Activation of postsynaptic 5-HT1A receptors improve stress adaptation
Abstract
Rationale Serotonin-1A (5-HT1A) receptors modulate the stress response and have been implicated in the etiology and treatment of depression and anxiety disorders. A reduction in postsynaptic 5-HT1A receptor function in limbic areas has consistently been observed following exposure to chronic stress.Objectives To investigate the hypothesis that increased activation of 5-HT1A receptors in rats having reduced 5-HT function may improve stress adaptation and the behavioral sequelae commonly associated with chronic stress.Methods One hundred forty-four Sprague-Dawley rats received injections of para-chlorophenylalanine to partially deplete 5-HT then were given daily systemic pretreatment with the 5-HT1A receptor agonist, 8-hydroxy-2- (di-n-propylamino) tetralin (8-OH-DPAT), the antagonist, WAY 100635, or vehicle prior to either restraint stress (6 h/day for 10 daily sessions) or control conditions. Anxiety- and depressive-like behaviors were then assessed using the open field and sucrose preference tests. Protein level of hippocampal glucocorticoid receptors (GR) and mineralocorticoid receptors was detected by immunohistochemistry and brain-derived neurotrophic factor (BDNF) was determined by in situ hybridization.Results 8-OH-DPAT pretreatment prior to stress exposure attenuated later stress-induced anxiety- and depression-like behaviors and increased GR and BDNF mRNA expression in the hippocampus relative to vehicle- and WAY 100635-pretreated, stressed animals.Conclusion The stress-related impairments associated with 5-HT deficiency can be improved by 8-OH-DPAT pretreatment prior to stress exposure and are associated with an augmentation of GR-like immunoreactivity and BDNF mRNA expression in the hippocampus. It suggested that selective activation of 5-HT1A receptors may be a potential treatment strategy for stress-related disorders such as anxiety and depression.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
5-HT1A-R agonists such as Buspirone display anxiolytic-like properties in assorted preclinical assays.
“5-HT1A-R agonists, such as Buspirone, display also anxiolytic-like properties in assorted preclinical assays (e.g., Roncon et al., 2013; Saito et al., 2013; Zhou et al., 2014)”
From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Zhou et al., 2014
Cites
International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).
Hoyer, D., Clarke, D. E., Fozard, J. R., Hartig, P. R., Martin, G. R., Mylecharane, E. J., Saxena, P. R., & Humphrey, P. P. A. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06783-3 · Cited by 2,997 · see citing works
Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders
Sapolsky, R. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.925 · Cited by 2,016 · see citing works
Neurotrophins and Neuronal Plasticity
Thoenen, H. (1995) · Science · doi:10.1126/science.270.5236.593 · Cited by 1,927 · see citing works
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654 · see citing works
Smith, M., Makino, S., Květňanský, R., & Post, R. M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-01768.1995 · Cited by 1,429 · see citing works
Conner, J. M., Lauterborn, J. C., Yan, Q., Gall, C. M., & Varon, S. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02295.1997 · Cited by 1,097 · see citing works
Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult
Gross, C. T., Zhuang, X., Stark, K. L., Ramboz, S., Oosting, R. S., Kirby, L. G., Santarelli, L., Beck, S. G., & Hen, R. (2002) · Nature · doi:10.1038/416396a · Cited by 906 · see citing works
Castrén, E., & Rantamäki, T. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20758 · Cited by 864 · see citing works
Pompeiano, M., Palacios, J., & Mengod, G. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00440.1992 · Cited by 699 · see citing works
5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants
Richardson-Jones, J. W., Craige, C. P., Guiard, B. P., Stephen, A., Metzger, K. L., Kung, H. F., Gardier, A. M., Dranovsky, A., David, D. J., Beck, S. G., et al. (2010) · Neuron · doi:10.1016/j.neuron.2009.12.003 · Cited by 450 · see citing works
Chalmers, D. T., & Watson, S. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)90748-k · Cited by 388 · see citing works
Vergé, D., Daval, G., Patey, A., GOZLAN, H., Mestikawy, S. E., & Hamon, M. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90099-8 · Cited by 385 · see citing works
Ridder, S., Chourbaji, S., Hellweg, R., Urani, A., Zacher, C., Schmid, W., Zink, M., Hörtnagl, H., Flor, H., Henn, F. A., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0736-05.2005 · Cited by 382 · see citing works
Russo-Neustadt, A., Ha, T., Ramirez, R., & Kesslak, J. P. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00364-8 · Cited by 346 · see citing works
Hormones and the Stressed Brain
DE KLOET, E. R. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.001 · Cited by 314 · see citing works
Immobilization stress reduced the expression of neurotrophins and their receptors in the rat brain
Ueyama, T., Kawai, Y., Nemoto, K., Sekimoto, M., Toné, S., & Senba, E. (1997) · Neuroscience Research · doi:10.1016/s0168-0102(97)00030-8 · Cited by 303 · see citing works
Corticosterone effects on BDNF expression in the hippocampus. Implications for memory formation
Schaaf, M. J. M., De Kloet, E. R., & Vreugdenhil, E. (2000) · Stress · doi:10.3109/10253890009001124 · Cited by 270 · cited 1× · see citing works
“This may be due to the binding of the cortisol–GR complex with phosphorylated cAMP response element binding protein (CREB), preventing CREB phosphorylation and blocking the expression of BDNF (Schaaf et al. 2000).”
BackgroundGap Junction Dysfunction in the Prefrontal Cortex Induces Depressive-Like Behaviors in Rats
Sun, J.-D., Liu, Y., Yuan, Y.-H., Li, J., & Chen, N.-H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.319 · Cited by 258 · see citing works
Glucocorticoid receptor overexpression in forebrain: A mouse model of increased emotional lability
Wei, Q., Lu, X., Liu, L., Schafer, G. L., Shieh, K.-R., Burke, S., Robinson, T. E., Watson, S. J., Seasholtz, A. F., & Akil, H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402208101 · Cited by 249 · see citing works
Smith, M. A., Makino, S., Kim, S. Y., & Květňanský, R. (1995) · Endocrinology · doi:10.1210/endo.136.9.7649080 · Cited by 226 · see citing works
Luo, D. D., An, S. C., & Zhang, X. (2008) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2008.05.010 · Cited by 155 · see citing works
Serotonin regulates type II corticosteroid receptor binding in hippocampal cell cultures
Mitchell, J., Rowe, W. B., Boksa, P., & Meaney, M. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-06-01745.1990 · Cited by 153 · see citing works
Transcriptional regulation of the 5-HT 1A receptor: implications for mental illness
Albert, P. R. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0376 · Cited by 137 · see citing works
Joca, S. R. L., Ferreira, F. R., & Guimarães, F. S. (2007) · Stress · doi:10.1080/10253890701223130 · Cited by 137 · see citing works
Bambico, F. R., Nguyen, N.-T., & Gobbi, G. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.11.005 · Cited by 127 · see citing works
Anterograde transport of endogenous brain-derived neurotrophic factor in hippocampal mossy fibers
Smith, M. A., Zhang, L., Lyons, W. E., & Mamounas, L. A. (1997) · Neuroreport · doi:10.1097/00001756-199705260-00008 · Cited by 122 · see citing works
Hippocampal 5-HT receptors and consolidation of stressful memories
Guimarães, F. S., Bel, E. A. D., Padovan, C. M., Netto, S. M., & Titze‐de‐Almeida, R. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90098-b · Cited by 112 · see citing works
Investigating anxiety and depressive-like phenotypes in genetic mouse models of serotonin depletion
Fernández, S. P., & Gaspar, P. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.049 · Cited by 108 · see citing works
Analysis of the role of 5-HT1A receptors in spatial and aversive learning in the rat
Lüttgen, M., Elvander-Tottie, E., Madjid, N., & Ögren, S. O. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.01.007 · Cited by 96 · see citing works
The 5-HT1A receptor and its ligands: structure and function
Olivier, B., Soudijn, W., & van Wijngaarden, I. (1999) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8730-4_3 · Cited by 83 · see citing works
Ferrés‐Coy, A., Santana, N., Castañé, A., Cortés, R., Carmona, M. C., Tóth, M., Montefeltro, A., Artigas, F., & Bortolozzi, A. A. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2795-9 · Cited by 69 · see citing works
Rainer, Q., Nguyen, H. T., Quesseveur, G., Gardier, A. M., David, D. J. P., & Guiard, B. P. (2011) · Molecular Pharmacology · doi:10.1124/mol.111.075796 · Cited by 64 · see citing works
Misane, I. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00109-8 · Cited by 62 · see citing works
Zhou, J., Li, L., Tang, S., Cao, X., Li, Z., Li, W., Li, C.-Q., & Zhang, X. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.06.009 · Cited by 62 · see citing works
Stress adaptation and hypersensitivity in 5-HT neuronal systems after repeated foot shock
Ohi, K., Mikuni, M., & Takahashi, K. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90566-2 · Cited by 57 · see citing works
Effects of intra-hippocampal infusion of WAY-100635 on plus-maze behavior in mice
Nunes‐de‐Souza, R. L., Canto‐de‐Souza, A., & Rodgers, R. J. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03335-2 · Cited by 56 · see citing works
First, M., Gil‐Ad, I., Taler, M., Tarasenko, I., Novak, N., & Weizman, A. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9872-8 · Cited by 44 · see citing works
Kornum, B. R., Licht, C. L., Weikop, P., Knudsen, G. M., & Aznar, S. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.09.013 · Cited by 39 · see citing works
Joca, S. R. L., Zanelati, T., & Guimarães, F. S. (2006) · Brain Research · doi:10.1016/j.brainres.2006.03.034 · Cited by 37 · see citing works
Haleem, D. J. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70604-1 · Cited by 34 · see citing works
Tsuji, M., Takeda, H., & Matsumiya, T. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704276 · Cited by 34 · see citing works
Haleem, D. J. (2008) · Appetite · doi:10.1016/j.appet.2008.07.009 · Cited by 32 · see citing works
Datla, K. P., & Curzon, G. (1996) · Neuropharmacology · doi:10.1016/0028-3908(96)00175-x · Cited by 29 · see citing works
Pre- or postsynaptic activity of 5-HT1A compounds in mice depends on the anxiety paradigm
López‐Rubalcava, C. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(96)00018-4 · Cited by 28 · see citing works
Body, S., Kheramin, S., Mobini, S., Ho, M.-Y., Velázquez-Martínez, D. N., Bradshaw, C. M., & Szabadi, E. (2002) · Behavioural Pharmacology · doi:10.1097/00008877-200212000-00001 · Cited by 28 · see citing works
Wesołowska, A., Paluchowska, M. H., & Chojnacka-Wójcik, E. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01814-4 · Cited by 22 · see citing works
Differences in 5-HT1A receptor-mediated hypothermia in rats with low or high exploratory activity
Kõiv, K., & Harro, J. (2010) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e328340a039 · Cited by 5 · see citing works
Zhou, J., Li, L., Cao, X., Zhang, X., Li, W., & Li, Z.-X. (2008) · PubMed · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Serotonin and brain function: a tale of two receptors
Carhart-Harris, R., & Nutt, D. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117725915 · Cited by 739 · see citing works
“…and although there are some contradictory findings (File et al., 1996), this effect appears to be mediated by postsynaptic 5-HT1AR signalling (Celada et al., 2013a; Gross et al., 2002; Piszczek et al., 2015; Stefanski et al., 1993; Tauscher et al., 2001; Tu et al., 2014; Zhou et al., 2008, 2014).”
BackgroundCannabidiol as a Potential Treatment for Anxiety Disorders
Blessing, E., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015) · Neurotherapeutics · doi:10.1007/s13311-015-0387-1 · Cited by 718 · see citing works
“In preclinical studies, 5-HT1AR agonists are anxiolytic in animal models of general anxiety [51], prevent the adverse effects of stress [52], and enhance fear extinction [53].”
BackgroundThe endocannabinoid system as a target for novel anxiolytic drugs
Patel, S., Hill, M. N., Cheer, J. F., Wotjak, C. T., & Holmes, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.033 · Cited by 233 · see citing works
“This is notable because 5-HT1A-R agonists, such as Buspirone, display also anxiolytic-like properties in assorted preclinical assays (e.g., Roncon et al., 2013; Saito et al., 2013; Zhou et al., 2014) and are clinically prescribed for various Anxiety Disorders, with reasonable response rates (Blessing et al.”
BackgroundForrester, S. D., & Towell, T. L. (2015) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2015.02.007 · Cited by 117 · see citing works
Neuronal and behavioral plasticity: the role of serotonin and BDNF systems tandem
Popova, N. K., & Naumenko, V. S. (2019) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2019.1572747 · Cited by 105 · see citing works
“induced by 5-HT1A receptor activation [157,158] and a decrease in BDNF level upon 5-HT1A receptor suppression [159].”
BackgroundBiomarkers of Epileptogenesis: Psychiatric Comorbidities (?)
Kanner, A. M., Mazarati, A. M., & Koepp, M. J. (2014) · Neurotherapeutics · doi:10.1007/s13311-014-0271-4 · Cited by 103 · see citing works
Silote, G. P., Sartim, A. G., Sales, A. J., Eskelund, A., Guimarães, F. S., Wegener, G., & Joca, S. R. L. (2019) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2019.04.006 · Cited by 93 · see citing works
Popova, N. K., Tsybko, A. S., & Naumenko, V. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158814 · Cited by 81 · see citing works
Circuits Regulating Pleasure and Happiness—Mechanisms of Depression
LOONEN, A. J. M., & Ivanova, S. А. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00571 · Cited by 71 · see citing works
“Also, chronic SSRI-mediated stimulation of 5-HT1A receptors appeared to repair the MR/GR imbalance (Lai et al., 2003; Zhou et al., 2014).”
BackgroundCommon Mechanisms Underlying Epileptogenesis and the Comorbidities of EpilepsyPreprint
Mazarati, A. M., & Sankar, R. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a022798 · Cited by 48 · see citing works
“Selective stimulation of postsynaptic 5-HT1A receptors ameliorates experimental models of depression (Llado-Pelfort et al. 2010; Zhou et al. 2014).”
BackgroundHe, C., Fan, K. C., Hao, Z., Tang, N., Li, G., & Wang, S. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.900847 · Cited by 40 · see citing works
Rossi, G. N., Guerra, L. T. L., Baker, G. B., Dursun, S. M., Bouso, J. C., Hallak, J. E. C., & SANTOS, R. G. D. (2022) · Biomolecules · doi:10.3390/biom12111618 · Cited by 33 · see citing works
The role of serotonin neurotransmission in rapid antidepressant actions
Pehrson, A. L., Roberts, D., Khawaja, A., & McNair, R. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06098-5 · Cited by 33 · see citing works
Murata, Y., Yanagihara, Y. T., Mori, M., Mine, K., & Enjoji, M. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.03.054 · Cited by 29 · see citing works
Takahashi, K., Hong, L., Kurokawa, K., Miyagawa, K., Mochida-Saito, A., Takeda, H., & Tsuji, M. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110666 · Cited by 23 · see citing works
Li, G., Ping, J., Liu, Z., Li, Z., Ma, H., Tu, W., Zhang, W., & Zhuo, C. (2017) · Oncotarget · doi:10.18632/oncotarget.17891 · Cited by 23 · see citing works
Zhong, Y., Du, Q., Wang, Z., Zheng, Q., Yang, M., Hu, P., Yang, Q., Xu, H., Wu, Z., Huang, X., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116840 · Cited by 22 · see citing works
5-HT1A Receptors on Dentate Gyrus Granule Cells Confer Stress Resilience
Bickle, J., Li, Y., Millette, A., Dixon, R. S., Wu, S. S., Arias, E. C., Luna, V. M., & Anacker, C. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.10.007 · Cited by 14 · see citing works
Kurokawa, K., Takahashi, K., Miyagawa, K., Mochida-Saito, A., Takeda, H., & Tsuji, M. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105213 · Cited by 12 · see citing works
Wang, L., Han, D., Yin, P., Teng, K., Xu, J., & Ma, Y. (2019) · Stress · doi:10.1080/10253890.2019.1625328 · Cited by 12 · see citing works
Guldager, M. B., Biojone, C., da Silva, N. R., Godoy, L. D., & Joca, S. R. L. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111029 · Cited by 10 · see citing works
“…with findings indicating both facilitatory, inhibitory or no effect of serotonin depletion on BDNF levels in the brain of animals treated with antidepressants (Zhou et al., 2014; Kronenberg et al., 2018; Jin et al., 2017; Saadati et al., 2021; N ¨ aslund et al., 2020; Foltran et al., 2019).”
BackgroundKang, Y., Jung, J., Han, K., Auer, D. P., & Ham, B. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120607 · Cited by 8 · see citing works
Borgmann, M., Holtkamp, M., Adli, M., & Behr, J. (2015) · Der Nervenarzt · doi:10.1007/s00115-015-0026-4 · Cited by 8 · see citing works
Liu, J., Tong, R., Lu, Z., Wang, Z., Wang, Y., Liu, Y., Yuan, H., Jia, F., Zhang, X., Li, Z., et al. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1398733 · Cited by 5 · see citing works
Mustafa, N., Afroz, R., Batool, Z., Salman, T., Nawaz, S., & Haleem, D. J. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177275 · Cited by 4 · see citing works
Peyton, J., Kramer, K., Quesnell, B., & Cital, S. N. (2021) · Springer eBooks · doi:10.1007/978-3-030-68317-7_7 · Cited by 3 · see citing works
Thakurdesai, P. A., Nimse, S. R., Kore, P. S., & Aswar, U. M. (2024) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/2896 · Cited by 3 · see citing works
Valerio, A. K. S., Pérez-Vielma, N. M., Miliar-García, Á., Gómez‐López, M., García-García, C., & Aguilera-Sosa, V. R. (2020) · Acta de Investigación Psicológica · doi:10.22201/fpsi.20074719e.2020.3.361 · Cited by 2 · see citing works
Indicadores sistêmicos de segurança da terapia canábica para dermatite atópica canina
Mariga, C., Villa, E. L., Joner, A. V., de Freitas, B. P., Coelho, P. F., Soares, A. V., Düllius, A. I. D. S., Amazonas, E. D. A., & Filho, S. T. L. P. (2024) · ACTA SCIENTIAE VETERINARIAE · doi:10.22456/1679-9216.134918 · Cited by 1 · see citing works
Depression und Epilepsie: Zwei Krankheitsbilder mit gemeinsamen Ursachen?
Borgmann, M., Holtkamp, M., Adli, M., & Behr, J. (2016) · Der Nervenarzt · Cited by 1 · see citing works
Dorsal raphe serotonergic neurons mediate depression in a mouse model of loss of control over stressPreprint
Li, Y., Li, Y., Zheng, Q., Qian, Z., Li, N., Wei, C., Han, J., Liu, Z., Ren, W., & Qiao, H. (2022) · Research Square · doi:10.21203/rs.3.rs-1645735/v1
Peyton, J., Kramer, K., Quesnell, B., & Cital, S. N. (2024) · Springer eBooks · doi:10.1007/978-3-031-67821-9_7
Kang, Y., Jung, J., Han, K., Auer, D. P., & Ham, B. (2025) · medRxiv · doi:10.1101/2025.08.26.25334436
“Several of these studies have revealed that chronic administration of antidepressants decreases excitatory neurotransmission and restores inhibitory control within the amygdala, contributing to improved emotional regulation (Pehrson et al., 2022; J. Zhou et al., 2014; W. Zhou et al., 2014).”
Abdolmaleki, N., Shahidi, ., Rohani, A. H., & Habibi, P. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115901
Yates, J. R. (2026) · Springer eBooks · doi:10.1007/978-3-032-15602-0_9
Anxiolytic Effects of Cannabigerol: Hype or Hope?
Rahimian, M., Ali, S., Obeng, S., & Tagne, A. M. (2026) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2026.105055
- Authors
- Zhou, J., Cao, X., Mar, A. C., Ding, Y.-Q., Wang, X., Li, Q., & Li, L.
- Affiliations
- Central South University (CN)
- University of Cambridge (GB)
- University of Hong Kong (HK)
- Corresponding author
- Li, Lingjiang
- Venue
- Psychopharmacology
- Published
- 2013-11-21
- Volume
- 231
- Issue
- 10
- Pages
- 2067-2075
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W1986039782
- Cited by
- 36
- References
- 48
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 2 · 2022: 6 · 2021: 2 · 2020: 1 · 2019: 3 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 1
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- 5-HT1A receptor, serotonin, chronic stress, stress adaptation, anxiety-like behavior, depression-like behavior, 8-OH-DPAT, WAY-100635, serotonin depletion, p-chlorophenylalanine, glucocorticoid receptor, mineralocorticoid receptor, brain-derived neurotrophic factor, hippocampus, restraint stress, stress-related disorders
- MeSH terms
- Adaptation, Psychological, Animals, Behavior, Animal, Brain, Male, Motor Activity, Fenclonine, Piperazines, Pyridines, Serotonin, Stress, Psychological, Rats, Sprague-Dawley, 8-Hydroxy-2-(di-n-propylamino)tetralin, Receptor, Serotonin, 5-HT1A, Rats, Serotonin 5-HT1 Receptor Agonists, Serotonin 5-HT1 Receptor Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
