002/syn.890070402 · Cited by 69 · see citing works
Murray, D. K., & Stoessl, A. (2013) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2013.07.009 · Cited by 67 · see citing works
Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear
Deschaux, O., Zheng, X., Lavigne, J., Nachon, O., Cleren, C., Moreau, J.-L., & Garcia, R. (2013) · Psychopharmacology · doi:10.1007/s00213-012-2806-x · Cited by 62 · see citing works
Synaptic rearrangements in medial prefrontal cortex of haloperidol-treated rats
Benes, F. M., Paskevich, P. A., Davidson, J., et al. (1985) · Brain Research · doi:10.1016/0006-8993(85)90353-1 · Cited by 61 · see citing works
Synaptic Plasticity in the Rat Striatum following Chronic Haloperidol Treatment
Kerns, J. M., Sierens, D. K., Kao, L. C., et al. (1992) · Clinical Neuropharmacology · doi:10.1097/00002826-199212000-00006 · Cited by 61 · see citing works
Hippocampal volume and cell proliferation after acute and chronic clozapine or haloperidol treatment
Schmitt, A., Weber, S., Jatzko, A., Braus, D. F., & Henn, F. A. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-003-0070-2 · Cited by 60 · see citing works
Amitriptyline versus placebo for major depressive disorder
Leucht, C., Huhn, M., & Leucht, S. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009138.pub2 · Cited by 60 · see citing works
Fluoxetine Exposure during Adolescence Alters Responses to Aversive Stimuli in Adulthood
Iñiguez, S. D., Parise, L. F., Warren, B. L., Riggs, L. M., Parise, E. M., Vialou, V., Wright, K. N., Dayrit, G., Nieto, S. J., Wilkinson, M. B., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.5725-12.2014 · Cited by 59 · see citing works
Ho, Y., & Wang, S. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.062 · Cited by 57 · see citing works
Chronic treatment with fluoxetine prevents the return of extinguished auditory-cued conditioned fear
Deschaux, O., Spennato, G., Moreau, J., & Garcia, R. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2134-y · Cited by 57 · see citing works
Pope, A., Adams, C. E., Paton, C., Weaver, T. D., & Barnes, T. R. E. (2010) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.109.070961 · Cited by 57 · see citing works
Amitriptyline versus placebo for major depressive disorder
Leucht, C., Huhn, M., & Leucht, S. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009138 · Cited by 57 · see citing works
Dean, C. E. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.08.019 · Cited by 56 · see citing works
Schizophrenia, antipsychotics and risk of hip fracture: A population-based analysis
Sørensen, H. J., Jensen, S. O. W., & Nielsen, J. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.04.002 · Cited by 54 · see citing works
Physical Skill Training Increases the Number of Surviving New Cells in the Adult Hippocampus
Curlik, D. M., Maeng, L. Y., Agarwal, P. R., & Shors, T. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055850 · Cited by 53 · see citing works
Listening to Prozac but hearing placebo: A meta-analysis of antidepressant medication.
Sapirstein, G. (1998) · Prevention & Treatment · doi:10.1037//1522-3736.1.0002a · Cited by 53 · see citing works
Early exposure to haloperidol or olanzapine induces long‐term alterations of dendritic form
Frost, D. O., Page, S. C., Carroll, C., & Kolb, B. E. (2009) · Synapse · doi:10.1002/syn.20715 · Cited by 52 · see citing works
Long-Term Antidepressant Use and the Risk of Type 2 Diabetes Mellitus
Wu, C., Gau, S. S., & Lai, M. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13m08421 · Cited by 46 · see citing works
Wiecki, T. V., Riedinger, K., von Ameln-Mayerhofer, A., Schmidt, W., & Frank, M. J. (2009) · Psychopharmacology · doi:10.1007/s00213-008-1457-4 · Cited by 46 · see citing works
Context-dependent catalepsy intensification is due to classical conditioning and sensitization
Amtage, J., & Schmidt, W. (2003) · Behavioural Pharmacology · doi:10.1097/00008877-200311000-00009 · Cited by 45 · see citing works
Nonpharmacological bases of drug tolerance and dependence
Hinson, R. E., & Siegel, S. (1982) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(82)90089-7 · Cited by 45 · see citing works
Teixeira, A. M., Pase, C. S., Boufleur, N., Roversi, K., Barcelos, R. C. S., Benvegnú, D. M., Segat, H. J., Dias, V. T., Reckziegel, P., Trevizol, F., et al. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.055 · Cited by 44 · see citing works
Haloperidol conditioned catalepsy in rats: a possible role for D1-like receptors
Banasikowski, T. J., & Beninger, R. J. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001696 · Cited by 41 · see citing works
Klein, A., & Schmidt, W. (2003) · Behavioural Pharmacology · doi:10.1097/00008877-200302000-00005 · Cited by 41 · see citing works
Psychotropic medication use among adolescents: United States, 2005-2010.
Jonas, B. S., Gu, Q., & Albertorio‐Diaz, J. R. (2013) · PubMed · Cited by 40 · see citing works
A follow-up fMRI study of a transferable placebo anxiolytic effect.
Zhang, W., Qin, S., Guo, J., & Luo, J. (2011) · Psychophysiology · doi:10.1111/j.1469-8986.2011.01178.x · Cited by 39 · see citing works
Green, W., Patil, P. G., Marsden, C. A., Bennett, G. W., & Wigmore, P. M. (2006) · Brain Research · doi:10.1016/j.brainres.2005.11.047 · Cited by 38 · see citing works
Amygdala-frontal couplings characterizing SSRI and placebo response in social anxiety disorder
Faria, V., Åhs, F., Appel, L., Linnman, C., Bani, M., Bettica, P., Pich, E. M., Fredrikson, M., & Furmark, T. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000352 · Cited by 37 · see citing works
Alves, F. D. S., Bakker, G., Schmitz, N., Abeling, N. G. G. M., Hasler, G., van der Meer, J. N., Nederveen, A. J., de Haan, L., LINSZEN, D. H., & van Amelsvoort, T. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.06.008 · Cited by 36 · see citing works
Facilitation of Serotonin Signaling by SSRIs is Attenuated by Social Isolation
Dankoski, E. C., Agster, K. L., Fox, M. E., Moy, S. S., & Wightman, R. M. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.162 · Cited by 36 · see citing works
Prenatal Antidepressant Exposure: Clinical and Preclinical Findings
Bourke, C. H., Stowe, Z. N., & Owens, M. J. (2014) · Pharmacological Reviews · doi:10.1124/pr.111.005207 · Cited by 36 · see citing works
Rethinking mental disorders: The role of learning and brain plasticity
Morris, S. E., Rumsey, J. M., & Cuthbert, B. N. (2014) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-139015 · Cited by 35 · see citing works
Yildirim, E. O., Erol, K., & Ulupınar, E. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.12.017 · Cited by 35 · see citing works
Haloperidol modulates midbrain-prefrontal functional connectivity in the rat brain
Gass, N., Schwarz, A. J., Sartorius, A., Cleppien, D., Zheng, L., Schenker, E., Risterucci, C., Meyer‐Lindenberg, A., & Weber‐Fahr, W. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.10.013 · Cited by 35 · see citing works
Neuroimaging and plasticity in schizophrenia
Meyer-Lindenberg, A., & Tost, H. (2014) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-139014 · Cited by 33 · see citing works
Simpson, J., & Kelly, J. P. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.06.015 · Cited by 32 · see citing works
Zhang, C., & Li, M. (2011) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32834ecac4 · Cited by 31 · see citing works
Possamai, F., dos Santos, J., Walber, T., Marcon, J. C., dos Santos, T. S., & de Oliveira, C. L. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.10.017 · Cited by 31 · see citing works
Antidepressants differentially modify the extinction of an aversive memory task in female rats
Melo, T. G., Izídio, G. S., Ferreira, L. S., Sousa, D. S., Macêdo, P. T., Cabral, A., Ribeiro, A. M., & Silva, R. H. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.01.012 · Cited by 30 · see citing works
Popova, D., Ágústsdóttir, A., Lindholm, J., Mazulis, U., Akamine, Y., Castrén, E., & Karpova, N. N. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.04.002 · Cited by 26 · see citing works
Barr, A. M., Wu, C. H., Wong, C., Hercher, C., Töpfer, E., Boyda, H. N., Procyshyn, R. M., Honer, W. G., & Beasley, C. L. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.10.010 · Cited by 26 · see citing works
Catatonic Behavior Induced by Haloperidol, Increased by Retesting and Elicited without Drug in Rats
Moreira, L. F. D. S., Pinheiro, M. D. C. C., & Masur, J. (2008) · Pharmacology · doi:10.1159/000137716 · Cited by 25 · see citing works
Baptista, P. P. A., de Senna, P. N., Paim, M. F., Saur, L., Blank, M., do Nascimento, P., Ilha, J., Vianna, M. R. M., Mestriner, R. G., Achaval, M., et al. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.12.020 · Cited by 23 · see citing works
Simpson, J., Bree, D., & Kelly, J. P. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.02.008 · Cited by 23 · see citing works
Price, R., Salavati, B., Graff‐Guerrero, A., Blumberger, D. M., Mulsant, B. H., Daskalakis, Z. J., & Rajji, T. K. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.05.001 · Cited by 22 · see citing works
Drug Approval and Drug Effectiveness
Spielmans, G. I., & Kirsch, I. (2013) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050212-185533 · Cited by 21 · see citing works
Dringenberg, H. C., Day, L. R. B., & Choi, D. H. (2014) · Neural Plasticity · doi:10.1155/2014/571285 · Cited by 18 · see citing works
Rabideau, D. J., Nierenberg, A. A., Sylvia, L. G., Friedman, E. S., Bowden, C. L., Thase, M. E., Ketter, T. A., Ostacher, M. J., Reilly-Harrington, N. A., Iosifescu, D. V., et al. (2014) · Clinical Trials · doi:10.1177/1740774514531096 · Cited by 17 · see citing works
Klinzova, A. J., Uranova, N. A., Haselhorst, U., et al. (1990) · PubMed · Cited by 11 · see citing works
The placebo response in pain and depression in search of a common pathway
Wernicke, J. (2009) · Frontiers in Bioscience-Scholar · doi:10.2741/s49 · Cited by 9 · see citing works
The role of NMDA and AMPA/Kainate receptors in the consolidation of catalepsy sensitization
Riedinger, K., Kulak, A., Schmidt, W., et al. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.055 · Cited by 9 · see citing works
Desvenlafaxine May Accelerate Neuronal Maturation in the Dentate Gyri of Adult Male Rats
Asokan, A., Ball, A. R., Laird, C. D., Hermer, L., & Ormerod, B. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098530 · Cited by 8 · see citing works
Sun, T., Liu, X., & Li, M. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000047 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Petrie, K. J., & Rief, W. (2019) · Annual Review of Psychology · doi:10.1146/annurev-psych-010418-102907 · Cited by 309 · see citing works
Self-citationRief, W., Shedden-Mora, M. C., Laferton, J. A. C., Auer, C., Petrie, K. J., Salzmann, S., Schedlowski, M., & Moosdorf, R. (2017) · BMC Medicine · doi:10.1186/s12916-016-0767-3 · Cited by 261 · see citing works
Self-citationKandola, A., Hendrikse, J., Lucassen, P. J., & Yücel, M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00373 · Cited by 155 · see citing works
“The efficacy of both antidepressant and antipsychotic medications could be improved should more attention be afforded to relevant lifestyle factors such as AE engagement (Rief et al., 2015).”
Molecular Mechanisms of Psilocybin and Implications for the Treatment of Depression
Ling, S., Ceban, F., Lui, L. M. W., Lee, Y., Teopiz, K. M., Rodrigues, N. B., Lipsitz, O., Gill, H., Subramaniapillai, M., Mansur, R. B., et al. (2022) · CNS Drugs · doi:10.1007/s40263-021-00877-y · Cited by 127 · see citing works
Kube, T., Glombiewski, J. A., & Rief, W. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000596 · Cited by 62 · see citing works
Self-citation
- Authors
- Rief, W., Barsky, A. J., Bingel, U., Doering, B. K., Schwarting, R., Wöhr, M., & Schweiger, U.
- Affiliations
- Philipps University of Marburg (DE)
- Brigham and Women's Hospital (US)
- Essen University Hospital (DE)
- University of Lübeck (DE)
- Corresponding author
- Rief, W.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 60
- Pages
- 51-64
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2172892932
- Cited by
- 67
- References
- 171
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 7 · 2023: 7 · 2022: 3 · 2021: 4 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 10 · 2016: 3
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- treatment context, antidepressants, antipsychotic drugs, placebo response, neuroplasticity, environmental enrichment, social stimulation, treatment expectations, prior treatment experience, physical activity, clinical trial design
- MeSH terms
- Animals, Antidepressive Agents, Mental Disorders, Brain, Environment, Humans, Neuronal Plasticity, Antipsychotic Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review