Cited by 1,083Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

Current understanding of Alzheimer’s disease diagnosis and treatment

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Weller, Jason, Budson, Andrew·2018·F1000Research

Abstract

Alzheimer’s disease is the most common cause of dementia worldwide, with the prevalence continuing to grow in part because of the aging world population. This neurodegenerative disease process is characterized classically by two hallmark pathologies: β-amyloid plaque deposition and neurofibrillary tangles of hyperphosphorylated tau. Diagnosis is based upon clinical presentation fulfilling several criteria as well as fluid and imaging biomarkers. Treatment is currently targeted toward symptomatic therapy, although trials are underway that aim to reduce the production and overall burden of pathology within the brain. Here, we discuss recent advances in our understanding of the clinical evaluation and treatment of Alzheimer’s disease, with updates regarding clinical trials still in progress.

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  • Both PET imaging and CSF analysis exhibit similar accuracy, and the optimum test for diagnosis depends upon patient/provider preference, cost and availability of facilities.

    “However, both PET imaging and CSF analysis exhibit similar accuracy, and suggest that the optimum test for the diagnosis will depend upon patient/provider preference, cost and availability of facilities [37].”
  • Current therapeutics targeting the NMDA receptor prevent Ca2+-induced excitotoxicity, and memantine was approved for this purpose in 2003.

    “Current therapeutics to ameliorate and control the cognitive and behavioral symptoms by targeting the NMDA receptor prevent Ca2+ induced excitotoxicity [2, 9–11], and memantine was approved for this purpose in 2003.”

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Authors
Weller, J., & Budson, A.
Affiliations
Boston University (US)
Corresponding author
Weller, Jason
Venue
F1000Research
Published
2018-07-31
Volume
7
Pages
1161
ISSN
2046-1402 (ISSN-L)
OpenAlex
W2885706121
Cited by
1,083
References
53
Citations by year
2026: 67 · 2025: 155 · 2024: 147 · 2023: 176 · 2022: 221 · 2021: 194 · 2020: 92 · 2019: 29 · 2018: 2
FWCI
12.28
Type
journal article
Language
en
Open access
Locations
  • F1000Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
National Institute on Aging (P30AG013846)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
Keywords
Alzheimer's disease, dementia, amyloid plaques, tau hyperphosphorylation, neurofibrillary tangles, biomarkers, diagnosis, symptomatic treatment, disease-modifying therapy, clinical trials, neurodegeneration
MeSH terms
Alzheimer Disease, Humans, Nerve Net, Amyloid beta-Peptides, tau Proteins

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