CRF system and mood disorders

Aubry, Jean-Michel

doi:10.1016/j.jchemneu.2013.09.003

Cited by 40Neuropeptides and Animal PhysiologyTreatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

CRF system and mood disorders

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Aubry, Jean-Michel·2013·Journal of Chemical Neuroanatomy

DOI 10.1016/j.jchemneu.2013.09.003

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Abstract

Since CRF discovery, there has been an impressive accumulation of data regarding the role of the CRF system in the regulation of the stress response. The link between stress and induction of a mood episode in the context of unipolar or bipolar disorder has been clearly demonstrated in several studies and is confirmed by clinical practice, particularly in bipolar disorder. Antidepressant-like effects of CRFR1 antagonists in different animal models of depression have generated a strong interest in the clinical development of CRFR1 antagonist for the treatment of major depressive disorder. These efforts have so far not been rewarded by clinical efficacy. However, this therapeutic approach is still being explored. Finally, the accumulated genetic findings, mostly those related to variants within CRFR1, point to a role of the CRF system in the pathophysiology of depression and anxiety.

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HPA alterations are more common and more pronounced in severely depressed patients with melancholic and/or psychotic features and in elderly depressed patients.
“they are more common and more pronounced in severely depressed patients with melancholic and/or psychotic features 68 and in elderly depressed patients 69”
From Major depressive disorder (2016) · cites this paper as [68]
CRF plays key role in orchestrating endocrine, behavioral, and GI responses to stress.
“CRF is a 41 amino-acid residue peptide that plays a key role in orchestrating the endocrine, behavioral, and GI responses to stress (for review, see [327][328][329]).”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [329]
When acute stress reactions become more frequent, it can lead to development of stress-related disorders, including anxiety and depression.
“However, when acute stress reactions become more frequent, it can lead to the development of stress-related disorders, including anxiety and depression (for review, see [329,339]).”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [329]
Antidepressant treatment normalizes expression of CRF and CRF1 receptors in association with remission of depression.
“Interestingly, antidepressant treatment normalizes expression of CRF and CRF 1 receptors in association with remission of depression [329,344,346].”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [329]

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Authors: Aubry, J.-M.
Affiliations: University Hospital of Geneva (CH)
Corresponding author: Aubry, Jean-Michel
ORCID: Aubry, Jean-Michel
Venue: Journal of Chemical Neuroanatomy
Publisher: Elsevier BV
Published: 2013-12
Volume: 54
Pages: 20-24
ISSN: 0891-0618 (ISSN-L)
DOI: 10.1016/j.jchemneu.2013.09.003
OpenAlex: W2049583584
Cited by: 40
References: 82
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 1
FWCI: 2.12
Type: journal article
Language: en
Open access: green
archive-ouverte.unige.ch
Licence: cc-by
Locations: Journal of Chemical Neuroanatomy (publishedVersion)
PubMed (publishedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: corticotropin-releasing factor, mood disorders, stress response, bipolar disorder, major depressive disorder, antidepressant effects, genetic variants, depression pathophysiology, anxiety
MeSH terms: Animals, Corticotropin-Releasing Hormone, Humans, Stress, Physiological, Stress, Psychological, Receptors, Corticotropin-Releasing Hormone, Mood Disorders

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