ω-3 Fatty Acid Treatment in 174 Patients With Mild to Moderate Alzheimer Disease: OmegAD Study: A Randomized Double-blind Trial
Abstract
BACKGROUND: Epidemiologic and animal studies have suggested that dietary fish or fish oil rich in omega-3 fatty acids, for example, docosahexaenoic acid and eicosapentaenoic acid, may prevent Alzheimer disease (AD). OBJECTIVE: To determine effects of dietary omega-3 fatty acid supplementation on cognitive functions in patients with mild to moderate AD. DESIGN: Randomized, double-blind, placebo-controlled clinical trial. PARTICIPANTS: Two hundred four patients with AD (age range [mean +/- SD], 74 +/- 9 years) whose conditions were stable while receiving acetylcholine esterase inhibitor treatment and who had a Mini-Mental State Examination (MMSE) score of 15 points or more were randomized to daily intake of 1.7 g of docosahexaenoic acid and 0.6 g of eicosapentaenoic acid (omega-3 fatty acid-treated group) or placebo for 6 months, after which all received omega-3 fatty acid supplementation for 6 months more. MAIN OUTCOME MEASURES: The primary outcome was cognition measured with the MMSE and the cognitive portion of the Alzheimer Disease Assessment Scale. The secondary outcome was global function as assessed with the Clinical Dementia Rating Scale; safety and tolerability of omega-3 fatty acid supplementation; and blood pressure determinations. RESULTS: One hundred seventy-four patients fulfilled the trial. At baseline, mean values for the Clinical Dementia Rating Scale, MMSE, and cognitive portion of the Alzheimer Disease Assessment Scale in the 2 randomized groups were similar. At 6 months, the decline in cognitive functions as assessed by the latter 2 scales did not differ between the groups. However, in a subgroup (n = 32) with very mild cognitive dysfunction (MMSE >27 points), a significant (P<.05) reduction in MMSE decline rate was observed in the omega-3 fatty acid-treated group compared with the placebo group. A similar arrest in decline rate was observed between 6 and 12 months in this placebo subgroup when receiving omega-3 fatty acid supplementation. The omega-3 fatty acid treatment was safe and well tolerated. CONCLUSIONS: Administration of omega-3 fatty acid in patients with mild to moderate AD did not delay the rate of cognitive decline according to the MMSE or the cognitive portion of the Alzheimer Disease Assessment Scale. However, positive effects were observed in a small group of patients with very mild AD (MMSE >27 points).
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A subgroup of patients with very mild impairment experienced a significant reduction in the rate of cognitive decline.
“However, a subgroup of patients with very mild impairment experienced a significant reduction in the rate of cognitive decline.”
From Role of n-3 long-chain polyunsaturated fatty acids in human nutrition and health: Review of recent studies and recommendations (2021) · cites this paper as [85]
In the OmegaAD trial, daily supplementation with 1,700 mg DHA and 600 mg EPA for 6 months in 174 older adults with mild to moderate Alzheimer's disease failed to slow down the rate of cognitive decline from placebo.
“In the OmegaAD trial, daily supplementation with 1,700 mg DHA and 600 mg EPA for 6 months in 174 older adults with mild to moderate AD also failed to slow down the rate of cognitive decline from that obtained in the placebo group [85].”
From Role of n-3 long-chain polyunsaturated fatty acids in human nutrition and health: Review of recent studies and recommendations (2021) · cites this paper as [85]
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882 · see citing works
(1999) · PubMed · Cited by 2,062 · see citing works
Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease
in 't Veld, B. A., Ruitenberg, A., Hofman, A., Launer, L. J., van Duijn, C. M., Stijnen, T., Breteler, M. M. B., & Stricker, B. H. C. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010178 · Cited by 1,196 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
Preedy, V., & Watson, R. (2010) · Springer eBooks · doi:10.1007/978-0-387-78665-0_5485 · Cited by 1,146 · see citing works
Consumption of Fish and n-3 Fatty Acids and Risk of Incident Alzheimer Disease
Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., Bennett, D. A., Wilson, R. S., Aggarwal, N., & Schneider, J. (2003) · Archives of Neurology · doi:10.1001/archneur.60.7.940 · Cited by 1,135 · see citing works
Dietary fat intake and the risk of incident dementia in the Rotterdam study
Kalmijn, S., Launer, L. J., Ott, A., Witteman, J. C. M., Hofman, A., & Breteler, M. M. B. (1997) · Annals of Neurology · doi:10.1002/ana.410420514 · Cited by 895 · see citing works
Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model
Calon, F., Lim, G. P., Yang, F., Morihara, T., Teter, B., Ubeda, O., Rostaing, P., Triller, A., Salem, N., Ashe, K. H., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.013 · Cited by 707 · see citing works
Development of Cognitive Instruments for Use in Clinical Trials of Antidementia Drugs
Mohs, R. C., Knopman, D. S., Petersen, R. C., Ferris, S. H., Ernesto, C., Grundman, M., Sano, M., Bieliauskas, L. A., Geldmacher, D., Clark, C. M., et al. (1997) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199700112-00003 · Cited by 693 · see citing works
Lim, G. P., Calon, F., Morihara, T., Yang, F., Teter, B., Ubeda, O. J., Salem, N., Frautschy, S. A., & Cole, G. M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4225-04.2005 · Cited by 687 · see citing works
Fatty acid composition of brain phospholipids in aging and in Alzheimer’s disease
Söderberg, M., Edlund, C., Kristensson, K., & Dallner, G. (1991) · Lipids · doi:10.1007/bf02536067 · Cited by 667 · see citing works
Fish, meat, and risk of dementia: cohort study
Barberger‐Gateau, P. (2002) · BMJ · doi:10.1136/bmj.325.7370.932 · Cited by 486 · see citing works
Regional Membrane Phospholipid Alterations in Alzheimer's Disease
Prasad, M. R., Lovell, M. A., Yatin, M., Dhillon, H. S., & Markesbery, W. R. (1998) · Neurochemical Research · doi:10.1023/a:1022457605436 · Cited by 440 · see citing works
CONNOR, W. E., Neuringer, M., & Lin, D. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43209-2 · Cited by 342 · see citing works
Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case–control study
Tully, A.-M., Roche, H. M., Doyle, R., Fallon, C., Bruce, I., LAWLOR, B. A., Coakley, D., & Gibney, M. J. (2003) · British Journal Of Nutrition · doi:10.1079/bjn2002804 · Cited by 309 · see citing works
n−3 Fatty acid supplements in rheumatoid arthritis
Kremer, J. M. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.349s · Cited by 305 · see citing works
Gamoh, S., Hashimoto, M., Sugioka, K., Hossain, S., Hata, N., Misawa, Y., & Masumura, S. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00107-4 · Cited by 301 · see citing works
Supplementation of fish oil and olive oil in patients with rheumatoid arthritis
Berbert, A. A., Kondo, C. R. M., Almendra, C. L., Matsuo, T., & Dichi, I. (2005) · Nutrition · doi:10.1016/j.nut.2004.03.023 · Cited by 287 · see citing works
Recovery of brain docosahexaenoate leads to recovery of spatial task performance
Moriguchi, T., & Salem, N. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01966.x · Cited by 209 · see citing works
Suzuki, H., Park, S. J., Tamura, M., & Ando, S. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00169-3 · Cited by 194 · see citing works
Boberg, M., Croon, L., Gustafsson, I., & Vessby, B. (1985) · Clinical Science · doi:10.1042/cs0680581 · Cited by 178 · see citing works
Self-citationIkemoto, A., Ohishi, M., Sato, Y., Hata, N., Misawa, Y., Fujii, Y. R., & Okuyama, H. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32220-3 · Cited by 150 · see citing works
Essential Fatty Acids Preparation (Sr-3) Improves Alzheimer's Patients Quality of Life
Yehuda, S., Rabinovtz, S., Carasso, R. L., & Mostofsky, D. I. (1996) · International Journal of Neuroscience · doi:10.3109/00207459609070833 · Cited by 142 · see citing works
Villardita, C. (1993) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1993.tb05512.x · Cited by 96 · see citing works
Ethyl-EPA in Alzheimer's disease—a pilot study
Boston, P. F., Bennett, A., Horrobin, D. F., & Bennett, C. N. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2004.07.001 · Cited by 94 · see citing works
Hassing, L. B., & Bäckman, L. (1997) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106658 · Cited by 28 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Defeating Alzheimer's disease and other dementias: a priority for European science and society
Winblad, B., Amouyel, P., Andrieu, S., Ballard, C., Brayne, C., Brodaty, H., Cedazo-Minguez, A., Dubois, B., Edvardsson, D., Feldman, H., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00062-4 · Cited by 1,676 · see citing works
Omega-3 fatty acids EPA and DHA: Health benefits throughout life
Swanson, D., Block, R., & Mousa, S. A. (2012) · Advances in Nutrition · doi:10.3945/an.111.000893 · Cited by 1,575 · see citing works
Alzheimer’s disease: Clinical trials and drug development
Mangialasche, F., Solomon, A., Winblad, B., Mecocci, P., & Kivipelto, M. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70119-8 · Cited by 1,217 · see citing works
Dyall, S. C. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00052 · Cited by 943 · see citing works
Oxidative Stress in Neurodegenerative Diseases
Niedzielska, E., Smaga, I., Gawlik, M., Moniczewski, A., Stankowicz, P., Pera, J., & Filip, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9337-5 · Cited by 800 · see citing works
Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease: A Randomized Trial
Quinn, J. F., Raman, R., Thomas, R. G., Yurko-Mauro, K., Nelson, E. B., Van Dyck, C., Galvin, J. E., Emond, J., Jack, C. R., Weiner, M., et al. (2010) · JAMA · doi:10.1001/jama.2010.1510 · Cited by 764 · see citing works
Kondo, T., Asai, M., Tsukita, K., Kutoku, Y., Ohsawa, Y., Sunada, Y., Imamura, K., Egawa, N., Yahata, N., Okita, K., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.01.009 · Cited by 741 · see citing works
Schneider, L. S., Mangialasche, F., Andreasen, N., Feldman, H., Giacobini, E., Jones, R., Mantua, V., Mecocci, P., Pani, L., Winblad, B., et al. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12191 · Cited by 651 · see citing works
Caloric restriction improves memory in elderly humans
Witte, A. V., Fobker, M., Gellner, R., Knecht, S., & Flöel, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808587106 · Cited by 574 · see citing works
Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives
Harris, W. S., Miller, M., Tighe, A. P., Davidson, M. H., & Schaefer, E. J. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.11.008 · Cited by 552 · see citing works
Stark, K. D., Van Elswyk, M. E., Higgins, M. R., Weatherford, C. A., & Salem, N. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.05.001 · Cited by 519 · see citing works
Nutritional considerations for healthy aging and reduction in age-related chronic disease
Shlisky, J., Bloom, D. E., Beaudreault, A. R., Tucker, K. L., Keller, H. H., Freund-Levi, Y., Fielding, R. A., Cheng, F. W., Jensen, G. L., Wu, D., et al. (2017) · Advances in Nutrition · doi:10.3945/an.116.013474 · Cited by 462 · see citing works
Self-citationBazan, N. G., Molina, M. F., & Gordon, W. C. (2011) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104635 · Cited by 441 · see citing works
Very long-chain <i>n</i> -3 fatty acids and human health: fact, fiction and the future
Calder, P. C. (2018) · Proceedings of the Nutrition Society · doi:10.1017/s0029665117003950 · Cited by 419 · see citing works
Layé, S., Nadjar, A., Joffre, C., & Bazinet, R. P. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014092 · Cited by 420 · see citing works
Towards establishing dietary reference intakes for eicosapentaenoic and docosahexaenoic acids
Harris, W. S., Mozaffarian, D., Lefevre, M., Toner, C. D., Colombo, J., Cunnane, S. C., Holden, J. M., Klurfeld, D. M., Morris, M. C., & Whelan, J. (2009) · The Journal of Nutrition · doi:10.3945/jn.108.101329 · Cited by 356 · see citing works
Snowden, S. G., Ebshiana, A. A., Hye, A., An, Y., Pletnikova, O., O’Brien, R., Troncoso, J., Legido-Quigley, C., & Thambisetty, M. (2017) · PLOS Medicine · doi:10.1371/journal.pmed.1002266 · Cited by 309 · see citing works
High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model
Julien, C., Tremblay, C., Phivilay, A., Berthiaume, L., Émond, V., Julien, P., & Calon, F. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.08.022 · Cited by 288 · see citing works
Dangour, A. D., Allen, E., Elbourne, D., Fasey, N., Fletcher, A. E., Hardy, P., Holder, G. E., Knight, R., Letley, L., Richards, M., et al. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.29121 · Cited by 296 · see citing works
Shinto, L., Quinn, J., Montine, T., Dodge, H. H., Woodward, W., Baldauf-Wagner, S., Waichunas, D., Bumgarner, L., Bourdette, D., Silbert, L., et al. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-130722 · Cited by 288 · see citing works
Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging
Tan, Z. S., Harris, W. S., Beiser, A. S., Au, R., Himali, J. J., Debette, S., Pikula, A., DeCarli, C., Wolf, P. A., Vasan, R. S., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e318249f6a9 · Cited by 265 · see citing works
Effects of omega-3 fatty acids on cognitive performance: a meta-analysis
Mazereeuw, G., Lanctôt, K. L., Chau, S. A., Swardfager, W., & Herrmann, N. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.12.014 · Cited by 253 · see citing works
Andrade, S., Ramalho, M. J., Loureiro, J. A., & Pereira, M. D. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092313 · Cited by 240 · see citing works
Heart disease as a risk factor for dementia
Hakim, A., Ng, & Turek (2013) · Clinical Epidemiology · doi:10.2147/clep.s30621 · Cited by 229 · see citing works
The Potential Role of Gut Microbiota in Alzheimer’s Disease: From Diagnosis to Treatment
Varesi, A., Pierella, E., Romeo, M., Piccini, G. B., Alfano, C., Bjørklund, G., Oppong, A., Ricevuti, G., Esposito, C., Chirumbolo, S., et al. (2022) · Nutrients · doi:10.3390/nu14030668 · Cited by 225 · see citing works
Lee, L. K., Shahar, S., Chin, A.-V., & Yusoff, N. A. M. (2013) · Psychopharmacology · doi:10.1007/s00213-012-2848-0 · Cited by 219 · see citing works
Omega-3 Fatty Acids and Neurodegenerative Diseases: New Evidence in Clinical Trials
Avallone, R., Vitale, G., & Bertolotti, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174256 · Cited by 218 · see citing works
Combination Drug Therapy for the Management of Alzheimer’s Disease
Kabir, M. T., Uddin, M. S., Mamun, A. A., Jeandet, P., Aleya, L., Mansouri, R. A., Ashraf, G. M., Mathew, B., Bin-Jumah, M. N., & Abdel-Daim, M. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093272 · Cited by 217 · see citing works
Diet, cognition, and alzheimer’s disease: food for thought
Otaegui-Arrazola, A., Amiano, P., Elbusto, A., Urdaneta, E., & Martínez-Lage, P. (2014) · European Journal of Nutrition · doi:10.1007/s00394-013-0561-3 · Cited by 214 · see citing works
Neuroinflammation and Cognitive Aging
Ownby, R. L. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-009-0082-1 · Cited by 212 · see citing works
Sugasini, D., Thomas, R., Yalagala, P. C. R., Tai, L. M., & Subbaiah, P. V. (2017) · Scientific Reports · doi:10.1038/s41598-017-11766-0 · Cited by 201 · see citing works
Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis
Zhu, M., Wang, X., Hjorth, E., Colas, R. A., Schroeder, L., Granholm, A.-C., Serhan, C. N., & Schultzberg, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9544-0 · Cited by 204 · see citing works
Samieri, C., Féart, C., Letenneur, L., Dartigues, J.-F., Pérès, K., Auriacombe, S., Peuchant, E., Delcourt, C., & Barberger-Gateau, P. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.3.714 · Cited by 184 · see citing works
Thomas, J., Thomas, C. J., Radcliffe, J., & Itsiopoulos, C. (2015) · BioMed Research International · doi:10.1155/2015/172801 · Cited by 173 · see citing works
Algae: Critical Sources of Very Long-Chain Polyunsaturated Fatty Acids
Harwood, J. (2019) · Biomolecules · doi:10.3390/biom9110708 · Cited by 171 · see citing works
Vedin, I., Cederholm, T., Freund Levi, Y., Basun, H., Garlind, A., Faxén Irving, G., Jönhagen, M. E., Vessby, B., Wahlund, L.-O., & Palmblad, J. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1616 · Cited by 171 · see citing works
Self-citationImpact of dietary fats on brain functions
Chianese, R., Coccurello, R., Viggiano, A., Scafuro, M., Fiore, M., Coppola, G., Operto, F. F., Fasano, S., Laye, S., Pierantoni, R., et al. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666171017102547 · Cited by 159 · see citing works
Omega-3 fatty acids' supplementation in Alzheimer's disease: A systematic review
Canhada, S., Castro, K., Perry, I. S., & Luft, V. C. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1321813 · Cited by 156 · see citing works
Omega-3 fatty acids and risk of dementia: the Canadian Study of Health and Aging
Kröger, E., Verreault, R., Carmichael, P.-H., Lindsay, J., Julien, P., Dewailly, É., Ayotte, P., & Laurin, D. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26987 · Cited by 149 · see citing works
Van Dael, P. (2021) · Nutrition Research and Practice · doi:10.4162/nrp.2021.15.2.137 · Cited by 138 · see citing works
Divino da Rocha, M., Pereira Dias Viegas, F., Cristina Campos, H., Carolina Nicastro, P., Calve Fossaluzza, P., Alberto Manssour Fraga, C., J. Barreiro, E., & Viegas, C. (2011) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152711794480429 · Cited by 126 · see citing works
Sinn, N., Milte, C., & Howe, P. R. C. (2010) · Nutrients · doi:10.3390/nu2020128 · Cited by 115 · see citing works
APP Function and Lipids: A Bidirectional Link
Grimm, M. O. W., Mett, J., Grimm, H. S., & Hartmann, T. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00063 · Cited by 104 · see citing works
Nutrition and AGE‐ing: Focusing on Alzheimer’s Disease
Abate, G., Marziano, M., Rungratanawanich, W., Memo, M., & Uberti, D. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7039816 · Cited by 103 · see citing works
Low Plasma N-3 Fatty Acids and Dementia in Older Persons: The InCHIANTI Study
Cherubini, A., Andres-Lacueva, C., Martin, A., Lauretani, F., Iorio, A. D., Bartali, B., Corsi, A., Bandinelli, S., Mattson, M. P., & Ferrucci, L. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.10.1120 · Cited by 95 · see citing works
Association of Serum Docosahexaenoic Acid With Cerebral Amyloidosis
Yassine, H. N., Feng, Q., Azizkhanian, I., Rawat, V., Castor, K., Fonteh, A. N., Harrington, M. G., Zheng, L., Reed, B. R., DeCarli, C., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.1924 · Cited by 94 · see citing works
Carotid sinus syndrome, should we pace? A multicentre, randomised control trial (Safepace 2)
Ryan, D. J., Nick, S., Colette, S. M., & Roseanne, K. (2010) · Heart · doi:10.1136/hrt.2009.176206 · Cited by 91 · see citing works
Role of amyloid beta in lipid homeostasis
Grösgen, S., Grimm, M. O. W., Frieß, P., & Hartmann, T. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.05.002 · Cited by 90 · see citing works
D’Cunha, N. M., Georgousopoulou, E. N., Dadigamuwage, L., Kellett, J., Panagiotakos, D. B., Thomas, J., McKune, A. J., Mellor, D. D., & Naumovski, N. (2018) · British Journal of Nutrition · doi:10.1017/s0007114517003452 · Cited by 68 · see citing works
N-3 Polyunsaturated Fatty Acids through the Lifespan: Implication for Psychopathology
Pusceddu, M. M., Kelly, P., Stanton, C., Cryan, J. F., & Dinan, T. G. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw078 · Cited by 70 · see citing works
B vitamins and n-3 fatty acids for brain development and function: review of human studies
van de Rest, O., van Hooijdonk, L. W. A., Doets, E., Schiepers, O. J. G., Eilander, A., & de Groot, L. C. P. G. M. (2012) · Annals of Nutrition and Metabolism · doi:10.1159/000337945 · Cited by 70 · see citing works
Dietary Regulation of Gut-Brain Axis in Alzheimer’s Disease: Importance of Microbiota Metabolites
Frausto, D. M., Forsyth, C. B., Keshavarzian, A., & Voigt, R. M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.736814 · Cited by 61 · see citing works
Walia, V., Kaushik, D., Mittal, V., Kumar, K., Verma, R., Parashar, J., Akter, R., Rahman, M. H., Bhatia, S., Al-Harrasi, A., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02617-1 · Cited by 47 · see citing works
- Authors
- Freund-Levi, Y., Eriksdotter-Jönhagen, M., Cederholm, T., Basun, H., Faxén-Irving, G., Garlind, A., Vedin, I., Vessby, B., Wahlund, L.-O., & Palmblad, J.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2006-10-01
- Volume
- 63
- Issue
- 10
- Pages
- 1402
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2109348896
- Cited by
- 751
- References
- 29
- Citations by year
- 2026: 12 · 2025: 31 · 2024: 24 · 2023: 19 · 2022: 32 · 2021: 32 · 2020: 44 · 2019: 41 · 2018: 31 · 2017: 47 · 2016: 37 · 2015: 49 · 2014: 53 · 2013: 44 · 2012: 42
- FWCI
- 34.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- omega-3 fatty acids, docosahexaenoic acid, eicosapentaenoic acid, fish oil supplementation, Alzheimer's disease, cognitive decline, dietary supplementation, acetylcholinesterase inhibitors, Clinical Dementia Rating, Mini-Mental State Examination, tolerability
- MeSH terms
- Aged, Alzheimer Disease, Blood Pressure, Brain, Cognition Disorders, Double-Blind Method, Female, Humans, Male, Middle Aged, Fatty Acids, Omega-3, Placebo Effect, Treatment Outcome, Disease Progression, Neuroprotective Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
