The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial
Abstract
Rationale Epidemiological studies have suggested a beneficial effect of fish oil supplementation in halting the initial progression of Alzheimer's disease. However, it remains unclear whether fish oil affects cognitive function in older people with mild cognitive impairment (MCI).Objectives This study investigated the effects of fish oil supplementation on cognitive function in elderly person with MCI.Methods This was a 12-month, randomised, double-blind, placebo-controlled study using fish oil supplementation with concentrated docosahexaenoic acid (DHA). Thirty six low-socioeconomic-status elderly subjects with MCI were randomly assigned to receive either concentrated DHA fish oil (n = 18) or placebo (n = 18) capsules. The changes of memory, psychomotor speed, executive function and attention, and visual-constructive skills were assessed using cognitive tests. Secondary outcomes were safety and tolerability of the DHA concentrate.Results The fish oil group showed significant improvement in short-term and working memory (F = 9.890; ηp (2) = 0.254; p < 0.0001), immediate verbal memory (F = 3.715; ηp (2) = 0.114; p < 0.05) and delayed recall capability (F = 3.986; ηp (2) = 0.121; p < 0.05). The 12-month change in memory (p < 0.01) was significantly better in the fish oil group. Fish oil consumption was well tolerated, and the side effects were minimal and self-limiting.Conclusions This study suggested the potential role of fish oil to improve memory function in MCI subjects. Studies with larger sample sizes, longer intervention periods, different fish oil dosages and genetic determinations should be investigated before definite recommendations can be made.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In a small trial (35 older adults with mild cognitive impairment) in Malaysia, fish oil supplementation (1,290 mg DHA and 450 mg EPA daily) for 12 months improved memory—particularly short-term, working, and verbal memory—and delayed recall compared to that in the placebo group [86].”
From Role of n-3 long-chain polyunsaturated fatty acids in human nutrition and health: Review of recent studies and recommendations (2021) · cites this paper as [86]
Citations
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189
Sheikh (1986) · doi:10.1300/j018v05n01_09 · Cited by 7,236
Gauthier, S. G., Reisberg, ., Zaudig, M., Petersen, R. C., Ritchie, K. A., Broich, K., Belleville, S., Brodaty, H., Bennett, D. A., Chertkow, H. M., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68542-5 · Cited by 4,094
L’examen Clinique en Psychologie
Rubé, P. (1959) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.1959.13.4.989 · Cited by 3,299
Wechsler Adult Intelligence Scale
Szczepkowski, K. V., & Demakis, G. J. (2020) · Springer eBooks · doi:10.1007/978-3-319-24612-3_1034 · Cited by 1,085
Clock Drawing in Alzheimer's Disease
Sunderland, T., Hill, J., Mellow, A. M., Lawlor, B. A., Gundersheimer, J., NEWHOUSE, P. A., & Grafman, J. H. (1989) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1989.tb02233.x · Cited by 1,058
Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease: A Randomized Trial
Quinn, J. F., Raman, R., Thomas, R. G., Yurko-Mauro, K., Nelson, E. B., Van Dyck, C., Galvin, J. E., Emond, J., Jack, C. R., Weiner, M., et al. (2010) · JAMA · doi:10.1001/jama.2010.1510 · Cited by 764
Freund-Levi, Y., Eriksdotter-Jönhagen, M., Cederholm, T., Basun, H., Faxén-Irving, G., Garlind, A., Vedin, I., Vessby, B., Wahlund, L.-O., & Palmblad, J. (2006) · Archives of Neurology · doi:10.1001/archneur.63.10.1402 · Cited by 751
Dietary patterns and risk of dementia: The Three-City cohort study
Barberger-Gateau, P., Raffaitin, C., Letenneur, L., Berr, C., Tzourio, C., Dartigues, J. F., & Alpérovitch, A. (2007) · Neurology · doi:10.1212/01.wnl.0000278116.37320.52 · Cited by 700
Research works printed but not linked: 2
- Shinto L, Quinn J, Montine T, Baldauf-Wagner SB, Bourdette D, Oken DB, Kaye J (2008) Omega-3 fatty acids and lipoic acid in Alzheimer’s disease. Neurology 70:A393
- Wechsler D (1984) Wechsler memory scale—revised manual. The Psychological Co, New York
Cited by
Sorted by citations
Current understanding of Alzheimer’s disease diagnosis and treatment
Weller, J., & Budson, A. (2018) · F1000Research · doi:10.12688/f1000research.14506.1 · Cited by 1,083
Dyall, S. C. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00052 · Cited by 943
Kirova, A.-M., Bays, R. B., & Lagalwar, S. (2015) · BioMed Research International · doi:10.1155/2015/748212 · Cited by 649
Apoptosis and Oxidative Stress in Neurodegenerative Diseases
Radi, E., Formichi, P., Battisti, C., & Federico, A. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132738 · Cited by 641
Janssen, C. I. F., & Kiliaan, A. J. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.10.002 · Cited by 528
Metadata
- Authors
- Lee, L. K., Shahar, S., Chin, A.-V., & Yusoff, N. A. M.
- Affiliations
- National University of Malaysia (MY)
- University of Malaya (MY)
- Corresponding author
- Shahar, Suzana
- Venue
- Psychopharmacology
- Published
- 2012-08-30
- Volume
- 225
- Issue
- 3
- Pages
- 605-612
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2075373003
- Cited by
- 219
- References
- 38
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 14 · 2023: 18 · 2022: 14 · 2021: 14 · 2020: 23 · 2019: 16 · 2018: 17 · 2017: 17 · 2016: 18 · 2015: 22 · 2014: 17 · 2013: 5
- FWCI
- 13.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- docosahexaenoic acid, fish oil supplementation, mild cognitive impairment, memory, working memory, verbal memory, executive function, attention, psychomotor speed, visual construction, older adults, low socioeconomic status, tolerability, Alzheimer's disease prevention
- MeSH terms
- Aged, Analysis of Variance, Cognition, Cognition Disorders, Docosahexaenoic Acids, Double-Blind Method, Female, Fish Oils, Humans, Male, Memory, Short-Term, Middle Aged, Psychomotor Performance, Severity of Illness Index, Socioeconomic Factors, Treatment Outcome, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
