Current understanding of Alzheimer’s disease diagnosis and treatment
Open accessAbstract
Alzheimer’s disease is the most common cause of dementia worldwide, with the prevalence continuing to grow in part because of the aging world population. This neurodegenerative disease process is characterized classically by two hallmark pathologies: β-amyloid plaque deposition and neurofibrillary tangles of hyperphosphorylated tau. Diagnosis is based upon clinical presentation fulfilling several criteria as well as fluid and imaging biomarkers. Treatment is currently targeted toward symptomatic therapy, although trials are underway that aim to reduce the production and overall burden of pathology within the brain. Here, we discuss recent advances in our understanding of the clinical evaluation and treatment of Alzheimer’s disease, with updates regarding clinical trials still in progress.
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Both PET imaging and CSF analysis exhibit similar accuracy, and the optimum test for diagnosis depends upon patient/provider preference, cost and availability of facilities.
“However, both PET imaging and CSF analysis exhibit similar accuracy, and suggest that the optimum test for the diagnosis will depend upon patient/provider preference, cost and availability of facilities [37].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [37]
Current therapeutics targeting the NMDA receptor prevent Ca2+-induced excitotoxicity, and memantine was approved for this purpose in 2003.
“Current therapeutics to ameliorate and control the cognitive and behavioral symptoms by targeting the NMDA receptor prevent Ca2+ induced excitotoxicity [2, 9–11], and memantine was approved for this purpose in 2003.”
From Current therapeutics for Alzheimer’s disease and clinical trials (2024) · cites this paper as [10]
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McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.005 · Cited by 18,657 · see citing works
Albert, M. S., DeKosky, S. T., Dickson, D., Dubois, B., Feldman, H. H., Fox, N. C., Gamst, A., Holtzman, D. M., Jagust, W. J., Petersen, R. C., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.008 · Cited by 10,152 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
Siegel, L. J., & Fletcher‐Janzen, E. (2008) · Wiley eBooks · doi:10.1002/9780470373699.speced0655 · Cited by 8,468 · see citing works
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155 · see citing works
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202753 · Cited by 3,814 · see citing works
Mechanisms of Gamma Oscillations
Buzsáki, G., & Wang, X.-J. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150444 · Cited by 2,796 · see citing works
Albert, M., DeKosky, S. T., Dickson, D. W., Dubois, B., Feldman, H., Fox, N. C., Gamst, A. C., Holtzman, D. M., Jagust, W. J., Petersen, R. C., et al. (2013) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.11.1.96 · Cited by 2,630 · see citing works
Olsson, B., Lautner, R., Andreasson, U., Öhrfelt, A., Portelius, E., Bjerke, M., Hölttä, M., Rosén, C., Olsson, C., Strobel, G., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00070-3 · Cited by 2,049 · see citing works
Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease
Salloway, S., Sperling, R., Fox, N. C., Blennow, K., Klunk, W., Raskind, M., Sabbagh, M., Honig, L. S., Porsteinsson, A. P., Ferris, S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1304839 · Cited by 1,960 · see citing works
Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease
Doody, R. S., Thomas, R. G., Farlow, M., Iwatsubo, T., Vellas, B., Joffe, S., Kieburtz, K., Raman, R., Sun, X., Aisen, P. S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1312889 · Cited by 1,668 · see citing works
Gamma frequency entrainment attenuates amyloid load and modifies microglia
Iaccarino, H. F., Singer, A. C., Martorell, A. J., Rudenko, A., Gao, F., Gillingham, T. Z., Mathys, H., Seo, J., Kritskiy, O., Abdurrob, F., et al. (2016) · Nature · doi:10.1038/nature20587 · Cited by 1,328 · see citing works
2017 Alzheimer's disease facts and figures
(, T. D. B. T. A.-R. C. C. A. S. O. A. C. B. S., different, ). J. A. I. A., destroyed, S. A. T. A. S. T. M. E. T. M. C. I. S. I. A. G. W. A. T. R. N. I. T. O. B. T. F. N. T. B. D. A. D. A. U. I. B. R. I. I. F. N. M. A. N. I. O. P. O. T. B. A. D. A., difficulties, I. E. O., agitation, I. N. S. S. A., & delusions., S. A. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.02.001 · Cited by 1,322 · see citing works
Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease
Honig, L. S., Vellas, B., Woodward, M., Boada, M., Bullock, R., Borrie, M., Hager, K., Andreasen, N., Scarpini, E., Liu-Seifert, H., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1705971 · Cited by 1,049 · see citing works
Clark, C. M., Pontecorvo, M. J., Beach, T. G., Bedell, B. J., Coleman, R. E., Doraiswamy, P. M., Fleisher, A. S., Reiman, E. M., Sabbagh, M. N., Sadowsky, C. H., et al. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70142-4 · Cited by 855 · see citing works
Donepezil and memantine for moderate-to-severe Alzheimer's disease
Howard, R., McShane, R., Lindesay, J., Ritchie, C., Baldwin, A., Barber, R., Burns, A., Dening, T., Findlay, D., Holmes, C., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1106668 · Cited by 782 · see citing works
Alzheimer’s disease prevention: from risk factors to early intervention
Crous‐Bou, M., Minguillón, C., Gramunt, N., & Molinuevo, J. L. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0297-z · Cited by 689 · see citing works
Singh, B., Parsaik, A. K., Mielke, M. M., Erwin, P. J., Knopman, D. S., Petersen, R. C., & Roberts, R. O. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-130830 · Cited by 667 · see citing works
Vitamin D and the risk of dementia and Alzheimer disease
Littlejohns, T. J., Henley, W., Lang, I., Annweiler, C., Beauchet, O., Chaves, P. H. M., Fried, L. F., Kestenbaum, B. R., Kuller, L. H., Langa, K. M., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000755 · Cited by 573 · see citing works
The road to restoring neural circuits for the treatment of Alzheimer's disease
Canter, R. G., Penney, J., & Tsai, L.-H. (2016) · Nature · doi:10.1038/nature20412 · Cited by 565 · see citing works
Core candidate neurochemical and imaging biomarkers of Alzheimer's disease
Hampel, H. J., Bürger, K., Teipel, S. J., Bokde, A. L. W., Zetterberg, H., & Blennow, K. (2007) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2007.08.006 · Cited by 532 · see citing works
Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review
Lourida, I., Soni, M., Thompson-Coon, J., Purandare, N., Lang, I. A., Ukoumunne, O. C., & Llewellyn, D. J. (2013) · Epidemiology · doi:10.1097/ede.0b013e3182944410 · Cited by 521 · see citing works
Kennedy, M. E., Stamford, A. W., Chen, X., Cox, K., Cumming, J. N., Dockendorf, M. F., Egan, M. F., Ereshefsky, L., Hodgson, R. A., Hyde, L. A., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad9704 · Cited by 432 · see citing works
BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease
Vassar, R. J. (2014) · Alzheimer s Research & Therapy · doi:10.1186/s13195-014-0089-7 · Cited by 413 · see citing works
Gorelick, P. B., Furie, K. L., Iadecola, C., Smith, E. E., Waddy, S. P., Lloyd-Jones, D. M., Bae, H.-J., Bauman, M. A., Dichgans, M., Duncan, P. W., et al. (2017) · Stroke · doi:10.1161/str.0000000000000148 · Cited by 411 · see citing works
Detailed comparison of amyloid PET and CSF biomarkers for identifying early Alzheimer disease
Palmqvist, S., Zetterberg, H., Mattsson, N., Johansson, P., Initiative, F. T. A. D. N., Minthon, L., Blennow, K., Olsson, M., For the Swedish BioFINDER study group, Hansson, O., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000001991 · Cited by 375 · see citing works
Novák, P., Schmidt, R., Kontseková, E., Žilka, N., Kováčech, B., Škrabana, R., Kazmerova, Z., Katina, S., Fialová, Ľ., Prčina, M., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30331-3 · Cited by 306 · see citing works
Takizawa, C., Thompson, P. L., van Walsem, A., Faure, C., & Maier, W. C. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141134 · Cited by 253 · see citing works
Tau immunotherapy for Alzheimer's disease
Pedersen, J. T., & Sigurdsson, E. M. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.03.003 · Cited by 247 · see citing works
Lee, L. K., Shahar, S., Chin, A.-V., & Yusoff, N. A. M. (2013) · Psychopharmacology · doi:10.1007/s00213-012-2848-0 · Cited by 219 · see citing works
Serum MicroRNA Profiles Serve as Novel Biomarkers for the Diagnosis of Alzheimer’s Disease
Dong, H., Li, J., Huang, L., Chen, X., Li, D., Wang, T., Hu, C., Xu, J. L., Zhang, C., Zen, K., et al. (2015) · Disease Markers · doi:10.1155/2015/625659 · Cited by 214 · see citing works
Beta-amyloid imaging with florbetaben
Sabri, O., Seibyl, J., Rowe, C., & Barthel, H. (2015) · Clinical and translational imaging · doi:10.1007/s40336-015-0102-6 · Cited by 167 · see citing works
Grossberg, G. T., Manes, F. F., Allegri, R., Gutiérrez‐Robledo, L. M., Gloger, S., Xie, L., Jia, X., Pejović, V., Miller, M. L., Perhach, J. L., et al. (2013) · CNS Drugs · doi:10.1007/s40263-013-0077-7 · Cited by 158 · see citing works
Physical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer's disease
Smith, J. C., Nielson, K. A., Woodard, J. L., Seidenberg, M., Durgerian, S., Hazlett, K. E., Figueroa, C. M., Kandah, C. C., Kay, C. D., Matthews, M. A., et al. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00061 · Cited by 156 · see citing works
Gamma Oscillations Distinguish True From False Memories
Sederberg, P. B., Schulze‐Bonhage, A., Madsen, J. R., Bromfield, E. B., Litt, B., Brandt, A., & Kahana, M. J. (2007) · Psychological Science · doi:10.1111/j.1467-9280.2007.02003.x · Cited by 153 · see citing works
Bo, Y., Zhang, X., Wang, Y., You, J., Cui, H., Zhu, Y., Pang, W., Liu, W. Y., Jiang, Y., & Lü, Q. (2017) · Nutrients · doi:10.3390/nu9010054 · Cited by 133 · see citing works
Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets
Pooler, A. M., Polydoro, M., Wegmann, S., Nicholls, S. B., Spires‐Jones, T. L., & Hyman, B. T. (2013) · Alzheimer s Research & Therapy · doi:10.1186/alzrt214 · Cited by 123 · see citing works
Shen, Y., Wang, H., Sun, Q., Yao, H., Keegan, A. P., Mullan, M., Wilson, J., Lista, S., Leyhe, T., Laske, C., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.02.007 · Cited by 123 · see citing works
Huperzine A in the Treatment of Alzheimer′s Disease and Vascular Dementia: A Meta‐Analysis
Xing, S.-H., Zhu, C., Zhang, R., & An, L. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/363985 · Cited by 117 · see citing works
Tau-Based Therapeutics for Alzheimer’s Disease: Active and Passive Immunotherapy
Panza, F., Solfrizzi, V., Seripa, D., Imbimbo, B. P., Lozupone, M., Santamato, A., Tortelli, R., Galizia, I., Prete, C., Daniele, A., et al. (2016) · Immunotherapy · doi:10.2217/imt-2016-0019 · Cited by 104 · see citing works
Jacobsen, H., Ozmen, L., Caruso, A., Narquizian, R., Hilpert, H., Jacobsen, B., Terwel, D., Tanghe, A., & Bohrmann, B. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1405-14.2014 · Cited by 97 · see citing works
A systematic review and meta‐analysis of 18F‐labeled amyloid imaging in Alzheimer's disease
Yeo, J. M., Waddell, B., Khan, Z. H., & Pal, S. (2015) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2014.11.004 · Cited by 78 · see citing works
Dregan, A., & Gulliford, M. C. (2013) · Psychological Medicine · doi:10.1017/s0033291713000305 · Cited by 72 · see citing works
Stella, F., Canonici, A. P., Gobbi, S., Galduróz, J. C. F., Cação, J. D. C., & Gobbi, L. T. B. (2011) · Clinics · doi:10.1590/s1807-59322011000800008 · Cited by 65 · see citing works
New Criteria for Alzheimer Disease and Mild Cognitive Impairment
Budson, A. E., & Solomon, P. R. (2012) · The Neurologist · doi:10.1097/nrl.0b013e31826a998d · Cited by 65 · see citing works
Self-citationBuilding a roadmap for developing combination therapies for Alzheimer’s disease
Perry, D. P., Sperling, R. A., Katz, R. G., Berry, D. A., Dilts, D. M., Hanna, D. L., Salloway, S., Trojanowski, J. Q., Bountra, C., Krams, M., et al. (2015) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.996551 · Cited by 54 · see citing works
Immunotherapy for Targeting Tau Pathology in Alzheimer’s Disease and Tauopathies
Rosenmann, H. (2013) · Current Alzheimer Research · doi:10.2174/1567205011310030001 · Cited by 52 · see citing works
Cortical florbetapir-PET amyloid load in prodromal Alzheimer’s disease patients
Saint‐Aubert, L., Barbeau, E. J., Péran, P., Nemmi, F., Vervueren, C., Mirabel, H., Payoux, P., Hitzel, A., Bonneville, F., Gramada, R., et al. (2013) · EJNMMI Research · doi:10.1186/2191-219x-3-43 · Cited by 49 · see citing works
Management of patients with Alzheimer’s disease: pharmacological treatment and quality of life
Mossello, E., & Ballini, E. (2012) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622312452387 · Cited by 48 · see citing works
Role of Traditional Nonsteroidal Anti-inflammatory Drugs in Alzheimer’s Disease
Gupta, P. P., Pandey, R. D., Jha, D., Shrivastav, V. K., & Kumar, S. (2014) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317514542644 · Cited by 46 · see citing works
EU/US/CTAD TASK FORCE: LESSONS LEARNED FROM RECENT AND CURRENT ALZHEIMER’S PREVENTION TRIALS
Aisen, P. S. S., Touchon, J., Amariglio, R. E., Andrieu, S., Bateman, R. J., Breitner, J. C. S., Donohue, M. A., Dunn, B., Doody, R. S., Fox, N. C., et al. (2017) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2017.13 · Cited by 42 · see citing works
Amyloid or tau: the chicken or the egg?
Mann, D. M. A., & Hardy, J. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1162-1 · Cited by 37 · see citing works
Reply: the early pathological process in sporadic Alzheimer’s disease
Braak, H., & Tredici, K. D. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1170-1 · Cited by 32 · see citing works
Diseases: Study neuron networks to tackle Alzheimer's
Kosik, K. S. (2013) · Nature · doi:10.1038/503031a · Cited by 15 · see citing works
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Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease
Khan, S., Barve, K. H., & Kumar, M. S. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200528142429 · Cited by 820 · see citing works
“However, both PET imaging and CSF analysis exhibit similar accuracy, and suggest that the optimum test for the diagnosis will depend upon patient/provider preference, cost and availability of facilities [37].”
BackgroundMolecular mechanisms of ferroptosis and their involvement in brain diseases
Costa, I., Barbosa, D. J., Benfeito, S., Silva, V., Chavarria, D., Borges, F., Remião, F., & Silva, R. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108373 · Cited by 402 · see citing works
The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications
Arranz, A. M., & Strooper, B. D. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30490-3 · Cited by 348 · see citing works
Monteiro, A. R., Barbosa, D. J., Remião, F., & Silva, R. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115522 · Cited by 358 · see citing works
The Microbiota–Gut–Brain Axis and Alzheimer’s Disease: Neuroinflammation Is to Blame?
Megur, A., Baltriukienė, D., Bukelskienė, V., & Burokas, A. (2020) · Nutrients · doi:10.3390/nu13010037 · Cited by 323 · see citing works
The complexity of Alzheimer’s disease: an evolving puzzle
Ferrari, C., & Sorbi, S. (2021) · Physiological Reviews · doi:10.1152/physrev.00015.2020 · Cited by 324 · see citing works
Biosensing based on field-effect transistors (FET): Recent progress and challenges
Sadighbayan, D., Hasanzadeh, M., & Ghafar‐Zadeh, E. (2020) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2020.116067 · Cited by 309 · see citing works
Intrinsically Disordered Proteins: An Overview
Trivedi, R., & Nagarajaram, H. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214050 · Cited by 253 · see citing works
Advances in the development of new biomarkers for Alzheimer’s disease
Klyucherev, T. O., Olszewski, P., Shalimova, A. A., Chubarev, V. N., Tarasov, V. V., Attwood, M. M., Syvänen, S., & Schiöth, H. B. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00296-z · Cited by 241 · see citing works
Microglia and Alzheimer’s Disease
Merighi, S., Nigro, M., Travagli, A., & Gessi, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112990 · Cited by 236 · see citing works
A review on advances of treatment modalities for Alzheimer's disease
Thoe, E. S., Fauzi, A., Tang, Y.-Q., Chamyuang, S., & Chia, A. Y. Y. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119129 · Cited by 224 · see citing works
Zhang, W., Xu, C., Sun, J., Shen, H., Wang, J., & Yang, C. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.01.008 · Cited by 213 · see citing works
Nimgampalle, M., Chakravarthy, H., Sharma, S., Shree, S., Bhat, A. R., Pradeepkiran, J. A., & Devanathan, V. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101994 · Cited by 207 · see citing works
Jan, H., Shah, M., Andleeb, A., Faisal, S., Khattak, A., Rizwan, M., Drouet, S., Hano, C., & Abbasi, B. H. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/4786227 · Cited by 182 · see citing works
Mitochondrial Dysfunction and Alzheimer’s Disease: Role of Microglia
Agrawal, I., & Jha, S. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00252 · Cited by 181 · see citing works
The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases
DeMaio, A., Mehrotra, S., Sambamurti, K., & Husain, S. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02605-9 · Cited by 184 · see citing works
Zarneshan, S. N., Fakhri, S., & Khan, H. Z. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106099 · Cited by 175 · see citing works
Feng, S., Wu, C., Zou, P., Deng, Q., Chen, Z., Li, M., Zhu, L., Li, F., Liu, T. C., Duan, R., et al. (2023) · Theranostics · doi:10.7150/thno.81951 · Cited by 170 · see citing works
Tripathi, M. K., Kartawy, M., & Amal, H. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101567 · Cited by 161 · see citing works
Roles and Mechanisms of Gut Microbiota in Patients With Alzheimer’s Disease
Wu, S., Liu, X., Jiang, R., Yan, X., & Ling, Z. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.650047 · Cited by 146 · see citing works
The Endosomal Recycling Pathway—At the Crossroads of the Cell
O’Sullivan, M. J., & Lindsay, A. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176074 · Cited by 131 · see citing works
Biosensors Based on Mechanical and Electrical Detection Techniques
Chalklen, T., Jing, Q., & Kar‐Narayan, S. (2020) · Sensors · doi:10.3390/s20195605 · Cited by 138 · see citing works
Neuroprotective effects of ononin against the aluminium chloride-induced Alzheimer’s disease in rats
Chen, X., Zhang, M., Ahmed, M., Surapaneni, K. M., Veeraraghavan, V. P., & Arulselvan, P. (2021) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2021.06.031 · Cited by 129 · see citing works
Expert systems: Definitions, advantages and issues in medical field applications
Saibene, A., Assale, M., & Giltri, M. (2021) · Expert Systems with Applications · doi:10.1016/j.eswa.2021.114900 · Cited by 133 · see citing works
Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical Studies
Zhang, X., Chen, J., Ouyang, D., & Lu, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020493 · Cited by 125 · see citing works
DHA/EPA (Omega-3) and LA/GLA (Omega-6) as Bioactive Molecules in Neurodegenerative Diseases
Kousparou, C. A., Fyrilla, M., Stephanou, A., & Patrikios, I. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310717 · Cited by 123 · see citing works
Faisal, S., Al‐Radadi, N. S., Jan, H., Abdullah, A., Shah, S. A., Shah, S., Rizwan, M., Afsheen, Z., Hussain, Z., Uddin, M. N., et al. (2021) · Coatings · doi:10.3390/coatings11070849 · Cited by 118 · see citing works
Nand, S., Mishra, D., Singh, P., Vamanu, E., & Singh, M. P. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111377 · Cited by 116 · see citing works
Wu, J., Yu, Y., Wan, Y., Xia, J., Xu, J., Zhang, L., Liu, D., Chen, L., Tang, F., Ao, H., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113207 · Cited by 115 · see citing works
Therapeutic Potential of Cannabis: A Comprehensive Review of Current and Future Applications
Leinen, Z. J., Mohan, R., Premadasa, L. S., Acharya, A., Mohan, M., & Byrareddy, S. N. (2023) · Biomedicines · doi:10.3390/biomedicines11102630 · Cited by 114 · see citing works
The Cognitive Control of Eating and Body Weight: It’s More Than What You “Think”
Davidson, T. L., Jones, S., Roy, M., & Stevenson, R. J. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00062 · Cited by 114 · see citing works
The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration
Pisani, A., Paciello, F., VECCHIO, V. D., Malesci, R., Corso, E. D., Cantone, E., & Fetoni, A. R. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13040652 · Cited by 120 · see citing works
Patella, B., Sortino, A., Mazzara, F., Aiello, G., Drago, G., Torino, C., Vilasi, A. D., O'Riordan, A. J., & Inguanta, R. (2021) · Analytica Chimica Acta · doi:10.1016/j.aca.2021.339124 · Cited by 109 · see citing works
Kim, M., Youn, Y. C., & Paik, J. (2023) · NeuroImage · doi:10.1016/j.neuroimage.2023.120054 · Cited by 109 · see citing works
Ubiquitous protein lactylation in health and diseases
Wang, J., Wang, Z., Wang, Q., Li, X., & Guo, Y. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00541-5 · Cited by 109 · see citing works
Beyond the average patient: how neuroimaging models can address heterogeneity in dementia
Verdi, S., Marquand, A. F., Schott, J. M., & Cole, J. H. (2021) · Brain · doi:10.1093/brain/awab165 · Cited by 106 · see citing works
Huggins, C. J., Escudero, J., Parra, M. A., Scally, B., Anghinah, R., Vitória Lacerda De Araújo, A., Basile, L. F., & Abasolo, D. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac05d8 · Cited by 105 · see citing works
Nanoemulsions for targeting the neurodegenerative diseases: Alzheimer's, Parkinson's and Prion's
Nirale, P., Paul, A., & Yadav, K. S. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117394 · Cited by 103 · see citing works
Farina, F. R., Emek‐Savaş, D. D., Rueda‐Delgado, L. M., Boyle, R. T., Kiiski, H. S. M., Yener, G., & Whelan, R. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116795 · Cited by 105 · see citing works
Guan, L., Mao, Z., Yang, S., Wu, G., Chen, Y., Yin, L., Qi, Y., Han, L., & Xu, L. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113248 · Cited by 100 · see citing works
Immunotherapy for Parkinson’s disease
Schwab, A. D., Thurston, M. J., Machhi, J., Olson, K. E., Namminga, K. L., Gendelman, H. E., & Mosley, R. L. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104760 · Cited by 98 · see citing works
P‐glycoprotein: a role in the export of amyloid‐β in Alzheimer's disease?
Chai, A. B., Leung, G. K. F., Callaghan, R., & Gelissen, I. C. (2019) · FEBS Journal · doi:10.1111/febs.15148 · Cited by 98 · see citing works
Gouveia, F., Camins, A., Ettcheto, M., Bicker, J., Falcão, A. C., Cruz, M. T., & Fortuna, A. C. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101612 · Cited by 96 · see citing works
Alzheimer's disease: Molecular aspects and treatment opportunities using herbal drugs
Thakral, S., Yadav, A., Singh, V., Kumar, M., Kumar, P., Narang, R., Sudhakar, K., Verma, A., Khalilullah, H., Jaremko, M., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101960 · Cited by 99 · see citing works
Oligodendroglial Cells in Alzheimer’s Disease
Butt, A. M., Rocha, I. C. D. L., & Rivera, A. D. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-9913-8_12 · Cited by 94 · see citing works
Garbuz, D. G., Zatsepina, O. G., & Evgen’ev, M. B. (2021) · Molecular Biology · doi:10.1134/s002689332104004x · Cited by 95 · see citing works
Zheng, M., & Wang, P. (2021) · 3 Biotech · doi:10.1007/s13205-021-02738-3 · Cited by 98 · see citing works
Deepa, N., & Chokkalingam, S. P. (2022) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2021.103455 · Cited by 92 · see citing works
Luo, S., Zhang, X., Huang, S. Q., Feng, X., Zhang, X., & Xiang, D.-X. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.05.185 · Cited by 92 · see citing works
Zhou, Y., Ge, Y., Liu, Q., Li, Y., Xu, C., Guan, J., Diwu, Y., & Zhang, Q. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.10.028 · Cited by 91 · see citing works
Moya, G. E., Rivera, P. D., & Dittenhafer‐Reed, K. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137030 · Cited by 88 · see citing works
Internal m7G methylation: A novel epitranscriptomic contributor in brain development and diseases
Xia, X., Wang, Y., & Zheng, J. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.01.003 · Cited by 87 · see citing works
Faisal, S., Abdullah, A., Jan, H., Shah, S. A., Shah, S., Rizwan, M., Zaman, N., Hussain, Z., Uddin, M. N., Bibi, N., et al. (2021) · Catalysts · doi:10.3390/catal11070780 · Cited by 86 · see citing works
Mesenchymal Stem Cell Therapy for Alzheimer’s Disease
Hernández, A., & García, E. (2021) · Stem Cells International · doi:10.1155/2021/7834421 · Cited by 88 · see citing works
Mimura, Y., Nishida, H., Nakajima, S., Tsugawa, S., Morita, S., Yoshida, K., Tarumi, R., Ogyu, K., Wada, M., Kurose, S., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.12.003 · Cited by 85 · see citing works
Speech- and language-based classification of Alzheimer's disease: a systematic review
Vigo, I., Coelho, L., & Reis, S. (2022) · Bioengineering · doi:10.3390/bioengineering9010027 · Cited by 83 · see citing works
Wee, J., Sukudom, S., Bhat, S., Marklund, M., Peiris, N. J., Hoyos, C. M., Patel, S., Naismith, S. L., Dwivedi, G., & Misra, A. (2023) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1002/dad2.12395 · Cited by 82 · see citing works
Mahim, S. M., Ali, M. S., Hasan, M. O., Nafi, A. A. N., Sadat, A. K. M., Hasan, S. A., Shareef, B., Ahsan, M. M., Islam, M. K., Miah, M. S., et al. (2024) · IEEE Access · doi:10.1109/access.2024.3351809 · Cited by 83 · see citing works
Iorio, R., Petricca, S., Emidio, G. D., Falone, S., & Tatone, C. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102522 · Cited by 81 · see citing works
The Links between Cardiovascular Diseases and Alzheimer's Disease
Leszek, J., Вячеславовна, М. Е., Belousov, D. M., Koutsouraki, E., Szczechowiak, K., Kobusiak−Prokopowicz, M., Mysiak, A., Diniz, B. S., Somasundaram, S. G., Kirkland, C. E., et al. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200729093724 · Cited by 84 · see citing works
Tzimourta, K. D., Christou, V., Tzallas, A. T., Giannakeas, N., Astrakas, L. G., Angelidis, P., Tsalikakis, D., & Tsipouras, M. G. (2021) · International Journal of Neural Systems · doi:10.1142/s0129065721300023 · Cited by 78 · see citing works
Fakhri, S., Abdian, S., Zarneshan, S. N., Moradi, S. Z., Farzaei, M. H., & Abdollahi, M. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s347187 · Cited by 80 · see citing works
An Attention-Based 3D CNN With Multi-Scale Integration Block for Alzheimer's Disease Classification
Wu, Y., Zhou, Y., Zeng, W., Qian, Q., & Song, M. (2022) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2022.3197331 · Cited by 78 · see citing works
O-GlcNAcylation as a Therapeutic Target for Alzheimer’s Disease
Park, J., Lai, M. K. P., Arumugam, T. V., & Jo, D. (2020) · NeuroMolecular Medicine · doi:10.1007/s12017-019-08584-0 · Cited by 75 · see citing works
Nanocarrier mediated drug delivery as an impeccable therapeutic approach against Alzheimer’s disease
Taliyan, R., Kakoty, V., Sarathlal, K. C., Kharavtekar, S. S., Karennanavar, C. R., Choudhary, Y. K., Singhvi, G., Riadi, Y., Dubey, S. K., & Kesharwani, P. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.01.044 · Cited by 76 · see citing works
Chabib, C., Hadjileontiadis, L. J., & Shehhi, A. A. (2023) · IEEE Access · doi:10.1109/access.2023.3272482 · Cited by 72 · see citing works
Mitochondrial RNA in Alzheimer’s Disease Circulating Extracellular Vesicles
Kim, K. M., Meng, Q., de Acha, O. P., Mustapić, M., Cheng, A., Eren, E., Kundu, G., Piao, Y.-L., Munk, R., Wood, W., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.581882 · Cited by 66 · see citing works
Phytotherapy: A promising approach for the treatment of Alzheimer's disease
John, O. O., Amarachi, I. S., Chinazom, A. P., Adaeze, E., Kale, M. B., Umare, M. D., & Upaganlawar, A. B. (2022) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2021.100030 · Cited by 69 · see citing works
Zhang, B., Zhao, J., Wang, Z., Xu, L., Liu, A., & Du, G. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106729 · Cited by 69 · see citing works
Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies
Londzin, P., Zamora, M., Kąkol, B., Taborek, A., & Folwarczna, J. (2021) · Nutrients · doi:10.3390/nu13020537 · Cited by 71 · see citing works
Jayaswamy, P. K., Vijaykrishnaraj, M., Patil, P., Alexander, L. M., Kellarai, A., & Shetty, P. K. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101791 · Cited by 69 · see citing works
Maqbool, Z., Arshad, M. S., Ali, A., Aziz, A., Khalid, W., Afzal, M. F., Bangar, S. P., Addi, M., Hano, C., & Lorenzo, J. M. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/6480590 · Cited by 67 · see citing works
Riccardi, C., Napolitano, F., Montesarchio, D., Sampaolo, S., & Melone, M. A. B. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111897 · Cited by 66 · see citing works
Did the Brain and Oral Microbiota Talk to Each Other? A Review of the Literature
Maitre, Y., Micheneau, P., Delpierre, A., Mahalli, R., Guérin, M., Amador, G., & Denis, F. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9123876 · Cited by 65 · see citing works
Role of Impaired Mitochondrial Dynamics Processes in the Pathogenesis of Alzheimer’s Disease
Blagov, A. V., Grechko, A. V., Nikiforov, N. G., Borisov, E. E., Sadykhov, N. K., & Orekhov, A. N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23136954 · Cited by 65 · see citing works
Associations Between Diabetes Mellitus and Neurodegenerative Diseases
Szablewski, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020542 · Cited by 74 · see citing works
Detecting retinal cell stress and apoptosis with DARC: Progression from lab to clinic
Cordeiro, M. F., Hill, D., Patel, R. P., Corazza, P., Maddison, J., & Younis, S. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.100976 · Cited by 64 · see citing works
Current Status, Issues and Future Prospects of Personalized Medicine for Each Disease
Yamamoto, Y., Kanayama, N., Nakayama, Y., & Matsushima, N. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12030444 · Cited by 66 · see citing works
Multifunctional Nanotheranostics for Overcoming the Blood–Brain Barrier
Beygi, M. H. M., Oroojalian, F., Azizi‐Arani, S., Hosseini, S. S., Mokhtarzadeh, A., Kesharwani, P., & Sahebkar, A. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202310881 · Cited by 65 · see citing works
Amyloid-β: A double agent in Alzheimer's disease?
Yu, H., & Wu, J. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111575 · Cited by 62 · see citing works
Impact of Alzheimer’s Disease on Caregivers in the United States
Vu, M., Mangal, R., Stead, T., Carlos Lopez-Ortiz, C., & Ganti, L. (2022) · Health Psychology Research · doi:10.52965/001c.37454 · Cited by 62 · see citing works
Li, X., Yang, S., Wang, S., Shi, Y., Dai, Y., Zhang, X., Liu, Y., Guo, Y., He, J., & Xiu, M. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123632 · Cited by 62 · see citing works
The Role of Resveratrol in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review
Buglio, D. S., Marton, L. T., Laurindo, L. F., Guiguer, É. L., Araújo, A. C., Buchaim, R. L., Goulart, R. D. Á., Rubira, C. J., & Barbalho, S. M. (2022) · Journal of Medicinal Food · doi:10.1089/jmf.2021.0084 · Cited by 61 · see citing works
Abdullah, S. A., Najm, L., Ladouceur, L., Ebrahimi, F., Shakeri, A., Al‐Jabouri, N., Didar, T. F., & Dellinger, K. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202302673 · Cited by 61 · see citing works
Roles and Mechanisms of Axon-Guidance Molecules in Alzheimer’s Disease
Zhang, L., Qi, Z., Li, J., Li, M., Du, X., Wang, S., Zhou, G., Xu, B., Liu, W., Xi, S., et al. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02311-2 · Cited by 57 · see citing works
Intracellular Calcium Dysregulation by the Alzheimer’s Disease-Linked Protein Presenilin 2
Galla, L., Redolfi, N., Pozzan, T., Pizzo, P., & Greotti, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030770 · Cited by 58 · see citing works
Nanaki, S. G., Spyrou, K., Bekiari, C., Veneti, P., Baroud, T. N., Karouta, N., Grivas, I. N., Papadopoulos, G. C., Gournis, D., & Bikiaris, D. Ν. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12030227 · Cited by 57 · see citing works
Learning Language and Acoustic Models for Identifying Alzheimer’s Dementia From Speech
Shah, Z., Sawalha, J., Tasnim, M., Qi, S.-A., Stroulia, E., & Greiner, R. (2021) · Frontiers in Computer Science · doi:10.3389/fcomp.2021.624659 · Cited by 56 · see citing works
Yan, X., Liu, H., Hong, Y.-X., Meng, T., Du, J., & Chang, C. (2022) · Journal of Neurogenetics · doi:10.1080/01677063.2022.2028784 · Cited by 56 · see citing works
Glycogen Synthase Kinase 3β Involvement in Neuroinflammation and Neurodegenerative Diseases
Gianferrara, T., Cescon, E., Grieco, I., Spalluto, G., & Federico, S. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220216113517 · Cited by 57 · see citing works
Treating disorders across the lifespan by modulating cholinergic signaling with galantamine
Metz, C. N., & Pavlov, V. A. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15243 · Cited by 55 · see citing works
Qi, C., Chen, X.-X., Gao, X., Xu, J., Liu, S., & Ge, J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.633495 · Cited by 54 · see citing works
Links between COVID-19 and Alzheimer’s Disease—What Do We Already Know?
Rudnicka-Drożak, E., Drożak, P., Mizerski, G., Zaborowski, T., Ślusarska, B. J., Nowicki, G., & Drożak, M. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20032146 · Cited by 56 · see citing works
Kumar, A., Zhou, L., Zhi, K., Raji, B., Pernell, S., Tadrous, E., Kodidela, S., Nookala, A. R., Kochat, H., & Kumar, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010138 · Cited by 53 · see citing works
Genetic associated complications of type 2 diabetes mellitus
WONG, Y. H., WONG, S. H., WONG, X. T., YAP, Q. Y., Yip, K. Y., WONG, L. Z., Chellappan, D. K., Bhattamisra, S. K., & Candasamy, M. (2021) · Panminerva Medica · doi:10.23736/s0031-0808.21.04285-3 · Cited by 52 · see citing works
Mitochondria break free: Mitochondria-derived vesicles in aging and associated conditions
Ferrucci, L., Guerra, F., Bucci, C., Marzetti, E., & Picca, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102549 · Cited by 52 · see citing works
The Role of DNA Damage in Neural Plasticity in Physiology and Neurodegeneration
Konopka, A., & Atkin, J. D. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.836885 · Cited by 51 · see citing works
Fan, M., Liu, S., Sun, H.-M., Ma, M.-D., Gao, Y.-J., Qi, C.-C., Xia, Q.-R., & Ge, J.-F. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113375 · Cited by 50 · see citing works
Plasma microRNAs as potential biomarkers in early Alzheimer disease expression
Peña‐Bautista, C., Tarazona-Sánchez, A., Braza‐Boïls, A., Balaguer, Á., Ferré‐González, L., Martínez, A. J. C., Baquero, M., & Cháfer‐Pericás, C. (2022) · Scientific Reports · doi:10.1038/s41598-022-19862-6 · Cited by 51 · see citing works
Patel, C. A., Pande, S. V., & Acharya, S. (2020) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-020-01904-3 · Cited by 51 · see citing works
- Authors
- Weller, J., & Budson, A.
- Affiliations
- Boston University (US)
- Corresponding author
- Weller, Jason
- Venue
- F1000Research
- Publisher
- F1000 Research Ltd
- Published
- 2018-07-31
- Volume
- 7
- Pages
- 1161
- ISSN
- 2046-1402 (ISSN-L)
- PMC
- PMC6073093
- OpenAlex
- W2885706121
- Cited by
- 1,083
- References
- 53
- Citations by year
- 2026: 67 · 2025: 155 · 2024: 147 · 2023: 176 · 2022: 221 · 2021: 194 · 2020: 92 · 2019: 29 · 2018: 2
- FWCI
- 12.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- F1000Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institute on Aging (P30AG013846)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- Alzheimer's disease, dementia, amyloid plaques, tau hyperphosphorylation, neurofibrillary tangles, biomarkers, diagnosis, symptomatic treatment, disease-modifying therapy, clinical trials, neurodegeneration
- MeSH terms
- Alzheimer Disease, Humans, Nerve Net, Amyloid beta-Peptides, tau Proteins
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