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Cited by 219Fatty Acid Research and HealthDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial

Lee, Lai Kuan, Shahar, Suzana, Chin, Ai-Vyrn, Yusoff, Noor Aini Mohd·2013·Psychopharmacology
DOI 10.1007/s00213-012-2848-0
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Abstract

Rationale Epidemiological studies have suggested a beneficial effect of fish oil supplementation in halting the initial progression of Alzheimer's disease. However, it remains unclear whether fish oil affects cognitive function in older people with mild cognitive impairment (MCI).Objectives This study investigated the effects of fish oil supplementation on cognitive function in elderly person with MCI.Methods This was a 12-month, randomised, double-blind, placebo-controlled study using fish oil supplementation with concentrated docosahexaenoic acid (DHA). Thirty six low-socioeconomic-status elderly subjects with MCI were randomly assigned to receive either concentrated DHA fish oil (n = 18) or placebo (n = 18) capsules. The changes of memory, psychomotor speed, executive function and attention, and visual-constructive skills were assessed using cognitive tests. Secondary outcomes were safety and tolerability of the DHA concentrate.Results The fish oil group showed significant improvement in short-term and working memory (F = 9.890; ηp (2) = 0.254; p < 0.0001), immediate verbal memory (F = 3.715; ηp (2) = 0.114; p < 0.05) and delayed recall capability (F = 3.986; ηp (2) = 0.121; p < 0.05). The 12-month change in memory (p < 0.01) was significantly better in the fish oil group. Fish oil consumption was well tolerated, and the side effects were minimal and self-limiting.Conclusions This study suggested the potential role of fish oil to improve memory function in MCI subjects. Studies with larger sample sizes, longer intervention periods, different fish oil dosages and genetic determinations should be investigated before definite recommendations can be made.

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Research works printed but not linked: 2

  1. Shinto L, Quinn J, Montine T, Baldauf-Wagner SB, Bourdette D, Oken DB, Kaye J (2008) Omega-3 fatty acids and lipoic acid in Alzheimer’s disease. Neurology 70:A393
  2. Wechsler D (1984) Wechsler memory scale—revised manual. The Psychological Co, New York

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Metadata

Authors
Lee, L. K., Shahar, S., Chin, A.-V., & Yusoff, N. A. M.
Affiliations
  • National University of Malaysia (MY)
  • University of Malaya (MY)
Corresponding author
Shahar, Suzana
ORCID
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2012-08-30
Volume
225
Issue
3
Pages
605-612
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/s00213-012-2848-0
OpenAlex
W2075373003
Cited by
219
References
38
Citations by year
2026: 10 · 2025: 13 · 2024: 14 · 2023: 18 · 2022: 14 · 2021: 14 · 2020: 23 · 2019: 16 · 2018: 17 · 2017: 17 · 2016: 18 · 2015: 22 · 2014: 17 · 2013: 5
FWCI
13.08
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords
docosahexaenoic acid, fish oil supplementation, mild cognitive impairment, memory, working memory, verbal memory, executive function, attention, psychomotor speed, visual construction, older adults, low socioeconomic status, tolerability, Alzheimer's disease prevention
MeSH terms
Aged, Analysis of Variance, Cognition, Cognition Disorders, Docosahexaenoic Acids, Double-Blind Method, Female, Fish Oils, Humans, Male, Memory, Short-Term, Middle Aged, Psychomotor Performance, Severity of Illness Index, Socioeconomic Factors, Treatment Outcome, Dietary Supplements

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