Effects of fluoxetine on CRF and CRF1 expression in rats exposed to the learned helplessness paradigm

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works

The Rat Brain in Stereotaxic Coordinates

Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works

The Epidemiology of Major Depressive Disorder: Results From the National Comorbidity Survey Replication (NCS-R)

Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988 · see citing works

Neurobiology of Depression

Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217 · see citing works

Failure to escape traumatic shock.

Seligman, M. E., & Maier, S. F. (1967) · Journal of Experimental Psychology · doi:10.1037/h0024514 · Cited by 1,981 · cited 1× · see citing works

Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study

Swanson, L. W., Sawchenko, P. E., Rivier, J., & Vale, W. W. (2008) · Neuroendocrinology · doi:10.1159/000123454 · Cited by 1,953 · see citing works

Hippocampal atrophy in recurrent major depression

Sheline, Y. I., Wang, P. W., Gado, M. H., Csernansky, J. G., & Vannier, M. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.3908 · Cited by 1,932 · see citing works

The rat brain in stereotaxic coordinates (2nd edn)

Herman, J. P., & Watson, S. J. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90017-8 · Cited by 1,751 · see citing works

Hippocampal Volume Reduction in Major Depression

Bremner, J. D., Narayan, M., Anderson, E. R., Staib, L. H., Miller, H. L., & Charney, D. S. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.115 · Cited by 1,670 · see citing works

Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons

Watanabe, Y., Gould, E., & McEwen, B. S. (1992) · Brain Research · doi:10.1016/0006-8993(92)91597-8 · Cited by 1,212 · see citing works

Untreated Depression and Hippocampal Volume Loss

Sheline, Y. I., Gado, M. H., & Kraemer, H. C. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.8.1516 · Cited by 1,180 · see citing works

Reciprocal Connections between the Amygdala and the Hippocampal Formation, Perirhinal Cortex, and Postrhinal Cortex in Rat: A Review

Pitkänen, A., Pikkarainen, M., Nurminen, N., & Ylinen, A. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06738.x · Cited by 962 · see citing works

Comorbidity Patterns of Anxiety and Depressive Disorders in a Large Cohort Study: the Netherlands Study of Depression and Anxiety (NESDA)

Lamers, F., van Oppen, P., Comijs, H. C., Smit, J. H., Spinhoven, P., van Balkom, A. J. L. M., Nolen, W. A., Zitman, F. G., Beekman, A. T. F., & Penninx, B. W. J. H. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.10m06176blu · Cited by 913 · see citing works

Chronic Psychosocial Stress Causes Apical Dendritic Atrophy of Hippocampal CA3 Pyramidal Neurons in Subordinate Tree Shrews

Magariños, A. M., McEwen, B. S., Flügge, G., & Fuchs, E. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03534.1996 · Cited by 864 · see citing works

Can’t shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals

Siegle, G. J., Steinhauer, S. R., Thase, M. E., Stenger, V. A., & Carter, C. S. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01314-8 · Cited by 859 · see citing works

Attenuation of the Neural Response to Sad Faces in Major Depressionby Antidepressant Treatment: A Prospective, Event-Related Functional Magnetic Resonance ImagingStudy

Fu, C. H. Y., Williams, S. C. R., Cleare, A. J., Brammer, M. J., Walsh, N. D., Kim, J., Andrew, C. M., Pich, E. M., Williams, P. M., Reed, L. J., et al. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.9.877 · Cited by 775 · see citing works

Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated

Zobel, A. W., Nickel, T., Künzel, H. E., Ackl, N., Sonntag, A., Ising, M., & Holsboer, F. (2000) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(00)00016-9 · Cited by 705 · see citing works

The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety

Holsboer, F. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(98)90056-5 · Cited by 654 · see citing works

The stress system in depression and neurodegeneration: Focus on the human hypothalamus

Bao, A., Meynen, G., & Swaab, D. F. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.04.005 · Cited by 547 · see citing works

Chronic stress alters synaptic terminal structure in hippocampus

Magariños, A. M., Verdugo, J. M. G., & McEwen, B. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.14002 · Cited by 543 · see citing works

Hippocampal Changes in Patients With a First Episode of Major Depression

Frodl, T., Meisenzahl, E. M., Zetzsche, T., Born, C., Groll, C., Jäger, M., Leinsinger, G. L., Ronald Bottlender, A., Hahn, K. M., & Möller, H. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.7.1112 · Cited by 525 · see citing works

Decreased Benzodiazepine Receptor Binding in Prefrontal Cortex in Combat-Related Posttraumatic Stress Disorder

Bremner, J. D., Innis, R. B., Southwick, S. M., Staib, L. H., Zoghbi, S. S., & Charney, D. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.7.1120 · Cited by 449 · see citing works

Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress

Müller, M. B., Zimmermann, S., Sillaber, I., Hagemeyer, T. P., Deussing, J. M., Timpl, P., Kormann, M., Droste, S. K., Kühn, R., Reul, J. M. H. M., et al. (2003) · Nature Neuroscience · doi:10.1038/nn1123 · Cited by 446 · see citing works

Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice

Elliott, E., Ezra-Nevo, G., Regev, L., Neufeld-Cohen, A., & Chen, A. (2010) · Nature Neuroscience · doi:10.1038/nn.2642 · Cited by 436 · see citing works

Mesolimbic dopamine neurons in the brain reward circuit mediate susceptibility to social defeat and antidepressant action

Cao, J.-L., Covington, H. E., Friedman, A. K., Wilkinson, M. B., Walsh, J. J., Cooper, D. C., Nestler, E. J., & Han, M.-H. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3177-10.2010 · Cited by 402 · see citing works

Central CRH system in depression and anxiety — Evidence from clinical studies with CRH1 receptor antagonists

Holsboer, F., & Ising, M. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.12.032 · Cited by 380 · see citing works

Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice

Wellman, C. L., Izquierdo, A., Garrett, J. E., Martin, K. P., Carroll, J., Millstein, R., Lesch, K.-P., Murphy, D. L., & Holmes, A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4595-06.2007 · Cited by 366 · see citing works

Corticotropin Releasing Factor (CRF) Receptor Signaling in the Central Nervous System: New Molecular Targets

Hauger, R., Risbrough, V. B., Brauns, O., & Dautzenberg, F. M. (2006) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152706777950684 · Cited by 341 · see citing works

Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress

Li, S., Wang, C., Wang, M., Murakami, Y., & Matsumoto, K. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.01.004 · Cited by 329 · see citing works

Glutamatergic and Dopaminergic Neurons Mediate Anxiogenic and Anxiolytic Effects of CRHR1

Refojo, D., Schweizer, M. C., Kühne, C., Ehrenberg, S., Thoeringer, C. K., Vogl, A. M., Dedic, N., Schumacher, M., von Wolff, G., Avrabos, C., et al. (2011) · Science · doi:10.1126/science.1202107 · Cited by 313 · see citing works

Effects of Corticotropin-Releasing Factor on Neuronal Activity in the Serotonergic Dorsal Raphe Nucleus

Kirby, L. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00093-7 · Cited by 307 · see citing works

Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects

Neumeister, A., Wood, S. E., Bonne, O. B., Nugent, A. C., Luckenbaugh, D. A., Young, T. A., Bain, E., Charney, D. S., & Drevets, W. C. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.016 · Cited by 276 · see citing works

A 6-Week Randomized, Placebo-Controlled Trial of CP-316,311 (a Selective CRH ₁ Antagonist) in the Treatment of Major Depression

Binneman, B., Feltner, D., Kolluri, S., Shi, Y., Qiu, R., & Stiger, T. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07071199 · Cited by 254 · see citing works

Individual Differences in Reactivity to Social Stress Predict Susceptibility and Resilience to a Depressive Phenotype: Role of Corticotropin-Releasing Factor

Wood, S. K., Walker, H. E., Valentino, R. J., & Bhatnagar, S. (2010) · Endocrinology · doi:10.1210/en.2009-1026 · Cited by 251 · see citing works

The Neural Network that Regulates Energy Balance Is Responsive to Glucocorticoids and Insulin and Also Regulates HPA Axis Responsivity at a Site Proximal to CRF Neuronsa

Dallman, M. F., Akana, S. F., Strack, A. M., Hanson, E. S., & Sebastian, R. J. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44724.x · Cited by 250 · see citing works

Short‐term treatment with the antidepressant fluoxetine triggers pyramidal dendritic spine synapse formation in rat hippocampus

Hajszán, T., MacLusky, N. J., & Leranth, C. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03968.x · Cited by 239 · see citing works

Role of stress, corticotrophin releasing factor (CRF) and amygdala plasticity in chronic anxiety

Shekhar, A., Truitt, W., Rainnie, D., & Sajdyk, T. (2005) · Stress · doi:10.1080/10253890500504557 · Cited by 237 · see citing works

Effects of Corticotropin-Releasing Factor on Brain Serotonergic Activity

M Price, B. A. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00197-8 · Cited by 226 · see citing works

Prenatal stress increases corticotropin-releasing factor (CRF) content and release in rat amygdala minces

Cratty, M. S., Ward, H. E., Johnson, E. A., Azzaro, A. J., & Birkle, D. L. (1995) · Brain Research · doi:10.1016/0006-8993(95)00087-7 · Cited by 201 · see citing works

CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling

Magalhães, A. C., Holmes, K. D., Dale, L. B., Comps‐Agrar, L., Lee, D., Yadav, P. N., Drysdale, L., Poulter, M. O., Roth, B. L., Pin, J., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2529 · Cited by 198 · see citing works

Corticotropin Releasing Hormone, Receptor Regulation and the Stress Response

Aguilera, G. (1998) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(98)00079-4 · Cited by 195 · see citing works

Stress sensitivity and resilience in the chronic mild stress rat model of depression; an in situ hybridization study

Bergström, A., Jayatissa, M. N., Mørk, A., & Wiborg, O. (2007) · Brain Research · doi:10.1016/j.brainres.2007.12.025 · Cited by 195 · see citing works

Antidepressant-like effects of CP-154,526, a selective CRF1 receptor antagonist

Mansbach, R. S., Brooks, E. N., & Chen, Y. L. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)00025-3 · Cited by 195 · see citing works

Selective Phosphorylation of Nuclear CREB by Fluoxetine is Linked to Activation of CaM Kinase IV and MAP Kinase Cascades

Tiraboschi, E., Tardito, D., Kasahara, J., Moraschi, S., Pruneri, P., Gennarelli, M., Racagni, G., & Popoli, M. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300488 · Cited by 186 · see citing works

Synaptic physiology of central CRH system

Gallagher, J. P., Orozco-Cabal, L. F., Liu, J., & Shinnick‐Gallagher, P. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.075 · Cited by 177 · see citing works

The Role of Corticotropin-Releasing Hormone in the Dorsal Raphe Nucleus in Mediating the Behavioral Consequences of Uncontrollable Stress

Hammack, S. E., Richey, K. J., Schmid, M. J., LoPresti, M. L., Watkins, L. R., & Maier, S. F. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-01020.2002 · Cited by 167 · see citing works

Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling

Wang, X., Chen, Y., Wolf, M., Wagner, K. V., Liebl, C., Scharf, S. H., Harbich, D., Mayer, B., Wurst, W., Holsboer, F., et al. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.020 · Cited by 157 · see citing works

Lithium blocks stress-induced changes in depressive-like behavior and hippocampal cell fate: The role of glycogen-synthase-kinase-3β

Silva, R., Mesquita, A. R., Bessa, J. M., Sousa, J. C., Sotiropoulos, I., Leão, P., Almeida, O. F. X., & Sousa, N. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.12.026 · Cited by 157 · see citing works

Phosphorylation of MEK1 by cdk5/p35 Down-regulates the Mitogen-activated Protein Kinase Pathway

Sharma, P., Veeranna, Sharma, M., Amin, N. D., Sihag, R. K., Grant, P. G., Ahn, N. G., Kulkarni, A. B., & Pant, H. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109324200 · Cited by 150 · see citing works

Stress‐Specific Regulation of Corticotropin Releasing Hormone Receptor Expression in the Paraventricular and Supraoptic Nuclei of the Hypothalamus in the Rat

Luo, X., Kiss, A., Makara, G. B., Lolait, S. J., & Aguilera, G. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00636.x · Cited by 148 · see citing works

Association of anxiety and depression with microtubule-associated protein 2- and synaptopodin-immunolabeled dendrite and spine densities in hippocampal CA3 of older humans

Soetanto, A., Wilson, R. S., Talbot, K., Un, A., Schneider, J. A., Sobiesk, M., Kelly, J., Leurgans, S., Bennett, D. A., & Arnold, S. E. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.48 · Cited by 148 · see citing works

High-Affinity CRF1 Receptor Antagonist NBI-34041: Preclinical and Clinical Data Suggest Safety and Efficacy in Attenuating Elevated Stress Response

Ising, M., Zimmermann, U. S., Kunzel, H. E., Uhr, M., Foster, A. C., Learned, S. M., Holsboer, F., & Grigoriadis, D. E. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301328 · Cited by 143 · see citing works

Forced swim stress activates rat hippocampal serotonergic neurotransmission involving a corticotropin‐releasing hormone receptor‐dependent mechanism

Linthorst, A. C. E., Peñalva, R. G., Flachskamm, C., Holsboer, F., & Reul, J. M. H. M. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02400.x · Cited by 142 · see citing works

Overlapping neurobiology of learned helplessness and conditioned defeat: Implications for PTSD and mood disorders

Hammack, S. E., Cooper, M. A., & Lezak, K. R. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.02.024 · Cited by 142 · see citing works

Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase

Wang, Q., Zhou, Y., Wang, X., & Evers, B. M. (2005) · Oncogene · doi:10.1038/sj.onc.1209004 · Cited by 141 · see citing works

Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior

Lu, A., Steiner, M. A., Whittle, N., Vogl, A. M., Walser, S. M., Ableitner, M., Refojo, D., Ekker, M., Rubenstein, J. L. R., Stalla, G. K., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.51 · Cited by 136 · see citing works

Neurocircuitry of Stress Integration: Anatomical Pathways Regulating the Hypothalamo-Pituitary-Adrenocortical Axis of the Rat

Ziegler, D. R. (2002) · Integrative and Comparative Biology · doi:10.1093/icb/42.3.541 · Cited by 127 · see citing works

Acute or chronic stress induce cell compartment-specific phosphorylation of glucocorticoid receptor and alter its transcriptional activity in Wistar rat brain

Adžić, M., Djordjevic, J., Djordjevic, A. D., Niciforovic, A. P., Demonacos, C., Radojcic, M. B., & Krstic–Demonacos, M. (2009) · Journal of Endocrinology · doi:10.1677/joe-08-0509 · Cited by 125 · see citing works

Regulation of corticotropin-releasing factor neuronal systems and hypothalamic-pituitary-adrenal axis activity by stress and chronic antidepressant treatment

Stout, S. C., Owens, M. J., & Nemeroff, C. B. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.3.1085 · Cited by 117 · see citing works

The Naturalistic Course of Unipolar Major Depression in the Absence of Somatic Therapy

Posternak, M. A., Solomon, D. A., Leon, A. C., Mueller, T. I., Shea, M. T., Endicott, J., & Keller, M. B. (2006) · The Journal of Nervous and Mental Disease · doi:10.1097/01.nmd.0000217820.33841.53 · Cited by 113 · see citing works

Rats with congenital learned helplessness respond less to sucrose but show no deficits in activity or learning

Vollmayr, B., Bachteler, D., Vengeliene, V., Gass, P., Spanagel, R., & Henn, F. A. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00259-6 · Cited by 113 · see citing works

Antidepressant-like effects of CRF1 receptor antagonist SSR125543 in an animal model of depression

Overstreet, D. H., & Griebel, G. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.06.035 · Cited by 112 · see citing works

Chronic Ethanol Ingestion Facilitates N-Methyl-d-aspartate Receptor Function and Expression in Rat Lateral/Basolateral Amygdala Neurons

Floyd, D. W., Jung, K.-Y., & McCool, B. A. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.057505 · Cited by 109 · see citing works

Antidepressant effects of citalopram and CRF receptor antagonist CP-154,526 in a rat model of depression

Overstreet, D. H., Keeney, A. J., & Hogg, S. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.04.010 · Cited by 104 · see citing works

Increased Amygdala Volumes in Female and Depressed Humans. A Quantitative Magnetic Resonance Imaging Study

Tebartz van Elst, L., Woermann, F., Lemieux, L., & Trimble, M. R. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)00815-6 · Cited by 104 · see citing works

Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas

Refojo, D., Echenique, C., Müller, M. B., Reul, J. M. H. M., Deussing, J. M., Wurst, W., Sillaber, I., Páez-Pereda, M., Holsboer, F., & ARZT, E. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502070102 · Cited by 103 · see citing works

The Striatal-Enriched Protein Tyrosine Phosphatase Gates Long-Term Potentiation and Fear Memory in the Lateral Amygdala

Paul, S., Olausson, P., Venkitaramani, D. V., Ruchkina, I., Moran, T. D., Tronson, N. C., Mills, E., Hakim, S., Salter, M. W., Taylor, J. R., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.005 · Cited by 103 · see citing works

Chronic Administration of the Selective Corticotropin-Releasing Factor 1 Receptor Antagonist CP-154,526: Behavioral, Endocrine and Neurochemical Effects in the Rat

Arborelius, L., Skelton, K. H., Thrivikraman, K. V., Plotsky, P. M., Schulz, D. W., & Owens, M. J. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39110-4 · Cited by 101 · see citing works

Antidepressant actions on brain noradrenergic neurons.

Valentino, R. J., Curtis, A. L., Parris, D. G., & Wehby, R. G. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)13053-x · Cited by 95 · see citing works

The role of corticotropin-releasing factor and noradrenaline in stress-related responses, and the inter-relationships between the two systems

Dunn, A. J., & Swiergiel, A. H. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.069 · Cited by 94 · see citing works

Desipramine prevents stress-induced changes in depressive-like behavior and hippocampal markers of neuroprotection

Bravo, J. A., Díaz‐Véliz, G., Mora, S., Ulloa, J. L., Berthoud, V. M., Morales, P., Arancibia, S., & Fiedler, J. L. (2009) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32832c70d9 · Cited by 94 · see citing works

Overexpression of corticotropin‐releasing hormone in transgenic mice and chronic stress‐like autonomic and physiological alterations

Dirks, A., Groenink, L., Bouwknecht, J. A., Hijzen, T. H., van der Gugten, J., Ronken, E., Verbeek, J. S., Veening, J. G., Dederen, P. J. W. C., Kőrösi, A., et al. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02245.x · Cited by 91 · see citing works

Hypothalamus–pituitary–adrenal modifications consequent to chronic stress exposure in an experimental model of depression in rats

Raone, A., Cassanelli, A., Scheggi, S., Rauggi, R., Danielli, B., & Montis, M. G. D. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.03.027 · Cited by 89 · see citing works

Is Corticotropin‐Releasing Factor a Mediator of Stress Responses?a

Dunn, A. J., & Berridge, C. W. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb48360.x · Cited by 86 · see citing works

The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats

Jutkiewicz, E. M., Wood, S. K., Houshyar, H., Hsin, L., Rice, K. C., & Woods, J. H. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2164-z · Cited by 83 · see citing works

Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression

Hodgson, R. A., Higgins, G. A., Guthrie, D. H., Lu, S. X., Pond, A. J., Mullins, D. E., Guzzi, M. F., Parker, E. M., & Varty, G. B. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.12.021 · Cited by 82 · see citing works

The GABAB receptor antagonist CGP36742 improves learned helplessness in rats

Nakagawa, Y., Sasaki, A., & Takashima, T. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00567-1 · Cited by 81 · see citing works

Corticotropin-Releasing Factor, Interleukin-6, Brain-Derived Neurotrophic Factor, Insulin-Like Growth Factor-1, and Substance P in the Cerebrospinal Fluid of Civilians With Posttraumatic Stress Disorder Before and After Treatment With Paroxetine

Bonne, O. B., Gill, J., Luckenbaugh, D. A., Collins, C., Owens, M. J., Alesci, S., Neumeister, A., Yuan, P., Kinkead, B. L., Manji, H. K., et al. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05106blu · Cited by 75 · see citing works

Maintenance Treatment with Fluoxetine is Necessary to Sustain Normal Levels of Synaptic Markers in an Experimental Model of Depression: Correlation with Behavioral Response

Reinés, A. G., Cereseto, M., Ferrero, A., Sifonios, L. L., Podestá, M. F., & Wikinski, S. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301596 · Cited by 72 · see citing works

Distribution and expression of CRF receptor 1 and 2 mRNAs in the CRF over-expressing mouse brain

Kőrösi, A., Veening, J. G., Kozicz, T., Henckens, M. J. A. G., Dederen, J., Groenink, L., van der Gugten, J., Olivier, B., & Roubos, E. W. (2006) · Brain Research · doi:10.1016/j.brainres.2005.12.034 · Cited by 72 · see citing works

Altered CB1receptor‐signaling in prefrontal cortex from an animal model of depression is reversed by chronic fluoxetine

Rodríguez‐Gaztelumendi, A., Rojo, M. L., Pazos, Á., & Díaz, Á. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05898.x · Cited by 68 · see citing works

Impaired hypothalamic-pituitary-adrenal axis and its feedback regulation in serotonin transporter knockout mice

Jiang, X. X., Wang, J., Luo, T., & Li, Q. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.09.011 · Cited by 63 · see citing works

Long-Term Fluoxetine Treatment Modulates Cannabinoid Type 1 Receptor-Mediated Inhibition of Adenylyl Cyclase in the Rat Prefrontal Cortex through 5-Hydroxytryptamine1A Receptor-Dependent Mechanisms

Mato, S., Vidal, R., Castro, E., Díaz, Á., Pazos, Á., & Valdizán, E. M. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.060079 · Cited by 63 · see citing works

Chronic ethanol ingestion modulates proanxiety factors expressed in rat central amygdala

Läck, A. K., Floyd, D. W., & McCool, B. A. (2005) · Alcohol · doi:10.1016/j.alcohol.2005.07.004 · Cited by 61 · see citing works

Fluoxetine affects hippocampal plasticity, apoptosis and depressive-like behavior of chronically isolated rats

Djordjevic, A. D., Djordjevic, J., Elaković, I., Adžić, M., Matić, G. M., & Radojcic, M. B. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.10.006 · Cited by 60 · see citing works

Exposure to neonatal separation stress alters exploratory behavior and corticotropin releasing factor expression in neurons in the amygdala and hippocampus

Becker, K., Abraham, A., Kindler, J., Helmeke, C., & Braun, K. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20372 · Cited by 60 · see citing works

Low doses of corticotropin-releasing hormone injected into the dorsal raphe nucleus block the behavioral consequences of uncontrollable stress

Hammack, S. E., Pepin, J. L., DesMarteau, J. S., Watkins, L. R., & Maier, S. F. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00133-5 · Cited by 60 · see citing works

Corticotropin releasing factor receptor antagonists for major depressive disorder

Páez-Pereda, M., Hausch, F., & Holsboer, F. (2011) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2011.565330 · Cited by 59 · see citing works

Corticotropin-releasing hormone receptors mediate consensus interferon-alpha YM643-induced depression-like behavior in mice.

Yamano, M., Yuki, H., Yasuda, S., & Miyata, K. (2000) · PubMed · Cited by 58 · see citing works

Depolarization Activates ERK and Proline-rich Tyrosine Kinase 2 (PYK2) Independently in Different Cellular Compartments in Hippocampal Slices

Corvol, J., Valjent, E., Toutant, M., Enslen, H., Irinopoulou, T., Lev, S., Hervé, D., & Girault, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411312200 · Cited by 55 · see citing works

Rodent Models of Depression: Learned Helplessness Induced in Mice

Anisman, H., & Merali, Z. (2001) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0810cs14 · Cited by 54 · see citing works

Neuronal cytoskeletal alterations in an experimental model of depression

Reinés, A. G., Cereseto, M., Ferrero, A., Bonavita, C. D., & Wikinski, S. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.026 · Cited by 53 · see citing works

Repeated treatment with imipramine, fluvoxamine and tranylcypromine decreases the number of escape failures by activating dopaminergic systems in a rat learned helplessness test

Takamori, K., Yoshida, S., & Okuyama, S. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)01279-6 · Cited by 50 · see citing works

Identification of Signaling Molecules Mediating Corticotropin-Releasing Hormone-R1α-Mitogen-Activated Protein Kinase (MAPK) Interactions: The Critical Role of Phosphatidylinositol 3-Kinase in Regulating ERK1/2 But Not p38 MAPK Activation

Punn, A., Levine, M. A., & Grammatopoulos, D. K. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0255 · Cited by 50 · see citing works

Increased Cdk5/p35 activity in the dentate gyrus mediates depressive-like behaviour in rats

Zhu, W., Shi, H., Wang, S., Xu, C., Jiang, W., Wang, X., Wu, P., Li, Q., Ding, Z., & Lü, L. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000915 · Cited by 50 · see citing works

Corticotropin-releasing factor type-1 receptor antagonists: The next class of antidepressants?

Nielsen, D. M. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.06.003 · Cited by 49 · see citing works

Effects of repeated tianeptine treatment on CRF mRNA expression in non-stressed and chronic mild stress-exposed rats

Kim, S.-J., Park, S.-H., Choi, S.-H., Moon, B., Lee, K. J., Kang, S., Lee, M.-S., Choi, S.-H., Chun, B., & Shin, K.-H. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.12.003 · Cited by 48 · see citing works

Hippocampal serotonergic system is involved in anxiety-like behavior induced by corticotropin-releasing factor

Kagamiishi, Y., Yamamoto, T., & Watanabe, S. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.021 · Cited by 47 · see citing works

Synaptoproteomics of learned helpless rats involve energy metabolism and cellular remodeling pathways in depressive-like behavior and antidepressant response

Mallei, A., Giambelli, R., Gass, P., Racagni, G., Mathé, A. A., Vollmayr, B., & Popoli, M. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.12.012 · Cited by 44 · see citing works

Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation

Cuadrado‐Tejedor, M., Ricobaraza, A., Río, J. D., Frechilla, D., Franco, R., Pérez‐Mediavilla, A., & García‐Osta, A. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.01.005 · Cited by 42 · see citing works

Chronic treatment with fluoxetine decreases seizure threshold in naïve but not in rats exposed to the learned helplessness paradigm: Correlation with the hippocampal glutamate release

Ferrero, A. J., Cereseto, M., Reinés, A. G., Bonavita, C. D., Sifonios, L. L., Rubio‐Terres, C., & Wikinski, S. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.04.013 · Cited by 42 · see citing works

Electroconvulsive stimulations prevent stress-induced morphological changes in the hippocampus

Hageman, I., Nielsen, M., Wörtwein, G., Diemer, N. H., & Jørgensen, M. B. (2008) · Stress · doi:10.1080/10253890701783794 · Cited by 39 · see citing works

Mild stress facilitates learning and exercise improves retention in aged mice

Adlard, P. A., Engesser‐Cesar, C., & Cotman, C. W. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.10.001 · Cited by 37 · see citing works

A Single Episode of Restraint Stress Regulates Central Corticotrophin‐Releasing Hormone Receptor Expression and Binding in Specific Areas of the Mouse Brain

Greetfeld, M., Schmidt, M. V., Ganea, K., Sterlemann, V., Liebl, C., & Müller, M. B. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01865.x · Cited by 34 · see citing works

Corticotropin-Releasing Hormone1 Receptors Mediate Consensus Interferon-α YM643-Induced Depression-Like Behavior in Mice

Yamano, M., Yuki, H., Yasuda, S., & Miyata, K. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35275-9 · Cited by 34 · see citing works

Influence of Different Antidepressant Drugs on the Effect of Chronic Variable Stress on Restraint-Induced Dopamine Release in Frontal Cortex

Cuadra, G. R. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00234-2 · Cited by 32 · see citing works

Altered behavioural adaptation in mice with neural corticotrophin-releasing factor overexpression

Kasahara, M., Groenink, L., Breuer, M., Olivier, B., & Sarnyai, Z. (2007) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2006.00286.x · Cited by 29 · see citing works

Chronic treatment with the antidepressant amitriptyline decreases CRF-R1 receptor mRNA levels in the rat amygdala

Aubry, J., Pozzoli, G., & Vale, W. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00295-5 · Cited by 29 · see citing works

An enriched environment restores normal behavior while providing cytoskeletal restoration and synaptic changes in the hippocampus of rats exposed to an experimental model of depression

Sifonios, L. L., Trinchero, M. F., Cereseto, M., Ferrero, A., Cladouchos, M. L., Macedo, G. F., Reinés, A. G., & Wikinski, S. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.059 · Cited by 28 · see citing works

Persisting changes in basolateral amygdala mRNAs after chronic ethanol consumption

Falco, A. M., Bergstrom, H. C., Bachus, S. E., & Smith, R. F. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.09.019 · Cited by 26 · see citing works

Desipramine prevents the sustained increase in corticotropin‐releasing hormone‐like immunoreactivity induced by repeated immobilization stress in the rat central extended amygdala

Santibañez, M., Gysling, K., & Forray, M. I. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.21023 · Cited by 26 · see citing works

Involvement of corticotropin-releasing factor subtype 1 receptor in the acquisition phase of learned helplessness in rats

Takamori, K., Kawashima, N., Chaki, S., et al. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)01217-6 · Cited by 25 · see citing works

Cocaine and fluoxetine induce the expression of the hVH-5 gene encoding a MAP kinase phosphatase

Thiriet, N., Humblot, N., Burgun, C., et al. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00226-5 · Cited by 23 · see citing works

Altered Extracellular Signal-regulated Kinase Signal Transduction by the Muscarinic Acetylcholine and Metabotropic Glutamate Receptors after Cerebral Ischemia

Takagi, N., Miyake‐Takagi, K., Takagi, K., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108081200 · Cited by 22 · see citing works

Persistent anxiolytic affects after chronic administration of the CRF1 receptor antagonist R121919 in rats

Gutman, D. A., Owens, M. J., Thrivikraman, K. V., & Nemeroff, C. B. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.10.004 · Cited by 20 · see citing works

Circadian rhythmicity and behavioral depression: II. Effects of lighting schedules

Stewart, K. T., Rosenwasser, A. M., Levine, J. D., McEachron, D. L., Volpicelli, J. R., & Adler, N. T. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90277-b · Cited by 13 · see citing works

Cytoskeleton of hippocampal neurons as a target for valproic acid in an experimental model of depression

Ferrero, A. J., Cereseto, M., Sifonios, L. L., Reinés, A. G., Peixoto, E., Rubio‐Terres, C., & Wikinski, S. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.06.014 · Cited by 11 · see citing works

Fluoxetine potentiates the effects of corticotropin-releasing factor on locomotor activity and serotonergic systems in the roughskin newt, Taricha granulosa

Lowry, C. A., Hale, M. W., Burke, K. A., Renner, K. J., & Moore, F. L. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.04.006 · Cited by 11 · see citing works

The L-type calcium channel blocker nimodipine mitigates “learned helplessness” in rats

Saade, S., Balleine, B. W., & Minor, T. R. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00957-7 · Cited by 10 · see citing works

Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse

Van Pett, K., Viau, V., Bittencourt, J. C., Chan, R. K. W., Li, H.-Y., Arias, C., Prins, G. S., Perrin, M., Vale, W., & Sawchenko, P. E. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001211)428:2

Anxiety, depression, and the microbiome: A role for gut peptides

Lach, G., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0585-0 · Cited by 573 · see citing works

Stress in adolescence and drugs of abuse in rodent models: role of dopamine, CRF, and HPA axis

Burke, A. R., & Miczek, K. A. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3369-1 · Cited by 207 · see citing works

Antidepressant administration modulates stress-induced DNA methylation and DNA methyltransferase expression in rat prefrontal cortex and hippocampus

Sales, A. J., & Joca, S. R. L. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.01.022 · Cited by 47 · see citing works

CRF system and mood disorders

Aubry, J.-M. (2013) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2013.09.003 · Cited by 40 · see citing works

Reduced cell proliferation in the dentate gyrusis not correlated with the development of learned helplessness

Vollmayr, B., Simonis, C., Weber, S., Gass, P., & Henn, F. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00527-4 · Cited by 229 · see citing works

Fluoxetine-Induced Memory Impairment in Four Family Members

Huang, S.-C., Tsai, S., & Chang, J. C. C. (2004) · The International Journal of Psychiatry in Medicine · doi:10.2190/dy6d-33bp-5wpb-1vdx · Cited by 13 · see citing works

Biological and behavioural antidepressant treatment responses with the selective serotonin reuptake inhibitor fluoxetine can be determined by the environment

Licinio, A. W., Wong, M., & Licinio, J. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.68 · Cited by 5 · see citing works

Adverse Effects and Drug Interactions Associated with Fluoxetine Therapy

Hartshorn, E. A., Levinson, M. L., Lipsy, R. J., et al. (1991) · DICP · doi:10.1177/106002809102500617 · Cited by 23 · see citing works

Fluoxetine and the bleeding time.

Humphries, J. E., Wheby, M. S., & VandenBerg, S. R. (1990) · PubMed · Cited by 66 · see citing works